{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:14:05Z","timestamp":1776942845593,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ir Vet J"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/2046-0481-66-22","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T20:01:32Z","timestamp":1383768092000},"source":"Crossref","is-referenced-by-count":23,"title":["Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options"],"prefix":"10.1186","volume":"66","author":[{"given":"Lucy VA","family":"Metcalfe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stratos","family":"Papakonstantinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D","family":"Cahalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hester","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne E","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"55_CR1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1053\/jcpa.2001.0481","volume":"125","author":"JC Patterson-Kane","year":"2001","unstructured":"Patterson-Kane JC, Sanchez LC, Uhl EW, Edens LM: Disseminated metastatic intramedullary melanoma in an aged grey horse. J Comp Path. 2001, 125: 204-207. 10.1053\/jcpa.2001.0481.","journal-title":"J Comp Path"},{"key":"55_CR2","volume-title":"Equine Dermatology","author":"DW Scott","year":"2003","unstructured":"Scott DW, Miller WH: Equine Dermatology. 2003, St. Louis: Saunders Elsevier"},{"key":"55_CR3","first-page":"446","volume":"81","author":"S Gorham","year":"1986","unstructured":"Gorham S, Robl M: Melanoma in the grey horse: the darker side of equine ageing. Vet Med. 1986, 81: 446-448.","journal-title":"Vet Med"},{"key":"55_CR4","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1939-1676.2002.tb01264.x","volume":"16","author":"KC MacGillivray","year":"2002","unstructured":"MacGillivray KC, Sweeney RW, Del Piero F: Metastatic melanoma in horses. J Vet Intern Med. 2002, 16: 452-456. 10.1111\/j.1939-1676.2002.tb01264.x.","journal-title":"J Vet Intern Med"},{"key":"55_CR5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2746\/042516403776114234","volume":"35","author":"MH Seltenhammer","year":"2003","unstructured":"Seltenhammer MH, Simhofer H, Scherzer S: Equine melanoma in a population of 296 grey Lippizaner horses. Equine Vet J. 2003, 35: 153-157.","journal-title":"Equine Vet J"},{"key":"55_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1939-1676.1995.tb01087.x","volume":"9","author":"BA Valentine","year":"1995","unstructured":"Valentine BA: Equine melanotic tumors: a retrospective study of 53 horses (1988-1991). J Vet Intern Med. 1995, 9: 291-297. 10.1111\/j.1939-1676.1995.tb01087.x.","journal-title":"J Vet Intern Med"},{"key":"55_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1034\/j.1600-0749.2000.130108.x","volume":"13","author":"C Fleury","year":"2000","unstructured":"Fleury C, Berard F, Balme B, Thomas L: The study of cutaneous melanomas in Camargue-type gray-skinned horses (1): Clinical-pathological characterization. Pigment Cell Res. 2000, 13: 39-46. 10.1034\/j.1600-0749.2000.130108.x.","journal-title":"Pigment Cell Res"},{"key":"55_CR8","first-page":"75","volume-title":"Tumors in Domestic Animals","author":"LT Pulley","year":"1990","unstructured":"Pulley LT, Stannard AA: Tumors of the skin and soft tissues. Tumors in Domestic Animals. Edited by: Moulton JE. 1990, Iowa: University of California Press, 75-82. 3rd edition.","edition":"3"},{"key":"55_CR9","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.2460\/javma.230.10.1506","volume":"230","author":"AP Theon","year":"2007","unstructured":"Theon AP, Wilson WD, Magdesian KG, Pusterla N, Snyder JR, Galuppo LD: Long-term outcome associated with intratumoral chemotherapy with cisplatin for cutaneous tumors in equidae: 573 cases (1995-2004). J Am Vet Med Ass. 2007, 230: 1506-1512. 10.2460\/javma.230.10.1506.","journal-title":"J Am Vet Med Ass"},{"key":"55_CR10","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.2460\/javma.229.10.1617","volume":"229","author":"CA Hewes","year":"2006","unstructured":"Hewes CA, Sullins KE: Use of cisplatin-containing biodegradable beads for treatment of cutaneous neoplasia in equidae: 59 cases (2000-2004). J Am Vet Med Ass. 2006, 229: 1617-1622. 10.2460\/javma.229.10.1617.","journal-title":"J Am Vet Med Ass"},{"key":"55_CR11","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1016\/S0140-6736(94)92907-6","volume":"344","author":"WJ Adams","year":"1994","unstructured":"Adams WJ, Morris DL: Short-course cimetidine and survival with colo-rectal cancer. Lancet. 1994, 344: 1768-1769. 10.1016\/S0140-6736(94)92907-6.","journal-title":"Lancet"},{"key":"55_CR12","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/BF00398182","volume":"114","author":"CM Moriarty","year":"1988","unstructured":"Moriarty CM, Stucky JL, Hamburger KW, Patil KD, Foley JF, Koefoot RR: Blood histamine and solid malignant tumours. J Cancer Res Clin Oncol. 1988, 114: 588-592. 10.1007\/BF00398182.","journal-title":"J Cancer Res Clin Oncol"},{"key":"55_CR13","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ejps.2011.02.004","volume":"42","author":"M Kubecova","year":"2011","unstructured":"Kubecova M, Kolostova K, Pinterova D, Kacprzak G, Bobek V: Cimetidine: an anticancer drug?. Eur J Pharm Sci. 2011, 42: 439-444. 10.1016\/j.ejps.2011.02.004.","journal-title":"Eur J Pharm Sci"},{"key":"55_CR14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2460\/javma.1990.196.03.449","volume":"196","author":"TE Goetz","year":"1990","unstructured":"Goetz TE, Ogilvie GK, Keegan KG, Johnson PJ: Cimetidine for treatment of melanomas in three horses. J Am Vet Med Ass. 1990, 196: 449-452.","journal-title":"J Am Vet Med Ass"},{"key":"55_CR15","first-page":"48","volume":"65","author":"F Laus","year":"2010","unstructured":"Laus F, Cerquetella M: Evaluation of cimetidine as a therapy for dermal melanomatosis in grey horse. Israel J Vet Med. 2010, 65: 48-52.","journal-title":"Israel J Vet Med"},{"key":"55_CR16","volume-title":"New developments in immunotherapy","author":"DJ Argyle","year":"2010","unstructured":"Argyle DJ: Proceedings of 35th World Small Animal Veterinary congress. New developments in immunotherapy. 2010, Geneva"},{"key":"55_CR17","first-page":"399","volume-title":"Current Therapy in Equine Medicine","author":"KA Jeglum","year":"1999","unstructured":"Jeglum KA: Melanomas. Current Therapy in Equine Medicine. Edited by: Robinson NE. 1999, Pennsylvania: WB Saunders Company, 399-400. 4th edition.","edition":"4"},{"key":"55_CR18","volume-title":"Immune response to Melanoma Surface Antigen (GD3) Vaccine in normal dogs","author":"R Milner","year":"2006","unstructured":"Milner R, Salute M, Farese J: Proceedings of 4th Annual Canine Cancer Conference. Immune response to Melanoma Surface Antigen (GD3) Vaccine in normal dogs. 2006, Chicago"},{"key":"55_CR19","volume-title":"The non-surgical management of the equine sarcoid","author":"DC Knottenbelt","year":"2009","unstructured":"Knottenbelt DC: Proceedings of the Annual Journal of the Association of French Veterinarians. The non-surgical management of the equine sarcoid. 2009"},{"key":"55_CR20","first-page":"3367","volume":"19","author":"RE Kinnunen","year":"1999","unstructured":"Kinnunen RE, Tallberg T, Stenback H, Sarna S: Equine sarcoid tumour treated by autogenous tumour vaccine. Anticancer Res. 1999, 19: 3367-3374.","journal-title":"Anticancer Res"},{"key":"55_CR21","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1007\/s001090000165","volume":"78","author":"LM Heinzerling","year":"2001","unstructured":"Heinzerling LM, Feige K, Rieder S, Akens MK, Dummer R, Stranzinger G, Moelling K: Tumor regression induced by intratumoral injection of DNA coding for human interleukin 12 into melanoma metastases in gray horses. J Mol Med. 2001, 78: 692-702. 10.1007\/s001090000165.","journal-title":"J Mol Med"},{"key":"55_CR22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/CJI.0b013e3181fe1997","volume":"34","author":"JV Muller","year":"2011","unstructured":"Muller JV, Feige K, Wunderlin P, Heinzerling LM: Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses. J Immunother. 2011, 34: 58-64. 10.1097\/CJI.0b013e3181fe1997.","journal-title":"J Immunother"},{"key":"55_CR23","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1136\/vr.164.9.278","volume":"164","author":"LME Finocchiaro","year":"2009","unstructured":"Finocchiaro LME, Riveros MD, Glikin GC: Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse. Vet Rec. 2009, 164: 278-279. 10.1136\/vr.164.9.278.","journal-title":"Vet Rec"},{"key":"55_CR24","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/ng.185","volume":"40","author":"PG Rosengre","year":"2008","unstructured":"Rosengre PG, Golovko A, Sundstrom E: A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet. 2008, 40: 1004-1009. 10.1038\/ng.185.","journal-title":"Nat Genet"},{"key":"55_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1439-0388.2000x.00245.x","volume":"117","author":"S Rieder","year":"2000","unstructured":"Rieder S, Stricker C, Joerg H, Dummer R, Stranzinger G: A comparative genetic approach for the investigation of ageing grey horse melanoma. J. anim Breed Genet. 2000, 117: 73-82. 10.1111\/j.1439-0388.2000x.00245.x.","journal-title":"J. anim Breed Genet"},{"key":"55_CR26","first-page":"631","volume":"46","author":"LE Millikan","year":"1973","unstructured":"Millikan LE, Hook RR, Manning PJ: Immunobiology of melanoma. Gross and ultrastructural studies in a new melanoma model: the sinclair swine. Yale J Biol Med. 1973, 46: 631-645.","journal-title":"Yale J Biol Med"}],"container-title":["Irish Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2046-0481-66-22.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2046-0481-66-22\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2046-0481-66-22.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T07:39:25Z","timestamp":1716104365000},"score":1,"resource":{"primary":{"URL":"https:\/\/irishvetjournal.biomedcentral.com\/articles\/10.1186\/2046-0481-66-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["55"],"URL":"https:\/\/doi.org\/10.1186\/2046-0481-66-22","relation":{},"ISSN":["2046-0481"],"issn-type":[{"value":"2046-0481","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]},"article-number":"22"}}