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The primary objective of this study was to assess the utility of unplanned medication discontinuation as a signal for possible ADRs in children and young people.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Using orlistat as an exemplar, all orlistat prescriptions issued to patients up to 18\u00a0years of age together with patient characteristics, prescription duration, co-prescribed medicines and recorded clinical (Read) codes were identified from the Primary Care Informatics Unit database between 1st Jan 2006-30th Nov 2009. Binary logistic regression was used to assess association between characteristics and discontinuation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>During the study period, 79 patients were prescribed orlistat (81% female, median age 17\u00a0years). Unplanned medication discontinuation rates for orlistat were 52% and 77% at 1 and 3-months. Almost 20% of patients were co-prescribed an anti-depressant. One month unplanned medication discontinuation was significantly lower in the least deprived group (SIMD 1\u20132 compared to SIMD 9\u201310 OR 0.09 (95% CI0.01 \u2013 0.83)) and those co-prescribed at least one other medication. At 3\u00a0months, discontinuation was higher in young people (\u226517\u00a0yr versus, OR 3.07 (95% CI1.03 \u2013 9.14)). Read codes were recorded for digestive, respiratory and urinary symptoms around the time of discontinuation for 24% of patients. Urinary retention was reported for 7.6% of patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Identification of unplanned medication discontinuation using large primary care datasets may be a useful tool for pharmacovigilance signal generation and detection of potential ADRs in children and young people.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/2050-6511-15-11","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T12:02:52Z","timestamp":1393934572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Unplanned medication discontinuation as a potential pharmacovigilance signal: a nested young person cohort study"],"prefix":"10.1186","volume":"15","author":[{"given":"Angela Peichen","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corri","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter John","family":"Helms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bennie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Stuart","family":"McLay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"issue":"9","key":"300_CR1","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1651-2227.1999.tb00191.x","volume":"88","author":"S Turner","year":"1999","unstructured":"Turner S, Nunn AJ, Fielding K, Choonara I: Adverse drug reactions to unlicensed and off-label drugs on paediatric wards. 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