{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:27:59Z","timestamp":1789504079654,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Syst Rev"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/2046-4053-2-40","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T22:19:15Z","timestamp":1371161955000},"source":"Crossref","is-referenced-by-count":27,"title":["A comparative assessment of three formulations of botulinum toxin A for facial rhytides: a systematic review and meta-analyses"],"prefix":"10.1186","volume":"2","author":[{"given":"James P","family":"Bonaparte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed T","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Rabski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun J","family":"Kilty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"103_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2147\/CIA.S9338","volume":"5","author":"K De Boulle","year":"2010","unstructured":"De Boulle K, Fagien S, Sommer B, Glogau R: Treating glabellar lines with botulinum toxin type A-hemagglutinin complex: a review of the science, the clinical data, and patient satisfaction. Clin Interv Aging. 2010, 5: 101-118.","journal-title":"Clin Interv Aging"},{"key":"103_CR2","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1111\/j.1524-4725.2011.02075.x","volume":"37","author":"J Schlessinger","year":"2011","unstructured":"Schlessinger J, Monheit G, Kane MA, Mendelsohn N: Time to onset of response of abobotulinumtoxina in the treatment of glabellar lines: a subset analysis of phase 3 clinical trials of a new botulinum toxin type A. Dermatol Surg. 2011, 37: 1434-1442. 10.1111\/j.1524-4725.2011.02075.x.","journal-title":"Dermatol Surg"},{"issue":"Suppl 1","key":"103_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1468-3083.2009.03475.x","volume":"24","author":"B Rzany","year":"2010","unstructured":"Rzany B, Ascher B, Monheit G: Treatment of glabellar lines with botulinum toxin type A (Speywood Unit): a clinical overview. J Eur Acad Dermatol Venereol. 2010, 24 (Suppl 1): 1-14.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"103_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1473-2165.2008.00361.x","volume":"7","author":"SH Cliff","year":"2008","unstructured":"Cliff SH, Judodihardjo H, Eltringham E: Different formulations of botulinum toxin type A have different migration characteristics: a double-blind, randomized study. J Cosmet Dermatol. 2008, 7: 50-54. 10.1111\/j.1473-2165.2008.00361.x.","journal-title":"J Cosmet Dermatol"},{"issue":"Suppl 1","key":"103_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/17429590701523794","volume":"9","author":"AT de Almeida","year":"2007","unstructured":"de Almeida AT, De Boulle K: Diffusion characteristics of botulinum neurotoxin products and their clinical significance in cosmetic applications. J Cosmet Laser Ther. 2007, 9 (Suppl 1): 17-22.","journal-title":"J Cosmet Laser Ther"},{"key":"103_CR6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1055\/s-0031-1298786","volume":"27","author":"S Stephan","year":"2011","unstructured":"Stephan S, Wang TD: Botulinum toxin: clinical techniques, applications, and complications. Facial Plast Surg. 2011, 27: 529-539. 10.1055\/s-0031-1298786.","journal-title":"Facial Plast Surg"},{"key":"103_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.toxicon.2012.11.011","volume":"67","author":"AP Tighe","year":"2013","unstructured":"Tighe AP, Schiavo G: Botulinum neurotoxins: mechanism of action. Toxicon. 2013, 67: 87-93.","journal-title":"Toxicon"},{"key":"103_CR8","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.toxicon.2010.12.019","volume":"57","author":"KH Eisele","year":"2011","unstructured":"Eisele KH, Fink K, Vey M, Taylor HV: Studies on the dissociation of botulinum neurotoxin type A complexes. Toxicon. 2011, 57: 555-565. 10.1016\/j.toxicon.2010.12.019.","journal-title":"Toxicon"},{"key":"103_CR9","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1126\/science.1214270","volume":"335","author":"S Gu","year":"2012","unstructured":"Gu S, Rumpel S, Zhou J, Strotmeier J, Bigalke H, Perry K, Shoemaker CB, Rummel A, Jin R: Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science. 2012, 335: 977-981. 10.1126\/science.1214270.","journal-title":"Science"},{"key":"103_CR10","first-page":"357","volume":"9","author":"SK Sharma","year":"2000","unstructured":"Sharma SK, Singh BR: Immunological properties of Hn-33 purified from type A Clostridium botulinum. J Nat Toxins. 2000, 9: 357-362.","journal-title":"J Nat Toxins"},{"key":"103_CR11","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1083\/jcb.200910119","volume":"189","author":"Y Sugawara","year":"2010","unstructured":"Sugawara Y, Matsumura T, Takegahara Y, Jin Y, Tsukasaki Y, Takeichi M, Fujinaga Y: Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin. J Cell Biol. 2010, 189: 691-700. 10.1083\/jcb.200910119.","journal-title":"J Cell Biol"},{"key":"103_CR12","first-page":"325","volume":"4","author":"J Frevert","year":"2010","unstructured":"Frevert J, Dressler D: Complexing proteins in botulinum toxin type A drugs: a help or a hindrance?. Biologics. 2010, 4: 325-332.","journal-title":"Biologics"},{"key":"103_CR13","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1016\/j.jbiomech.2008.03.030","volume":"41","author":"KR Aoki","year":"2008","unstructured":"Aoki KR, Irvine R, Gallagher C: Botox produces functional weakness in non-injected muscles adjacent to the target muscle. J Biomech. 2008, 41: 2066-2067. 10.1016\/j.jbiomech.2008.03.030. author reply 2067","journal-title":"J Biomech"},{"key":"103_CR14","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1097\/00042728-200510000-00006","volume":"31","author":"A Carruthers","year":"2005","unstructured":"Carruthers A, Carruthers J: Prospective, double-blind, randomized, parallel-group, dose-ranging study of botulinum toxin type A in men with glabellar rhytids. Dermatol Surg. 2005, 31: 1297-1303.","journal-title":"Dermatol Surg"},{"key":"103_CR15","first-page":"731","volume":"11","author":"R Jandhyala","year":"2012","unstructured":"Jandhyala R: Relative potency of incobotulinumtoxinA vs onabotulinumtoxinA a meta-analysis of key evidence. J Drugs Dermatol. 2012, 11: 731-736.","journal-title":"J Drugs Dermatol"},{"key":"103_CR16","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1111\/j.1524-4725.2012.02582.x","volume":"38","author":"R Glogau","year":"2012","unstructured":"Glogau R, Kane M, Beddingfield F, Somogyi C, Lei X, Caulkins C, Gallagher C: OnabotulinumtoxinA: a meta-analysis of duration of effect in the treatment of glabellar lines. Dermatol Surg. 2012, 38: 1794-1803. 10.1111\/j.1524-4725.2012.02582.x.","journal-title":"Dermatol Surg"},{"key":"103_CR17","doi-asserted-by":"publisher","first-page":"E9","DOI":"10.1038\/sj.bdj.2009.813","volume":"207","author":"K Gadhia","year":"2009","unstructured":"Gadhia K, Walmsley AD: Facial aesthetics: is botulinum toxin treatment effective and safe? A systematic review of randomised controlled trials. Br Dent J. 2009, 207: E9-10.1038\/sj.bdj.2009.813. discussion 216\u2013217","journal-title":"Br Dent J"},{"key":"103_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2165\/11530110-000000000-00000","volume":"11","author":"TC Flynn","year":"2010","unstructured":"Flynn TC: Botulinum toxin: examining duration of effect in facial aesthetic applications. Am J Clin Dermatol. 2010, 11: 183-199. 10.2165\/11530110-000000000-00000.","journal-title":"Am J Clin Dermatol"},{"key":"103_CR19","unstructured":"PROSPERO international prospective register of systematic reviews.\n                    http:\/\/www.crd.york.ac.uk\/PROSPERO\/\n                    \n                  ,"},{"key":"103_CR20","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011)","author":"JPT Higgins","year":"2011","unstructured":"Higgins JPT, Green S: Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). 2011, Oxford: The Cochrane Collaboration,\n                    http:\/\/www.cochrane-handbook.org\n                    \n                  ,"},{"key":"103_CR21","unstructured":"Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA).\n                    http:\/\/www.prisma-statement.org\/statement.htm\n                    \n                  ,"},{"key":"103_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3109\/14764172.2010.514920","volume":"12","author":"A Carruthers","year":"2010","unstructured":"Carruthers A, Carruthers J: A validated facial grading scale: the future of facial ageing measurement tools? J Cosmet. Laser Ther. 2010, 12: 235-241. 10.3109\/14764172.2010.514920.","journal-title":"Laser Ther"},{"key":"103_CR23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1046\/j.1365-2133.2003.05436.x","volume":"149","author":"P Honeck","year":"2003","unstructured":"Honeck P, Weiss C, Sterry W, Rzany B: Reproducibility of a four-point clinical severity score for glabellar frown lines. Br J Dermatol. 2003, 149: 306-310. 10.1046\/j.1365-2133.2003.05436.x.","journal-title":"Br J Dermatol"},{"key":"103_CR24","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA: The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011, 343: d5928-10.1136\/bmj.d5928.","journal-title":"BMJ"},{"key":"103_CR25","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.jclinepi.2010.08.010","volume":"64","author":"R Fu","year":"2011","unstructured":"Fu R, Gartlehner G, Grant M, Shamliyan T, Sedrakyan A, Wilt TJ, Griffith L, Oremus M, Raina P, Ismaila A, Santaguidag P, Lauh J, Trikalinosh TA: Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program. J Clin Epidemiol. 2011, 64: 1187-1197. 10.1016\/j.jclinepi.2010.08.010.","journal-title":"J Clin Epidemiol"},{"key":"103_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials. 1986, 7: 177-188. 10.1016\/0197-2456(86)90046-2.","journal-title":"Control Clin Trials"},{"key":"103_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1017\/S2045796011000837","volume":"21","author":"A Cipriani","year":"2012","unstructured":"Cipriani A, Barbui C, Rizzo C, Salanti G: What is a multiple treatments meta-analysis?. Epidemiol Psychiatr Sci. 2012, 21: 151-153. 10.1017\/S2045796011000837.","journal-title":"Epidemiol Psychiatr Sci"},{"key":"103_CR28","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2147\/CLEP.S16526","volume":"3","author":"EJ Mills","year":"2011","unstructured":"Mills EJ, Bansback N, Ghement I, Thorlund K, Kelly S, Puhan MA, Wright J: Multiple treatment comparison meta-analyses: a step forward into complexity. Clin Epidemiol. 2011, 3: 193-202.","journal-title":"Clin Epidemiol"},{"key":"103_CR29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1177\/0962280207080643","volume":"17","author":"G Salanti","year":"2008","unstructured":"Salanti G, Higgins JP, Ades AE, Ioannidis JP: Evaluation of networks of randomized trials. Stat Methods Med Res. 2008, 17: 279-301.","journal-title":"Stat Methods Med Res"},{"key":"103_CR30","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.jclinepi.2009.03.009","volume":"63","author":"DK Owens","year":"2010","unstructured":"Owens DK, Lohr KN, Atkins D, Treadwell JR, Reston JT, Bass EB, Chang S, Helfand M: AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions\u2013agency for healthcare research and quality and the effective health-care program. J Clin Epidemiol. 2010, 63: 513-523. 10.1016\/j.jclinepi.2009.03.009.","journal-title":"J Clin Epidemiol"},{"key":"103_CR31","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1097\/SAP.0b013e31824a43e0","volume":"69","author":"N Conkling","year":"2012","unstructured":"Conkling N, Bishawi M, Phillips BT, Bui DT, Khan SU, Dagum AB: Subjective rating of cosmetic treatment with botulinum toxin type A: do existing measures demonstrate interobserver validity?. Ann Plast Surg. 2012, 69: 350-355. 10.1097\/SAP.0b013e31824a43e0.","journal-title":"Ann Plast Surg"},{"key":"103_CR32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/jocd.12001","volume":"11","author":"W Prager","year":"2012","unstructured":"Prager W, Rappl T: Phase IV study comparing incobotulinumtoxinA and onabotulinumtoxinA using a 1:1.5 dose-conversion ratio for the treatment of glabellar frown lines. J Cosmet Dermatol. 2012, 11: 267-271. 10.1111\/jocd.12001.","journal-title":"J Cosmet Dermatol"},{"key":"103_CR33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/01.iop.0000217703.80859.a3","volume":"22","author":"G Borodic","year":"2006","unstructured":"Borodic G: Immunologic resistance after repeated botulinum toxin type a injections for facial rhytides. Ophthal Plast Reconstr Surg. 2006, 22: 239-240. 10.1097\/01.iop.0000217703.80859.a3.","journal-title":"Ophthal Plast Reconstr Surg"},{"issue":"Suppl 4","key":"103_CR34","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1111\/j.1524-4725.2010.01710.x","volume":"36","author":"D Dressler","year":"2010","unstructured":"Dressler D, Wohlfahrt K, Meyer-Rogge E, Wiest L, Bigalke H: Antibody-induced failure of botulinum toxin a therapy in cosmetic indications. Dermatol Surg. 2010, 36 (Suppl 4): 2182-2187.","journal-title":"Dermatol Surg"}],"container-title":["Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2046-4053-2-40\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2046-4053-2-40.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2046-4053-2-40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2046-4053-2-40.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T20:02:34Z","timestamp":1548187354000},"score":1,"resource":{"primary":{"URL":"https:\/\/systematicreviewsjournal.biomedcentral.com\/articles\/10.1186\/2046-4053-2-40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,13]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["103"],"URL":"https:\/\/doi.org\/10.1186\/2046-4053-2-40","relation":{},"ISSN":["2046-4053"],"issn-type":[{"value":"2046-4053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,13]]},"article-number":"40"}}