{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:13:36Z","timestamp":1793236416288,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T00:00:00Z","timestamp":1339632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Haemophilus influenzae<\/jats:italic> is present as a commensal organism in the nasopharynx of most healthy adults from where it can spread to cause both systemic and respiratory tract infection. This bacterium is divided into typeable forms (such as type b) or nontypeable forms based on the presence or absence of a tough polysaccharide capsule. Respiratory disease is predominantly caused by the nontypeable forms (NTHi). <jats:italic>Haemophilus influenzae<\/jats:italic> has evolved a number of strategies to evade the host defense including the ability to invade into local tissue. Pathogenic properties of this bacterium as well as defects in host defense may result in the spread of this bacterium from the upper airway to the bronchi of the lung. This can result in airway inflammation and colonization particularly in chronic obstructive pulmonary disease. Treatment of respiratory tract infection with <jats:italic>Haemophilus influenzae<\/jats:italic> is often only partially successful with ongoing infection and inflammation. Improvement in patient outcome will be dependent on a better understanding of the pathogenesis and host immune response to this bacterium.<\/jats:p>","DOI":"10.1186\/2001-1326-1-10","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T14:34:40Z","timestamp":1340634880000},"source":"Crossref","is-referenced-by-count":136,"title":["<i>Haemophilus influenzae<\/i> and the lung (<i>Haemophilus<\/i> and the lung)"],"prefix":"10.1002","volume":"1","author":[{"given":"Paul","family":"King","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine and Department of Medicine Monash University Monash Medical Centre 246 Clayton Rd, Clayton 3168 Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,14]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"939","volume-title":"Harrisons Principles of Internal Medicine","author":"Murphy TF","year":"2001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111214"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(89)90058-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.2.337"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800067327"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/jcm.33.8.2027-2031.1995","article-title":"Turnover of nonencapsulated Haemophilus influenzae in the nasopharynges of otitis\u2010prone children","volume":"33","author":"Samuelson A","year":"1995","journal-title":"J Clin Microbiol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/314870"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00277-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012561"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.41.3.987-991.1983"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770321-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1996.0067"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.2.93"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1086\/314921","article-title":"Effects on the ciliated epithelium of protein D\u2010producing and \u2010nonproducing nontypeable Haemophilus influenzae in nasopharyngeal tissue cultures","volume":"180","author":"Cervin A","year":"1999","journal-title":"J Infect Dis"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.4.1302-1313.1992"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199005000-00006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1073\/pnas.90.7.2875","article-title":"High\u2010molecular\u2010weight proteins of nontypable Haemophilus influenzae mediate attachment to human epithelial cells","volume":"90","author":"Falkow S","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1073\/pnas.93.21.11913","article-title":"Haemophilus influenzae pili are composite structures assembled via the HifB chaperone","volume":"93","author":"Krasan GP","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb00461.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.11.4922-4928.1994"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.1.449-454.1999"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1996.tb02467.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.2.266"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.37.100183.003131"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90647-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.11.4673-4679.1996"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb10820.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2001.0456"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/322016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700660114"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.5.752"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.2.673-679.1994"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.9707010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-67"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.11.2104093"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2728-2735.2005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.04.041"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151236098"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-16"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.6042"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/431990"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03697.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-728OC"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03667.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2008.01078.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","unstructured":"KnoblochJ SchildK JungckD et al: The T\u2010Helper Cell Type 1 Immune Response to Gram\u2010Negative Bacterial Infections Is Impaired in COPD.Am J Respir Crit Care Med 183:204\u2013214.","DOI":"10.1164\/rccm.201002-0199OC"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2530"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.8.825"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90493-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1306OC"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-859OC"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.317"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.081752"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-136OC"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1086\/591708"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70466-2"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00100-7"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.891"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(03)00026-X"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-354OC"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00507-6"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.9.759"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0366OC"},{"key":"e_1_2_9_65_1","unstructured":"KingPT HoldsworthSR FreezerNJ VillanuevaE GallagherM HolmesPW: Outcome in Adult Bronchiectasis.Journal of Chronic Obstructive Pulmonary Disease2005 In Press."},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S15417"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107484200"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0198OC"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl142"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00354-07"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf221"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.06.029"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1382"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04142.x"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1186%2F2001-1326-1-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1186\/2001-1326-1-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1186\/2001-1326-1-10","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1186\/2001-1326-1-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T11:42:08Z","timestamp":1694000528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1186\/2001-1326-1-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,14]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1186\/2001-1326-1-10"],"URL":"https:\/\/doi.org\/10.1186\/2001-1326-1-10","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,14]]},"article-number":"e10"}}