{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:40:02Z","timestamp":1767174002891,"version":"build-2238731810"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. However, the molecular pathogenesis of HCC is not well-understood, and the prognosis for patients with HCC remains very poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To disclose detailed genetic mechanisms in hepatocellular carcinoma (HCC) with a view toward development of novel therapeutic targets, we analyzed expression profiles HCCs and their corresponding noncancerous tissues by using bioinformatics method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this paper, we report the identification of genes whose expression has been altered and the changed bio-pathways during hepatocarcinogenesis. Hepatoma cells infect intracellular and intercellular signal transduction through Focal adhesion and cause abnormal expression of important intracellular signaling pathway. In addition, it is worth mentioning that some small molecules still restored to the state similar to normal cells, such as bambuterol and lovastatin. This member gene set would serve as a pool of lead gene targets for the identification and development of novel diagnostic and therapeutic biomarkers to greatly improve the clinical management of HCC patients with different risks of recurrence after curative partial hepatectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study has great significance for gene therapy and pharmacotherapy and provides a new treatment entry point and a potential new clinical drug for HCC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/2047-783x-18-44","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T15:01:10Z","timestamp":1384441270000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["RETRACTED ARTICLE: Gene expression profiling analysis of hepatocellular carcinoma"],"prefix":"10.1186","volume":"18","author":[{"given":"Deyong","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tangwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongda","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingzhi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"77_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/73448","volume":"24","author":"S Satoh","year":"2000","unstructured":"Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000, 24: 245\u2013250. 10.1038\/73448","journal-title":"Nat Genet"},{"key":"77_CR2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1006\/scbi.1998.0079","volume":"8","author":"SO Stuver","year":"1998","unstructured":"Stuver SO: Towards global control of liver cancer? Semin Cancer Biol 1998, 8: 299\u2013306. 10.1006\/scbi.1998.0079","journal-title":"Semin Cancer Biol"},{"key":"77_CR3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/hep.510270211","volume":"27","author":"N Ghebranious","year":"1998","unstructured":"Ghebranious N, Sell S: Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice. Hepatology 1998, 27: 383\u2013391. 10.1002\/hep.510270211","journal-title":"Hepatology"},{"key":"77_CR4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1349-7006.2001.tb01089.x","volume":"92","author":"T Nakatani","year":"2001","unstructured":"Nakatani T, Roy G, Fujimoto N, Asahara T, Ito A: Sex hormone dependency of diethylnitrosamine\u2012induced liver tumors in mice and chemoprevention by leuprorelin. Jpn J Cancer Res 2001, 92: 249\u2013256. 10.1111\/j.1349-7006.2001.tb01089.x","journal-title":"Jpn J Cancer Res"},{"key":"77_CR5","doi-asserted-by":"publisher","first-page":"11536","DOI":"10.1158\/0008-5472.CAN-07-1479","volume":"67","author":"AB Rogers","year":"2007","unstructured":"Rogers AB, Theve EJ, Feng Y, Fry RC, Taghizadeh K, Clapp KM, Boussahmain C, Cormier KS, Fox JG: Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res 2007, 67: 11536\u201311546. 10.1158\/0008-5472.CAN-07-1479","journal-title":"Cancer Res"},{"key":"77_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1126\/science.1140485","volume":"317","author":"WE Naugler","year":"2007","unstructured":"Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007, 317: 121\u2013124. 10.1126\/science.1140485","journal-title":"Science"},{"key":"77_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s10120-005-0315-x","volume":"8","author":"T Ashizawa","year":"2005","unstructured":"Ashizawa T, Okada R, Suzuki Y, Takagi M, Yamazaki T, Sumi T, Aoki T, Ohnuma S, Aoki T: Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: role of IL-6 as a prognostic factor. Gastric Cancer 2005, 8: 124\u2013131. 10.1007\/s10120-005-0315-x","journal-title":"Gastric Cancer"},{"key":"77_CR8","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/annonc\/mdm448","volume":"19","author":"C Porta","year":"2008","unstructured":"Porta C, De Amici M, Quaglini S, Paglino C, Tagliani F, Boncimino A, Moratti R, Corazza GR: Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma. Ann Oncol 2008, 19: 353\u2013358. 10.1093\/annonc\/mdm448","journal-title":"Ann Oncol"},{"key":"77_CR9","volume-title":"R: A Language and Environment for Statistical Computing","author":"The R Development Core Team","year":"2010","unstructured":"The R Development Core Team: R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing; 2010. Available at (accessed 20 September 2013) [http:\/\/www.lsw.uni-heidelberg.de\/users\/christlieb\/teaching\/UKStaSS10\/R-refman.pdf]"},{"key":"77_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer\u2012Barclay YD, Antonellis KJ, Scherf U, Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003, 4: 249\u2013264. 10.1093\/biostatistics\/4.2.249","journal-title":"Biostatistics"},{"key":"77_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-29362-0","volume-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor (Statistics for Biology and Health Series)","author":"R Gentleman","year":"2005","unstructured":"Gentleman R, Carey V, Huber W, Irizarry R, Dudoit S: Bioinformatics and Computational Biology Solutions Using R and Bioconductor (Statistics for Biology and Health Series). New York: Springer; 2005."},{"key":"77_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G, the Gene Ontology Consortium: Gene Ontology: tool for the unification of biology. Nat Genet 2000, 25: 25\u201329. 10.1038\/75556","journal-title":"Nat Genet"},{"key":"77_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4: 44\u201357.","journal-title":"Nat Protoc"},{"key":"77_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009, 37: 1\u201313. 10.1093\/nar\/gkn923","journal-title":"Nucleic Acids Res"},{"key":"77_CR15","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1126\/science.1132939","volume":"313","author":"J Lamb","year":"2006","unstructured":"Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR: The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313: 1929\u20131935. 10.1126\/science.1132939","journal-title":"Science"},{"key":"77_CR16","doi-asserted-by":"publisher","first-page":"e18278","DOI":"10.1371\/journal.pone.0018278","volume":"6","author":"Z Wen","year":"2011","unstructured":"Wen Z, Wang Z, Wang S, Ravula R, Yang L, Xu J, Wang C, Zuo Z, Chow MSS, Shi L: Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. PLoS One 2011, 6: e18278. 10.1371\/journal.pone.0018278","journal-title":"PLoS One"},{"key":"77_CR17","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0140-6736(85)91785-4","volume":"325","author":"SN Zaman","year":"1985","unstructured":"Zaman SN, Johnson RD, Johnson PJ, Melia WM, Portmann BC, Williams R: Risk factors in development of hepatocellular carcinoma in cirrhosis: prospective study of 613 patients. Lancet 1985, 325: 1357\u20131360. 10.1016\/S0140-6736(85)91785-4","journal-title":"Lancet"},{"key":"77_CR18","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1056\/NEJM199306243282501","volume":"328","author":"H Tsukuma","year":"1993","unstructured":"Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, Nakanishi K, Fujimoto I, Inoue A, Yamazaki H: Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993, 328: 1797\u20131801. 10.1056\/NEJM199306243282501","journal-title":"N Engl J Med"},{"key":"77_CR19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1136\/gut.48.2.251","volume":"48","author":"L Bolondi","year":"2001","unstructured":"Bolondi L, Sofia S, Siringo S, Gaiani S, Casali A, Zironi G, Piscaglia F, Gramantieri L, Zanetti M, Sherman M: Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis. Gut 2001, 48: 251\u2013259. 10.1136\/gut.48.2.251","journal-title":"Gut"},{"key":"77_CR20","first-page":"2506","volume":"49","author":"FS Yeh","year":"1989","unstructured":"Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, Henderson BE: Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi China. Cancer Res 1989, 49: 2506.","journal-title":"Cancer Res"},{"key":"77_CR21","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1200\/JCO.2005.03.196","volume":"23","author":"MB Thomas","year":"2005","unstructured":"Thomas MB, Zhu AX: Hepatocellular carcinoma: the need for progress. J Clin Oncol 2005, 23: 2892\u20132899. 10.1200\/JCO.2005.03.196","journal-title":"J Clin Oncol"},{"key":"77_CR22","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.1158\/1078-0432.CCR-06-2236","volume":"13","author":"SM Wang","year":"2007","unstructured":"Wang SM, Ooi LLPJ, Hui KM: Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma. Clin Cancer Res 2007, 13: 6275\u20136283. 10.1158\/1078-0432.CCR-06-2236","journal-title":"Clin Cancer Res"},{"key":"77_CR23","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1002\/hep.20375","volume":"40","author":"JS Lee","year":"2004","unstructured":"Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, Durnez A, Demetris AJ, Thorgeirsson SS: Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 2004, 40: 667\u2013676. 10.1002\/hep.20375","journal-title":"Hepatology"},{"key":"77_CR24","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/nm843","volume":"9","author":"QH Ye","year":"2003","unstructured":"Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, Simon R, Li Y, Robles AI, Chen Y: Predicting hepatitis B virus\u2013positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003, 9: 416\u2013423. 10.1038\/nm843","journal-title":"Nat Med"},{"key":"77_CR25","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/S0140-6736(03)12775-4","volume":"361","author":"N Iizuka","year":"2003","unstructured":"Iizuka N, Oka M, Yamada-Okabe H, Nishida M, Maeda Y, Mori N, Takao T, Tamesa T, Tangoku A, Tabuchi H: Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 2003, 361: 923\u2013929. 10.1016\/S0140-6736(03)12775-4","journal-title":"Lancet"},{"key":"77_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jhep.2004.04.031","volume":"41","author":"Y Kurokawa","year":"2004","unstructured":"Kurokawa Y, Matoba R, Takemasa I, Nagano H, Dono K, Nakamori S, Umeshita K, Sakon M, Ueno N, Oba S: Molecular-based prediction of early recurrence in hepatocellular carcinoma. J Hepatol 2004, 41: 284\u2013291. 10.1016\/j.jhep.2004.04.031","journal-title":"J Hepatol"},{"key":"77_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0168-8278(90)90211-9","volume":"11","author":"F Farinati","year":"1990","unstructured":"Farinati F, Salvagnini M, De Maria N, Fornasiero A, Chiaramonte M, Rossaro L, Naccarato R: Unresectable hepatocellular carcinoma: a prospective controlled trial with tamoxifen. J Hepatol 1990, 11: 297\u2013301. 10.1016\/0168-8278(90)90211-9","journal-title":"J Hepatol"}],"updated-by":[{"DOI":"10.1186\/s40001-015-0120-x","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"record-id":"1966"},{"DOI":"10.1186\/s40001-015-0120-x","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000}}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/2047-783X-18-44.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T22:21:10Z","timestamp":1630534870000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/2047-783X-18-44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["77"],"URL":"https:\/\/doi.org\/10.1186\/2047-783x-18-44","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]},"assertion":[{"value":"12 July 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"44"}}