{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:38:02Z","timestamp":1756384682657},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cases Journal"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Nasal mucosal melanoma presents usually with epistaxis, nasal obstruction and facial pain. However melanoma tends to give distant metastases at an early stage, having rare clinical presentations.<\/jats:p>\n          <jats:p>We present a 74-year old female patient with symptoms of central type vertigo caused by brain metastases. Clinical assessment for the detection of the primary site revealed a nasal mucosal melanoma originating from the posterior end of the left inferior turbinate. The patient received a combination of radio and chemotherapy being in relatively good condition 8 months later. This is the first reported case of a nasal mucosal melanoma with vertigo as the first presenting symptom.<\/jats:p>","DOI":"10.1186\/1757-1626-2-7149","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T12:32:43Z","timestamp":1248265963000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nasal mucosal melanoma presenting as central type vertigo: a case report"],"prefix":"10.1186","volume":"2","author":[{"given":"Konstantinos","family":"Nellas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iordanis","family":"Konstantinidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Zevgaridis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia","family":"Printza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Efstratiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,5,5]]},"reference":[{"key":"702_CR1","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G","volume":"83","author":"AE Chang","year":"1998","unstructured":"Chang AE, Karnell LH, Menck HR: The National Cancer Data Base report on cutaneous and non-cutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998, 83: 1664-1678. 10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G.","journal-title":"Cancer"},{"key":"702_CR2","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/1097-0142(197408)34:2<358::AID-CNCR2820340221>3.0.CO;2-D","volume":"34","author":"M Takagi","year":"1974","unstructured":"Takagi M, Ishikawa G, Mori W: Primary malignant melanoma of the oral cavity in Japan. With special reference to mucosal melanosis. Cancer. 1974, 34: 358-370. 10.1002\/1097-0142(197408)34:2<358::AID-CNCR2820340221>3.0.CO;2-D.","journal-title":"Cancer"},{"key":"702_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0748-7983(98)80011-5","volume":"24","author":"M Pandey","year":"1998","unstructured":"Pandey M, Mathew A, Abraham EK, Ahamed IM, Nair KM: Primary malignant melanoma of the mucous membranes. Eur J Surg Oncol. 1998, 24: 303-307. 10.1016\/S0748-7983(98)80011-5.","journal-title":"Eur J Surg Oncol"},{"key":"702_CR4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/COC.0b013e318134ee88","volume":"31","author":"M Wagner","year":"2008","unstructured":"Wagner M, Morris CG, Werning JW, Mendenhall WM: Mucosal melanoma of the head and neck. Am J Clin Oncol. 2008, 31: 43-48. 10.1097\/COC.0b013e318134ee88.","journal-title":"Am J Clin Oncol"},{"key":"702_CR5","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1097\/00005537-199904000-00015","volume":"109","author":"MG Stewart","year":"1999","unstructured":"Stewart MG, Chen AY, Wyatt JR, Favrot S, Beinart S, Coker NJ, Jenkins HA: Cost- effectiveness of the diagnostic evaluation of vertigo. Laryngoscope. 1999, 109: 600-605. 10.1097\/00005537-199904000-00015.","journal-title":"Laryngoscope"},{"key":"702_CR6","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1097\/00000478-200305000-00004","volume":"27","author":"LD Thompson","year":"2003","unstructured":"Thompson LD, Wieneke JA, Miettinen M: Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol. 2003, 27: 594-611. 10.1097\/00000478-200305000-00004.","journal-title":"Am J Surg Pathol"},{"key":"702_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.otohns.2007.12.013","volume":"138","author":"EH Dauer","year":"2008","unstructured":"Dauer EH, Lewis JE, Rohlinger AL, Weaver AL, Olsen KD: Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg. 2008, 138: 347-352. 10.1016\/j.otohns.2007.12.013.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"702_CR8","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1080\/000164801317166907","volume":"121","author":"A Rinaldo","year":"2001","unstructured":"Rinaldo A, Shaha AR, Patel SG, Ferlito A: Primary mucosal melanoma of the nasal cavity and paranasal sinuses. Acta Otolaryngol. 2001, 121: 979-982. 10.1080\/000164801317166907.","journal-title":"Acta Otolaryngol"},{"key":"702_CR9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2310\/7070.2007.0010","volume":"36","author":"SF Huang","year":"2007","unstructured":"Huang SF, Liao CT, Kan CR, Chen IH: Primary mucosal melanoma of the nasal cavity and paranasal sinuses: 12 years of experience. J Otolaryngol. 2007, 36: 124-129. 10.2310\/7070.2007.0010.","journal-title":"J Otolaryngol"},{"key":"702_CR10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/01.moo.0000193176.54450.c4","volume":"14","author":"PJ Bradley","year":"2006","unstructured":"Bradley PJ: Primary malignant mucosal melanoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg. 2006, 14: 100-104.","journal-title":"Curr Opin Otolaryngol Head Neck Surg"}],"container-title":["Cases Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1757-1626-2-7149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T20:08:39Z","timestamp":1630613319000},"score":1,"resource":{"primary":{"URL":"https:\/\/casesjournal.biomedcentral.com\/articles\/10.1186\/1757-1626-2-7149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,5]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["702"],"URL":"https:\/\/doi.org\/10.1186\/1757-1626-2-7149","relation":{},"ISSN":["1757-1626"],"issn-type":[{"value":"1757-1626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,5]]},"assertion":[{"value":"12 December 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"7149"}}