{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:42:34Z","timestamp":1774449754464,"version":"3.50.1"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cases Journal"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Seborrheic keratosis is a very common benign skin tumor in man. Melanoma is rare but is the most dreaded of all malignant skin tumors. A melanoma arising in a seborrheic keratosis is distinctly rare. We are reporting such a case occurring in an 86-year-old man.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>An-86-year-old male with a history of multiple actinic keratoses and seborrheic keratoses of the head and trunk presented with a mid-back skin lesion. The lesion was poorly circumscribed, flat, and gray, with a pink-tan, well-circumscribed scaly nodule within it. The biopsied lesion was composed of the usual features of hyperkeratotic seborrheic keratosis, but with focal atypical melanocytic proliferation with nesting along the dermal-epidermal junction. We interpreted this lesion as a melanoma in-situ arising within a seborrheic keratosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>It is not uncommon for many physicians to remove a typical seborrheic keratosis without a confirmatory microscopic confirmation. We urge that all such lesions be examined by the pathologist to avoid missing another concomitant malignant lesion such as melanoma which needs adequate resection and close follow-up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1757-1626-1-263","type":"journal-article","created":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T18:14:10Z","timestamp":1224785650000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Melanoma in-situ arising in seborrheic keratosis: a case report"],"prefix":"10.1186","volume":"1","author":[{"given":"Susan","family":"Repertinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Adickes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deba P","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,10,23]]},"reference":[{"issue":"4 Pt 1","key":"256_CR1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1524-4725.2004.30178.x","volume":"30","author":"I Thomas","year":"2004","unstructured":"Thomas I, Kihiczak NI, Rothenberg J, Ahmed S, Schwartz RA: Melanoma within the seborrheic keratosis. Dermatol Surg. 2004, 30 (4 Pt 1): 559-61. 10.1111\/j.1524-4725.2004.30178.x.","journal-title":"Dermatol Surg"},{"issue":"2","key":"256_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1440-0960.2006.00258.x","volume":"47","author":"C Lim","year":"2006","unstructured":"Lim C: Seborrheic keratoses with associated lesions: a retrospective analysis of 85 lesions. Australas J Dermatol. 2006, 47 (2): 109-13. 10.1111\/j.1440-0960.2006.00258.x.","journal-title":"Australas J Dermatol"},{"issue":"3","key":"256_CR3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/00000372-199606000-00007","volume":"18","author":"CD Cascajo","year":"1996","unstructured":"Cascajo CD, Reichel M, Sanchez JL: Malignant neoplasms associated with seborrheic keratoses; an analysis of 54 cases. Am J Dermatopath. 1996, 18 (3): 278-282. 10.1097\/00000372-199606000-00007.","journal-title":"Am J Dermatopath"},{"issue":"5 Pt 1","key":"256_CR4","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1067\/mjd.2000.103634","volume":"42","author":"RJ Zabel","year":"2000","unstructured":"Zabel RJ, Vinson RP, McCollough ML: Malignant melanoma arising in a seborrheic keratosis. J Am Acad Dermatol. 2000, 42 (5 Pt 1): 831-3. 10.1067\/mjd.2000.103634.","journal-title":"J Am Acad Dermatol"}],"container-title":["Cases Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1757-1626-1-263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T12:47:51Z","timestamp":1630586871000},"score":1,"resource":{"primary":{"URL":"https:\/\/casesjournal.biomedcentral.com\/articles\/10.1186\/1757-1626-1-263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,23]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["256"],"URL":"https:\/\/doi.org\/10.1186\/1757-1626-1-263","relation":{},"ISSN":["1757-1626"],"issn-type":[{"value":"1757-1626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,23]]},"assertion":[{"value":"8 August 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"263"}}