{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:47:57Z","timestamp":1770414477881,"version":"3.49.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["acta neuropathol commun"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/2051-5960-2-3","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T18:01:03Z","timestamp":1388685663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease"],"prefix":"10.1186","volume":"2","author":[{"given":"Reas S","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Dine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayasri","family":"Das Sarma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S","family":"Shindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"81_CR1","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1056\/NEJM200009283431307","volume":"343","author":"JH Noseworthy","year":"2000","unstructured":"Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG: Multiple sclerosis. N Engl J Med 2000, 343: 938\u2013952. 10.1056\/NEJM200009283431307","journal-title":"N Engl J Med"},{"key":"81_CR2","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/brain\/118.6.1583","volume":"118","author":"CA Davie","year":"1995","unstructured":"Davie CA, Barker GJ, Webb S, Tofts PS, Thompson AJ, Harding AE, McDonald WI, Miller DH: Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995, 118: 1583\u20131592. 10.1093\/brain\/118.6.1583","journal-title":"Brain"},{"key":"81_CR3","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/brain\/119.3.701","volume":"119","author":"NA Losseff","year":"1996","unstructured":"Losseff NA, Webb SL, O'Riordan JI, Page R, Wang L, Barker GJ, Tofts PS, McDonald WI, Miller DH, Thompson AJ: Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996, 119: 701\u2013708. 10.1093\/brain\/119.3.701","journal-title":"Brain"},{"key":"81_CR4","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1093\/brain\/119.6.2009","volume":"119","author":"NA Losseff","year":"1996","unstructured":"Losseff NA, Wang L, Lai HM, Yoo DS, Gawne-Cain ML, McDonald WI, Miller DH, Thompson AJ: Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Brain 1996, 119: 2009\u20132019. 10.1093\/brain\/119.6.2009","journal-title":"Brain"},{"key":"81_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/ana.20575","volume":"58","author":"SA Trip","year":"2005","unstructured":"Trip SA, Schlottmann PG, Jones SJ, Altmann DR, Garway-Heath DF, Thompson AJ, Plant GT, Miller DH: Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 2005, 58: 383\u2013391. 10.1002\/ana.20575","journal-title":"Ann Neurol"},{"key":"81_CR6","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ophtha.2005.10.040","volume":"113","author":"JB Fisher","year":"2006","unstructured":"Fisher JB, Jacobs DA, Markowitz CE, Galetta SL, Volpe NJ, Nano-Schiavi ML, Baier ML, Frohman EM, Winslow H, Frohman TC, Calabresi PA, Maguire MG, Cutter GR, Balcer LJ: Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology 2006, 113: 324\u2013332. 10.1016\/j.ophtha.2005.10.040","journal-title":"Ophthalmology"},{"key":"81_CR7","first-page":"S16","volume":"57","author":"KP Johnson","year":"2001","unstructured":"Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB, Vollmer T, Weiner LP, Wolinsky JS: Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind, placebo-controlled trial. Neurology 2001, 57: S16-S24.","journal-title":"Neurology"},{"key":"81_CR8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ana.410390304","volume":"39","author":"LD Jacobs","year":"1996","unstructured":"Jacobs LD, Cookfair DL, Rudick RA, Herndon RM, Richert JR, Salazar AM, Fischer JS, Goodkin DE, Granger CV, Simon JH, Alam JJ, Bartoszak DM, Bourdette DN, Braiman J, Brownscheidle CM, Coats ME, Cohan SL, Dougherty DS, Kinkel RP, Mass MK, et al.: Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 1996, 39: 285\u2013294. 10.1002\/ana.410390304","journal-title":"Ann Neurol"},{"key":"81_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00415-003-0965-8","volume":"250","author":"A Parry","year":"2003","unstructured":"Parry A, Corkill R, Blamire AM, Palace J, Narayanan S, Arnold D, Styles P, Matthews PM: Beta-Interferon treatment does not always slow the progression of axonal injury in multiple sclerosis. J Neurol 2003, 250: 171\u2013178. 10.1007\/s00415-003-0965-8","journal-title":"J Neurol"},{"key":"81_CR10","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1136\/jnnp.74.8.1139","volume":"74","author":"SJ Hickman","year":"2003","unstructured":"Hickman SJ, Kapoor R, Jones SJ, Altmann DR, Plant GT, Miller DH: Corticosteroids do not prevent optic nerve atrophy following optic neuritis. J Neurol Neurosurg Psychiatry 2003, 74: 1139\u20131141. 10.1136\/jnnp.74.8.1139","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"81_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S1474-4422(05)70023-5","volume":"4","author":"DH Gilden","year":"2005","unstructured":"Gilden DH: Infectious causes of multiple sclerosis. Lancet Neurol 2005, 4: 195\u2013202.","journal-title":"Lancet Neurol"},{"key":"81_CR12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/BF02786446","volume":"17","author":"CS Constantinescu","year":"1998","unstructured":"Constantinescu CS, Hilliard B, Fujioka T, Bhopale MK, Calida D, Rostami AM: Pathogenesis of neuroimmunologic diseases, Experimental models. Immunol Res 1998, 17: 217\u2013227. 10.1007\/BF02786446","journal-title":"Immunol Res"},{"key":"81_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0002-9440(10)64537-3","volume":"157","author":"B Kornek","year":"2000","unstructured":"Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H: Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000, 157: 267\u2013276. 10.1016\/S0002-9440(10)64537-3","journal-title":"Am J Pathol"},{"key":"81_CR14","doi-asserted-by":"crossref","first-page":"6214","DOI":"10.1523\/JNEUROSCI.21-16-06214.2001","volume":"21","author":"R Meyer","year":"2001","unstructured":"Meyer R, Weissert R, Diem R, Storch MK, de Graaf KL, Kramer B, Bahr M: Acute neuronal apoptosis in a rat model of multiple sclerosis. J Neurosci 2001, 21: 6214\u20136220.","journal-title":"J Neurosci"},{"key":"81_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/jnen\/61.1.23","volume":"61","author":"JR Wujek","year":"2002","unstructured":"Wujek JR, Bjartmar C, Richer E, Ransohoff RM, Yu M, Tuohy VK, Trapp BD: Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol 2002, 61: 23\u201332.","journal-title":"J Neuropathol Exp Neurol"},{"key":"81_CR16","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1212\/WNL.34.5.597","volume":"34","author":"E Lavi","year":"1984","unstructured":"Lavi E, Gilden DH, Wroblewska Z, Rorke LB, Weiss SR: Experimental demyelination produced by the A59 strain of mouse hepatitis virus. Neurology 1984, 34: 597\u2013603. 10.1212\/WNL.34.5.597","journal-title":"Neurology"},{"key":"81_CR17","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-4615-9373-7_24","volume":"173","author":"E Lavi","year":"1984","unstructured":"Lavi E, Gilden DH, Highkin MK, Weiss SR: MHV-A59 pathogenesis in mice. Adv Exp Med Biol 1984, 173: 237\u2013245. 10.1007\/978-1-4615-9373-7_24","journal-title":"Adv Exp Med Biol"},{"key":"81_CR18","doi-asserted-by":"publisher","first-page":"10272","DOI":"10.1523\/JNEUROSCI.1975-09.2009","volume":"29","author":"J Das Sarma","year":"2009","unstructured":"Das Sarma J, Kenyon LC, Hingley ST, Shindler KS: Mechanisms of primary axonal damage in a viral model of multiple sclerosis. J Neurosci 2009, 29: 10272\u201310280. 10.1523\/JNEUROSCI.1975-09.2009","journal-title":"J Neurosci"},{"key":"81_CR19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.ajo.2005.01.031","volume":"139","author":"AC Arnold","year":"2005","unstructured":"Arnold AC: Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 2005, 139: 1101\u20131108. 10.1016\/j.ajo.2005.01.031","journal-title":"Am J Ophthalmol"},{"key":"81_CR20","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1177\/1352458506070629","volume":"12","author":"KS Shindler","year":"2006","unstructured":"Shindler KS, Guan Y, Ventura E, Bennett J, Rostami A: Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Mult Scler 2006, 12: 526\u2013532. 10.1177\/1352458506070629","journal-title":"Mult Scler"},{"key":"81_CR21","doi-asserted-by":"publisher","first-page":"8882","DOI":"10.1128\/JVI.00920-08","volume":"82","author":"KS Shindler","year":"2008","unstructured":"Shindler KS, Kenyon LC, Dutt M, Hingley ST, Das Sarma J: Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J Virol 2008, 82: 8882\u20138886. 10.1128\/JVI.00920-08","journal-title":"J Virol"},{"key":"81_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fneur.2011.00050","volume":"2","author":"TA Quinn","year":"2011","unstructured":"Quinn TA, Dutt M, Shindler KS: Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis. Front Neurol 2011, 2: 50.","journal-title":"Front Neurol"},{"key":"81_CR23","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1167\/iovs.07-0131","volume":"48","author":"KS Shindler","year":"2007","unstructured":"Shindler KS, Ventura E, Rex TS, Elliott P, Rostami A: SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis. Invest Ophthalmol Vis Sci 2007, 48: 3602\u20133609. 10.1167\/iovs.07-0131","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"81_CR24","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/WNO.0b013e3181f7f833","volume":"30","author":"KS Shindler","year":"2010","unstructured":"Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A: Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol 2010, 30: 328\u2013339. 10.1097\/WNO.0b013e3181f7f833","journal-title":"J Neuroophthalmol"},{"key":"81_CR25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fneur.2012.00084","volume":"3","author":"Z Fonseca-Kelly","year":"2012","unstructured":"Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS: Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front Neurol 2012, 3: 84.","journal-title":"Front Neurol"},{"key":"81_CR26","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"M Lagouge","year":"2006","unstructured":"Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127: 1109\u20131122. 10.1016\/j.cell.2006.11.013","journal-title":"Cell"},{"key":"81_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2012.00063","volume":"6","author":"RS Khan","year":"2012","unstructured":"Khan RS, Fonseca-Kelly Z, Callinan C, Zuo L, Sachdeva MM, Shindler KS: SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. Front Cell Neurosci 2012, 6: 1\u201313.","journal-title":"Front Cell Neurosci"},{"key":"81_CR28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000267321","volume":"25","author":"J Guy","year":"1993","unstructured":"Guy J, Ellis EA, Mames R, Rao NA: Role of hydrogen peroxide in experimental optic neuritis. A serial quantitative ultrastructural study. Ophthalmic Res 1993, 25: 253\u2013264. 10.1159\/000267321","journal-title":"Ophthalmic Res"},{"key":"81_CR29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ana.20736","volume":"59","author":"R Dutta","year":"2006","unstructured":"Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, Gudz T, Macklin WB, Lewis DA, Fox RJ, Rudick R, Mirnics K, Trapp BD: Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 2006, 59: 478\u2013489. 10.1002\/ana.20736","journal-title":"Ann Neurol"},{"key":"81_CR30","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1167\/iovs.06-0553","volume":"48","author":"X Qi","year":"2007","unstructured":"Qi X, Lewin AS, Sun L, Hauswirth WW, Guy J: Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci 2007, 48: 681\u2013691. 10.1167\/iovs.06-0553","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"81_CR31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-4615-1325-4_21","volume":"494","author":"J Das Sarma","year":"2001","unstructured":"Das Sarma J, Fu L, Weiss SR, Lavi E: Demyelination determinants in the S gene of MHV. Adv Exp Med Biol 2001, 494: 133\u2013137. 10.1007\/978-1-4615-1325-4_21","journal-title":"Adv Exp Med Biol"},{"key":"81_CR32","doi-asserted-by":"publisher","first-page":"5519","DOI":"10.1128\/JVI.01488-07","volume":"82","author":"J Das Sarma","year":"2008","unstructured":"Das Sarma J, Iacono K, Gard L, Marek R, Kenyon LC, Koval M, Weiss SR: Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism. J Virol 2008, 82: 5519\u20135526. 10.1128\/JVI.01488-07","journal-title":"J Virol"},{"key":"81_CR33","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nature06261","volume":"450","author":"JC Milne","year":"2007","unstructured":"Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, et al.: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450: 712\u2013716. 10.1038\/nature06261","journal-title":"Nature"},{"key":"81_CR34","first-page":"OR24","volume":"34","author":"E Cohen-Kfir","year":"2013","unstructured":"Cohen-Kfir E, Artsi H, Bajayo A, Gabet Y, Gurt I, Kalish N, Shahar R, Dresner-Pollak R: The Sirtuin 1 Activator SRTAW04 restores Bone Mass and Structure in Ovariectomized Mice A Potential Novel Therapy for Osteoporosis. Endocr Rev 2013, 34: OR24\u201326.","journal-title":"Endocr Rev"},{"key":"81_CR35","doi-asserted-by":"publisher","first-page":"11815","DOI":"10.1523\/JNEUROSCI.2234-10.2010","volume":"30","author":"MO Dietrich","year":"2010","unstructured":"Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL: Agrp neurons mediate Sirt1\u2019s action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci 2010, 30: 11815\u201311825. 10.1523\/JNEUROSCI.2234-10.2010","journal-title":"J Neurosci"},{"key":"81_CR36","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1158\/1535-7163.MCT-09-0971","volume":"4","author":"B Peck","year":"2010","unstructured":"Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW: SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther 2010, 4: 844\u2013855.","journal-title":"Mol Cancer Ther"},{"key":"81_CR37","doi-asserted-by":"publisher","first-page":"11171","DOI":"10.1074\/jbc.M809268200","volume":"284","author":"H Yamaguchi","year":"2009","unstructured":"Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, Monteiro A, Liu X, Hung MC, Wang HG: p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem 2009, 284: 11171\u201383.","journal-title":"J Biol Chem"},{"key":"81_CR38","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1167\/iovs.13-12157","volume":"54","author":"L Zuo","year":"2013","unstructured":"Zuo L, Khan RS, Lee V, Dine K, Wu W, Shindler KS: SIRT1 Promotes RGC Survival and Delays Loss of Function Following Optic Nerve Crush. Invest Ophthalmol Vis Sci 2013, 54: 5097\u20135102. 10.1167\/iovs.13-12157","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"81_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.visres.2008.09.029","volume":"49","author":"M Salinas-Navarro","year":"2009","unstructured":"Salinas-Navarro M, Mayor-Torroglosa S, Jimenez-Lopez M, Aviles-Trigueros M, Holmes TM, Lund RD, Villegas-Perez MP, Vidal-Sanz M: A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats. Vision Res 2009, 49: 115\u2013126. 10.1016\/j.visres.2008.09.029","journal-title":"Vision Res"},{"key":"81_CR40","doi-asserted-by":"publisher","first-page":"7558","DOI":"10.1073\/pnas.0702228104","volume":"18","author":"M Forte","year":"2007","unstructured":"Forte M, Gold BG, Marracci G, Chaudhary P, Basso E, Johnsen D, Yu X, Fowlkes J, Rahder M, Stem K, Bernardi P, Bourdette D: Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis an animal model of multiple sclerosis. Proc Natl Acad Sci 2007, 18: 7558\u20137563.","journal-title":"Proc Natl Acad Sci"},{"key":"81_CR41","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/13550280260422686","volume":"8","author":"J Das Sarma","year":"2002","unstructured":"Das Sarma J, Scheen E, Seo SH, Koval M, Weiss SR: Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system. J Neurovirol 2002, 8: 381\u2013391. 10.1080\/13550280260422686","journal-title":"J Neurovirol"},{"key":"81_CR42","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/NEN.0b013e31821da499","volume":"70","author":"KS Shindler","year":"2011","unstructured":"Shindler KS, Chatterjee D, Biswas K, Goyal A, Dutt D, Nassrallah M, Khan RS, Das Sarma J: Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus. J Neuropathol Exp Neurol 2011, 70: 470\u2013480. 10.1097\/NEN.0b013e31821da499","journal-title":"J Neuropathol Exp Neurol"},{"key":"81_CR43","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1016\/S0021-9258(18)90926-9","volume":"259","author":"BA Ackrell","year":"1984","unstructured":"Ackrell BA, Maguire JJ, Dallman PR, Kearney EB: Effect of iron deficiency on succinate- and NADH-ubiquinone oxidoreductases in skeletal muscle mitochondria. J Biol Chem 1984, 259: 10053\u201310059.","journal-title":"J Biol Chem"},{"key":"81_CR44","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1196\/annals.1353.024","volume":"1073","author":"BE Baysal","year":"2006","unstructured":"Baysal BE: A phenotypic perspective on Mammalian oxygen sensor candidates. Ann N Y Acad Sci 2006, 1073: 221\u2013233. 10.1196\/annals.1353.024","journal-title":"Ann N Y Acad Sci"},{"key":"81_CR45","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/978-1-61779-382-0_12","volume":"810","author":"JM Suski","year":"2012","unstructured":"Suski JM, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR: Relation between mitochondrial membrane potential and ROS formation. Methods Mol Biol 2012, 810: 183\u2013205. 10.1007\/978-1-61779-382-0_12","journal-title":"Methods Mol Biol"},{"key":"81_CR46","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1161\/01.RES.0000117088.36577.EB","volume":"94","author":"LK Russell","year":"2004","unstructured":"Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE: Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res 2004, 94: 525\u2013533. 10.1161\/01.RES.0000117088.36577.EB","journal-title":"Circ Res"},{"key":"81_CR47","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.exer.2008.05.017","volume":"87","author":"KS Shindler","year":"2008","unstructured":"Shindler KS, Ventura E, Dutt M, Rostami AM: Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Exp Eye Res 2008, 87: 208\u2013213. 10.1016\/j.exer.2008.05.017","journal-title":"Exp Eye Res"},{"key":"81_CR48","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1167\/iovs.09-4009","volume":"51","author":"M Dutt","year":"2010","unstructured":"Dutt M, Tabuena P, Ventura E, Rostami AM, Shindler KS: Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis. Invest Ophthalmol Vis Sci 2010, 51: 1439\u20131445. 10.1167\/iovs.09-4009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"81_CR49","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/13550280290049697","volume":"8","author":"AE Matthews","year":"2002","unstructured":"Matthews AE, Lavi E, Weiss SR: Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59. J Neurovirol 2002, 8: 257\u2013264. 10.1080\/13550280290049697","journal-title":"J Neurovirol"},{"key":"81_CR50","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/mnfr.200500022","volume":"49","author":"CA de la Lastra","year":"2005","unstructured":"de la Lastra CA, Villegas I: Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 2005, 49: 405\u2013430. 10.1002\/mnfr.200500022","journal-title":"Mol Nutr Food Res"},{"key":"81_CR51","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/ng1534","volume":"37","author":"JA Parker","year":"2005","unstructured":"Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, Catoire H, N\u00e9ri C: Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet 2005, 37: 349\u2013350. 10.1038\/ng1534","journal-title":"Nat Genet"},{"key":"81_CR52","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","volume":"26","author":"D Kim","year":"2007","unstructured":"Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH: SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis. EMBO J 2007, 26: 3169\u20133179. 10.1038\/sj.emboj.7601758","journal-title":"EMBO J"},{"key":"81_CR53","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1126\/science.1098014","volume":"305","author":"T Araki","year":"2004","unstructured":"Araki T, Sasaki Y, Millbrandt J: Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004, 305: 1010\u20131013. 10.1126\/science.1098014","journal-title":"Science"},{"key":"81_CR54","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1126\/science.275.5297.218","volume":"275","author":"M Jang","year":"1997","unstructured":"Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275: 218\u2013220. 10.1126\/science.275.5297.218","journal-title":"Science"},{"key":"81_CR55","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/35001622","volume":"403","author":"S Imai","year":"2000","unstructured":"Imai S, Armstrong CM, Kaeberlein M, Guarente L: Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000, 403: 795\u2013800. 10.1038\/35001622","journal-title":"Nature"},{"key":"81_CR56","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1073\/pnas.110148297","volume":"97","author":"J Landry","year":"2000","unstructured":"Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R: The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 2000, 97: 5807\u20135811. 10.1073\/pnas.110148297","journal-title":"Proc Natl Acad Sci U S A"},{"key":"81_CR57","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","volume":"73","author":"G Blander","year":"2004","unstructured":"Blander G, Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem 2004, 73: 417\u2013435. 10.1146\/annurev.biochem.73.011303.073651","journal-title":"Annu Rev Biochem"},{"key":"81_CR58","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.tips.2004.12.009","volume":"26","author":"M Porcu","year":"2005","unstructured":"Porcu M, Chiarugi A: The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol Sci 2005, 26: 94\u2013103. 10.1016\/j.tips.2004.12.009","journal-title":"Trends Pharmacol Sci"},{"key":"81_CR59","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s00125-011-2064-1","volume":"54","author":"SM Lee","year":"2011","unstructured":"Lee SM, Yang H, Tartar DM, Gao B, Luo X, Ye SQ, Zaghouani H, Fang D: Prevention and treatment of diabetes with resveratrol in a non obese mouse model of type 1 diabetes. Diabetologia 2011, 54: 1136\u20131146. 10.1007\/s00125-011-2064-1","journal-title":"Diabetologia"},{"key":"81_CR60","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/nbm.1229","volume":"21","author":"MD Budde","year":"2008","unstructured":"Budde MD, Kim JH, Liang HF, Russell JH, Cross AH, Song SK: Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis. NMR Biomed 2008, 21: 589\u2013597. 10.1002\/nbm.1229","journal-title":"NMR Biomed"},{"key":"81_CR61","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1523\/JNEUROSCI.4605-08.2009","volume":"29","author":"MD Budde","year":"2009","unstructured":"Budde MD, Xie M, Cross AH, Song SK: Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci 2009, 29: 2805\u20132813. 10.1523\/JNEUROSCI.4605-08.2009","journal-title":"J Neurosci"},{"key":"81_CR62","doi-asserted-by":"publisher","first-page":"6115","DOI":"10.1128\/JVI.75.13.6115-6120.2001","volume":"75","author":"AA Dandekar","year":"2001","unstructured":"Dandekar AA, Wu GF, Pewe L, Perlman S: Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus. J Virol 2001, 75: 6115\u20136120. 10.1128\/JVI.75.13.6115-6120.2001","journal-title":"J Virol"},{"key":"81_CR63","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.4049\/jimmunol.1202584","volume":"190","author":"VK Nimmagadda","year":"2013","unstructured":"Nimmagadda VK, Bever CT, Vattikunta NR, Talat S, Ahmad V, Nagalla NK, Trisler D, Judge SI, Royal W 3rd, Chandrasekaran K, Russell JW, Makar TK: Overexpression of SIRT1 protein in neurons protects against autoimmune encephalomyelitis through activation of multiple SIRT1 targets. J Immunol 2013, 190: 4595\u20134607.","journal-title":"J Immunol"}],"container-title":["Acta Neuropathologica Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2051-5960-2-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2051-5960-2-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2051-5960-2-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/2051-5960-2-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:37:13Z","timestamp":1630550233000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaneurocomms.biomedcentral.com\/articles\/10.1186\/2051-5960-2-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,2]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["81"],"URL":"https:\/\/doi.org\/10.1186\/2051-5960-2-3","relation":{},"ISSN":["2051-5960"],"issn-type":[{"value":"2051-5960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,2]]},"assertion":[{"value":"29 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}