{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:35:57Z","timestamp":1761975357487,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immediate type allergy to latex is still a widespread problem. Latex\u2010allergic patients undergoing diagnostic and operative medical procedures are at risk of potentially life\u2010threatening reactions. Accurate diagnostic methods are therefore crucial. The aim of this retrospective study was to discriminate between sensitization and relevant allergy to latex based on an easy and suitable diagnostic approach. In 14 patients with clinical symptoms and 27 controls, latex skin prick tests (SPT), IgE against latex (CAP) and serological component resolved specific latex\u2010allergen determination (Hev b1, b3, b5, b6, b7, b8, b9, b10, b11) based on ImmunoCAP ISAC were performed. SPT correlated very well with clinically manifest latex\u2010allergy demonstrating a high specificity (95%) (and a low sensitivity). However, CAP levels to crude latex could not safely discriminate between purely sensitized and latex\u2010allergic patients. The majority of patients mono\u2010sensitized to the latex profilin Hev b8 did not suffer from any relevant symptoms upon contact with latex. However, in two patients with latex\u2010allergy diagnosed by elevated specific IgE only sensitized against Hev b8, additional sensitization to carbohydrate cross\u2010reactive determinants (CCD) was found. In the case of positive serum IgE against latex and negative SPT, component\u2010resolved diagnosis including IgE against specific latex\u2010proteins, specially Hev b8, and carbohydrate cross\u2010reactive determinants (CCD) is a useful tool to discriminate between latex\u2010sensitization and latex\u2010allergy.<\/jats:p>","DOI":"10.1186\/2045-7022-3-11","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T15:15:30Z","timestamp":1364483730000},"source":"Crossref","is-referenced-by-count":32,"title":["Microarray\u2010based component\u2010resolved diagnosis of latex allergy: isolated IgE\u2010mediated sensitization to latexprofilin Hev b8\u00a0may act as confounder"],"prefix":"10.1002","volume":"3","author":[{"given":"Sarah","family":"Schuler","sequence":"first","affiliation":[{"name":"Allergy Unit Department of Dermatology University Hospital of Zurich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Servizio di allergologia e immunologia clinica Ospedali Regionali di Bellinzona e di Lugano Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schmid\u2010Grendelmeier","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Dermatology University Hospital of Zurich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Harr","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Dermatology University Hospital of Zurich Z\u00fcrich Switzerland"},{"name":"Service d'immunologie et d'allergologie, Unit\u00e9 d'allergologie H\u00f4pitaux Universitaires Geneva 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