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Evidence suggests that due to misdiagnosis and later recognition, foot melanoma has a poorer prognosis than cutaneous melanoma elsewhere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A panel of experts representing podiatry and dermatologists with a special interest in skin oncology was assembled to review the literature and clinical evidence to develop a clinical guide for the early recognition of plantar and nail unit melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A systematic review of the literature revealed little high quality data to inform the guide. However a significant number of case reports and series were available for analysis. From these, the salient features were collated and summarised into the guide. Based on these features a new acronym \u201cCUBED\u201d for foot melanoma was drafted and incorporated in the guide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of this guide may help clinicians in their assessment of suspicious lesions on the foot (including the nail unit). Earlier detection of suspicious pedal lesions may facilitate earlier referral for expert assessment and definitive diagnosis. The guide is currently being field tested amongst practitioners.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1757-1146-3-22","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T18:14:14Z","timestamp":1285697654000},"source":"Crossref","is-referenced-by-count":15,"title":["Development of a practical guide for the early recognition for malignant melanoma of the foot and nail unit"],"prefix":"10.1002","volume":"3","author":[{"given":"Ivan R","family":"Bristow","sequence":"first","affiliation":[{"name":"School of Health Sciences University of Southampton SO17 1BJ Highfield Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David AR","family":"de Berker","sequence":"additional","affiliation":[{"name":"Bristol Dermatology Centre Bristol Royal Infirmary BS2 8HW Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.015"},{"key":"e_1_2_8_3_1","unstructured":"UK Skin Cancer mortality statistics. 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