{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:40:27Z","timestamp":1782603627869,"version":"3.54.5"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Secondary sclerosing cholangitis is a severe disease of the biliary tract. Over the last decade, several cases of sclerosing cholangitis in critically ill patients (SC-CIP) were reported. Reports in the literature so far are characterized by a wide variety of underlying causes of critical illness, thereby hindering a risk-factor analysis. We report on a homogenous cohort of critically ill patients with influenza A (H1N1) pneumonia and severe acute respiratory distress syndrome (ARDS), of whom a subgroup developed sclerosing cholangitis, allowing for probing of risk factors associated with SC-CIP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Twenty-one patients (5 female, 16 male, 46.3 \u00b1 10.8 years) with severe ARDS due to H1N1 pneumonia were retrospectively divided into two groups, characterized by the presence (n = 5) and absence of SC-CIP (n = 16). A large array of clinical data, laboratory parameters, and multi-detector computed tomography-derived measures were compared.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Both patient groups showed severe pulmonary impairment. Severity of disease on admission day and during the first 14 days of treatment showed no difference. The patients developing SC-CIP had a higher body mass index (BMI) (37.4 \u00b1 6.0 kg\/m<jats:sup>2<\/jats:sup> vs. 29.3 \u00b1 6.8 kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic> = 0.029) and a higher volume of intraperitoneal fat (8273 \u00b1 3659 cm<jats:sup>3<\/jats:sup> vs. 5131 \u00b1 2268 cm<jats:sup>3<\/jats:sup>; <jats:italic>P<\/jats:italic> = 0.033) and spent a longer cumulative period in the prone position during the first 14 days (165 \u00b1 117 h vs. 78 \u00b1 61 h; <jats:italic>P<\/jats:italic> = 0.038).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our results suggest that obesity, intraperitoneal fat volume, and a longer cumulative duration spent in the prone position may put patients with ARDS at risk of developing SC-CIP. These results lead us to propose that the prone position should be carefully deployed, particularly in abdominally obese patients, and that frequent checks be made for early hepatic dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/2047-783x-17-30","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T23:14:31Z","timestamp":1356218071000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza A-associated ARDS"],"prefix":"10.1186","volume":"17","author":[{"given":"Thomas","family":"Weig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam I","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gruener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Dolch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Irlbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,22]]},"reference":[{"issue":"5","key":"28_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrgastro.2009.46","volume":"6","author":"P Ruemmele","year":"2009","unstructured":"Ruemmele P, Hofstaedter F, Gelbmann CM: Secondary sclerosing cholangitis. Nat Rev Gastroenterol Hepatol 2009, 6(5):287\u2013295. 10.1038\/nrgastro.2009.46","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"28_CR2","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/j.1572-0241.2007.01118.x","volume":"102","author":"CM Gelbmann","year":"2007","unstructured":"Gelbmann CM, Rummele P, Wimmer M, Hofstadter F, Gohlmann B, Endlicher E, Kullmann F, Langgartner J, Scholmerich J: Ischemic-like cholangiopathy with secondary sclerosing cholangitis in critically ill patients. Am J Gastroenterol 2007, 102(6):1221\u20131229. 10.1111\/j.1572-0241.2007.01118.x","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"28_CR3","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3109\/00365521.2010.537683","volume":"46","author":"GI Kirchner","year":"2011","unstructured":"Kirchner GI, Scherer MN, Obed A, Ruemmele P, Wiest R, Froh M, Loss M, Schlitt HJ, Scholmerich J, Gelbmann CM: Outcome of patients with ischemic-like cholangiopathy with secondary sclerosing cholangitis after liver transplantation. Scand J Gastroenterol 2011, 46(4):471\u2013478. 10.3109\/00365521.2010.537683","journal-title":"Scand J Gastroenterol"},{"issue":"27","key":"28_CR4","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.3748\/wjg.v11.i27.4199","volume":"11","author":"J Benninger","year":"2005","unstructured":"Benninger J, Grobholz R, Oeztuerk Y, Antoni CH, Hahn EG, Singer MV, Strauss R: Sclerosing cholangitis following severe trauma: description of a remarkable disease entity with emphasis on possible pathophysiologic mechanisms. World J Gastroenterol 2005, 11(27):4199\u20134205.","journal-title":"World J Gastroenterol"},{"issue":"24","key":"28_CR5","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","volume":"270","author":"JR Le Gall","year":"1993","unstructured":"Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study. JAMA 1993, 270(24):2957\u20132963. 10.1001\/jama.1993.03510240069035","journal-title":"JAMA"},{"issue":"7","key":"28_CR6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22(7):707\u2013710. 10.1007\/BF01709751","journal-title":"Intensive Care Med"},{"issue":"3","key":"28_CR7","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1164\/ajrccm\/138.3.720","volume":"138","author":"JF Murray","year":"1988","unstructured":"Murray JF, Matthay MA, Luce JM, Flick MR: An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1988, 138(3):720\u2013723.","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"28_CR8","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1055\/s-2007-967024","volume":"40","author":"H Kulaksiz","year":"2008","unstructured":"Kulaksiz H, Heuberger D, Engler S, Stiehl A: Poor outcome in progressive sclerosing cholangitis after septic shock. Endoscopy 2008, 40(3):214\u2013218. 10.1055\/s-2007-967024","journal-title":"Endoscopy"},{"issue":"7","key":"28_CR9","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1055\/s-2006-925241","volume":"38","author":"C Jaeger","year":"2006","unstructured":"Jaeger C, Mayer G, Henrich R, Gossner L, Rabenstein T, May A, Guenter E, Ell C: Secondary sclerosing cholangitis after long-term treatment in an intensive care unit: clinical presentation, endoscopic findings, treatment, and follow-up. Endoscopy 2006, 38(7):730\u2013734. 10.1055\/s-2006-925241","journal-title":"Endoscopy"},{"issue":"5","key":"28_CR10","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1136\/gut.52.5.688","volume":"52","author":"S Engler","year":"2003","unstructured":"Engler S, Elsing C, Flechtenmacher C, Theilmann L, Stremmel W, Stiehl A: Progressive sclerosing cholangitis after septic shock: a new variant of vanishing bile duct disorders. Gut 2003, 52(5):688\u2013693. 10.1136\/gut.52.5.688","journal-title":"Gut"},{"issue":"9","key":"28_CR11","first-page":"439","volume":"9","author":"B Terjung","year":"2004","unstructured":"Terjung B, Bogsch F, Klein R, Sohne J, Reichel C, Wasmuth JC, Beuers U, Sauerbruch T, Spengler U: Diagnostic accuracy of atypical p-ANCA in autoimmune hepatitis using ROC- and multivariate regression analysis. Eur J Med Res 2004, 9(9):439\u2013448.","journal-title":"Eur J Med Res"},{"issue":"3","key":"28_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1177\/0885066609332603","volume":"24","author":"JE Levitt","year":"2009","unstructured":"Levitt JE, Gould MK, Ware LB, Matthay MA: The pathogenetic and prognostic value of biologic markers in acute lung injury. J Intensive Care Med 2009, 24(3):151\u2013167. 10.1177\/0885066609332603","journal-title":"J Intensive Care Med"},{"issue":"6","key":"28_CR13","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1111\/j.1572-0241.2005.41526.x","volume":"100","author":"AA Gossard","year":"2005","unstructured":"Gossard AA, Angulo P, Lindor KD: Secondary sclerosing cholangitis: a comparison to primary sclerosing cholangitis. Am J Gastroenterol 2005, 100(6):1330\u20131333. 10.1111\/j.1572-0241.2005.41526.x","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"28_CR14","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/00003246-200102000-00042","volume":"29","author":"W Scheppach","year":"2001","unstructured":"Scheppach W, Druge G, Wittenberg G, Mueller JG, Gassel AM, Gassel HJ, Richter F: Sclerosing cholangitis and liver cirrhosis after extrabiliary infections: report on three cases. Crit Care Med 2001, 29(2):438\u2013441. 10.1097\/00003246-200102000-00042","journal-title":"Crit Care Med"},{"issue":"6","key":"28_CR15","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/j.burns.2010.01.015","volume":"36","author":"S Al-Benna","year":"2010","unstructured":"Al-Benna S, Willert J, Steinau HU, Steinstraesser L: Secondary sclerosing cholangitis, following major burn injury. Burns 2010, 36(6):e106-e110. 10.1016\/j.burns.2010.01.015","journal-title":"Burns"},{"issue":"2","key":"28_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/ncpgasthep1333","volume":"6","author":"AA Schnitzbauer","year":"2009","unstructured":"Schnitzbauer AA, Tsui TY, Kirchner G, Scherer MN, Bein T, Schlitt HJ, Obed A: Liver transplantation for sclerosing cholangitis in a polytraumatized patient. Nat Clin Pract Gastroenterol Hepatol 2009, 6(2):121\u2013126. 10.1038\/ncpgasthep1333","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"issue":"3","key":"28_CR17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/0885066610396168","volume":"27","author":"KM Sundar","year":"2011","unstructured":"Sundar KM, Thaut P, Nielsen DB, Alward WT, Pearce MJ: Clinical course of ICU patients with severe pandemic 2009 influenza A (H1N1) pneumonia: single center experience with proning and pressure release ventilation. J Intensive Care Med 2011, 27(3):184\u2013190.","journal-title":"J Intensive Care Med"},{"issue":"17","key":"28_CR18","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1001\/jama.2009.1496","volume":"302","author":"A Kumar","year":"2009","unstructured":"Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, et al.: Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA 2009, 302(17):1872\u20131879. 10.1001\/jama.2009.1496","journal-title":"JAMA"},{"issue":"3","key":"28_CR19","first-page":"170","volume":"11","author":"SA Webb","year":"2009","unstructured":"Webb SA, Seppelt IM: Pandemic (H1N1) 2009 influenza (\u201cswine flu\u201d) in Australian and New Zealand intensive care. Crit Care Resusc 2009, 11(3):170\u2013172.","journal-title":"Crit Care Resusc"},{"issue":"20","key":"28_CR20","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1056\/NEJMoa0908481","volume":"361","author":"SA Webb","year":"2009","unstructured":"Webb SA, Pettil\u00e4 V, Seppelt I, Bellomo R, Bailey M, Cooper DJ, Cretikos M, Davies AR, Finfer S, Harrigan PW, Hart GK, Howe B, Iredell JR, McArthur C, Mitchell I, Morrison S, Nichol AD, Paterson DL, Peake S, Richards B, Stephens D, Turner A, Yung M, ANZIC Influenza Investigators: Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med 2009, 361(20):1925\u20131934.","journal-title":"N Engl J Med"},{"issue":"1","key":"28_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1164\/201001-0037OC","volume":"182","author":"E Estenssoro","year":"2010","unstructured":"Estenssoro E, R\u00edos FG, Apeztegu\u00eda C, Reina R, Neira J, Ceraso DH, Orlandi C, Valentini R, Tiribelli N, Brizuela M, Balasini C, Mare S, Domeniconi G, Ilutovich S, G\u00f3mez A, Giuliani J, Barrios C, Valdez P, Registry of the Argentinian Society of Intensive Care SATI: Pandemic 2009 influenza A in Argentina: a study of 337 patients on mechanical ventilation. Am J Respir Crit Care Med 2010, 182(1):41\u201348. 10.1164\/201001-0037OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"28_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/01.CCM.0000297885.60037.6E","volume":"36","author":"ME Akinnusi","year":"2008","unstructured":"Akinnusi ME, Pineda LA, El Solh AA: Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med 2008, 36(1):151\u2013158. 10.1097\/01.CCM.0000297885.60037.6E","journal-title":"Crit Care Med"},{"issue":"11","key":"28_CR23","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00134-008-1243-0","volume":"34","author":"Y Sakr","year":"2008","unstructured":"Sakr Y, Madl C, Filipescu D, Moreno R, Groeneveld J, Artigas A, Reinhart K, Vincent JL: Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med 2008, 34(11):1999\u20132009. 10.1007\/s00134-008-1243-0","journal-title":"Intensive Care Med"},{"issue":"1","key":"28_CR24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/thx.2010.145086","volume":"66","author":"A Anzueto","year":"2011","unstructured":"Anzueto A, Frutos-Vivar F, Esteban A, Bensalami N, Marks D, Raymondos K, Apeztegu\u00eda C, Arabi Y, Hurtado J, Gonz\u00e1lez M, Tomicic V, Abroug F, Elizalde J, Cakar N, Pelosi P, Ferguson ND, Ventila Group: Influence of body mass index on outcome of the mechanically ventilated patients. Thorax 2011, 66(1):66\u201373. 10.1136\/thx.2010.145086","journal-title":"Thorax"},{"issue":"17","key":"28_CR25","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1001\/jama.2009.1535","volume":"302","author":"A Davies","year":"2009","unstructured":"Davies A, Jones D, Bailey M, Beca J, Bellomo R, Blackwell N, Forrest P, Gattas D, Granger E, Herkes R, Jackson A, McGuinness S, Nair P, Pellegrino V, Pettil\u00e4 V, Plunkett B, Pye R, Torzillo P, Webb S, Wilson M, Ziegenfuss M, Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators: Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA 2009, 302(17):1888\u20131895.","journal-title":"JAMA"},{"issue":"1","key":"28_CR26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/thx.2009.117572","volume":"65","author":"MN Gong","year":"2010","unstructured":"Gong MN, Bajwa EK, Thompson BT, Christiani DC: Body mass index is associated with the development of acute respiratory distress syndrome. Thorax 2010, 65(1):44\u201350. 10.1136\/thx.2009.117572","journal-title":"Thorax"},{"issue":"5","key":"28_CR27","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1097\/CCM.0b013e3181d8cd8b","volume":"38","author":"JB Paolini","year":"2010","unstructured":"Paolini JB, Mancini J, Genestal M, Gonzalez H, McKay RE, Samii K, Fourcade OA: Predictive value of abdominal obesity vs. body mass index for determining risk of intensive care unit mortality. Crit Care Med 2010, 38(5):1308\u20131314.","journal-title":"Crit Care Med"},{"issue":"5","key":"28_CR28","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s00134-004-2169-9","volume":"30","author":"ML Malbrain","year":"2004","unstructured":"Malbrain ML, Chiumello D, Pelosi P, Wilmer A, Brienza N, Malcangi V, Bihari D, Innes R, Cohen J, Singer P, Japiassu A, Kurtop E, De Keulenaer BL, Daelemans R, Del Turco M, Cosimini P, Ranieri M, Jacquet L, Laterre PF, Gattinoni L: Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med 2004, 30(5):822\u2013829. 10.1007\/s00134-004-2169-9","journal-title":"Intensive Care Med"},{"issue":"6","key":"28_CR29","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s00134-009-1445-0","volume":"35","author":"BL De Keulenaer","year":"2009","unstructured":"De Keulenaer BL, De Waele JJ, Powell B, Malbrain ML: What is normal intra-abdominal pressure and how is it affected by positioning, body mass and positive end-expiratory pressure? Intensive Care Med 2009, 35(6):969\u2013976. 10.1007\/s00134-009-1445-0","journal-title":"Intensive Care Med"},{"issue":"1","key":"28_CR30","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00134-001-1166-5","volume":"28","author":"R Hering","year":"2002","unstructured":"Hering R, Vorwerk R, Wrigge H, Zinserling J, Schroder S, von Spiegel T, Hoeft A, Putensen C: Prone positioning, systemic hemodynamics, hepatic indocyanine green kinetics, and gastric intramucosal energy balance in patients with acute lung injury. Intensive Care Med 2002, 28(1):53\u201358. 10.1007\/s00134-001-1166-5","journal-title":"Intensive Care Med"},{"issue":"1","key":"28_CR31","doi-asserted-by":"publisher","first-page":"R6","DOI":"10.1186\/cc9403","volume":"15","author":"F Abroug","year":"2011","unstructured":"Abroug F, Ouanes-Besbes L, Dachraoui F, Ouanes I, Brochard L: An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury. Crit Care 2011, 15(1):R6. 10.1186\/cc9403","journal-title":"Crit Care"},{"issue":"4","key":"28_CR32","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s00134-009-1748-1","volume":"36","author":"S Sud","year":"2010","unstructured":"Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK, Latini R, Pesenti A, Gu\u00e9rin C, Mancebo J, Curley MA, Fernandez R, Chan MC, Beuret P, Voggenreiter G, Sud M, Tognoni G, Gattinoni L: Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med 2010, 36(4):585\u2013599. 10.1007\/s00134-009-1748-1","journal-title":"Intensive Care Med"},{"issue":"4 Suppl","key":"28_CR33","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1097\/CCM.0b013e3181cde600","volume":"38","author":"CD Ramsey","year":"2010","unstructured":"Ramsey CD, Funk D, Miller RR 3rd, Kumar A: Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus. Crit Care Med 2010, 38(4 Suppl):e58-e65.","journal-title":"Crit Care Med"},{"issue":"11","key":"28_CR34","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1164\/rccm.200503-353OC","volume":"173","author":"J Mancebo","year":"2006","unstructured":"Mancebo J, Fern\u00e1ndez R, Blanch L, Rialp G, Gordo F, Ferrer M, Rodr\u00edguez F, Garro P, Ricart P, Vallverd\u00fa I, Gich I, Casta\u00f1o J, Saura P, Dom\u00ednguez G, Bonet A, Albert RK: A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 2006, 173(11):1233\u20131239. 10.1164\/rccm.200503-353OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"18","key":"28_CR35","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1001\/jama.2009.1614","volume":"302","author":"P Taccone","year":"2009","unstructured":"Taccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C, Caspani L, Raimondi F, Bordone G, Iapichino G, Mancebo J, Gu\u00e9rin C, Ayzac L, Blanch L, Fumagalli R, Tognoni G, Gattinoni L, Prone-Supine II Study Group: Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA 2009, 302(18):1977\u20131984. 10.1001\/jama.2009.1614","journal-title":"JAMA"},{"issue":"3","key":"28_CR36","doi-asserted-by":"publisher","first-page":"R251","DOI":"10.1186\/cc3513","volume":"9","author":"P Michelet","year":"2005","unstructured":"Michelet P, Roch A, Gainnier M, Sainty JM, Auffray JP, Papazian L: Influence of support on intra-abdominal pressure, hepatic kinetics of indocyanine green and extravascular lung water during prone positioning in patients with ARDS: a randomized crossover study. Crit Care 2005, 9(3):R251-R257. 10.1186\/cc3513","journal-title":"Crit Care"},{"issue":"7","key":"28_CR37","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s001340100999","volume":"27","author":"P Kiefer","year":"2001","unstructured":"Kiefer P, Morin A, Putzke C, Wiedeck H, Georgieff M, Radermacher P: Influence of prone position on gastric mucosal-arterial PCO2 gradients. Intensive Care Med 2001, 27(7):1227\u20131230. 10.1007\/s001340100999","journal-title":"Intensive Care Med"},{"issue":"12","key":"28_CR38","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1007\/s00134-002-1524-y","volume":"28","author":"M Matejovic","year":"2002","unstructured":"Matejovic M, Rokyta R Jr, Radermacher P, Krouzecky A, Sramek V, Novak I: Effect of prone position on hepato-splanchnic hemodynamics in acute lung injury. Intensive Care Med 2002, 28(12):1750\u20131755. 10.1007\/s00134-002-1524-y","journal-title":"Intensive Care Med"},{"issue":"3","key":"28_CR39","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/ALN.0b013e31820bfc81","volume":"114","author":"LB Hiltebrand","year":"2011","unstructured":"Hiltebrand LB, Koepfli E, Kimberger O, Sigurdsson GH, Brandt S: Hypotension during fluid-restricted abdominal surgery: effects of norepinephrine treatment on regional and microcirculatory blood flow in the intestinal tract. Anesthesiology 2011, 114(3):557\u2013564. 10.1097\/ALN.0b013e31820bfc81","journal-title":"Anesthesiology"},{"issue":"6","key":"28_CR40","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1097\/CCM.0b013e3181a00a1c","volume":"37","author":"S Jhanji","year":"2009","unstructured":"Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM: The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med 2009, 37(6):1961\u20131966. 10.1097\/CCM.0b013e3181a00a1c","journal-title":"Crit Care Med"},{"issue":"5","key":"28_CR41","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/shk.0b013e318063e71f","volume":"28","author":"A Nygren","year":"2007","unstructured":"Nygren A, Thoren A, Ricksten SE: Norepinephrine and intestinal mucosal perfusion in vasodilatory shock after cardiac surgery. Shock 2007, 28(5):536\u2013543.","journal-title":"Shock"},{"issue":"5","key":"28_CR42","doi-asserted-by":"publisher","first-page":"R306","DOI":"10.1186\/cc2905","volume":"8","author":"A Bruhn","year":"2004","unstructured":"Bruhn A, Hernandez G, Bugedo G, Castillo L: Effects of positive end-expiratory pressure on gastric mucosal perfusion in acute respiratory distress syndrome. Crit Care 2004, 8(5):R306-R311. 10.1186\/cc2905","journal-title":"Crit Care"},{"key":"28_CR43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1177\/0267659108096260","volume":"23","author":"K Wagner","year":"2008","unstructured":"Wagner K, Risnes I, Abdelnoor M, Karlsen HM, Svennevig JL: Is it possible to predict outcome in pulmonary ECMO? Analysis of pre-operative risk factors. Perfusion 2008, 23: 95\u201399. 10.1177\/0267659108096260","journal-title":"Perfusion"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/2047-783X-17-30.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T21:18:19Z","timestamp":1630531099000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/2047-783X-17-30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["28"],"URL":"https:\/\/doi.org\/10.1186\/2047-783x-17-30","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"2 July 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"30"}}