{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:07:43Z","timestamp":1771718863776,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cheminform"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Cardiovascular disease (CVD) is the leading cause of death and associates with multiple risk factors. Herb medicines have been used to treat CVD long ago in china and several natural products or derivatives (e.g., aspirin and reserpine) are most common drugs all over the world. The objective of this work was to construct a systematic database for drug discovery based on natural products separated from CVD-related medicinal herbs and to research on action mechanism of herb medicines.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Description<\/jats:title>\n            <jats:p>The cardiovascular disease herbal database (CVDHD) was designed to be a comprehensive resource for virtual screening and drug discovery from natural products isolated from medicinal herbs for cardiovascular-related diseases. CVDHD comprises 35230 distinct molecules and their identification information (chemical name, CAS registry number, molecular formula, molecular weight, international chemical identifier (InChI) and SMILES), calculated molecular properties (AlogP, number of hydrogen bond acceptor and donors, etc.), docking results between all molecules and 2395 target proteins, cardiovascular-related diseases, pathways and clinical biomarkers. All 3D structures were optimized in the MMFF94 force field and can be freely accessed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>CVDHD integrated medicinal herbs, natural products, CVD-related target proteins, docking results, diseases and clinical biomarkers. By using the methods of virtual screening and network pharmacology, CVDHD will provide a platform to streamline drug\/lead discovery from natural products and explore the action mechanism of medicinal herbs. CVDHD is freely available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/pkuxxj.pku.edu.cn\/CVDHD\" ext-link-type=\"uri\">http:\/\/pkuxxj.pku.edu.cn\/CVDHD<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1758-2946-5-51","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T02:02:39Z","timestamp":1387332159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology"],"prefix":"10.1186","volume":"5","author":[{"given":"Jiangyong","family":"Gu","sequence":"first","affiliation":[]},{"given":"Yuanshen","family":"Gui","sequence":"additional","affiliation":[]},{"given":"Lirong","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Gu","family":"Yuan","sequence":"additional","affiliation":[]},{"given":"Xiaojie","family":"Xu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,12,18]]},"reference":[{"issue":"3","key":"487_CR1","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1021\/np200906s","volume":"75","author":"DJ Newman","year":"2012","unstructured":"Newman DJ, Cragg GM: Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012, 75 (3): 311-335. 10.1021\/np200906s.","journal-title":"J Nat Prod"},{"issue":"19\u201320","key":"487_CR2","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","volume":"13","author":"AL Harvey","year":"2008","unstructured":"Harvey AL: Natural products in drug discovery. Drug Discov Today. 2008, 13 (19\u201320): 894-901.","journal-title":"Drug Discov Today"},{"issue":"2","key":"487_CR3","doi-asserted-by":"publisher","first-page":"E239","DOI":"10.1007\/BF02854894","volume":"8","author":"YW Chin","year":"2006","unstructured":"Chin YW, Balunas MJ, Chai HB, Kinghorn AD: Drug discovery from natural sources. AAPS J. 2006, 8 (2): E239-E253.","journal-title":"AAPS J"},{"issue":"3","key":"487_CR4","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cbpa.2011.03.004","volume":"15","author":"J Hong","year":"2011","unstructured":"Hong J: Role of natural product diversity in chemical biology. Curr Opin Chem Biol. 2011, 15 (3): 350-354. 10.1016\/j.cbpa.2011.03.004.","journal-title":"Curr Opin Chem Biol"},{"issue":"4","key":"487_CR5","doi-asserted-by":"publisher","first-page":"e62839","DOI":"10.1371\/journal.pone.0062839","volume":"8","author":"JY Gu","year":"2013","unstructured":"Gu JY, Gui YS, Chen LR, Yuan G, Lu HZ, Xu XJ: Use of natural products as chemical library for drug discovery and network pharmacology. PLoS One. 2013, 8 (4): e62839-10.1371\/journal.pone.0062839.","journal-title":"PLoS One"},{"issue":"13\u201314","key":"487_CR6","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.drudis.2012.04.001","volume":"17","author":"F Lopez-Vallejo","year":"2012","unstructured":"Lopez-Vallejo F, Giulianotti MA, Houghten RA, Medina-Franco JL: Expanding the medicinally relevant chemical space with compound libraries. Drug Discov Today. 2012, 17 (13\u201314): 718-726.","journal-title":"Drug Discov Today"},{"issue":"5","key":"487_CR7","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/cbdd.12011","volume":"80","author":"AB Yongye","year":"2012","unstructured":"Yongye AB, Waddell J, Medina-Franco JL: Molecular scaffold analysis of natural products databases in the public domain. Chem Biol Drug Des. 2012, 80 (5): 717-724. 10.1111\/cbdd.12011.","journal-title":"Chem Biol Drug Des"},{"issue":"9\u201310","key":"487_CR8","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.drudis.2009.02.010","volume":"14","author":"M Cases","year":"2009","unstructured":"Cases M, Mestres J: A chemogenomic approach to drug discovery: focus on cardiovascular diseases. Drug Discov Today. 2009, 14 (9\u201310): 479-485.","journal-title":"Drug Discov Today"},{"issue":"1","key":"487_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrg2918","volume":"12","author":"AL Barabasi","year":"2011","unstructured":"Barabasi AL, Gulbahce N, Loscalzo J: Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011, 12 (1): 56-68. 10.1038\/nrg2918.","journal-title":"Nat Rev Genet"},{"issue":"6","key":"487_CR10","doi-asserted-by":"publisher","first-page":"e40262","DOI":"10.1371\/journal.pone.0040262","volume":"7","author":"JJ Lu","year":"2012","unstructured":"Lu JJ, Pan W, Hu YJ, Wang YT: Multi-target drugs: the trend of drug research and development. PLoS One. 2012, 7 (6): e40262-10.1371\/journal.pone.0040262.","journal-title":"PLoS One"},{"issue":"5","key":"487_CR11","doi-asserted-by":"publisher","first-page":"422","DOI":"10.2174\/092986708783503212","volume":"15","author":"A Petrelli","year":"2008","unstructured":"Petrelli A, Giordano S: From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage. Curr Med Chem. 2008, 15 (5): 422-432. 10.2174\/092986708783503212.","journal-title":"Curr Med Chem"},{"issue":"4","key":"487_CR12","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.tips.2005.02.007","volume":"26","author":"P Csermely","year":"2005","unstructured":"Csermely P, Agoston V, Pongor S: The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol Sci. 2005, 26 (4): 178-182. 10.1016\/j.tips.2005.02.007.","journal-title":"Trends Pharmacol Sci"},{"key":"487_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1472-6904-5-3","volume":"5","author":"SK Mencher","year":"2005","unstructured":"Mencher SK, Wang LG: Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin Pharmacol. 2005, 5: 3-10.1186\/1472-6904-5-3.","journal-title":"BMC Clin Pharmacol"},{"issue":"4","key":"487_CR14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/bib\/bbp063","volume":"11","author":"J Zhao","year":"2010","unstructured":"Zhao J, Jiang P, Zhang WD: Molecular networks for the study of TCM Pharmacology. Brief Bioinform. 2010, 11 (4): 417-430. 10.1093\/bib\/bbp063.","journal-title":"Brief Bioinform"},{"issue":"11","key":"487_CR15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins AL: Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008, 4 (11): 682-690. 10.1038\/nchembio.118.","journal-title":"Nat Chem Biol"},{"issue":"1","key":"487_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2012.09.051","volume":"145","author":"WY Tao","year":"2013","unstructured":"Tao WY, Xu X, Wang X, Li BH, Wang YH, Li Y, Yang L: Network pharmacology-based prediction of the active ingredients and potential targets of chinese herbal radix curcumae formula for application to cardiovascular disease. J Ethnopharmacol. 2013, 145 (1): 1-10. 10.1016\/j.jep.2012.09.051.","journal-title":"J Ethnopharmacol"},{"key":"487_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1752-0509-6-20","volume":"6","author":"AH Zhang","year":"2012","unstructured":"Zhang AH, Sun H, Yang B, Wang XJ: Predicting new molecular targets for rhein using network pharmacology. BMC Syst Biol. 2012, 6: 20-10.1186\/1752-0509-6-20.","journal-title":"BMC Syst Biol"},{"key":"487_CR18","first-page":"149762","volume":"2012","author":"J Li","year":"2012","unstructured":"Li J, Lu C, Jiang M, Niu XY, Guo HT, Li L, Bian ZX, Lin N, Lu AP: Traditional chinese medicine-based network pharmacology could lead to New multicompound drug discovery. Evid-Based Compl Alt Med. 2012, 2012: 149762-","journal-title":"Evid-Based Compl Alt Med"},{"key":"487_CR19","first-page":"425707","volume":"2013","author":"JY Gu","year":"2013","unstructured":"Gu JY, Li Q, Chen LR, Li YY, Hou TJ, Yuan G, Xu XJ: Platelet aggregation pathway network-based approach for evaluating compounds efficacy. Evid-Based Compl Alt. 2013, 2013: 425707-","journal-title":"Evid-Based Compl Alt"},{"issue":"2","key":"487_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","volume":"11","author":"S Li","year":"2013","unstructured":"Li S, Zhang B: Traditional chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 2013, 11 (2): 110-120.","journal-title":"Chin J Nat Med"},{"issue":"19","key":"487_CR21","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1093\/bioinformatics\/btp465","volume":"25","author":"SI Berger","year":"2009","unstructured":"Berger SI, Iyengar R: Network analyses in systems pharmacology. Bioinformatics. 2009, 25 (19): 2466-2472. 10.1093\/bioinformatics\/btp465.","journal-title":"Bioinformatics"},{"issue":"10","key":"487_CR22","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"AL Hopkins","year":"2007","unstructured":"Hopkins AL: Network pharmacology. Nat Biotechnol. 2007, 25 (10): 1110-1111. 10.1038\/nbt1007-1110.","journal-title":"Nat Biotechnol"},{"issue":"7","key":"487_CR23","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nbt1228","volume":"24","author":"GV Paolini","year":"2006","unstructured":"Paolini GV, Shapland RHB, van Hoorn WP, Mason JS, Hopkins AL: Global mapping of pharmacological space. Nat Biotechnol. 2006, 24 (7): 805-815. 10.1038\/nbt1228.","journal-title":"Nat Biotechnol"},{"key":"487_CR24","volume-title":"Chinese Herbalism","author":"Chinese Herbalism Editorial Board, State Administration of Traditional Chinese Medicine of the People\u2019s Republic of China","year":"1999","unstructured":"Chinese Herbalism Editorial Board, State Administration of Traditional Chinese Medicine of the People\u2019s Republic of China: Chinese Herbalism. 1999, Shanghai: Shanghai scientific & Technical Publishers"},{"key":"487_CR25","volume-title":"Chinese Pharmacopoeia","author":"Chinese Pharmacopoeia Commission","year":"2010","unstructured":"Chinese Pharmacopoeia Commission: Chinese Pharmacopoeia. 2010, Beijing: China Medical Science Press"},{"issue":"3","key":"487_CR26","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1021\/ci010113h","volume":"42","author":"XB Qiao","year":"2002","unstructured":"Qiao XB, Hou TJ, Zhang W, Guo SL, Xu SJ: A 3D structure database of components from chinese traditional medicinal herbs. J Chem Inf Comp Sci. 2002, 42 (3): 481-489.","journal-title":"J Chem Inf Comp Sci"},{"key":"487_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NM O\u2019Boyle","year":"2011","unstructured":"O\u2019Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR: Open babel: an open chemical toolbox. J Cheminformatics. 2011, 3: 33-10.1186\/1758-2946-3-33.","journal-title":"J Cheminformatics"},{"key":"487_CR28","doi-asserted-by":"publisher","first-page":"D1035","DOI":"10.1093\/nar\/gkq1126","volume":"39","author":"C Knox","year":"2011","unstructured":"Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, et al: DrugBank 3.0: a comprehensive resource for \u2018Omics\u2019 research on drugs. Nucleic Acids Res. 2011, 39: D1035-D1041. 10.1093\/nar\/gkq1126.","journal-title":"Nucleic Acids Res"},{"key":"487_CR29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1752-153X-2-18","volume":"2","author":"XH Jiang","year":"2008","unstructured":"Jiang XH, Kumar K, Hu X, Wallqvist A, Reifman J: DOVIS 2.0: an efficient and easy to use parallel virtual screening tool based on AutoDock 4.0. Chem Cent J. 2008, 2: 18-10.1186\/1752-153X-2-18.","journal-title":"Chem Cent J"},{"issue":"D1","key":"487_CR30","doi-asserted-by":"publisher","first-page":"D109","DOI":"10.1093\/nar\/gkr988","volume":"40","author":"M Kanehisa","year":"2012","unstructured":"Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M: KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012, 40 (D1): D109-D114. 10.1093\/nar\/gkr988.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"487_CR31","doi-asserted-by":"publisher","first-page":"D1128","DOI":"10.1093\/nar\/gkr797","volume":"40","author":"F Zhu","year":"2012","unstructured":"Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F, Zhang L, Song Y, Liu XH, Zhang JX, et al: Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012, 40 (D1): D1128-D1136. 10.1093\/nar\/gkr797.","journal-title":"Nucleic Acids Res"},{"issue":"15\u201316","key":"487_CR32","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.drudis.2006.06.016","volume":"11","author":"GM Keseru","year":"2006","unstructured":"Keseru GM, Makara GM: Hit discovery and hit-to-lead approaches. Drug Discov Today. 2006, 11 (15\u201316): 741-748.","journal-title":"Drug Discov Today"},{"issue":"5","key":"487_CR33","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nrd1086","volume":"2","author":"KH Bleicher","year":"2003","unstructured":"Bleicher KH, Bohm HJ, Muller K, Alanine AI: Hit and lead generation: beyond high-throughput screening. Nat Rev Drug Discov. 2003, 2 (5): 369-378. 10.1038\/nrd1086.","journal-title":"Nat Rev Drug Discov"},{"issue":"1\u20133","key":"487_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"CA Lipinski","year":"1997","unstructured":"Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 1997, 23 (1\u20133): 3-25.","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"487_CR35","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1023\/A:1008980200583","volume":"11","author":"HR Shin","year":"2000","unstructured":"Shin HR, Kim JY, Yun TK, Morgan G, Vainio H: The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control. 2000, 11 (6): 565-576. 10.1023\/A:1008980200583.","journal-title":"Cancer Causes Control"},{"key":"487_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev.pharmtox.37.1.71","volume":"37","author":"TJ Marrone","year":"1997","unstructured":"Marrone TJ, Briggs JM, McCammon JA: Structure-based drug design: computational advances. Annu Rev Pharmacol. 1997, 37: 71-90. 10.1146\/annurev.pharmtox.37.1.71.","journal-title":"Annu Rev Pharmacol"},{"issue":"12","key":"487_CR37","doi-asserted-by":"publisher","first-page":"e1002820","DOI":"10.1371\/journal.pcbi.1002820","volume":"8","author":"DY Cho","year":"2012","unstructured":"Cho DY, Kim YA, Przytycka TM: Chapter 5: network biology approach to complex diseases. PLoS Comput Biol. 2012, 8 (12): e1002820-10.1371\/journal.pcbi.1002820.","journal-title":"PLoS Comput Biol"},{"issue":"11","key":"487_CR38","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s11426-009-0274-x","volume":"52","author":"JY Gu","year":"2009","unstructured":"Gu JY, Yuan G, Zhu YH, Xu XJ: Computational pharmacological studies on cardiovascular disease by Qishen Yiqi Diwan. Sci China Ser B. 2009, 52 (11): 1871-1878. 10.1007\/s11426-009-0274-x.","journal-title":"Sci China Ser B"},{"issue":"3","key":"487_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.tips.2009.11.006","volume":"31","author":"A Pujol","year":"2010","unstructured":"Pujol A, Mosca R, Farres J, Aloy P: Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol Sci. 2010, 31 (3): 115-123. 10.1016\/j.tips.2009.11.006.","journal-title":"Trends Pharmacol Sci"},{"issue":"8","key":"487_CR40","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrd2084","volume":"5","author":"J Drews","year":"2006","unstructured":"Drews J: Case histories, magic bullets and the state of drug discovery. Nat Rev Drug Discov. 2006, 5 (8): 635-640. 10.1038\/nrd2084.","journal-title":"Nat Rev Drug Discov"},{"issue":"15","key":"487_CR41","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S1359-6446(04)03163-0","volume":"9","author":"R Morphy","year":"2004","unstructured":"Morphy R, Kay C, Rankovic Z: From magic bullets to designed multiple ligands. Drug Discov Today. 2004, 9 (15): 641-651. 10.1016\/S1359-6446(04)03163-0.","journal-title":"Drug Discov Today"},{"issue":"12","key":"487_CR42","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1039\/b908147j","volume":"5","author":"SC Janga","year":"2009","unstructured":"Janga SC, Tzakos A: Structure and organization of drug-target networks: insights from genomic approaches for drug discovery. Mol Biosyst. 2009, 5 (12): 1536-1548. 10.1039\/b908147j.","journal-title":"Mol Biosyst"},{"issue":"1\u20132","key":"487_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/minf.200900069","volume":"29","author":"I Vogt","year":"2010","unstructured":"Vogt I, Mestres J: Drug-target networks. Mol Inform. 2010, 29 (1\u20132): 10-14.","journal-title":"Mol Inform"},{"issue":"10","key":"487_CR44","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nbt1338","volume":"25","author":"MA Yildirim","year":"2007","unstructured":"Yildirim MA, Goh KI, Cusick ME, Barabasi AL, Vidal M: Drug-target network. Nat Biotechnol. 2007, 25 (10): 1119-1126. 10.1038\/nbt1338.","journal-title":"Nat Biotechnol"},{"issue":"9","key":"487_CR45","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1039\/b905821b","volume":"5","author":"J Mestres","year":"2009","unstructured":"Mestres J, Gregori-Puigjane E, Valverde S, Sole RV: The topology of drug-target interaction networks: implicit dependence on drug properties and target families. Mol Biosyst. 2009, 5 (9): 1051-1057. 10.1039\/b905821b.","journal-title":"Mol Biosyst"},{"issue":"25","key":"487_CR46","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1161\/01.CIR.103.25.3051","volume":"103","author":"CJ O\u2019Donnell","year":"2001","unstructured":"O\u2019Donnell CJ, Larson MG, Feng DL, Sutherland PA, Lindpaintner K, Myers RH, D\u2019Agostino RA, Levy D, Tofler GH: Genetic and environmental contributions to platelet aggregation - the framingham heart study. Circulation. 2001, 103 (25): 3051-3056. 10.1161\/01.CIR.103.25.3051.","journal-title":"Circulation"},{"issue":"3","key":"487_CR47","doi-asserted-by":"publisher","first-page":"e14774","DOI":"10.1371\/journal.pone.0014774","volume":"6","author":"Q Li","year":"2011","unstructured":"Li Q, Li XD, Li CH, Chen LR, Song J, Tang YL, Xu XJ: A network-based multi-target computational estimation scheme for anticoagulant activities of compounds. PLoS One. 2011, 6 (3): e14774-10.1371\/journal.pone.0014774.","journal-title":"PLoS One"},{"issue":"3","key":"487_CR48","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","volume":"27","author":"ME Smoot","year":"2011","unstructured":"Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T: Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011, 27 (3): 431-432. 10.1093\/bioinformatics\/btq675.","journal-title":"Bioinformatics"}],"container-title":["Journal of Cheminformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1758-2946-5-51.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1758-2946-5-51\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1758-2946-5-51.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:33:34Z","timestamp":1630550014000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcheminf.biomedcentral.com\/articles\/10.1186\/1758-2946-5-51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["487"],"URL":"https:\/\/doi.org\/10.1186\/1758-2946-5-51","relation":{},"ISSN":["1758-2946"],"issn-type":[{"value":"1758-2946","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"30 July 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"51"}}