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In cervical specimen, we identified HPV DNA of different oncogenic risk types by polymerase chain reaction (PCR). Enzyme-linked immunosorbent assay (ELISA) kits (JSC SPC \u2018DiaprofMed\u2019) were used for detecting antibodies to HSV1 and\/or HSV2 and for determining the avidity index. The production of pro-inflammatory cytokines, interferon-\u03b3 (IFN-\u03b3), IFN-\u03b1, TNF-\u03b1, and interleukin-1\u03b2 (IL-1\u03b2), and anti-inflammatory cytokines, IL-4, IL-10, and transforming growth factor-\u03b21 (TGF-\u03b21), were studied by ELISA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In HPV-induced cervix precancerous diseases, we identified low-avidity IgG antibodies to HSV serum of 20 patients; in the serum of 17 patients, we identified average-avidity antibodies, and high-avidity antibodies were found in 2 patients only. In 14 HPV-negative patients, we found low-avidity IgG antibodies to HSV; in 10 patients, medium avidity. Patients with low-avidity IgG antibodies to herpes virus showed high and medium oncogenic risk HPV types and a decrease of IFN-\u03b3 compared to patients with medium-avidity IgG antibodies. Production of IFN-\u03b3 was suppressed also in HPV-negative patients with cervical precancers, but we found low- and medium-avidity IgG antibodies to herpes virus. In patients with low-avidity antibodies, we observed increased level of IL-10. Level of IFN-\u03b1, IL-1\u03b2, IL-2, and IL-4 did not change in patients of all groups, but TGF-\u03b21 increased.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In HPV-positive patients, those with low-avidity IgG antibodies to HSV had immunosuppression, confirmed by increased TGF-\u03b21 and violation of IFN-\u03b3 production. Therefore, in pro- and anti-inflammatory cytokines and IgG antibodies to HSV, their avidity is an important diagnostic biomarker of HPV-induced precancerous cervical diseases. Low-avidity IgG antibodies may be an indication for treatment with immunomodulators and antiviral drugs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1878-5085-5-1","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T10:01:25Z","timestamp":1389002485000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Development of biomarker panel to predict, prevent and create treatments tailored to the persons with human papillomavirus-induced cervical precancerous lesions"],"prefix":"10.1186","volume":"5","author":[{"given":"Liudmyla M","family":"Lazarenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena E","family":"Nikitina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgen V","family":"Nikitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga M","family":"Demchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galyna V","family":"Kovtonyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larysa O","family":"Ganova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostyslav V","family":"Bubnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika O","family":"Shevchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia M","family":"Nastradina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria V","family":"Bila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykola Ya","family":"Spivak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"5031_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1878-5085-3-14","volume":"3","author":"O Golubnitschaja","year":"2012","unstructured":"Golubnitschaja O, Costigliola V, EPMA: General report & recommendations in predictive, preventive and personalised medicine 2012: white paper of the European association for predictive preventive and personalised medicine. 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