{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:05:08Z","timestamp":1790039108272,"version":"4.0.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Semant"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In prior work, we presented the Ontology of Physics for Biology (OPB) as a computational ontology for use in the annotation and representations of biophysical knowledge encoded in repositories of physics-based biosimulation models. We introduced OPB:\n                      <jats:italic>Physical entity<\/jats:italic>\n                      and OPB:\n                      <jats:italic>Physical property<\/jats:italic>\n                      classes that extend available spatiotemporal representations of physical entities and processes to explicitly represent the thermodynamics and dynamics of physiological processes. Our utilitarian, long-term aim is to develop computational tools for creating and querying formalized physiological knowledge for use by multiscale \u201cphysiome\u201d projects such as the EU\u2019s Virtual Physiological Human (VPH) and NIH\u2019s Virtual Physiological Rat (VPR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Here we describe the OPB:\n                      <jats:italic>Physical dependency<\/jats:italic>\n                      taxonomy of classes that represent of the laws of classical physics that are the \u201crules\u201d by which physical properties of physical entities change during occurrences of physical processes. For example, the fluid analog of Ohm\u2019s law (as for electric currents) is used to describe how a blood flow rate depends on a blood pressure gradient. Hooke\u2019s law (as in elastic deformations of springs) is used to describe how an increase in vascular volume increases blood pressure. We classify such dependencies according to the flow, transformation, and storage of thermodynamic energy that occurs during processes governed by the dependencies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have developed the OPB and annotation methods to represent the meaning\u2014the biophysical semantics\u2014of the mathematical statements of physiological analysis and the biophysical content of models and datasets. Here we describe and discuss our approach to an ontological representation of physical laws (as dependencies) and properties as encoded for the mathematical analysis of biophysical processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/2041-1480-4-41","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T09:02:52Z","timestamp":1385974972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ontology of physics for biology: representing physical dependencies as a basis for biological processes"],"prefix":"10.1186","volume":"4","author":[{"given":"Daniel L","family":"Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell L","family":"Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred L","family":"Bookstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"Gennari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"221_CR1","first-page":"20","volume-title":"Ontologies in Medicine","author":"P Grenon","year":"2004","unstructured":"Grenon P, Smith B, Goldberg L: Biodynamic ontology: applying BFO in the biomedical domain. 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