{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:57:29Z","timestamp":1793829449588,"version":"4.6.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":120,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The type of allergic sensitization is of central importance in the diagnosis and treatment of respiratory allergic diseases. At least 10% of the general population (and more than 50% of patients consulting for respiratory allergies) are polysensitized. Here, we review the recent literature on (i) the concepts of polysensitization, paucisensitization, co\u2010sensitization, co\u2010recognition, cross\u2010reactivity, cross\u2010sensitization, and polyallergy, (ii) the prevalence of polysensitization and (iii) the relationships between sensitization status, disease severity and treatment strategies. In molecular terms, clinical polysensitization can be divided into cross\u2010sensitization (also known as cross\u2010reactivity, in which the same IgE molecule binds to several allergens with common structural features) and co\u2010sensitization (the simultaneous presence of different IgEs binding to allergens that may not necessarily have common structural features). There is a strong overall association between sensitization in skin prick tests and total IgE values but there is debate as to whether IgE thresholds are useful guides to the presence or absence of clinical symptoms in individual cases. Molecular information from component\u2010resolved techniques appears to be of value for diagnosis and treatment decisions. Polysensitization develops over time and is a risk factor for respiratory allergy (being associated with disease severity) and therefore has clinical relevance for treatment decisions. The subterm polysensitization has been defined as polysensitization to between two and four allergens. Polyallergy is defined as clinically confirmed allergy to two or more allergens. Single\u2010allergen grass pollen allergen immunotherapy (AIT) is safe and effective in polysensitized patients, whereas multi\u2010allergen AIT requires more supporting evidence. Given that AIT may be more efficacious in moderate\u2010to\u2010severe disease than in mild disease, polysensitization could be an indication for this type of treatment. There is a need for flowcharts or decision trees for choosing the allergens for AIT in polysensitized patients and polyallergic patients.<\/jats:p>","DOI":"10.1186\/2045-7022-4-16","type":"journal-article","created":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T11:13:42Z","timestamp":1398942822000},"source":"Crossref","is-referenced-by-count":126,"title":["Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Michel","family":"Migueres","sequence":"first","affiliation":[{"name":"Service de Pneumologie et Allergologie Clinique de L'Union Saint\u2010Jean France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"D\u00e1vila","sequence":"additional","affiliation":[{"name":"Allergy Department IBSAL University Hospital of Salamanca Salamanca 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Ciprandi","sequence":"additional","affiliation":[{"name":"Department of Medicine IRCCS\u2010Azienda Ospedaliera Universitaria San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PlurAL study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_8_3_1","author":"Global Initiative for Asthma","year":"2012","journal-title":"Global strategy for asthma management and 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