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Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet <jats:italic>in vivo<\/jats:italic> results are lacking. Here, experiments were performed to test the hypothesis that the PNS of insulin-resistant mice displays altered insulin signal transduction <jats:italic>in vivo<\/jats:italic>. For these studies, nondiabetic control and type 2 diabetic <jats:italic>ob\/ob<\/jats:italic> mice were challenged with an intrathecal injection of insulin or insulin-like growth factor 1 (IGF-1) and downstream signaling was evaluated in the DRG and sciatic nerve using Western blot analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results indicate that insulin signaling abnormalities documented in other \u201cinsulin sensitive\u201d tissues (i.e. muscle, fat, liver) of <jats:italic>ob\/ob<\/jats:italic> mice are also present in the PNS. A robust increase in Akt activation was observed with insulin and IGF-1 stimulation in nondiabetic mice in both the sciatic nerve and DRG; however this response was blunted in both tissues from <jats:italic>ob\/ob<\/jats:italic> mice. The results also suggest that upregulated JNK activation and reduced insulin receptor expression could be contributory mechanisms of PNS insulin resistance within sensory neurons.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These findings contribute to the growing body of evidence that alterations in insulin signaling occur in the PNS and may be a key factor in the pathogenesis of diabetic neuropathy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/2051-5960-1-15","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T16:16:58Z","timestamp":1368202618000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Peripheral nervous system insulin resistance in ob\/ob mice"],"prefix":"10.1186","volume":"1","author":[{"given":"Caleb W","family":"Grote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L","family":"Groover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle M","family":"Ryals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige C","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva L","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"issue":"3","key":"14_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.tem.2011.12.004","volume":"23","author":"B Kim","year":"2012","unstructured":"Kim B, Feldman EL: Insulin resistance in the nervous system. 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