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Low acetylcholine (ACh) concentration in hippocampus and cortex areas of the brain is one of the main reasons for this disease. In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer\u2019s disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Design, synthesis and assessment of anticholinesterase activity of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives showed prepared compounds can function as potential acetylcholinesterase inhibitor. Among 12 synthesized derivatives, compound 4a with <jats:italic>ortho<\/jats:italic> chlorine moiety as electron withdrawing group exhibited the highest potency in these series (IC<jats:sub>50<\/jats:sub>\u2009=\u20090.91\u2009\u00b1\u20090.045 \u03bcM) compared to donepezil (IC<jats:sub>50<\/jats:sub>\u2009=\u20090.14\u2009\u00b1\u20090.03 \u03bcM). The results of the enzyme inhibition test (Ellman test) showed that electron withdrawing groups like Cl, F and NO<jats:sub>2<\/jats:sub> can render the best effect at position <jats:italic>ortho<\/jats:italic> and <jats:italic>para<\/jats:italic> of the phenyl ring. But compound 4g with methoxy group at position 3(<jats:italic>meta<\/jats:italic>) afforded a favorable potency (IC<jats:sub>50<\/jats:sub>\u2009=\u20095.5\u2009\u00b1\u20090.7 \u03bcM). Furthermore, docking study confirmed a same binding mode like donepezil for compound 4a.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Synthesized compounds 4a-4l could be proposed as potential anticholinesterase agents.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/2008-2231-21-47","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T16:16:27Z","timestamp":1370621787000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects"],"prefix":"10.1186","volume":"21","author":[{"given":"Ahmad","family":"Mohammadi-Farani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Nadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Aliabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,7]]},"reference":[{"key":"152_CR1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/0929867003375191","volume":"7","author":"H Sugimoto","year":"2000","unstructured":"Sugimoto H, Yamanishi Y, Iimura Y, Kawakami Y: Donepezil Hydrochloride (E2020) and Other Acetylcholinesterase Inhibitors. 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