{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:55:28Z","timestamp":1774421728309,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cheminform"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1758-2946-1-20","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T17:26:07Z","timestamp":1261157167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["The PubChem chemical structure sketcher"],"prefix":"10.1186","volume":"1","author":[{"given":"Wolf D","family":"Ihlenfeldt","sequence":"first","affiliation":[]},{"given":"Evan E","family":"Bolton","sequence":"additional","affiliation":[]},{"given":"Stephen H","family":"Bryant","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,12,17]]},"reference":[{"key":"20_CR1","doi-asserted-by":"crossref","unstructured":"Sayers EW, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, DiCuccio M, Edgar R, Federhen S, Feolo M, Geer LY, Helmberg W, Kapustin Y, Landsman D, Lipman DJ, Madden TL, Maglott DR, Miller V, Mizrachi I, Ostell J, Pruitt KD, Schuler GD, Sequeira E, Sherry ST, Shumway M, Sirotkin K, Souvorov A, Starchenko G, Tatusova TA, Wagner L, Yaschenko E, Ye J: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 2009, D5-15. 10.1093\/nar\/gkn741. 37 Database","DOI":"10.1093\/nar\/gkn741"},{"key":"20_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1574-1400(08)00012-1","volume":"4","author":"EE Bolton","year":"2008","unstructured":"Bolton EE, Wang Y, Thiessen PA, Bryant SH: PubChem: Integrated Platform of Small Molecules and Biological Activities. Annu Rep Comput Chem. 2008, 4: 217-241. 10.1016\/S1574-1400(08)00012-1.","journal-title":"Annu Rep Comput Chem"},{"issue":"1","key":"20_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1021\/ci00057a005","volume":"28","author":"D Weininger","year":"1988","unstructured":"Weininger D: SMILES, a chemical language and information system. 1. Introduction to methodology and encoding rules. J Chem Inf Comput Sci. 1988, 28 (1): 31-36. 10.1021\/ci00057a005.","journal-title":"J Chem Inf Comput Sci"},{"key":"20_CR4","unstructured":"Molinspiration Cheminformatics. [http:\/\/www.molinspiration.com]"},{"key":"20_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/50100093","volume":"5","author":"S Krause","year":"2000","unstructured":"Krause S, Willighagen E, Steinbeck C: JChemPaint - Using the Collaborative Forces of the Internet to Develop a Free Editor for 2D Chemical Structures. Molecules. 2000, 5: 93-98. 10.3390\/50100093.","journal-title":"Molecules"},{"key":"20_CR6","unstructured":"JMolDraw. [http:\/\/sourceforge.net\/projects\/jmoldraw\/]"},{"key":"20_CR7","unstructured":"MCDL. [http:\/\/sourceforge.net\/projects\/mcdl\/]"},{"key":"20_CR8","unstructured":"ACD\/Structure Drawing Applet. [http:\/\/www.acdlabs.com\/products\/java\/sda\/]"},{"key":"20_CR9","unstructured":"ChemAxon chemistry software toolkit. [http:\/\/www.chemaxon.com\/]"},{"key":"20_CR10","unstructured":"CambridgeSoft Desktop Software - ChemDraw. [http:\/\/www.cambridgesoft.com\/software\/ChemDraw\/]"},{"key":"20_CR11","unstructured":"jsMolEditor - Molecule Editor of JavaScript. [https:\/\/github.com\/chemhack\/jsmoleditor\/]"},{"key":"20_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0166-1280(97)00179-6","volume":"419","author":"P Ertl","year":"1997","unstructured":"Ertl P, Jacob O: WWW-based chemical information system. Theochem. 1997, 419: 113-130. 10.1016\/S0166-1280(97)00179-6.","journal-title":"Theochem"},{"key":"20_CR13","unstructured":"FastCGI. [http:\/\/www.fastcgi.com\/]"},{"issue":"1","key":"20_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1021\/ci00017a013","volume":"34","author":"WD Ihlenfeldt","year":"1994","unstructured":"Ihlenfeldt WD, Takahashi Y, Abe H, Sasaki S: Computation and management of chemical properties in CACTVS: An extensible networked approach toward modularity and compatibility. J Chem Inf Comput Sci. 1994, 34 (1): 109-116. 10.1021\/ci00017a013.","journal-title":"J Chem Inf Comput Sci"},{"key":"20_CR15","unstructured":"gdLibrary. [http:\/\/www.libgd.org\/Main_Page]"},{"key":"20_CR16","unstructured":"Portable Network Graphics. [http:\/\/www.libpng.org\/pub\/png\/]"},{"key":"20_CR17","unstructured":"GIF89a Specification. [http:\/\/www.w3.org\/Graphics\/GIF\/spec-gif89a.txt]"},{"key":"20_CR18","unstructured":"Multiple-image Network Graphics. [http:\/\/www.libpng.org\/pub\/mng\/]"},{"key":"20_CR19","unstructured":"Memcached: a distributed memory object caching system. [http:\/\/www.danga.com\/memcached\/]"}],"container-title":["Journal of Cheminformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1758-2946-1-20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1758-2946-1-20\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1758-2946-1-20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T01:58:55Z","timestamp":1630461535000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcheminf.biomedcentral.com\/articles\/10.1186\/1758-2946-1-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1186\/1758-2946-1-20","relation":{},"ISSN":["1758-2946"],"issn-type":[{"value":"1758-2946","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"8 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"20"}}