{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:28:56Z","timestamp":1759073336732},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/2047-783x-19-34","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T07:05:22Z","timestamp":1403593522000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Combination of BCL11A siRNA with vincristine increases the apoptosis of SUDHL6 cells"],"prefix":"10.1186","volume":"19","author":[{"given":"Dongmei","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"148_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrc1589","volume":"5","author":"R K\u00fcppers","year":"2005","unstructured":"K\u00fcppers R: Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005, 5: 251\u2013262.","journal-title":"Nat Rev Cancer"},{"key":"148_CR2","first-page":"83","volume":"102","author":"E Sabattini","year":"2010","unstructured":"Sabattini E, Bacci F, Sagramoso C, Pileri SA: WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica 2010, 102: 83\u201387.","journal-title":"Pathologica"},{"key":"148_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1756-8722-5-54","volume":"5","author":"CA Tirado","year":"2012","unstructured":"Tirado CA, Chen W, Garc\u00eda R, Kohlman KA, Rao N: Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large B-cell lymphoma: a review of the literature. J Hematol Oncol 2012, 5: 54.","journal-title":"J Hematol Oncol"},{"key":"148_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1756-8722-3-45","volume":"3","author":"PB Johnston","year":"2010","unstructured":"Johnston PB, Yuan R, Cavalli F, Witzig TE: Targeted therapy in lymphoma. J Hematol Oncol 2010, 3: 45.","journal-title":"J Hematol Oncol"},{"key":"148_CR5","doi-asserted-by":"publisher","first-page":"4538","DOI":"10.1158\/1078-0432.CCR-12-0217","volume":"8","author":"JJ Steinhardt","year":"2012","unstructured":"Steinhardt JJ, Gartenhaus RB: Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions. Clin Cancer Res 2012, 8: 4538\u20134548.","journal-title":"Clin Cancer Res"},{"key":"148_CR6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/ni925","volume":"4","author":"P Liu","year":"2003","unstructured":"Liu P, Keller JR, Ortiz M, Tessarollo L, Rachel RA, Nakamura T, Jenkins NA, Copeland NG: Bcl11a is essential for normal lymphoid development. Nat Immunol 2003, 4: 525\u2013532.","journal-title":"Nat Immunol"},{"key":"148_CR7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1188989","volume":"329","author":"L Li","year":"2010","unstructured":"Li L, Leid M, Rothenberg EV: An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b. Science 2010, 329: 89\u201393.","journal-title":"Science"},{"key":"148_CR8","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1084\/jem.20121846","volume":"209","author":"Y Yu","year":"2012","unstructured":"Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, Yang W, Jenkins NA, Copeland NG, Zhang S, Liu P: Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med 2012, 209: 2467\u20132483.","journal-title":"J Exp Med"},{"key":"148_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/2162-3619-1-22","volume":"1","author":"X Huang","year":"2012","unstructured":"Huang X, Du X, Li Y: The role of BCL11B in hematological malignancy. Exp Hematol Oncol 2012, 1: 22.","journal-title":"Exp Hematol Oncol"},{"key":"148_CR10","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/sj.leu.2402480","volume":"16","author":"R K\u00fcppers","year":"2002","unstructured":"K\u00fcppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG, Tucker PW, Dyer MJ, Siebert R: Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene. Leukemia 2002, 16: 937\u2013939.","journal-title":"Leukemia"},{"key":"148_CR11","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1182\/blood.V98.12.3413","volume":"98","author":"E Satterwhite","year":"2001","unstructured":"Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ: The BCL11 gene family: involvement of BCL11 A in lymphoid malignancies. Blood 2001, 98: 3413\u20133420.","journal-title":"Blood"},{"key":"148_CR12","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1182\/blood-2008-03-144436","volume":"113","author":"B Yin","year":"2009","unstructured":"Yin B, Delwel R, Valk PJ, Wallace MR, Loh ML, Shannon KM, Largaespada DA: A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood 2009, 113: 1075\u20131085.","journal-title":"Blood"},{"key":"148_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1476-4598-5-18","volume":"5","author":"H Liu","year":"2006","unstructured":"Liu H, Ippolito GC, Wall JK, Niu T, Probst L, Lee BS, Pulford K, Banham AH, Stockwin L, Shaffer AL, Staudt LM, Das C, Dyer MJ, Tucker PW: Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells. Mol Cancer 2006, 5: 18.","journal-title":"Mol Cancer"},{"key":"148_CR14","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1038\/sj.leu.2404324","volume":"20","author":"MA Weniger","year":"2006","unstructured":"Weniger MA, Pulford K, Gesk S, Ehrlich S, Banham AH, Lyne L, Martin-Subero JI, Siebert R, Dyer MJ, M\u00f6ller P, Barth TF: Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma. Leukemia 2006, 20: 1880\u20131882.","journal-title":"Leukemia"},{"key":"148_CR15","first-page":"147","volume":"32","author":"Y Gao","year":"2011","unstructured":"Gao Y, He D, Chen S, Yan X, Hu X, Li Y: Quantitative detection of BCL11A gene expression B cell malignancies by real-time RT-PCR. J Jinan Univ Med Ed 2011, 32: 147\u2013150. (In Chinese)","journal-title":"J Jinan Univ Med Ed"},{"key":"148_CR16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s11805-011-0588-2","volume":"8","author":"Y Gao","year":"2011","unstructured":"Gao Y, He D, Chen S, Yan X, Hu X, Li Y: Expression of the B-cell lymphoma\/leukemia BCL11A gene in malignant hematological cell lines through quantitative reverse transcription polymerase chain reaction. Clin Oncol Cancer Res 2011, 8: 242\u2013246.","journal-title":"Clin Oncol Cancer Res"},{"key":"148_CR17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/br.2012.9","volume":"1","author":"Y Gao","year":"2013","unstructured":"Gao Y, Wu H, He D, Hu X, Li Y: Downregulation of BCL11A by siRNA induces apoptosis in B lymphoma cell lines. Biomed Rep 2013, 1: 47\u201352.","journal-title":"Biomed Rep"},{"key":"148_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/(SICI)1097-0169(1998)39:2<107::AID-CM2>3.0.CO;2-3","volume":"39","author":"S Lobert","year":"1998","unstructured":"Lobert S, Frankfurter A, Correia JJ: Energetics of vinca alkaloid interactions with tubulin isotypes: implications for drug efficacy and toxicity. Cell Motil Cytoskeleton 1998, 39: 107\u2013121.","journal-title":"Cell Motil Cytoskeleton"},{"key":"148_CR19","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1126\/science.1241145","volume":"341","author":"MX Sliwkowski","year":"2013","unstructured":"Sliwkowski MX, Mellman I: Antibody therapeutics in cancer. Science 2013, 341: 192\u2013198.","journal-title":"Science"},{"key":"148_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/jjco\/hyq189","volume":"41","author":"Y Kobayashi","year":"2011","unstructured":"Kobayashi Y: Molecular target therapy in hematological malignancy: front-runners and prototypes of small molecule and antibody therapy. Jpn J Clin Oncol 2011, 41: 157\u2013164.","journal-title":"Jpn J Clin Oncol"},{"key":"148_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1756-8722-6-23","volume":"6","author":"MN Saha","year":"2013","unstructured":"Saha MN, Qiu L, Chang H: Targeting p53 by small molecules in hematological malignancies. J Hematol Oncol 2013, 6: 23.","journal-title":"J Hematol Oncol"},{"key":"148_CR22","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/biot.201100054","volume":"6","author":"JC Burnett","year":"2011","unstructured":"Burnett JC, Rossi JJ, Tiemann K: Current progress of siRNA\/shRNA therapeutics in clinical trials. Biotechnol J 2011, 6: 1130\u20131146.","journal-title":"Biotechnol J"},{"key":"148_CR23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/2162-3619-2-11","volume":"2","author":"F Kwong-Lam","year":"2013","unstructured":"Kwong-Lam F, Chi-Fung CG: Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment. Exp Hematol Oncol 2013, 2: 11.","journal-title":"Exp Hematol Oncol"},{"key":"148_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1475-2867-13-8","volume":"13","author":"B Huang","year":"2013","unstructured":"Huang B, Zhou H, Wang X, Liu Z: Silencing SATB1 with siRNA inhibits the proliferation and invasion of small cell lung cancer cells. Cancer Cell Int 2013, 13: 8.","journal-title":"Cancer Cell Int"},{"key":"148_CR25","doi-asserted-by":"publisher","first-page":"5828","DOI":"10.1038\/sj.onc.1210363","volume":"26","author":"G Brien","year":"2007","unstructured":"Brien G, Trescol-Biemont MC, Bonnefoy-B\u00e9rard N: Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis. Oncogene 2007, 26: 5828\u20135832.","journal-title":"Oncogene"},{"key":"148_CR26","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1182\/blood-2007-03-080325","volume":"110","author":"MH Kang","year":"2007","unstructured":"Kang MH, Kang YH, Szymanska B, Wilczynska-Kalak U, Sheard MA, Harned TM, Lock RB, Reynolds CP: Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood 2007, 110: 2057\u20132066.","journal-title":"Blood"},{"key":"148_CR27","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1124\/mol.109.060780","volume":"77","author":"LM High","year":"2010","unstructured":"High LM, Szymanska B, Wilczynska-Kalak U, Barber N, O'Brien R, Khaw SL, Vikstrom IB, Roberts AW, Lock RB: The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol Pharmacol 2010, 77: 483\u2013494.","journal-title":"Mol Pharmacol"},{"key":"148_CR28","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1111\/j.1582-4934.2008.00539.x","volume":"13","author":"J George","year":"2009","unstructured":"George J, Banik NL, Ray SK: Combination of taxol and Bcl-2 siRNA induces poptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth. J Cell Mol Med 2009, 13: 4205\u20134218.","journal-title":"J Cell Mol Med"},{"key":"148_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.rvsc.2007.03.012","volume":"84","author":"K Nagamatsu","year":"2008","unstructured":"Nagamatsu K, Tsuchiya F, Oguma K, Maruyama H, Kano R, Hasegawa A: The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line. Res Vet Sci 2008, 84: 49\u201355.","journal-title":"Res Vet Sci"},{"key":"148_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/abbs\/gmn015","volume":"41","author":"D He","year":"2009","unstructured":"He D, Fang B: Small hairpin RNA targeting at Bcl-2 increases cytarabine-induced apoptosis in Raji cells. Acta Biochim Biophys Sin 2009, 41: 131\u2013136.","journal-title":"Acta Biochim Biophys Sin"},{"key":"148_CR31","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ccr.2009.03.002","volume":"15","author":"L Gu","year":"2009","unstructured":"Gu L, Zhu N, Zhang H, Durden DL, Feng Y, Zhou M: Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell 2009, 15: 363\u2013375.","journal-title":"Cancer Cell"},{"key":"148_CR32","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1158\/1535-7163.MCT-06-0305","volume":"5","author":"E Barbieri","year":"2006","unstructured":"Barbieri E, Mehta P, Chen Z, Zhang L, Slack A, Berg S, Shohet JM: MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death. Mol Cancer Ther 2006, 5: 2358\u20132365.","journal-title":"Mol Cancer Ther"},{"key":"148_CR33","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1158\/0008-5472.CAN-08-1856","volume":"69","author":"M Michaelis","year":"2009","unstructured":"Michaelis M, Rothweiler F, Klassert D, von Deimling A, Weber K, Fehse B, Kammerer B, Doerr HW, Cinatl J Jr: Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3. Cancer Res 2009, 69: 416\u2013421.","journal-title":"Cancer Res"},{"key":"148_CR34","first-page":"4450","volume":"61","author":"M Fan","year":"2001","unstructured":"Fan M, Goodwin ME, Birrer MJ, Chambers TC: The c-Jun NH(2)-terminal protein inase\/AP-1 pathway is required for efficient apoptosis induced by vinblastine. Cancer Res 2001, 61: 4450\u20134458.","journal-title":"Cancer Res"},{"key":"148_CR35","first-page":"1339","volume":"21","author":"E Groninger","year":"2002","unstructured":"Groninger E, Meeuwsen-De Boer GJ, De Graaf SS, Kamps WA, De Bont ES: Vincristine induced apoptosis in acute lymphoblastic leukaemia cells: a mitochondrial controlled pathway regulated by reactive oxygen species? Int J Oncol 2002, 21: 1339\u20131345.","journal-title":"Int J Oncol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2047-783X-19-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T23:52:37Z","timestamp":1548201157000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/2047-783X-19-34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,24]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["148"],"URL":"https:\/\/doi.org\/10.1186\/2047-783x-19-34","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,24]]},"assertion":[{"value":"18 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"34"}}