{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:47:44Z","timestamp":1791226064914,"version":"4.1.0"},"reference-count":221,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sensitization to fungi and long term or uncontrolled fungal infection are associated with poor control of asthma, the likelihood of more severe disease and complications such as bronchiectasis and chronic pulmonary aspergillosis. Modelling suggests that &gt;6.5\u00a0million people have severe asthma with fungal sensitizations (SAFS), up to 50% of adult asthmatics attending secondary care have fungal sensitization, and an estimated 4.8\u00a0million adults have allergic bronchopulmonary aspergillosis (ABPA). There is much uncertainty about which fungi and fungal allergens are relevant to asthma, the natural history of sensitisation to fungi, if there is an exposure response relationship for fungal allergy, and the pathogenesis and frequency of exacerbations and complications. Genetic associations have been described but only weakly linked to phenotypes. The evidence base for most management strategies in ABPA, SAFS and related conditions is weak. Yet straightforward clinical practice guidelines for management are required. The role of environmental monitoring and optimal means of controlling disease to prevent disability and complications are not yet clear. In this paper we set out the key evidence supporting the role of fungal exposure, sensitisation and infection in asthmatics, what is understood about pathogenesis and natural history and identify the numerous areas for research studies.<\/jats:p>","DOI":"10.1186\/2045-7022-4-14","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T07:02:53Z","timestamp":1397545373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":298,"title":["Fungal allergy in asthma\u2013state of the art and research needs"],"prefix":"10.1002","volume":"4","author":[{"given":"David W","family":"Denning","sequence":"first","affiliation":[{"name":"The National Aspergillosis Centre University Hospital of South Manchester The University of Manchester Manchester Academic Health Science Centre Manchester UK"},{"name":"Education and Research Centre UHSM Southmoor Road M23 9LT Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Pashley","sequence":"additional","affiliation":[{"name":"Leicester Institute for Lung Health and Respiratory Biomedical Research Unit Department of Infection Immunity and Inflammation University of Leicester Glenfield Hospital Groby Road LE3 9QP Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domink","family":"Hartl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Infectious Diseases &amp; Immunology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wardlaw","sequence":"additional","affiliation":[{"name":"Leicester Institute for Lung Health and Respiratory Biomedical Research Unit Department of Infection Immunity and Inflammation University of Leicester Glenfield Hospital Groby Road LE3 9QP Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cendrine","family":"Godet","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases CHU la Mil\u00e9trie Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Del Giacco","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences \u201cM. Aresu\u201d University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Delhaes","sequence":"additional","affiliation":[{"name":"Biology &amp; Diversity of Emerging Eukaryotic Pathogens (BDEEP) Center for Infection and Immunity of Lille (CIIL), INSERM U1019, CNRS UMR8204 IFR142 Lille Pasteur Institute Lille Nord de France University (EA4547) Lille France"},{"name":"Department of Parasitology\u2013Mycology Regional Hospital Center Faculty of Medicine Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Sergejeva","sequence":"additional","affiliation":[{"name":"Translational Immunology Group Institute of Technology Tartu University Tartu Estonia"},{"name":"North Estonia Medical Centre Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200305000-00006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/376525"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.970"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12141"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.61.1.35"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/007641-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x-i1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09550-9_11"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03321.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.037"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.7.4.317"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)91034-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1971.tb00793.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-4-405"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1971.tb00779.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.007"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061105"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2011.08.006"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.059"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06816.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/376526"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0087OC"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2012.754401"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00074705"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200805-737OC"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834487ae"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2012.662568"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/526500"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802314809"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20520"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162912"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02542.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61447-6"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.57"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08264"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.009"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92863-8"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1783"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104381"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056006558.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03339.x"},{"key":"e_1_2_5_45_1","first-page":"1127","article-title":"Allergic bronchopulmonary aspergillosis in infants","volume":"131","author":"Imbeau SA","year":"1977","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80574-0"},{"key":"e_1_2_5_47_1","first-page":"46","article-title":"Allergic bronchopulmonary aspergillosis in Indian children with bronchial asthma","volume":"54","author":"Chetty A","year":"1985","journal-title":"Ann Allergy"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360170130020"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-3-286"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.140.2.7255737"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.2741\/945"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054810"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.1.7"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.3.890"},{"key":"e_1_2_5_55_1","first-page":"333","article-title":"Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis","volume":"70","author":"Greenberger PA","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770900009055429"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.03.001"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.2.442"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0808"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.140.2.307"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198007000-00007"},{"key":"e_1_2_5_62_1","first-page":"232","article-title":"Allergic bronchopulmonary aspergillosis: evidence of limited tissue invasion","volume":"111","author":"Riley DJ","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.738312"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2012.02.011"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.030"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.04.018"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2012146"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10355"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02386.x"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.12.823"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90470-M"},{"key":"e_1_2_5_75_1","first-page":"346","article-title":"Bread eating induced oral angioedema due to alpha\u2010amylase allergy","volume":"14","author":"Moreno\u2010Ancillo A","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.30"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2005.024448"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.11.786"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00293.x"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102073240602"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.97105622"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.045"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20755"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.135762"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12082"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056005419.x"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126383"},{"key":"e_1_2_5_88_1","first-page":"368","article-title":"Current asthma and biochemical signs of inflammation in relation to building dampness in dwellings","volume":"3","author":"Norback D","year":"1999","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03987.x"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90130-T"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.037"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.3.229"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.2.358"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.52.6.388"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6689.1673"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.003"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/ina.12020"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90244-B"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60311-0"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.02.003"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0749-x"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002908"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2010.00698.x"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8265-y"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036313"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs036"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0693OC"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008578"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-69"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2012.08.007"},{"key":"e_1_2_5_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.145"},{"key":"e_1_2_5_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2011.11.004"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.08.031"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1159\/000154957"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295716"},{"key":"e_1_2_5_116_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.511286"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.503320"},{"key":"e_1_2_5_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780400025211"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101229"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003593"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003730"},{"key":"e_1_2_5_123_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00001-10"},{"key":"e_1_2_5_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2011.04.012"},{"key":"e_1_2_5_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.07.002"},{"key":"e_1_2_5_126_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152806779010972"},{"key":"e_1_2_5_127_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802189938"},{"key":"e_1_2_5_128_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1271OC"},{"key":"e_1_2_5_129_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00078107"},{"key":"e_1_2_5_130_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0211099"},{"key":"e_1_2_5_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.39"},{"key":"e_1_2_5_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200439"},{"key":"e_1_2_5_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1685"},{"key":"e_1_2_5_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802140766"},{"key":"e_1_2_5_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06471"},{"key":"e_1_2_5_136_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5157"},{"key":"e_1_2_5_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2939"},{"key":"e_1_2_5_138_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233734"},{"key":"e_1_2_5_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.05.007"},{"key":"e_1_2_5_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0834-z"},{"key":"e_1_2_5_141_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/252460"},{"key":"e_1_2_5_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2369"},{"key":"e_1_2_5_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10071"},{"key":"e_1_2_5_144_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035675"},{"key":"e_1_2_5_145_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901053"},{"key":"e_1_2_5_146_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810719"},{"key":"e_1_2_5_147_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100102"},{"key":"e_1_2_5_148_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206778743538"},{"key":"e_1_2_5_149_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44999"},{"key":"e_1_2_5_150_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.93"},{"key":"e_1_2_5_151_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7406"},{"key":"e_1_2_5_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802629"},{"key":"e_1_2_5_153_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1358.012"},{"key":"e_1_2_5_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-4-3"},{"key":"e_1_2_5_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.9"},{"key":"e_1_2_5_156_1","doi-asserted-by":"publisher","DOI":"10.1086\/429964"},{"key":"e_1_2_5_157_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.033"},{"key":"e_1_2_5_158_1","first-page":"45","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis","volume":"59","author":"Miller PW","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_159_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.762"},{"key":"e_1_2_5_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02130.x"},{"key":"e_1_2_5_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70306-4"},{"key":"e_1_2_5_162_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/843763"},{"key":"e_1_2_5_163_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107578"},{"key":"e_1_2_5_164_1","first-page":"936","article-title":"Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta\u2010analysis","volume":"13","author":"Agarwal R","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_5_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.8.1211"},{"key":"e_1_2_5_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1155::AID-IMMU1155>3.0.CO;2-6"},{"key":"e_1_2_5_167_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00837.x"},{"key":"e_1_2_5_168_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.130179"},{"key":"e_1_2_5_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00887.x"},{"key":"e_1_2_5_170_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2586"},{"key":"e_1_2_5_171_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.615762"},{"key":"e_1_2_5_172_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.511287"},{"key":"e_1_2_5_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2011.01.024"},{"key":"e_1_2_5_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12103"},{"key":"e_1_2_5_175_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir179"},{"key":"e_1_2_5_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03189.x"},{"key":"e_1_2_5_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.06.011"},{"key":"e_1_2_5_178_1","first-page":"CD007897","article-title":"Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma","author":"Sauni R","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_179_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070847"},{"key":"e_1_2_5_180_1","doi-asserted-by":"publisher","DOI":"10.1080\/104732201750154242"},{"key":"e_1_2_5_181_1","first-page":"36","article-title":"The remediation of mold damaged school\u2013a three\u2010year follow\u2010up study on teachers\u2019 health","volume":"12","author":"Patovirta RL","year":"2004","journal-title":"Cent Eur J Public Health"},{"key":"e_1_2_5_182_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0668.2002.02141.x"},{"key":"e_1_2_5_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthplace.2005.10.004"},{"key":"e_1_2_5_184_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39070.573032.80"},{"key":"e_1_2_5_185_1","doi-asserted-by":"publisher","DOI":"10.1080\/09603120400012876"},{"key":"e_1_2_5_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199808)34:2<183::AID-AJIM12>3.0.CO;2-R"},{"key":"e_1_2_5_187_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0668.2002.01112.x"},{"key":"e_1_2_5_188_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459624.2013.877141"},{"key":"e_1_2_5_189_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.065946-0"},{"key":"e_1_2_5_190_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-009-0487-5"},{"key":"e_1_2_5_191_1","first-page":"1110","article-title":"Respiratory health and immunological profile of poultry workers","volume":"88","author":"Rees D","year":"1998","journal-title":"S Afr Med J"},{"key":"e_1_2_5_192_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqt097"},{"issue":"4","key":"e_1_2_5_193_1","first-page":"349","volume":"73","author":"Inhaled beclomethasone dipropionate in allergic bronchopulmonary aspergillosis","year":"1979","journal-title":"Report to the Research Committee of the British Thoracic Association. Br J Dis Chest"},{"key":"e_1_2_5_194_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4665"},{"key":"e_1_2_5_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60326-3"},{"key":"e_1_2_5_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.04.017"},{"key":"e_1_2_5_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.02.005"},{"key":"e_1_2_5_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.01.009"},{"key":"e_1_2_5_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03979.x"},{"key":"e_1_2_5_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.05.006"},{"key":"e_1_2_5_201_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132006000300004"},{"key":"e_1_2_5_202_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421102"},{"key":"e_1_2_5_203_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1388"},{"key":"e_1_2_5_204_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0114"},{"key":"e_1_2_5_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70321-0"},{"key":"e_1_2_5_206_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051668"},{"key":"e_1_2_5_207_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01640.x"},{"key":"e_1_2_5_208_1","article-title":"Effectiveness of voriconazole in the treatment of Aspergillus fumigatus\u2010associated asthma (EVITA3 study)","author":"Agbetile J","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_5_209_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1937-1938.2001"},{"key":"e_1_2_5_210_1","doi-asserted-by":"publisher","DOI":"10.2165\/11592900-000000000-00000"},{"key":"e_1_2_5_211_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0478OC"},{"key":"e_1_2_5_212_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1507.090043"},{"key":"e_1_2_5_213_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq279"},{"key":"e_1_2_5_214_1","volume-title":"European Lung White Book","author":"Foundation ERSEL","year":"2003"},{"key":"e_1_2_5_215_1","first-page":"51","article-title":"Immune responses to pneumococcal vaccines in children and adults: rationale for age\u2010specific vaccination","volume":"3","author":"Westerink MA","year":"2012","journal-title":"Aging Dis"},{"key":"e_1_2_5_216_1","first-page":"453","article-title":"Pneumonia immunization in older adults: review of vaccine effectiveness and strategies","volume":"7","author":"Assaad U","year":"2012","journal-title":"Clin Interv Aging"},{"key":"e_1_2_5_217_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6879"},{"key":"e_1_2_5_218_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.11.176"},{"key":"e_1_2_5_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.11.018"},{"key":"e_1_2_5_220_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt028"},{"key":"e_1_2_5_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22667"},{"key":"e_1_2_5_222_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200832"}],"container-title":["Clinical and Translational Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1186\/2045-7022-4-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1186\/2045-7022-4-14","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2045-7022-4-14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1186\/2045-7022-4-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T18:24:37Z","timestamp":1693679077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1186\/2045-7022-4-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":221,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1186\/2045-7022-4-14"],"URL":"https:\/\/doi.org\/10.1186\/2045-7022-4-14","archive":["Portico"],"relation":{},"ISSN":["2045-7022","2045-7022"],"issn-type":[{"value":"2045-7022","type":"print"},{"value":"2045-7022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"14"}}