{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:00:28Z","timestamp":1790485228832,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/2051-5960-2-16","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T12:01:43Z","timestamp":1391774503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury"],"prefix":"10.1186","volume":"2","author":[{"given":"Jennifer D","family":"Sokolowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana K","family":"Gamage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S","family":"Heffron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Deppmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W","family":"Mandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"196_CR1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1124\/mol.51.6.897","volume":"51","author":"M Deshmukh","year":"1997","unstructured":"Deshmukh M, Johnson EM Jr: Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. Mol Pharmacol 1997, 51: 897\u2013906.","journal-title":"Mol Pharmacol"},{"key":"196_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.nbd.2013.03.009","volume":"56","author":"M Ma","year":"2013","unstructured":"Ma M, Ferguson TA, Schoch KM, Li J, Qian Y, Shofer FS, Saatman KE, Neumar RW: Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration. Neurobiol Dis 2013, 56: 34\u201346. Doi:10.1016\/j.nbd.2013.03.009","journal-title":"Neurobiol Dis"},{"key":"196_CR3","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.pneurobio.2007.07.007","volume":"83","author":"S Saxena","year":"2007","unstructured":"Saxena S, Caroni P: Mechanisms of axon degeneration: from development to disease. Prog Neurobiol 2007, 83: 174\u2013191. Doi:10.1016\/j.pneurobio.2007.07.007 10.1016\/j.pneurobio.2007.07.007","journal-title":"Prog Neurobiol"},{"key":"196_CR4","doi-asserted-by":"publisher","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","volume":"272","author":"NA Thornberry","year":"1997","unstructured":"Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW: A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 1997, 272: 17907\u201317911. 10.1074\/jbc.272.29.17907","journal-title":"J Biol Chem"},{"key":"196_CR5","doi-asserted-by":"publisher","first-page":"7320","DOI":"10.1074\/jbc.M008363200","volume":"276","author":"EA Slee","year":"2001","unstructured":"Slee EA, Adrain C, Martin SJ: Executioner caspase-3, -6, and \u22127 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 2001, 276: 7320\u20137326. Doi:10.1074\/jbc.M008363200 10.1074\/jbc.M008363200","journal-title":"J Biol Chem"},{"key":"196_CR6","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1146\/annurev-biochem-061809-121639","volume":"80","author":"ED Crawford","year":"2011","unstructured":"Crawford ED, Wells JA: Caspase substrates and cellular remodeling. Annu Rev Biochem 2011, 80: 1055\u20131087. Doi:10.1146\/annurev-biochem-061809\u2013121639 10.1146\/annurev-biochem-061809-121639","journal-title":"Annu Rev Biochem"},{"key":"196_CR7","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","volume":"147","author":"Y Fuchs","year":"2011","unstructured":"Fuchs Y, Steller H: Programmed cell death in animal development and disease. Cell 2011, 147: 742\u2013758. Doi:10.1016\/j. cell .2011.10.033 10.1016\/j.cell.2011.10.033","journal-title":"Cell"},{"key":"196_CR8","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1038\/ncomms2910","volume":"4","author":"CL Cusack","year":"2013","unstructured":"Cusack CL, Swahari V, Hampton Henley W, Michael Ramsey J, Deshmukh M: Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning. Nat Commun 2013, 4: 1876. Doi:10.1038\/ncomms2910","journal-title":"Nat Commun"},{"key":"196_CR9","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1523\/JNEUROSCI.20-04-01333.2000","volume":"20","author":"JT Finn","year":"2000","unstructured":"Finn JT, Weil M, Archer F, Siman R, Srinivasan A, Raff MC: Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases. J Neurosci 2000, 20: 1333\u20131341.","journal-title":"J Neurosci"},{"key":"196_CR10","doi-asserted-by":"publisher","first-page":"17540","DOI":"10.1523\/JNEUROSCI.3012-12.2012","volume":"32","author":"DJ Simon","year":"2012","unstructured":"Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O\u2019Leary DD, Hannoush RN, Tessier-Lavigne M: A caspase cascade regulating developmental axon degeneration. J Neurosci 2012, 32: 17540\u201317553. Doi:10.1523\/JNEUROSCI.3012\u201312.2012 10.1523\/JNEUROSCI.3012-12.2012","journal-title":"J Neurosci"},{"key":"196_CR11","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/nature07767","volume":"457","author":"A Nikolaev","year":"2009","unstructured":"Nikolaev A, McLaughlin T, O\u2019Leary DD, Tessier-Lavigne M: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457: 981\u2013989. Doi:10.1038\/nature07767 10.1038\/nature07767","journal-title":"Nature"},{"key":"196_CR12","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.celrep.2013.07.015","volume":"4","author":"N Unsain","year":"2013","unstructured":"Unsain N, Higgins JM, Parker KN, Johnstone AD, Barker PA: XIAP regulates caspase activity in degenerating axons. Cell Rep 2013, 4: 751\u2013763. Doi:10.1016\/j.celrep.2013.07.015 10.1016\/j.celrep.2013.07.015","journal-title":"Cell Rep"},{"key":"196_CR13","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1126\/science.287.5455.1056","volume":"287","author":"C Ikonomidou","year":"2000","unstructured":"Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Horster F, Tenkova T, Dikranian K, Olney JW: Ethanol-induced apoptotic neurodegeneration and fetal ethanol syndrome. Science 2000, 287: 1056\u20131060. 10.1126\/science.287.5455.1056","journal-title":"Science"},{"key":"196_CR14","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1097\/NEN.0b013e3181a9d524","volume":"68","author":"AP Ghosh","year":"2009","unstructured":"Ghosh AP, Walls KC, Klocke BJ, Toms R, Strasser A, Roth KA: The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis. J Neuropathol Exp Neurol 2009, 68: 747\u2013756. Doi:10.1097\/NEN.0b013e3181a9d524 10.1097\/NEN.0b013e3181a9d524","journal-title":"J Neuropathol Exp Neurol"},{"key":"196_CR15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/mrdd.1037","volume":"7","author":"JW Olney","year":"2001","unstructured":"Olney JW, Wozniak DF, Jevtovic-Todorovic V, Ikonomidou C: Glutamate signaling and the fetal ethanol syndrome. Ment Retard Dev Disabil Res Rev 2001, 7: 267\u2013275. Doi:10.1002\/mrdd.1037 10.1002\/mrdd.1037","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"196_CR16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1006\/nbdi.2001.0475","volume":"9","author":"JW Olney","year":"2002","unstructured":"Olney JW, Tenkova T, Dikranian K, Muglia LJ, Jermakowicz WJ, D\u2019Sa C, Roth KA: Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis 2002, 9: 205\u2013219. Doi:10.1006\/nbdi.2001.0475 10.1006\/nbdi.2001.0475","journal-title":"Neurobiol Dis"},{"key":"196_CR17","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1038\/sj.cdd.4401277","volume":"10","author":"C Young","year":"2003","unstructured":"Young C, Klocke BJ, Tenkova T, Choi J, Labruyere J, Qin YQ, Holtzman DM, Roth KA, Olney JW: Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ 2003, 10: 1148\u20131155. Doi:10.1038\/sj.cdd.4401277 10.1038\/sj.cdd.4401277","journal-title":"Cell Death Differ"},{"key":"196_CR18","doi-asserted-by":"publisher","first-page":"23426","DOI":"10.1074\/jbc.274.33.23426","volume":"274","author":"A LeBlanc","year":"1999","unstructured":"LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J: Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer\u2019s disease. J Biol Chem 1999, 274: 23426\u201323436. 10.1074\/jbc.274.33.23426","journal-title":"J Biol Chem"},{"key":"196_CR19","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2004.06.021","volume":"118","author":"R Kuruvilla","year":"2004","unstructured":"Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD: A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 2004, 118: 243\u2013255. Doi:10.1016\/j.cell.2004.06.021 10.1016\/j.cell.2004.06.021","journal-title":"Cell"},{"key":"196_CR20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2144\/000112257","volume":"42","author":"MR Lamprecht","year":"2007","unstructured":"Lamprecht MR, Sabatini DM, Carpenter AE: Cell Profiler: free, versatile software for automated biological image analysis. Biotechniques 2007, 42: 71\u201375. 10.2144\/000112257","journal-title":"Biotechniques"},{"key":"196_CR21","first-page":"379","volume":"152","author":"F Yang","year":"1998","unstructured":"Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM: Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer\u2019s disease. Am J Pathol 1998, 152: 379\u2013389.","journal-title":"Am J Pathol"},{"key":"196_CR22","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1074\/mcp.M800007-MCP200","volume":"7","author":"G Klaiman","year":"2008","unstructured":"Klaiman G, Petzke TL, Hammond J, Leblanc AC: Targets of caspase-6 activity in human neurons and Alzheimer disease. Mol Cell Proteomics 2008, 7: 1541\u20131555. Doi:10.1074\/mcp.M800007-MCP200 10.1074\/mcp.M800007-MCP200","journal-title":"Mol Cell Proteomics"},{"key":"196_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0006-8993(79)90265-8","volume":"167","author":"CA Marotta","year":"1979","unstructured":"Marotta CA, Strocchi P, Gilbert JM: Sununit structure of synaptosomal tubulin. Brain Res 1979, 167: 93\u2013106. 10.1016\/0006-8993(79)90265-8","journal-title":"Brain Res"},{"key":"196_CR24","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/emm.2006.75","volume":"38","author":"SB Yee","year":"2006","unstructured":"Yee SB, Baek SJ, Park HT, Jeong SH, Jeong JH, Kim TH, Kim JM, Jeong BK, Park BS, Kwon TK, Yoon I, Yoo YH: zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14\u20133-3\/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med 2006, 38: 634\u2013642. Doi:10.1038\/emm.2006.75 10.1038\/emm.2006.75","journal-title":"Exp Mol Med"},{"key":"196_CR25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jns.2005.03.015","volume":"233","author":"A Petzold","year":"2005","unstructured":"Petzold A: Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss. J Neurol Sci 2005, 233: 183\u2013198. Doi:10.1016\/j.jns.2005.03.015 10.1016\/j.jns.2005.03.015","journal-title":"J Neurol Sci"},{"key":"196_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/35070009","volume":"3","author":"ML Coleman","year":"2001","unstructured":"Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF: Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 2001, 3: 339\u2013345. Doi:10.1038\/35070009 10.1038\/35070009","journal-title":"Nat Cell Biol"},{"key":"196_CR27","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1213\/ane.0b013e318168514b","volume":"106","author":"P Lirk","year":"2008","unstructured":"Lirk P, Haller I, Colvin HP, Lang L, Tomaselli B, Klimaschewski L, Gerner P: In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity. Anesth Analg 2008, 106: 1456\u20131464. table of contents. Doi:10.1213\/ane.0b013e318168514b 10.1213\/ane.0b013e318168514b","journal-title":"Anesth Analg"},{"key":"196_CR28","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1213\/01.ane.0000286171.78182.e2","volume":"105","author":"P Lirk","year":"2007","unstructured":"Lirk P, Haller I, Colvin HP, Frauscher S, Kirchmair L, Gerner P, Klimaschewski L: In vitro, lidocaine-induced axonal injury is prevented by peripheral inhibition of the p38 mitogen-activated protein kinase, but not by inhibiting caspase activity. Anesth Analg 2007, 105: 1657\u20131664. table of contents. Doi:10.1213\/01.ane.0000286171.78182.e2 10.1213\/01.ane.0000286171.78182.e2","journal-title":"Anesth Analg"},{"key":"196_CR29","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/nn1774","volume":"9","author":"DW Williams","year":"2006","unstructured":"Williams DW, Kondo S, Krzyzanowska A, Hiromi Y, Truman JW: Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci 2006, 9: 1234\u20131236. Doi:10.1038\/nn1774 10.1038\/nn1774","journal-title":"Nat Neurosci"},{"key":"196_CR30","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.neuron.2004.10.026","volume":"44","author":"DL Bishop","year":"2004","unstructured":"Bishop DL, Misgeld T, Walsh MK, Gan WB, Lichtman JW: Axon branch removal at developing synapses by axosome shedding. Neuron 2004, 44: 651\u2013661. 10.1016\/j.neuron.2004.10.026","journal-title":"Neuron"},{"key":"196_CR31","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.neuron.2006.05.013","volume":"50","author":"ED Hoopfer","year":"2006","unstructured":"Hoopfer ED, McLaughlin T, Watts RJ, Schuldiner O, O\u2019Leary DD, Luo L: Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron 2006, 50: 883\u2013895. Doi:10.1016\/j.neuron.2006.05.013 10.1016\/j.neuron.2006.05.013","journal-title":"Neuron"},{"key":"196_CR32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S0002-9440(10)63317-2","volume":"165","author":"H Guo","year":"2004","unstructured":"Guo H, Albrecht S, Bourdeau M, Petzke T, Bergeron C, LeBlanc AC: Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer\u2019s disease. Am J Pathol 2004, 165: 523\u2013531. Doi:10.1016\/S0002\u20139440(10)63317\u20132 10.1016\/S0002-9440(10)63317-2","journal-title":"Am J Pathol"},{"key":"196_CR33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s004010100432","volume":"103","author":"JP Rossiter","year":"2002","unstructured":"Rossiter JP, Anderson LL, Yang F, Cole GM: Caspase-3 activation and caspase-like proteolytic activity in human perinatal hypoxic-ischemic brain injury. Acta Neuropathol 2002, 103: 66\u201373. 10.1007\/s004010100432","journal-title":"Acta Neuropathol"},{"key":"196_CR34","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1046\/j.1365-2990.2000.00252.x","volume":"26","author":"JP Rossiter","year":"2000","unstructured":"Rossiter JP, Anderson LL, Yang F, Cole GM: Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies. Neuropathol Appl Neurobiol 2000, 26: 342\u2013346. 10.1046\/j.1365-2990.2000.00252.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"196_CR35","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1365-2990.2005.00645.x","volume":"31","author":"RR Reichard","year":"2005","unstructured":"Reichard RR, Smith C, Graham DI: The significance of beta-APP immunoreactivity in forensic practice. Neuropathol Appl Neurobiol 2005, 31: 304\u2013313. Doi:10.1111\/j.1365\u20132990.2005.00645.x 10.1111\/j.1365-2990.2005.00645.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"196_CR36","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1016\/j.forsciint.2011.04.027","volume":"212","author":"W Squier","year":"2011","unstructured":"Squier W, Scheimberg I, Smith C: Spinal nerve root beta-APP staining in infants is not a reliable indicator of trauma. Forensic Sci Int 2011, 212: e31-e35. Doi:10.1016\/j.forsciint.2011.04.027 10.1016\/j.forsciint.2011.04.027","journal-title":"Forensic Sci Int"},{"issue":"Suppl 1","key":"196_CR37","doi-asserted-by":"publisher","first-page":"S171","DOI":"10.1016\/j.legalmed.2009.01.076","volume":"11","author":"T Hayashi","year":"2009","unstructured":"Hayashi T, Ago K, Ago M, Ogata M: Two patterns of beta-amyloid precursor protein (APP) immunoreactivity in cases of blunt head injury. Leg Med (Tokyo) 2009, 11(Suppl 1):S171-S173. Doi:10.1016\/j.legalmed.2009.01.076","journal-title":"Leg Med (Tokyo)"},{"issue":"Suppl 1","key":"196_CR38","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1016\/j.legalmed.2009.01.113","volume":"11","author":"M Oehmichen","year":"2009","unstructured":"Oehmichen M, Meissner C: Routine techniques in forensic neuropathology as demonstrated by gunshot injury to the head. Leg Med (Tokyo) 2009, 11(Suppl 1):S50-S53. Doi:10.1016\/j.legalmed.2009.01.113","journal-title":"Leg Med (Tokyo)"},{"key":"196_CR39","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1038\/sj.onc.1202558","volume":"18","author":"T Mashima","year":"1999","unstructured":"Mashima T, Naito M, Tsuruo T: Caspase-mediated cleavage of cytoskeletal actin plays a positive role in the process of morphological apoptosis. Oncogene 1999, 18: 2423\u20132430. Doi:10.1038\/sj.onc.1202558 10.1038\/sj.onc.1202558","journal-title":"Oncogene"},{"key":"196_CR40","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1523\/JNEUROSCI.15-10-06445.1995","volume":"15","author":"EB George","year":"1995","unstructured":"George EB, Glass JD, Griffin JW: Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci 1995, 15: 6445\u20136452.","journal-title":"J Neurosci"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2051-5960-2-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2051-5960-2-16\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2051-5960-2-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/2051-5960-2-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T11:57:31Z","timestamp":1630583851000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/2051-5960-2-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["196"],"URL":"https:\/\/doi.org\/10.1186\/2051-5960-2-16","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,7]]},"assertion":[{"value":"28 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}