{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:38:26Z","timestamp":1785454706421,"version":"3.56.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T00:00:00Z","timestamp":1288396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetol Metab Syndr"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Conjugated linoleic acid (CLA) is a class of 28 positional and geometric isomers of linoleic acid octadecadienoic.Currently, it has been described many benefits related to the supplementation of CLA in animals and humans, as in the treatment of cancer, oxidative stress, in atherosclerosis, in bone formation and composition in obesity, in diabetes and the immune system. However, our results show that, CLA appears to be not a good supplement in patients with cachexia.<\/jats:p>","DOI":"10.1186\/1758-5996-2-62","type":"journal-article","created":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T18:13:52Z","timestamp":1288462432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Conjugated Linoleic Acid: good or bad nutrient"],"prefix":"10.1186","volume":"2","author":[{"given":"Daniela C","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio S","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Luiz C","family":"Carnevali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia","family":"Seelaender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,30]]},"reference":[{"issue":"11","key":"91_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jnutbio.2007.12.007","volume":"19","author":"S Rayalam","year":"2008","unstructured":"Rayalam S, Della-Fera MA, Baile CA: Phytochemicals and regulation of the adipocyte life cycle. J Nutr Biochem. 2008, 19 (11): 717-26. 10.1016\/j.jnutbio.2007.12.007.","journal-title":"J Nutr Biochem"},{"issue":"3","key":"91_CR2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/00041433-200206000-00005","volume":"3","author":"S Banni","year":"2002","unstructured":"Banni S: Conjugated linoleic acid metabolism. Curr Opin Lipidol. 2002, 3 (3): 261-6. 10.1097\/00041433-200206000-00005. Review","journal-title":"Curr Opin Lipidol"},{"issue":"10A","key":"91_CR3","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1017\/S1368980007000687","volume":"10","author":"MB Silveira","year":"2007","unstructured":"Silveira MB, Carraro R, Monereo S, T\u00e9bar J: Conjugated linoleic acid (CLA) and obesity. Public Health Nutr. 2007, 10 (10A): 1181-6. 10.1017\/S1368980007000687.","journal-title":"Public Health Nutr"},{"issue":"1","key":"91_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/biof.13","volume":"35","author":"I Churruca","year":"2009","unstructured":"Churruca I, Fern\u00e1ndez-Quintela A, Portillo MP: Conjugated linoleic acid isomers: differences in metabolism and biological effects. Biofactors. 2009, 35 (1): 105-11. 10.1002\/biof.13. Review","journal-title":"Biofactors"},{"issue":"1","key":"91_CR5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/153537020322800107","volume":"228","author":"M Yang","year":"2003","unstructured":"Yang M, Cook ME: Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-alpha production, and modifies splenocyte cytokines production. Exp Biol Med (Maywood). 2003, 228 (1): 51-8.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"91_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/nur.20052","volume":"28","author":"E Graves","year":"2005","unstructured":"Graves E, Hitt A, Pariza MW, Cook ME, McCarthy DO: Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res Nurs Health. 2005, 28 (1): 48-55. 10.1002\/nur.20052.","journal-title":"Res Nurs Health"},{"key":"91_CR7","volume-title":"Efeitos do \u00e1cido linol\u00e9ico conjugado sobre par\u00e2metros do metabolismo lip\u00eddico na caquexia associada ao c\u00e2ncer","author":"DC Gon\u00e7alves","year":"2010","unstructured":"Gon\u00e7alves DC: Efeitos do \u00e1cido linol\u00e9ico conjugado sobre par\u00e2metros do metabolismo lip\u00eddico na caquexia associada ao c\u00e2ncer. 2010, Tese de doutorado, Instituto de Ci\u00eancias Biom\u00e9dicas- Universidade de S\u00e3o Paulo"}],"container-title":["Diabetology &amp; Metabolic Syndrome"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1758-5996-2-62.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1758-5996-2-62\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1758-5996-2-62.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:35:09Z","timestamp":1630456509000},"score":1,"resource":{"primary":{"URL":"https:\/\/dmsjournal.biomedcentral.com\/articles\/10.1186\/1758-5996-2-62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,30]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["91"],"URL":"https:\/\/doi.org\/10.1186\/1758-5996-2-62","relation":{},"ISSN":["1758-5996"],"issn-type":[{"value":"1758-5996","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,30]]},"assertion":[{"value":"3 August 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"62"}}