{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:25:48Z","timestamp":1791379548082,"version":"4.3.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T00:00:00Z","timestamp":1337472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1756-9966-31-48","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T15:54:47Z","timestamp":1337529287000},"source":"Crossref","is-referenced-by-count":62,"title":["Down-regulation of the PI3K\/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin"],"prefix":"10.1186","volume":"31","author":[{"given":"Yi","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiannan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,20]]},"reference":[{"key":"570_CR1","volume-title":"J Oncol","author":"JM God","year":"2010","unstructured":"God JM, Haque A: Burkitt lymphoma: pathogenesis and immune evasion. J Oncol. 2010, pii: 516047. Epub 2010 Oct 5. PMID: 20953370"},{"issue":"7","key":"570_CR2","first-page":"CD005198","volume":"6","author":"JU Okebe","year":"2011","unstructured":"Okebe JU, Skoetz N, Meremikwu MM, Richards S: Therapeutic interventions for Burkitt lymphoma in children. Cochrane Database Syst Rev. 2011, 6 (7): CD005198-","journal-title":"Cochrane Database Syst Rev"},{"key":"570_CR3","volume-title":"Biopharm Drug Dispos","author":"C Li","year":"2011","unstructured":"Li C, Lin G, Zuo Z: Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. Biopharm Drug Dispos. 2011, 10.1002\/bdd.771. [Epub ahead of print]"},{"key":"570_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ctrv.2008.09.005","volume":"35","author":"M Li-Weber","year":"2009","unstructured":"Li-Weber M: New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009, 35: 57-68. 10.1016\/j.ctrv.2008.09.005.","journal-title":"Cancer Treat Rev"},{"key":"570_CR5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3109\/00498251003663724","volume":"40","author":"NR Srinivas","year":"2010","unstructured":"Srinivas NR: Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 2010, 40: 357-10.3109\/00498251003663724.","journal-title":"Xenobiotica"},{"key":"570_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1142\/S0192415X06003801","volume":"34","author":"DE Shieh","year":"2006","unstructured":"Shieh DE, Cheng HY, Yen MH, Chiang LC, Lin CC: Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Am J Chin Med. 2006, 34: 245-261. 10.1142\/S0192415X06003801.","journal-title":"Am J Chin Med"},{"key":"570_CR7","first-page":"117","volume":"27","author":"HF Lu","year":"2007","unstructured":"Lu HF, Hsueh SC, Ho YT, Kao MC, Yang JS, Chiu TH, Huamg SY, Lin CC, Chung JG: ROS mediates baicalin-induced apoptosis in human promyelotic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. Anticancer Res. 2007, 27: 117-126.","journal-title":"Anticancer Res"},{"key":"570_CR8","first-page":"1198","volume":"17","author":"J Zheng","year":"2009","unstructured":"Zheng J, Hu JD, Huang Y, Chen BY: Effects of baicalin on proliferation and apoptosis of adriamycin-resistant human leukemia HL-60\/ADR cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009, 17: 1198-1202.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"570_CR9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.leukres.2006.08.019","volume":"31","author":"T Kumagai","year":"2007","unstructured":"Kumagai T, M\u00fcller CI, Desmond JC, Imai Y, Heber D, Koeffler HP: Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk Res. 2007, 31: 523-530. 10.1016\/j.leukres.2006.08.019.","journal-title":"Leuk Res"},{"key":"570_CR10","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2174\/187152009788451851","volume":"9","author":"K Kawauchi","year":"2009","unstructured":"Kawauchi K, Ogasawara T, Yasuyama M, Otsuka K, Yamada O: The PI3K\/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009, 9: 550-559.","journal-title":"Anticancer Agents Med Chem"},{"key":"570_CR11","doi-asserted-by":"publisher","first-page":"5374","DOI":"10.1158\/1078-0432.CCR-10-0480","volume":"16","author":"C Vu","year":"2010","unstructured":"Vu C, Fruman DA: Target of rapamycin signaling in leukemia and lymphoma. Clin Cancer Res. 2010, 16: 5374-5380. 10.1158\/1078-0432.CCR-10-0480.","journal-title":"Clin Cancer Res"},{"key":"570_CR12","first-page":"477","volume":"64","author":"IT Magrath","year":"1980","unstructured":"Magrath IT, Freeman CB, Pizzo P, Gadek J, Jaffe E, Santaella M, Hammer C, Frank M, Reaman G, Novikovs L: Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen. II. Surface markers. J Natl Cancer Inst. 1980, 64: 477-483.","journal-title":"J Natl Cancer Inst"},{"key":"570_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1600-0609.2009.01365.x","volume":"84","author":"S Liu","year":"2009","unstructured":"Liu S, Ma Z, Cai H, Qian L, Rong W, Kawano M: Inhibitory effect of baicalein on IL-6-mediated cascades in human myeloma cells. Eur J Hematol. 2009, 84: 137-144.","journal-title":"Eur J Hematol"},{"key":"570_CR14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1055\/s-2002-20246","volume":"68","author":"WH Chang","year":"2002","unstructured":"Chang WH, Chen CH, Lu FJ: Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Med. 2002, 68: 128-132.","journal-title":"Planta Med"},{"key":"570_CR15","first-page":"2885","volume":"22","author":"E Ciesielska","year":"2002","unstructured":"Ciesielska E, Gwardys A, Metodiewa D: Anticancer, antiradical and antioxidative actions of novel Antoksyd S and its major components, baicalin and baicalein. Anticancer Res. 2002, 22: 2885-2891.","journal-title":"Anticancer Res"},{"key":"570_CR16","doi-asserted-by":"publisher","first-page":"3312","DOI":"10.1182\/blood-2004-10-3915","volume":"105","author":"Z Ma","year":"2005","unstructured":"Ma Z, Otsuyama K, Liu S, Abroun S, Ishikawa H, Tsuyama N, Obata M, Li FJ, Zheng X, Maki Y, Miyamoto K, Kawano MM: Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood. 2005, 105: 3312-3318. 10.1182\/blood-2004-10-3915.","journal-title":"Blood"},{"key":"570_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.taap.2006.05.008","volume":"216","author":"YC Chen","year":"2006","unstructured":"Chen YC, Chow JM, Lin CW, Wu CY, Shen SC: Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6. Toxicol Appl Pharmacol. 2006, 216: 263-273. 10.1016\/j.taap.2006.05.008.","journal-title":"Toxicol Appl Pharmacol"},{"key":"570_CR18","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.bbamcr.2007.04.008","volume":"1773","author":"HY Lin","year":"2007","unstructured":"Lin HY, Shen SC, Lin CW, Yang LY, Chen YC: Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim Biophys Acta. 2007, 1773: 1073-1086. 10.1016\/j.bbamcr.2007.04.008.","journal-title":"Biochim Biophys Acta"},{"key":"570_CR19","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1038\/aps.2009.166","volume":"30","author":"QM Zhou","year":"2009","unstructured":"Zhou QM, Wang S, Zhang H, Lu YY, Wang XF, Motoo Y, Su SB: The combination of baicalin and baicalein enhances apoptosis via the ERK\/p38 MAPK pathway in human breast cancer cells. Acta Pharmacol Sin. 2009, 30: 1648-1658. 10.1038\/aps.2009.166.","journal-title":"Acta Pharmacol Sin"},{"key":"570_CR20","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/sj.leu.2402824","volume":"17","author":"F Chang","year":"2003","unstructured":"Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA: Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia. 2003, 17: 590-603. 10.1038\/sj.leu.2402824.","journal-title":"Leukemia"},{"key":"570_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2174\/156800908783497140","volume":"8","author":"E Tokunaga","year":"2008","unstructured":"Tokunaga E, Oki E, Egashira A, Sadanaga N, Morita M, Kakeji Y, Maehara Y: Deregulation of the Akt pathway in human cancer. Curr Cancer Drug Targets. 2008, 8: 27-36. 10.2174\/156800908783497140.","journal-title":"Curr Cancer Drug Targets"},{"key":"570_CR22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/sj.cdd.4401549","volume":"12","author":"SM Uriarte","year":"2005","unstructured":"Uriarte SM, Joshi-Barve S, Song Z, Sahoo R, Gobejishvili L, Jala VR, Haribabu B, McClain C, Barve S: Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes. Cell Death Differ. 2005, 12: 233-242. 10.1038\/sj.cdd.4401549.","journal-title":"Cell Death Differ"},{"key":"570_CR23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.leu.2403679","volume":"19","author":"E Escobar-D\u00edaz","year":"2005","unstructured":"Escobar-D\u00edaz E, L\u00f3pez-Mart\u00edn EM, Hern\u00e1ndez Del Cerro M, Puig-Kroger A, Soto-Cerrato V, Montaner B, Giralt E, Garc\u00eda-Marco JA, P\u00e9rez-Tom\u00e1s R, Garcia-Pardo A: AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt\/NF-kappaB survival pathway. Leukemia. 2005, 19: 572-579.","journal-title":"Leukemia"},{"key":"570_CR24","volume-title":"J Cell Physiol","author":"Y Chen","year":"2011","unstructured":"Chen Y, Wang BC, Xiao Y: PI3K: A potential therapeutic target for cancer. J Cell Physiol. 2011, 10.1002\/jcp.23038. Sep 21. [Epub ahead of print]"},{"key":"570_CR25","volume-title":"Curr Opin Cell Biol","author":"E Dazert","year":"2011","unstructured":"Dazert E, Hall MN: mTOR signaling in disease. Curr Opin Cell Biol. 2011, Sep 29 [Epub ahead of print]"}],"container-title":["Journal of Experimental & Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-9966-31-48.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-9966-31-48\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-9966-31-48.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T08:28:45Z","timestamp":1548232125000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/1756-9966-31-48"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,20]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["570"],"URL":"https:\/\/doi.org\/10.1186\/1756-9966-31-48","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,20]]},"article-number":"48"}}