{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:50:52Z","timestamp":1753883452020,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T00:00:00Z","timestamp":1395792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tympanic membrane perforations (TMP) are relatively common but are typically not treated in their acute stage, as most will heal spontaneously in 7\u201310 days. Those cases which fail to heal within 3 months are called chronic TMP which attract surgical intervention (e.g. myringoplasty), typically with a temporalis fascia autograft. New materials for the repair of chronic TMP are being developed to address deficiencies in the performance of autografts by undergoing evaluation in animal models prior to clinical study. However, there is currently a lack of ideal chronic TMP animal models available, hindering the development of new treatments. Various techniques and animal species have been investigated for the creation of chronic TMP with varied success. In the present commentary, we bring to the attention of readers the recent report by Shen et al. in Journal of Translational Medicine. The study reported the creation of a chronic TMP animal model in plasminogen gene deficient mice. However, the short observation time (9, 19 days), lack of success rate and the scarcity of solid evidence (e.g. otoscopic &amp; histologic images) to confirm the chronicity of TMP warrant a more thorough discussion.<\/jats:p>","DOI":"10.1186\/2001-1326-3-5","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T10:04:31Z","timestamp":1395828271000},"source":"Crossref","is-referenced-by-count":17,"title":["Animal models of chronic tympanic membrane perforation: in response to plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice"],"prefix":"10.1002","volume":"3","author":[{"given":"Allen Y","family":"Wang","sequence":"first","affiliation":[{"name":"Ear Sciences Centre School of Surgery The University of Western Australia 35 Stirling Highway 6009 Nedlands WA Australia"},{"name":"Department of Otolaryngology, Head, Neck and Skull Base Surgery Sir Charles Gairdner Hospital Nedlands WA Australia"},{"name":"Ear Science Institute Australia Subiaco WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Ear Sciences Centre School of Surgery The University of Western Australia 35 Stirling Highway 6009 Nedlands WA Australia"},{"name":"Department of Otolaryngology, Head and Neck Ningbo Lihuili Hospital (Ningbo Medical Centre); School of Medicine, Ningbo University Ningbo Zhejiang China"},{"name":"Ear Science Institute Australia Subiaco WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T","family":"Wang","sequence":"additional","affiliation":[{"name":"Ear Sciences Centre School of Surgery The University of Western Australia 35 Stirling Highway 6009 Nedlands WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Ear Sciences Centre School of Surgery The University of Western Australia 35 Stirling Highway 6009 Nedlands WA Australia"},{"name":"Department of Speech\u2010Language Pathology and Audiology University of Pretoria Pretoria South Africa"},{"name":"Ear Science Institute Australia Subiaco WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J","family":"Dilley","sequence":"additional","affiliation":[{"name":"Ear Sciences Centre School of Surgery The University of Western Australia 35 Stirling Highway 6009 Nedlands WA Australia"},{"name":"Ear Science Institute Australia Subiaco WA 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