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The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with <jats:italic>dupA<\/jats:italic> gene.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A meta-analysis of case-control studies which provided raw data on the infection rates with the <jats:italic>dupA<\/jats:italic>-positive <jats:italic>H. pylori<\/jats:italic> detected by polymerase chain reaction was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Seventeen studies with a total of 2,466 patients were identified in the search. Infection with the <jats:italic>dupA<\/jats:italic>-positive <jats:italic>H. pylori<\/jats:italic> increased the risk for duodenal ulcer by 1.41-fold (95% confidence interval [CI], 1.12-1.76) overall. Subgroup analysis showed that the summary odds ratio (OR) was 1.57 (95% CI, 1.19-2.06) in Asian countries and 1.09 (95% CI, 0.73-1.62) in Western countries. There was no association between the presence of the <jats:italic>dupA<\/jats:italic> gene and gastric cancer and gastric ulcer. Publication bias did not exist.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our meta-analysis confirmed the importance of the presence of the <jats:italic>dupA<\/jats:italic> gene for duodenal ulcer, especially in Asian countries.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1757-4749-2-13","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T19:15:17Z","timestamp":1290194117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes"],"prefix":"10.1186","volume":"2","author":[{"given":"Seiji","family":"Shiota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Matsunari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Watada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Yamaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,31]]},"reference":[{"key":"39_CR1","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1056\/NEJMra020542","volume":"347","author":"S Suerbaum","year":"2002","unstructured":"Suerbaum S, Michetti P: Helicobacter pylori infection. 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