{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:13Z","timestamp":1761986473425,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter\u2010linked evidence syntheses that are being undertaken in order to provide a state\u2010of\u2010the\u2010art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management and impact on quality of life, which will be used to inform clinical recommendations.<\/jats:p><jats:p>The aims of this systematic review will be to assess the effectiveness of interventions for the acute management of anaphylaxis, and pharmacological and non\u2010pharmacological approaches for the long\u2010term management of anaphylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A highly sensitive search strategy has been developed, and validated study design filters will be applied to retrieve all articles pertaining to the management of anaphylaxis from electronic bibliographic databases. We will systematically review the literature on the acute management of anaphylaxis by assessing the effectiveness of epinephrine, H1\u2010antihistamines (versus placebo), systemic glucocorticosteroids, methylxanthines or any other treatments for the emergency management of people experiencing anaphylaxis. The main interventions that have been studied in the context of long\u2010term management are anaphylaxis management plans and allergen\u2010specific immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>There is at present little in the way of robust evidence to guide decisions on the acute and\/or long\u2010term management of anaphylaxis. Given the risk of death and the considerable morbidity associated with anaphylaxis these evidence gaps need to be filled wherever possible; this systematic review will make a start in this area.<\/jats:p><\/jats:sec>","DOI":"10.1186\/2045-7022-3-14","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T14:42:00Z","timestamp":1365604920000},"source":"Crossref","is-referenced-by-count":13,"title":["The acute and long\u2010term management of anaphylaxis: protocol for a systematic review"],"prefix":"10.1002","volume":"3","author":[{"given":"Sangeeta","family":"Dhami","sequence":"first","affiliation":[{"name":"Evidence\u2010Based Health Care Ltd 113 The Murrays EH17 8UD Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhmeet S","family":"Panesar","sequence":"additional","affiliation":[{"name":"Medical School Doorway 3 University of Edinburgh Teviot Place EH8 9AG Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Rader","sequence":"additional","affiliation":[{"name":"University of Ottawa 75\u00a0Laurier Avenue East K1N 6N5 Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Muraro","sequence":"additional","affiliation":[{"name":"Padua General University Hospital Via Giustiniani 3 35128 Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Roberts","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton SO171BJ Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University Charitestra\u00dfe 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Medical School Doorway 3 University of Edinburgh Teviot Place EH8 9AG Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EAACI Food Allergy and Anaphylaxis Guidelines group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01421.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1542\/peds.86.6.999","article-title":"Committee on School Health. 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