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The approximate prevalence of shellfish allergy is estimated at 0.5\u20102.5% of the general population, depending on degree of consumption by age and geographic regions. The manifestations of shellfish allergy vary widely, but it tends to be more severe than most other food allergens.<\/jats:p>\n                  <jats:p>Tropomyosin is the major allergen and is responsible for cross\u2010reactivity between members of the shellfish family, particularly among the crustacea. Newly described allergens and subtle differences in the structures of tropomyosin between different species of shellfish could account for the discrepancy between in vitro cross\u2010antigenicity and clinical cross\u2010allergenicity. The diagnosis requires a thorough medical history supported by skin testing or measurement of specific IgE level, and confirmed by appropriate oral challenge testing unless the reaction was life\u2010threatening.<\/jats:p>\n                  <jats:p>Management of shellfish allergy is basically strict elimination, which in highly allergic subjects may include avoidance of touching or smelling and the availability of self\u2010administered epinephrine. Specific immunotherapy is not currently available and requires the development of safe and effective protocols.<\/jats:p>","DOI":"10.1186\/2045-7022-1-3","type":"journal-article","created":{"date-parts":[[2011,6,11]],"date-time":"2011-06-11T02:20:26Z","timestamp":1307758826000},"source":"Crossref","is-referenced-by-count":57,"title":["Not all shellfish \u201callergy\u201d is allergy!"],"prefix":"10.1002","volume":"1","author":[{"given":"Chee K","family":"Woo","sequence":"first","affiliation":[{"name":"Allergy and Immunology Section Louisiana State University Health Sciences Center 71130 Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami L","family":"Bahna","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Section Louisiana State University Health Sciences Center 71130 Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,10]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"U.S. Seafood Consumption Declines Slightly in 2009. 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