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The secondary aim is to determine whether treatment effects differ depending on important pre-specified participant and treatment characteristics, such as reasons at risk of preterm birth, gestational age, or type, dose and mode of administration of magnesium sulphate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The Antenatal Magnesium Individual Participant Data (IPD) International Collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE) Group will perform an IPD meta-analysis to answer these important clinical questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting\/Timeline<\/jats:title><jats:p>The AMICABLE Group was formed in 2009 with data collection commencing late 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Inclusion Criteria<\/jats:title><jats:p>Five trials involving a total 6,145 babies are eligible for inclusion in the IPD meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Primary study outcomes<\/jats:title><jats:p>For the infants\/children: Death or cerebral palsy. For the women: Any severe maternal outcome potentially related to treatment (death, respiratory arrest or cardiac arrest).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Results are expected to be publicly available in 2012.<\/jats:p><\/jats:sec>","DOI":"10.1186\/2046-4053-1-21","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T23:09:14Z","timestamp":1332457754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antenatal magnesium individual participant data international collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE)"],"prefix":"10.1186","volume":"1","author":[{"name":"The AMICABLE Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,21]]},"reference":[{"issue":"1","key":"17_CR1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1542\/peds.108.1.134","volume":"108","author":"LW Doyle","year":"2001","unstructured":"Doyle LW, Victorian Infant Collaborative S: Outcome at 5 years of age of children 23 to 27 weeks' gestation: Refining the prognosis. 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