{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:34:47Z","timestamp":1761975287749,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently we reported the validation of the \u201cAllergy\u2010Control\u2010SCORE<jats:sup>\u00a9<\/jats:sup> (ACS)\u201d which assesses symptom severity as well as medication use on three dimensions lung, nose and eyes. The aim of this study was to test the validity of the score for eyes and nose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred\u2010twenty\u2010one consenting subjects (age 19\u201065y), including 81 patients with allergic rhino\u2010conjunctivitis (RC) and 40 healthy controls, participated in the study. Patients rated daily nasal and eye symptoms using a 4\u2010point scale (none, mild, moderate, and severe) and their use of anti\u2010symptomatic medication. Validation criteria were pollen counts in the course of the study period. Discrimination capacity was analyzed by comparing the rhino\u2010conjunctivitis Allergy\u2010Control\u2010SCORE<jats:sup>\u00a9<\/jats:sup> (RC\u2010ACS<jats:sup>\u00a9<\/jats:sup>) values of allergic patients and healthy controls. Convergent reliability was assessed by correlating RC\u2010ACS<jats:sup>\u00a9<\/jats:sup> values with the global severity of allergy, the quality of life, and the allergy\u2010related medical consultations. Retest reliability was assessed by the correlation of the repeated measured RC\u2010ACS<jats:sup>\u00a9<\/jats:sup> scores during each of two consecutive weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Convergent reliability analysis indicated a significant correlation between RC\u2010Allergy\u2010Control\u2010SCORE<jats:sup>\u00a9<\/jats:sup> and global severity of allergy (<jats:italic>r<\/jats:italic>\u2009=\u20090.691; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), quality of life (<jats:italic>r<\/jats:italic>\u2009=\u20090.757; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and allergy\u2010related medical consultations (<jats:italic>r<\/jats:italic>\u2009=\u20090.329; <jats:italic>p<\/jats:italic>\u2009=\u20090.0019). RC\u2010Allergy\u2010Control\u2010SCORE<jats:sup>\u00a9<\/jats:sup> showed a good retest reliability (<jats:italic>r<\/jats:italic>\u2009=\u20090.813; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and discriminated extremely well between allergic patients and healthy controls (Median: 3.7 range: 0; 14.1 vs. Median: 0 range: 0; 2.9; p\u2009&lt;\u20090.001), with a sensitivity of 93.8% and a specificity of 92.5% at a score value of 0.786.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The RC\u2010ACS<jats:sup>\u00a9<\/jats:sup> can be considered as valid and reliable to assess the severity of rhino\u2010conjunctivitis severity in clinical trials and observational studies.<\/jats:p><\/jats:sec>","DOI":"10.1186\/2045-7022-2-17","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T12:14:18Z","timestamp":1348056858000},"source":"Crossref","is-referenced-by-count":7,"title":["Prospective validation of the \u201crhino conjunctivitis allergy\u2010control\u2010SCORE<sup>\u00a9<\/sup>\u201d (RC\u2010ACS<sup>\u00a9<\/sup>)"],"prefix":"10.1002","volume":"2","author":[{"given":"Dietrich","family":"H\u00e4fner","sequence":"first","affiliation":[{"name":"Medical Department Allergopharma J. Ganzer KG Hermann\u2010K\u00f6rner\u2010Str. 52 21465 Reinbek Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Reich","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Zschocke","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annett","family":"Lotzin","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanns","family":"Meyer","sequence":"additional","affiliation":[{"name":"Medical Department Allergopharma J. Ganzer KG Hermann\u2010K\u00f6rner\u2010Str. 52 21465 Reinbek Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kettner","sequence":"additional","affiliation":[{"name":"Medical Department Allergopharma J. Ganzer KG Hermann\u2010K\u00f6rner\u2010Str. 52 21465 Reinbek Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemie","family":"Narkus","sequence":"additional","affiliation":[{"name":"Medical Department Allergopharma J. Ganzer KG Hermann\u2010K\u00f6rner\u2010Str. 52 21465 Reinbek Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1111\/j.1398-9995.2010.02531.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1111\/j.1398-9995.2006.01312.x"},{"volume-title":"Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases","year":"2008","author":"European Medicines Agency CHMP\/EWP\/18504\/2006)","key":"e_1_2_9_4_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1111\/j.1398-9995.2005.00790.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1016\/S1081-1206(10)60451-6"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1016\/j.otohns.2005.07.020"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1111\/j.1398-9995.2006.01276.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1111\/j.1365-2222.1991.tb00807.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1111\/j.1398-9995.2009.02263.x"},{"volume-title":"Statistical power analysis for the behavioral sciences","year":"1988","author":"Cohen J","key":"e_1_2_9_11_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1111\/j.1399-3038.2011.01228.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1111\/j.1398-9995.2007.01469.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1016\/j.iac.2011.02.004"}],"container-title":["Clinical and Translational Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1186\/2045-7022-2-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2045-7022-2-17\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1186\/2045-7022-2-17","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2045-7022-2-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1186\/2045-7022-2-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T04:46:36Z","timestamp":1693716396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1186\/2045-7022-2-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1186\/2045-7022-2-17"],"URL":"https:\/\/doi.org\/10.1186\/2045-7022-2-17","archive":["Portico"],"relation":{},"ISSN":["2045-7022","2045-7022"],"issn-type":[{"type":"print","value":"2045-7022"},{"type":"electronic","value":"2045-7022"}],"subject":[],"published":{"date-parts":[[2012,1]]},"article-number":"17"}}