{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:40:35Z","timestamp":1793529635524,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurofibromatosis type 1 (NF1) is a relatively common autosomal dominant disorder. The most common vascular abnormality in patients with NF1 is bilateral or unilateral renal artery stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 16-year-old boy presented with a headache of 4-year duration and was found to be moderately hypertensive. On physical examination, axillary freckling and multiple caf\u00e9-au-lait spots were revealed over the trunk, while numerous small nodules were palpable on the limbs. Biopsy of subcutaneous nodule showed neurofibroma. Lisch nodules were identified on slit-lamp examination and grade I hypertensive retinopathy was present on fundoscopy. Clinical laboratory investigations revealed that renal and liver function tests, blood cells count, urinalysis, serum electrolytes, serum levels of renin and aldosterone, and 24-hour urine levels of catecholamines were all within normal ranges. Abdominal ultrasound and CT were normal. Both kidneys were of normal size. CT angiography showed right renal artery stenosis (&gt;90%) at the ostium. The final diagnosis of NF1 with right renal artery stenosis and secondary hypertension was then made. The patient was treated with Procardin (30\u00a0mg\/d) and improved with a significant decline in blood pressure. The main outcomes were to control blood pressure without necessarily proceeding with PTRA. We also present a review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NF1 may present with hypertension due to renal artery stenosis in children. All young patients (&lt;30\u00a0year) with hypertension should be clinically screened for secondary causes of hypertension, including NF1, so that renal revascularization can be offered before permanent end organ damage has occurred. First-line management using medication alone could be appropriate, keeping the interventional options for when the patient's condition deteriorates.<\/jats:p><\/jats:sec>","DOI":"10.1186\/2047-783x-19-17","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T23:02:54Z","timestamp":1396047774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Renal artery stenosis due to neurofibromatosis type 1: case report and literature review"],"prefix":"10.1186","volume":"19","author":[{"given":"Lian","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anli","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"102_CR1","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/S0140-6736(03)13166-2","volume":"361","author":"RM Reynolds","year":"2003","unstructured":"Reynolds RM, Browning GG, Nawroz I, Campbell IW: Von Recklinghausen's neurofibromatosis: neurofibromatosis type 1. Lancet 2003, 361: 1552\u20131554. 10.1016\/S0140-6736(03)13166-2","journal-title":"Lancet"},{"key":"102_CR2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1542\/peds.2007-3204","volume":"123","author":"VC Williams","year":"2009","unstructured":"Williams VC, Lucas J, Babcock MA, Gutmann DH, Korf B, Maria BL: Neurofibromatosis type 1 revisited. Pediatrics 2009, 123: 124\u2013133. 10.1542\/peds.2007-3204","journal-title":"Pediatrics"},{"key":"102_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jvs.2007.03.055","volume":"46","author":"GS Oderich","year":"2007","unstructured":"Oderich GS, Sullivan TM, Bower TC, Gloviczki P, Miller DV, Babovic-Vuksanovic D, Macedo TA, Stanson A: Vascular abnormalities in patients with neurofibromatosis syndrome type I: clinical spectrum, management, and results. J Vasc Surg 2007, 46: 475\u2013484. 10.1016\/j.jvs.2007.03.055","journal-title":"J Vasc Surg"},{"key":"102_CR4","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0895-7061(00)01303-0","volume":"14","author":"MA Tedesco","year":"2001","unstructured":"Tedesco MA, Di Salvo G, Ratti G, Natale F, Calabrese E, Grassia C, Iacono A, Lama G: Arterial distensibility and ambulatory blood pressure monitoring in young patients with neurofibromatosis type 1. Am J Hypertens 2001, 14: 559\u2013566. 10.1016\/S0895-7061(00)01303-0","journal-title":"Am J Hypertens"},{"key":"102_CR5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00247-010-1854-9","volume":"41","author":"A Srinivasan","year":"2011","unstructured":"Srinivasan A, Krishnamurthy G, Fontalvo-Herazo L, Nijs E, Meyers K, Kaplan B, Cahill AM: Spectrum of renal findings in pediatric fibromuscular dysplasia and neurofibromatosis type 1. Pediatr Radiol 2011, 41: 308\u2013316. 10.1007\/s00247-010-1854-9","journal-title":"Pediatr Radiol"},{"key":"102_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4103\/0974-2069.58323","volume":"2","author":"IC Malav","year":"2009","unstructured":"Malav IC, Kothari SS: Renal artery stenosis due to neurofibromatosis. Ann Pediatr Cardioly 2009, 2: 167\u2013169. 10.4103\/0974-2069.58323","journal-title":"Ann Pediatr Cardioly"},{"key":"102_CR7","first-page":"97","volume":"51","author":"DL Elias","year":"1985","unstructured":"Elias DL, Ricketts RR, Smith RB 3rd: Renovascular hypertension complicating neurofibromatosis. Am Surg 1985, 51: 97\u2013106.","journal-title":"Am Surg"},{"key":"102_CR8","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1677\/ERC-07-0142","volume":"14","author":"A Karagiannis","year":"2007","unstructured":"Karagiannis A, Mikhailidis DP, Athyros VG, Harsoulis F: Pheochromocytoma: an update on genetics and management. Endoc Relat Cancer 2007, 14: 935\u2013956. 10.1677\/ERC-07-0142","journal-title":"Endoc Relat Cancer"},{"key":"102_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/00125817-200205000-00002","volume":"4","author":"JM Friedman","year":"2002","unstructured":"Friedman JM, Arbiser J, Epstein JA, Gutmann DH, Huot SJ, Lin AE, McManus B, Korf BR: Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force. Genet Med 2002, 4: 105\u2013111. 10.1097\/00125817-200205000-00002","journal-title":"Genet Med"},{"key":"102_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/jmg.2006.045906","volume":"44","author":"RE Ferner","year":"2007","unstructured":"Ferner RE, Huson SM, Thomas N, Moss C, Willshaw H, Evans DG, Upadhyaya M, Towers R, Gleeson M, Steiger C, Kirby A: Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. J Med Genet 2007, 44: 81\u201388. 10.1136\/jmg.2007.049122","journal-title":"J Med Genet"},{"key":"102_CR11","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1002\/ajmg.a.35829","volume":"161A","author":"K Ueda","year":"2013","unstructured":"Ueda K, Awazu M, Konishi Y, Takenouchi T, Shimozato S, Kosaki K, Takahashi T: Persistent hypertension despite successful dilation of a stenotic renal artery in a boy with neurofibromatosis type 1. Am J Med Genet Part A 2013, 161A: 1154\u20131157.","journal-title":"Am J Med Genet Part A"},{"key":"102_CR12","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.ejvs.2010.03.019","volume":"39","author":"H Kimura","year":"2010","unstructured":"Kimura H, Sato O, Deguchi JO, Miyata T: Surgical treatment and long-term outcome of renovascular hypertension in children and adolescents. Eur J Vasc Endovasc Surg 2010, 39: 731\u2013737. 10.1016\/j.ejvs.2010.03.019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"102_CR13","first-page":"503","volume":"28","author":"H Kimura","year":"2009","unstructured":"Kimura H, Sato O, Deguchi JO, Miyata T: Surgical treatment of a patient with progressive thrombosis of the renal artery associated with neurofibromatosis. Int Angiol 2009, 28: 503\u2013506.","journal-title":"Int Angiol"},{"key":"102_CR14","first-page":"487","volume":"47","author":"H Li","year":"2009","unstructured":"Li H, Ji CY, Zong XN, Zhang YQ: Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18\u00a0years [Article in Chinese]. Zhonghua er ke za zhi 2009, 47: 487\u2013492.","journal-title":"Zhonghua er ke za zhi"},{"key":"102_CR15","first-page":"579","volume":"39","author":"LS Liu","year":"2011","unstructured":"Liu LS: Writing Group of Chinese Guidelines for the Management of H: 2010 Chinese guidelines for the management of hypertension [Article in Chinese]. Zhonghua xin xue guan bing za zhi 2011, 39: 579\u2013615.","journal-title":"Zhonghua xin xue guan bing za zhi"},{"key":"102_CR16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0031-3955(16)38485-1","volume":"40","author":"LB Hiner","year":"1993","unstructured":"Hiner LB, Falkner B: Renovascular hypertension in children. Pediatr Clin North Am 1993, 40: 123\u2013140.","journal-title":"Pediatr Clin North Am"},{"key":"102_CR17","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.jvs.2006.08.009","volume":"44","author":"JC Stanley","year":"2006","unstructured":"Stanley JC, Criado E, Upchurch GR Jr, Brophy PD, Cho KJ, Rectenwald JE, Michigan Pediatric Renovascular G, Kershaw DB, Williams DM, Berguer R, Henke PK, Wakefield TW: Pediatric renovascular hypertension: 132 primary and 30 secondary operations in 97 children. J Vasc Surg 2006, 44: 1219\u20131228. 10.1016\/j.jvs.2006.08.009","journal-title":"J Vasc Surg"},{"key":"102_CR18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000174160","volume":"20","author":"P Arora","year":"1997","unstructured":"Arora P, Kher V, Singhal MK, Kumar P, Gulati S, Baijal SS, Jain S, Kumar A: Renal artery stenosis in aortoarteritis: spectrum of disease in children and adults. Kidney Blood Press Res 1997, 20: 285\u2013289. 10.1159\/000174160","journal-title":"Kidney Blood Press Res"},{"key":"102_CR19","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1542\/peds.80.5.698","volume":"80","author":"SR Daniels","year":"1987","unstructured":"Daniels SR, Loggie JM, McEnery PT, Towbin RB: Clinical spectrum of intrinsic renovascular hypertension in children. Pediatrics 1987, 80: 698\u2013704.","journal-title":"Pediatrics"},{"key":"102_CR20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/ajcp\/62.4.481","volume":"62","author":"JF Greene Jr","year":"1974","unstructured":"Greene JF Jr, Fitzwater JE, Burgess J: Arterial lesions associated with neurofibromatosis. Am J Clin Pathol 1974, 62: 481\u2013487.","journal-title":"Am J Clin Pathol"},{"key":"102_CR21","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(08)60626-1","volume":"371","author":"K Tullus","year":"2008","unstructured":"Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD, Roebuck DJ: Renovascular hypertension in children. Lancet 2008, 371: 1453\u20131463. 10.1016\/S0140-6736(08)60626-1","journal-title":"Lancet"},{"key":"102_CR22","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1093\/ndt\/17.7.1235","volume":"17","author":"C Booth","year":"2002","unstructured":"Booth C, Preston R, Clark G, Reidy J: Management of renal vascular disease in neurofibromatosis type 1 and the role of percutaneous transluminal angioplasty. Neph Dial Transplant 2002, 17: 1235\u20131240. 10.1093\/ndt\/17.7.1235","journal-title":"Neph Dial Transplant"},{"key":"102_CR23","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00467-006-0010-0","volume":"21","author":"K Konig","year":"2006","unstructured":"Konig K, Gellermann J, Querfeld U, Schneider MB: Treatment of severe renal artery stenosis by percutaneous transluminal renal angioplasty and stent implantation: review of the pediatric experience: apropos of two cases. Pediatr Nephrol 2006, 21: 663\u2013671. 10.1007\/s00467-006-0010-0","journal-title":"Pediatr Nephrol"},{"key":"102_CR24","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jvs.2004.12.021","volume":"41","author":"M Han","year":"2005","unstructured":"Han M, Criado E: Renal artery stenosis and aneurysms associated with neurofibromatosis. J Vasc Surg 2005, 41: 539\u2013543. 10.1016\/j.jvs.2004.12.021","journal-title":"J Vasc Surg"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/2047-783X-19-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T06:37:22Z","timestamp":1648708642000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/2047-783X-19-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,28]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["102"],"URL":"https:\/\/doi.org\/10.1186\/2047-783x-19-17","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,28]]},"assertion":[{"value":"26 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"17"}}