{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:47:02Z","timestamp":1759063622420},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Exp Clin Cancer Res"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1756-9966-32-27","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T10:14:07Z","timestamp":1368526447000},"source":"Crossref","is-referenced-by-count":21,"title":["Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines"],"prefix":"10.1186","volume":"32","author":[{"given":"Ina","family":"Patties","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf-Dieter","family":"Kortmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annegret","family":"Glasow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"667_CR1","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/nature09587","volume":"468","author":"P Gibson","year":"2010","unstructured":"Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J: Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010, 468: 1095-1099. 10.1038\/nature09587.","journal-title":"Nature"},{"key":"667_CR2","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1215\/15228517-2008-059","volume":"10","author":"JM de Bont","year":"2008","unstructured":"de Bont JM, Packer RJ, Michiels EM, den Boer ML, Pieters R: Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective. Neuro Oncol. 2008, 10: 1040-1060. 10.1215\/15228517-2008-059.","journal-title":"Neuro Oncol"},{"key":"667_CR3","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/ijc.24331","volume":"125","author":"A Rossi","year":"2009","unstructured":"Rossi A, Russo G, Puca A, La MR, Caputo M, Mattioli E, Lopez M, Giordano A, Pentimalli F: The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells. Int J Cancer. 2009, 125: 235-243. 10.1002\/ijc.24331.","journal-title":"Int J Cancer"},{"key":"667_CR4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1593\/neo.08304","volume":"10","author":"LJ Yu","year":"2008","unstructured":"Yu LJ, Wu ML, Li H, Chen XY, Wang Q, Sun Y, Kong QY, Liu J: Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia. 2008, 10: 736-744.","journal-title":"Neoplasia"},{"key":"667_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neulet.2003.07.002","volume":"351","author":"Q Wang","year":"2003","unstructured":"Wang Q, Li H, Wang XW, Wu DC, Chen XY, Liu J: Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells. Neurosci Lett. 2003, 351: 83-86. 10.1016\/j.neulet.2003.07.002.","journal-title":"Neurosci Lett"},{"key":"667_CR6","doi-asserted-by":"publisher","first-page":"e2445","DOI":"10.1371\/journal.pone.0002445","volume":"3","author":"G Chai","year":"2008","unstructured":"Chai G, Li L, Zhou W, Wu L, Zhao Y, Wang D, Lu S, Yu Y, Wang H, McNutt MA: HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells. PLoS One. 2008, 3: e2445-10.1371\/journal.pone.0002445.","journal-title":"PLoS One"},{"key":"667_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.molonc.2011.11.004","volume":"6","author":"YS Fu","year":"2012","unstructured":"Fu YS, Wang Q, Ma JX, Yang XH, Wu ML, Zhang KL, Kong QY, Chen XY, Sun Y, Chen NN: CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells. Mol Oncol. 2012, 6: 48-61. 10.1016\/j.molonc.2011.11.004.","journal-title":"Mol Oncol"},{"key":"667_CR8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00066-009-1956-1","volume":"185","author":"I Patties","year":"2009","unstructured":"Patties I, Jahns J, Hildebrandt G, Kortmann RD, Glasow A: Additive effects of 5-aza-2'-deoxycytidine and irradiation on clonogenic survival of human medulloblastoma cell lines. Strahlenther Onkol. 2009, 185: 331-338. 10.1007\/s00066-009-1956-1.","journal-title":"Strahlenther Onkol"},{"key":"667_CR9","doi-asserted-by":"publisher","first-page":"e17388","DOI":"10.1371\/journal.pone.0017388","volume":"6","author":"S Hagemann","year":"2011","unstructured":"Hagemann S, Heil O, Lyko F, Brueckner B: Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One. 2011, 6: e17388-10.1371\/journal.pone.0017388.","journal-title":"PLoS One"},{"key":"667_CR10","first-page":"2770","volume":"30","author":"LH Li","year":"1970","unstructured":"Li LH, Olin EJ, Fraser TJ, Bhuyan BK: Phase specificity of 5-azacytidine against mammalian cells in tissue culture. Cancer Res. 1970, 30: 2770-2775.","journal-title":"Cancer Res"},{"key":"667_CR11","doi-asserted-by":"publisher","first-page":"6993","DOI":"10.1073\/pnas.81.22.6993","volume":"81","author":"DV Santi","year":"1984","unstructured":"Santi DV, Norment A, Garrett CE: Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci USA. 1984, 81: 6993-6997. 10.1073\/pnas.81.22.6993.","journal-title":"Proc Natl Acad Sci USA"},{"key":"667_CR12","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1128\/MCB.01799-07","volume":"28","author":"SS Palii","year":"2008","unstructured":"Palii SS, Van Emburgh BO, Sankpal UT, Brown KD, Robertson KD: DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol. 2008, 28: 752-771. 10.1128\/MCB.01799-07.","journal-title":"Mol Cell Biol"},{"key":"667_CR13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2407-8-128","volume":"8","author":"M Lemaire","year":"2008","unstructured":"Lemaire M, Chabot GG, Raynal NJ, Momparler LF, Hurtubise A, Bernstein ML, Momparler RL: Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer. BMC Cancer. 2008, 8: 128-10.1186\/1471-2407-8-128.","journal-title":"BMC Cancer"},{"key":"667_CR14","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1097\/00001813-200209000-00013","volume":"13","author":"AJ Boivin","year":"2002","unstructured":"Boivin AJ, Momparler LF, Hurtubise A, Momparler RL: Antineoplastic action of 5-aza-2'-deoxycytidine and phenylbutyrate on human lung carcinoma cells. Anticancer Drugs. 2002, 13: 869-874. 10.1097\/00001813-200209000-00013.","journal-title":"Anticancer Drugs"},{"key":"667_CR15","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1158\/1535-7163.MCT-05-0184","volume":"4","author":"XN Li","year":"2005","unstructured":"Li XN, Shu Q, Su JM, Perlaky L, Blaney SM, Lau CC: Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. Mol Cancer Ther. 2005, 4: 1912-1922. 10.1158\/1535-7163.MCT-05-0184.","journal-title":"Mol Cancer Ther"},{"key":"667_CR16","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1158\/1078-0432.CCR-05-2849","volume":"12","author":"Q Shu","year":"2006","unstructured":"Shu Q, Antalffy B, Su JM, Adesina A, Ou CN, Pietsch T, Blaney SM, Lau CC, Li XN: Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Clin Cancer Res. 2006, 12: 4687-4694. 10.1158\/1078-0432.CCR-05-2849.","journal-title":"Clin Cancer Res"},{"key":"667_CR17","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1158\/0008-5472.CAN-08-0946","volume":"69","author":"I Ecke","year":"2009","unstructured":"Ecke I, Petry F, Rosenberger A, Tauber S, Monkemeyer S, Hess I, Dullin C, Kimmina S, Pirngruber J, Johnsen SA: Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. Cancer Res. 2009, 69: 887-895. 10.1158\/0008-5472.CAN-08-0946.","journal-title":"Cancer Res"},{"key":"667_CR18","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/43710","volume":"401","author":"MS Finnin","year":"1999","unstructured":"Finnin MS, Donigian JR, Cohen A, Richon VM, Rifkind RA, Marks PA, Breslow R, Pavletich NP: Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature. 1999, 401: 188-193. 10.1038\/43710.","journal-title":"Nature"},{"key":"667_CR19","doi-asserted-by":"publisher","first-page":"10014","DOI":"10.1073\/pnas.180316197","volume":"97","author":"VM Richon","year":"2000","unstructured":"Richon VM, Sandhoff TW, Rifkind RA, Marks PA: Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA. 2000, 97: 10014-10019. 10.1073\/pnas.180316197.","journal-title":"Proc Natl Acad Sci USA"},{"key":"667_CR20","first-page":"1181","volume":"30","author":"H Rikiishi","year":"2007","unstructured":"Rikiishi H, Shinohara F, Sato T, Sato Y, Suzuki M, Echigo S: Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid. Int J Oncol. 2007, 30: 1181-1188.","journal-title":"Int J Oncol"},{"key":"667_CR21","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1038\/onc.2010.599","volume":"30","author":"S Hacker","year":"2011","unstructured":"Hacker S, Karl S, Mader I, Cristofanon S, Schweitzer T, Krauss J, Rutkowski S, Debatin KM, Fulda S: Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. Oncogene. 2011, 30: 2275-2281. 10.1038\/onc.2010.599.","journal-title":"Oncogene"},{"key":"667_CR22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/mol.57.4.695","volume":"57","author":"SW Tendian","year":"2000","unstructured":"Tendian SW, Parker WB: Interaction of deoxyguanosine nucleotide analogs with human telomerase. Mol Pharmacol. 2000, 57: 695-699.","journal-title":"Mol Pharmacol"},{"key":"667_CR23","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","volume":"33","author":"JW Shay","year":"1997","unstructured":"Shay JW, Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer. 1997, 33: 787-791. 10.1016\/S0959-8049(97)00062-2.","journal-title":"Eur J Cancer"},{"key":"667_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/ijc.11689","volume":"109","author":"Q Chang","year":"2004","unstructured":"Chang Q, Pang JC, Li J, Hu L, Kong X, Ng HK: Molecular analysis of PinX1 in medulloblastomas. Int J Cancer. 2004, 109: 309-314. 10.1002\/ijc.11689.","journal-title":"Int J Cancer"},{"key":"667_CR25","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1128\/MCB.3.12.2271","volume":"3","author":"EM Jones-Villeneuve","year":"1983","unstructured":"Jones-Villeneuve EM, Rudnicki MA, Harris JF, McBurney MW: Retinoic acid-induced neural differentiation of embryonal carcinoma cells. Mol Cell Biol. 1983, 3: 2271-2279.","journal-title":"Mol Cell Biol"},{"key":"667_CR26","first-page":"287","volume":"54","author":"N Sidell","year":"1986","unstructured":"Sidell N, Sarafian T, Kelly M, Tsuchida T, Haussler M: Retinoic acid-induced differentiation of human neuroblastoma: a cell variant system showing two distinct responses. Exp Cell Biol. 1986, 54: 287-300.","journal-title":"Exp Cell Biol"},{"key":"667_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0165-5728(86)90076-7","volume":"11","author":"M Webb","year":"1986","unstructured":"Webb M, Graham C, Walsh F: Neuronal differentiation of cloned human teratoma cells in response to retinoic acid in vitro. J Neuroimmunol. 1986, 11: 67-86. 10.1016\/0165-5728(86)90076-7.","journal-title":"J Neuroimmunol"},{"key":"667_CR28","first-page":"4052","volume":"9","author":"K Gumireddy","year":"2003","unstructured":"Gumireddy K, Sutton LN, Phillips PC, Reddy CD: All-trans-retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3\/poly(ADP-ribose) polymerase 1 pathway. Clin Cancer Res. 2003, 9: 4052-4059.","journal-title":"Clin Cancer Res"},{"key":"667_CR29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s11060-007-9380-9","volume":"84","author":"Q Chang","year":"2007","unstructured":"Chang Q, Chen Z, You J, McNutt MA, Zhang T, Han Z, Zhang X, Gong E, Gu J: All-trans-retinoic acid induces cell growth arrest in a human medulloblastoma cell line. J Neurooncol. 2007, 84: 263-267. 10.1007\/s11060-007-9380-9.","journal-title":"J Neurooncol"},{"key":"667_CR30","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nm904","volume":"9","author":"AR Hallahan","year":"2003","unstructured":"Hallahan AR, Pritchard JI, Chandraratna RA, Ellenbogen RG, Geyer JR, Overland RP, Strand AD, Tapscott SJ, Olson JM: BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat Med. 2003, 9: 1033-1038. 10.1038\/nm904.","journal-title":"Nat Med"},{"key":"667_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/mnfr.201100400","volume":"56","author":"E Scott","year":"2012","unstructured":"Scott E, Steward WP, Gescher AJ, Brown K: Resveratrol in human cancer chemoprevention\u2013choosing the 'right' dose. Mol Nutr Food Res. 2012, 56: 7-13. 10.1002\/mnfr.201100400.","journal-title":"Mol Nutr Food Res"},{"key":"667_CR32","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1080\/01635581.2012.667862","volume":"64","author":"NC Whitlock","year":"2012","unstructured":"Whitlock NC, Baek SJ: The anticancer effects of resveratrol: modulation of transcription factors. Nutr Cancer. 2012, 64: 493-502. 10.1080\/01635581.2012.667862.","journal-title":"Nutr Cancer"},{"key":"667_CR33","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.2174\/138161212799958567","volume":"18","author":"I Muqbil","year":"2012","unstructured":"Muqbil I, Beck FW, Bao B, Sarkar FH, Mohammad RM, Hadi SM, Azmi AS: Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol. Curr Pharm Des. 2012, 18: 1645-1654. 10.2174\/138161212799958567.","journal-title":"Curr Pharm Des"},{"key":"667_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11060-006-9172-7","volume":"80","author":"P Zhang","year":"2006","unstructured":"Zhang P, Li H, Wu ML, Chen XY, Kong QY, Wang XW, Sun Y, Wen S, Liu J: c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells. J Neurooncol. 2006, 80: 123-131. 10.1007\/s11060-006-9172-7.","journal-title":"J Neurooncol"},{"key":"667_CR35","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","volume":"26","author":"CI Bliss","year":"1939","unstructured":"Bliss CI: The toxicity of poisons applied jointly1. Ann Appl Biol. 1939, 26: 585-615. 10.1111\/j.1744-7348.1939.tb06990.x.","journal-title":"Ann Appl Biol"},{"key":"667_CR36","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0166-3542(90)90001-N","volume":"14","author":"MN Prichard","year":"1990","unstructured":"Prichard MN, Shipman C: A three-dimensional model to analyze drug-drug interactions. Antiviral Res. 1990, 14: 181-205. 10.1016\/0166-3542(90)90001-N.","journal-title":"Antiviral Res"},{"key":"667_CR37","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.leukres.2004.11.022","volume":"29","author":"H Yang","year":"2005","unstructured":"Yang H, Hoshino K, Sanchez-Gonzalez B, Kantarjian H, Garcia-Manero G: Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acid. Leuk Res. 2005, 29: 739-748. 10.1016\/j.leukres.2004.11.022.","journal-title":"Leuk Res"},{"key":"667_CR38","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.4049\/jimmunol.1103035","volume":"188","author":"D Yang","year":"2012","unstructured":"Yang D, Torres CM, Bardhan K, Zimmerman M, McGaha TL, Liu K: Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo. J Immunol. 2012, 188: 4441-4449. 10.4049\/jimmunol.1103035.","journal-title":"J Immunol"},{"key":"667_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11010-010-0683-3","volume":"350","author":"B Brodska","year":"2011","unstructured":"Brodska B, Otevrelova P, Holoubek A: Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA. Mol Cell Biochem. 2011, 350: 71-80. 10.1007\/s11010-010-0683-3.","journal-title":"Mol Cell Biochem"},{"key":"667_CR40","doi-asserted-by":"publisher","first-page":"4424","DOI":"10.1002\/cncr.26073","volume":"117","author":"MY Chen","year":"2011","unstructured":"Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast RC: Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2\/M arrest, and autophagy. Cancer. 2011, 117: 4424-4438. 10.1002\/cncr.26073.","journal-title":"Cancer"},{"key":"667_CR41","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1158\/0008-5472.919.65.3","volume":"65","author":"C Di","year":"2005","unstructured":"Di C, Liao S, Adamson DC, Parrett TJ, Broderick DK, Shi Q, Lengauer C, Cummins JM, Velculescu VE, Fults DW: Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. Cancer Res. 2005, 65: 919-924.","journal-title":"Cancer Res"},{"key":"667_CR42","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","volume":"16","author":"DJ Boocock","year":"2007","unstructured":"Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, Booth TD, Crowell JA, Perloff M, Gescher AJ: Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev. 2007, 16: 1246-1252. 10.1158\/1055-9965.EPI-07-0022.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"667_CR43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00019606-199303000-00004","volume":"2","author":"M Badiali","year":"1993","unstructured":"Badiali M, Iolascon A, Loda M, Scheithauer BW, Basso G, Trentini GP, Giangaspero F: p53 gene mutations in medulloblastoma. Immunohistochemistry, gel shift analysis, and sequencing. Diagn Mol Pathol. 1993, 2: 23-28.","journal-title":"Diagn Mol Pathol"},{"key":"667_CR44","first-page":"849","volume":"18","author":"W Wang","year":"1998","unstructured":"Wang W, Kumar P, Wang W, Whalley J, Schwarz M, Malone G, Haworth A, Kumar S: The mutation status of PAX3 and p53 genes in medulloblastoma. Anticancer Res. 1998, 18: 849-853.","journal-title":"Anticancer Res"},{"key":"667_CR45","first-page":"5649","volume":"54","author":"AM Adesina","year":"1994","unstructured":"Adesina AM, Nalbantoglu J, Cavenee WK: p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res. 1994, 54: 5649-5651.","journal-title":"Cancer Res"},{"key":"667_CR46","first-page":"4721","volume":"51","author":"RL Saylors III","year":"1991","unstructured":"Saylors RL, Sidransky D, Friedman HS, Bigner SH, Bigner DD, Vogelstein B, Brodeur GM: Infrequent p53 gene mutations in medulloblastomas. Cancer Res. 1991, 51: 4721-4723.","journal-title":"Cancer Res"},{"key":"667_CR47","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1200\/JCO.2009.23.5952","volume":"28","author":"U Tabori","year":"2010","unstructured":"Tabori U, Baskin B, Shago M, Alon N, Taylor MD, Ray PN, Bouffet E, Malkin D, Hawkins C: Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations. J Clin Oncol. 2010, 28: 1345-1350. 10.1200\/JCO.2009.23.5952.","journal-title":"J Clin Oncol"},{"key":"667_CR48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/carcin\/20.2.237","volume":"20","author":"C Huang","year":"1999","unstructured":"Huang C, Ma WY, Goranson A, Dong Z: Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis. 1999, 20: 237-242. 10.1093\/carcin\/20.2.237.","journal-title":"Carcinogenesis"},{"key":"667_CR49","doi-asserted-by":"publisher","first-page":"28749","DOI":"10.1074\/jbc.M110.202440","volume":"286","author":"R Gogada","year":"2011","unstructured":"Gogada R, Prabhu V, Amadori M, Scott R, Hashmi S, Chandra D: Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. J Biol Chem. 2011, 286: 28749-28760. 10.1074\/jbc.M110.202440.","journal-title":"J Biol Chem"},{"key":"667_CR50","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1080\/09553008514552861","volume":"49","author":"IR Radford","year":"1986","unstructured":"Radford IR: Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. Int J Radiat Biol Relat Stud Phys Chem Med. 1986, 49: 611-620.","journal-title":"Int J Radiat Biol Relat Stud Phys Chem Med"},{"key":"667_CR51","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1093\/carcin\/bgi165","volume":"26","author":"A Tyagi","year":"2005","unstructured":"Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R: Resveratrol causes Cdc2-tyr15 phosphorylation via ATM\/ATR-Chk1\/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis. 2005, 26: 1978-1987. 10.1093\/carcin\/bgi165.","journal-title":"Carcinogenesis"},{"key":"667_CR52","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1093\/nar\/gkp1039","volume":"38","author":"T Yamamori","year":"2010","unstructured":"Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, Kasuno K, Jung SB, Kim CS, Irani K: SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res. 2010, 38: 832-845. 10.1093\/nar\/gkp1039.","journal-title":"Nucleic Acids Res"},{"key":"667_CR53","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/emboj\/20.4.914","volume":"20","author":"J Zhou","year":"2001","unstructured":"Zhou J, Ahn J, Wilson SH, Prives C: A role for p53 in base excision repair. EMBO J. 2001, 20: 914-923. 10.1093\/emboj\/20.4.914.","journal-title":"EMBO J"},{"key":"667_CR54","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s00405-012-2183-4","volume":"270","author":"G Simsek","year":"2012","unstructured":"Simsek G, Tokgoz SA, Vuralkan E, Caliskan M, Besalti O, Akin I: Protective effects of resveratrol on cisplatin-dependent inner-ear damage in rats. Eur Arch Otorhinolaryngol. 2012, 270: 1789-1793.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"667_CR55","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1080\/07391102.2008.10507191","volume":"25","author":"U Subbiah","year":"2008","unstructured":"Subbiah U, Raghunathan M: Chemoprotective action of resveratrol and genistein from apoptosis induced in human peripheral blood lymphocytes. J Biomol Struct Dyn. 2008, 25: 425-434. 10.1080\/07391102.2008.10507191.","journal-title":"J Biomol Struct Dyn"}],"container-title":["Journal of Experimental & Clinical Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-9966-32-27.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1756-9966-32-27\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1756-9966-32-27.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T18:43:35Z","timestamp":1688237015000},"score":1,"resource":{"primary":{"URL":"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/1756-9966-32-27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["667"],"URL":"https:\/\/doi.org\/10.1186\/1756-9966-32-27","relation":{},"ISSN":["1756-9966"],"issn-type":[{"value":"1756-9966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]},"article-number":"27"}}