{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:03:04Z","timestamp":1761580984593},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:00:00Z","timestamp":1336694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/2047-783x-17-9","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T12:15:13Z","timestamp":1336738513000},"source":"Crossref","is-referenced-by-count":3,"title":["Cytokine\/chemokine patterns connect host and viral characteristics with clinics during chronic hepatitis C"],"prefix":"10.1186","volume":"17","author":[{"given":"Antonios","family":"Katsounas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Trippler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Kottilil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Lempicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Gerken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg F","family":"Schlaak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,11]]},"reference":[{"key":"24_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1046\/j.1365-2249.2002.01840.x","volume":"128","author":"S Ward","year":"2002","unstructured":"Ward S, Lauer G, Isba R, Walker B, Klenerman P: Cellular immune responses against hepatitis C virus: the evidence base 2002. Clin Exp Immunol 2002, 128: 195\u2013203. 10.1046\/j.1365-2249.2002.01840.x","journal-title":"Clin Exp Immunol"},{"key":"24_CR2","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1053\/j.gastro.2007.08.003","volume":"133","author":"A Dolganiuc","year":"2007","unstructured":"Dolganiuc A, Norkina O, Kodys K, Catalano D, Bakis G, Marshall C, Mandrekar P, Szabo G: Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 2007, 133: 1627\u20131636. 10.1053\/j.gastro.2007.08.003","journal-title":"Gastroenterology"},{"key":"24_CR3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/S0168-8278(97)80412-6","volume":"26","author":"M Shindo","year":"1997","unstructured":"Shindo M, Arai K, Okuno T: The clinical value of grading and staging scores for predicting a long-term response and evaluating the efficacy of interferon therapy in chronic hepatitis C. J Hepatol 1997, 26: 492\u2013497. 10.1016\/S0168-8278(97)80412-6","journal-title":"J Hepatol"},{"key":"24_CR4","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/S0140-6736(01)06102-5","volume":"358","author":"MP Manns","year":"2001","unstructured":"Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK: Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001, 358: 958\u2013965. 10.1016\/S0140-6736(01)06102-5","journal-title":"Lancet"},{"key":"24_CR5","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1056\/NEJMra065142","volume":"356","author":"MJ Koziel","year":"2007","unstructured":"Koziel MJ, Peters MG: Viral hepatitis in HIV infection. N Engl J Med 2007, 356: 1445\u20131454. 10.1056\/NEJMra065142","journal-title":"N Engl J Med"},{"key":"24_CR6","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1097\/00000478-199512000-00007","volume":"19","author":"KP Batts","year":"1995","unstructured":"Batts KP, Ludwig J: Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 1995, 19: 1409\u20131417. 10.1097\/00000478-199512000-00007","journal-title":"Am J Surg Pathol"},{"key":"24_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W da Huang","year":"2009","unstructured":"da Huang W, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4: 44\u201357.","journal-title":"Nat Protoc"},{"key":"24_CR8","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.ydbio.2007.07.024","volume":"310","author":"J Jemc","year":"2007","unstructured":"Jemc J, Rebay I: Identification of transcriptional targets of the dual function transcription factor\/phosphatase eyes absent. Dev Biol 2007, 310: 416\u2013429. 10.1016\/j.ydbio.2007.07.024","journal-title":"Dev Biol"},{"key":"24_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/00001432-200106000-00006","volume":"14","author":"M Heydtmann","year":"2001","unstructured":"Heydtmann M, Shields P, McCaughan G, Adams D: Cytokines and chemokines in the immune response to hepatitis C infection. Curr Opin Infect Dis 2001, 14: 279\u2013287. 10.1097\/00001432-200106000-00006","journal-title":"Curr Opin Infect Dis"},{"key":"24_CR10","doi-asserted-by":"publisher","first-page":"d1899","DOI":"10.2741\/marra","volume":"7","author":"F Marra","year":"2002","unstructured":"Marra F: Chemokines in liver inflammation and fibrosis. Front Biosci 2002, 7: d1899-d1914. 10.2741\/marra","journal-title":"Front Biosci"},{"key":"24_CR11","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/hep.20139","volume":"39","author":"B Gao","year":"2004","unstructured":"Gao B, Hong F, Radaeva S: Host factors and failure of interferon-alpha treatment in hepatitis C virus. Hepatology 2004, 39: 880\u2013890. 10.1002\/hep.20139","journal-title":"Hepatology"},{"key":"24_CR12","doi-asserted-by":"publisher","first-page":"e11049","DOI":"10.1371\/journal.pone.0011049","volume":"5","author":"HW Zimmermann","year":"2010","unstructured":"Zimmermann HW, Seidler S, Nattermann J, Gassler N, Hellerbrand C, Zernecke A, Tischendorf JJ, Luedde T, Weiskirchen R, Trautwein C, Tacke F: Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One 2010, 5: e11049. 10.1371\/journal.pone.0011049","journal-title":"PLoS One"},{"key":"24_CR13","doi-asserted-by":"publisher","first-page":"7821","DOI":"10.1038\/sj.onc.1208066","volume":"23","author":"PL Cheng","year":"2004","unstructured":"Cheng PL, Chang MH, Chao CH, Lee YH: Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta\/Smad3-mediated transcriptional activation. Oncogene 2004, 23: 7821\u20137838. 10.1038\/sj.onc.1208066","journal-title":"Oncogene"},{"key":"24_CR14","first-page":"429243","volume":"2010","author":"R Cubillas","year":"2010","unstructured":"Cubillas R, Kintner K, Phillips F, Karandikar NJ, Thiele DL, Brown GR: Tumor necrosis factor receptor 1 expression is upregulated in dendritic cells in patients with chronic HCV who respond to therapy. Hepat Res Treat 2010, 2010: 429243.","journal-title":"Hepat Res Treat"},{"key":"24_CR15","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/hep.20322","volume":"40","author":"HE Wasmuth","year":"2004","unstructured":"Wasmuth HE, Werth A, Mueller T, Berg T, Dietrich CG, Geier A, Gartung C, Lorenzen J, Matern S, Lammert F: Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Hepatology 2004, 40: 327\u2013334.","journal-title":"Hepatology"},{"key":"24_CR16","doi-asserted-by":"publisher","first-page":"5277","DOI":"10.4049\/jimmunol.164.10.5277","volume":"164","author":"LE Jensen","year":"2000","unstructured":"Jensen LE, Muzio M, Mantovani A, Whitehead AS: IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. J Immunol 2000, 164: 5277\u20135286.","journal-title":"J Immunol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2047-783X-17-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2047-783X-17-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2047-783X-17-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:24:04Z","timestamp":1548192244000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/2047-783X-17-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,11]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["24"],"URL":"https:\/\/doi.org\/10.1186\/2047-783x-17-9","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,11]]},"article-number":"9"}}