{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:19:34Z","timestamp":1776673174182,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":5071,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Intensive Care"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1186\/2110-5820-2-50","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T02:14:15Z","timestamp":1356920055000},"page":"50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic alcohol exposure, infection, extended circulating white blood cells differentiated by flow cytometry and neutrophil CD64 expression: a prospective, descriptive study of critically ill medical patients"],"prefix":"10.1016","volume":"2","author":[{"given":"Arnaud","family":"Gacouin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Gros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Sauvadet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Uhel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loic","family":"Chimot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Marque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Camus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Fest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Le Tulzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1186\/2110-5820-2-50_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1128\/CMR.16.2.209-219.2003","article-title":"Microbial infections, immunomodulation, and drugs of abuse","volume":"16","author":"Friedman","year":"2003","journal-title":"Clinical Microbiol Rev"},{"key":"10.1186\/2110-5820-2-50_bb0015","first-page":"291","article-title":"Alcohol and infection","volume":"17","author":"MacGregor","year":"1997","journal-title":"Curr Clin Top Infect Dis"},{"issue":"Suppl 7","key":"10.1186\/2110-5820-2-50_bb0020","doi-asserted-by":"crossref","first-page":"S490","DOI":"10.1086\/432003","article-title":"Epidemiology of sepsis: race, sex, and chronic alcohol abuse","volume":"41","author":"Moss","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1186\/2110-5820-2-50_bb0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.alcohol.2008.12.006","article-title":"Alcohol and trauma: a summary of the satellite symposium at the 30th annual meeting of the shock society","volume":"43","author":"Bird","year":"2009","journal-title":"Alcohol"},{"issue":"4","key":"10.1186\/2110-5820-2-50_bb0030","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00134-003-2121-4","article-title":"EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units","volume":"30","author":"Brun-Buisson","year":"2004","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1186\/2110-5820-2-50_bb0035","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1378\/chest.09-1425","article-title":"Alcohol-use disorders in the critically ill patient","volume":"138","author":"de Wit","year":"2010","journal-title":"Chest"},{"issue":"1","key":"10.1186\/2110-5820-2-50_bb0040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1001\/jama.1996.03530250054027","article-title":"The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults","volume":"75","author":"Moss","year":"1996","journal-title":"JAMA"},{"issue":"9554","key":"10.1186\/2110-5820-2-50_bb0045","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/S0140-6736(06)69490-7","article-title":"Alcohol abuse in the critically ill patient","volume":"368","author":"Moss","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"10.1186\/2110-5820-2-50_bb0050","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.4049\/jimmunol.0803206","article-title":"The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes","volume":"183","author":"Mandrekar","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"10.1186\/2110-5820-2-50_bb0055","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1530-0277.2008.00842.x","article-title":"A recent perspective on alcohol, immunity, and host defense","volume":"33","author":"Szabo","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"issue":"9","key":"10.1186\/2110-5820-2-50_bb0060","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1530-0277.2006.00195.x","article-title":"Acute and chronic alcohol abuse modulate immunity","volume":"30","author":"Brown","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"issue":"9","key":"10.1186\/2110-5820-2-50_bb0065","first-page":"1927","article-title":"Alcohol abuse, alcoholism, and damage to the immune system\u2013a review","volume":"22","author":"Cook","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"issue":"Suppl 3","key":"10.1186\/2110-5820-2-50_bb0070","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1038\/sj.ejcn.1601486","article-title":"Influence of alcohol consumption on immunological status: a review","volume":"56","author":"Diaz","year":"2002","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"10.1186\/2110-5820-2-50_bb0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.alcohol.2004.06.006","article-title":"Alcohol and immunology: introduction to and summary of the 2003 alcohol and immunology research interest group (AIRIG) meeting","volume":"33","author":"Kovacs","year":"2004","journal-title":"Alcohol"},{"issue":"5","key":"10.1186\/2110-5820-2-50_bb0080","doi-asserted-by":"crossref","first-page":"338346","DOI":"10.1007\/s00335-007-9025-5","article-title":"Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system","volume":"18","author":"Lu","year":"2007","journal-title":"Mamm Genome"},{"key":"10.1186\/2110-5820-2-50_bb0085","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-59745-242-7_20","article-title":"B-cell studies in chronic ethanol mice","volume":"447","author":"Verma","year":"2008","journal-title":"Methods Mol Biol"},{"issue":"2","key":"10.1186\/2110-5820-2-50_bb0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.alcohol.2007.11.003","article-title":"Alcohol and inflammation and immune responses: summary of the 2006 alcohol and immunology research interest group (AIRIG) meeting","volume":"42","author":"Waldschmidt","year":"2008","journal-title":"Alcohol"},{"issue":"6","key":"10.1186\/2110-5820-2-50_bb0095","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.4049\/jimmunol.170.6.2923","article-title":"Acute alcohol inhibits TNF-alpha processing in human monocytes by inhibiting TNF\/TNF-alpha-converting enzyme interactions in the cell membrane","volume":"170","author":"Zhao","year":"2003","journal-title":"J Immunol"},{"issue":"3","key":"10.1186\/2110-5820-2-50_bb0100","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1213\/ane.0b013e318193fd89","article-title":"Alcohol use disorder and perioperative immune dysfunction","volume":"108","author":"Lau","year":"2009","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1186\/2110-5820-2-50_bb0105","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1164\/rccm.200506-907OC","article-title":"Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics","volume":"174","author":"Spies","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1186\/2110-5820-2-50_bb0110","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/00000542-200405000-00010","article-title":"Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients","volume":"100","author":"Spies","year":"2004","journal-title":"Anesthesiology"},{"issue":"4 Suppl","key":"10.1186\/2110-5820-2-50_bb0115","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1097\/01.CCM.0000057845.77458.25","article-title":"Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction","volume":"31","author":"Moss","year":"2003","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1186\/2110-5820-2-50_bb0120","doi-asserted-by":"crossref","first-page":"R312","DOI":"10.1186\/cc2911","article-title":"Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock","volume":"8","author":"von Dossow","year":"2004","journal-title":"Crit Care"},{"issue":"10","key":"10.1186\/2110-5820-2-50_bb0125","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7326\/0003-4819-133-10-200011210-00015","article-title":"Outpatient management of patients with alcohol problems","volume":"133","author":"Fiellin","year":"2000","journal-title":"Ann Intern Med"},{"issue":"9","key":"10.1186\/2110-5820-2-50_bb0130","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1056\/NEJM199802263380907","article-title":"Patients with alcohol problems","volume":"338","author":"O\u2019Connor","year":"1998","journal-title":"New Engl J Med"},{"issue":"6","key":"10.1186\/2110-5820-2-50_bb0135","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/CCM.0b013e318174dd75","article-title":"At-risk drinkers are at higher risk to acquire a bacterial infection during an intensive care unit stay than abstinent or moderate drinkers","volume":"36","author":"Gacouin","year":"2008","journal-title":"Crit Care Med"},{"issue":"13","key":"10.1186\/2110-5820-2-50_bb0140","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1001\/archinte.160.13.1977","article-title":"Screening for alcohol problems in primary care: a systematic review","volume":"160","author":"Fiellin","year":"2000","journal-title":"Arch Intern Med"},{"issue":"6","key":"10.1186\/2110-5820-2-50_bb0145","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1056\/NEJMcp042262","article-title":"Clinical Practice: Unhealthy alcohol use","volume":"352","author":"Saitz","year":"2005","journal-title":"New Engl J Med"},{"issue":"6","key":"10.1186\/2110-5820-2-50_bb0150","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM consensus conference committee. American college of chest physicians\/society of critical care medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"issue":"6","key":"10.1186\/2110-5820-2-50_bb0155","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1056\/NEJM199908053410607","article-title":"Guidelines for healthy weight","volume":"341","author":"Willett","year":"1999","journal-title":"New Engl J Med"},{"issue":"6","key":"10.1186\/2110-5820-2-50_bb0160","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cyto.a.20893","article-title":"Refining the white blood cell differential: the first flow cytometry routine application","volume":"77","author":"Roussel","year":"2010","journal-title":"Cytometry A"},{"issue":"8","key":"10.1186\/2110-5820-2-50_bb0165","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1515\/CCLM.2009.224","article-title":"Neutrophil CD64: a diagnostic marker for infection and sepsis","volume":"47","author":"Hoffmann","year":"2009","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"10.1186\/2110-5820-2-50_bb0170","first-page":"270","article-title":"In vitro ethanol suppresses alveolar macrophage TNF-alpha during simian immunodeficiency virus infection","volume":"176","author":"Stoltz","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1186\/2110-5820-2-50_bb0175","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1097\/01.ALC.0000095634.82310.53","article-title":"Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae","volume":"27","author":"Boe","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"issue":"5","key":"10.1186\/2110-5820-2-50_bb0180","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1128\/IAI.72.5.2556-2563.2004","article-title":"Alcohol exacerbates murine pulmonary tuberculosis","volume":"72","author":"Mason","year":"2004","journal-title":"Infect Immun"},{"issue":"9","key":"10.1186\/2110-5820-2-50_bb0185","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/j.1530-0277.1996.tb01700.x","article-title":"Distribution of peripheral blood lymphoid subsets in alcoholic liver cirrhosis: influence of ethanol intake","volume":"20","author":"Laso","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"issue":"4","key":"10.1186\/2110-5820-2-50_bb0190","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1530-0277.1997.tb03821.x","article-title":"Abnormalities of peripheral blood T lymphocytes and natural killer cells in alcoholic hepatitis persist after a 3-month withdrawal period","volume":"21","author":"Laso","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"issue":"5","key":"10.1186\/2110-5820-2-50_bb0195","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1378\/chest.129.5.1219","article-title":"Impact of alcohol abuse in the etiology and severity of community-acquired pneumonia","volume":"129","author":"de Roux","year":"2006","journal-title":"Chest"},{"issue":"3","key":"10.1186\/2110-5820-2-50_bb0200","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/01.CCM.0000055389.64497.11","article-title":"Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock","volume":"31","author":"Moss","year":"2003","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1186\/2110-5820-2-50_bb0205","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF01700448","article-title":"Intercurrent complications in chronic alcoholic men admitted to the intensive care unit following trauma","volume":"22","author":"Spies","year":"1996","journal-title":"Intensive Care Med"}],"container-title":["Annals of Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025016346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2110582025016346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:12:23Z","timestamp":1776669143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2110582025016346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"alternative-id":["S2110582025016346"],"URL":"https:\/\/doi.org\/10.1186\/2110-5820-2-50","relation":{},"ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic alcohol exposure, infection, extended circulating white blood cells differentiated by flow cytometry and neutrophil CD64 expression: a prospective, descriptive study of critically ill medical patients","name":"articletitle","label":"Article Title"},{"value":"Annals of Intensive Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1186\/2110-5820-2-50","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Gacouin et al.; licensee Springer. 2012. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}],"article-number":"50"}}