{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:30:21Z","timestamp":1791905421194,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Org Med Chem Lett"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The biological importance of members of genus <jats:italic>Ferula<\/jats:italic> promoted us to investigate the leaves of <jats:italic>Ferula vesceritensis<\/jats:italic> Coss et Dur. (endemic plant) previously not investigated. This study presents the chemical composition and antibacterial activities of the hydrodistilled oils.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Volatile components of the leaves of <jats:italic>F. vesceritensis<\/jats:italic> have been studied by gas chromatography\u2013mass spectrometry to afford 23 compounds. The major components were found to be 5,9-tetradecadiyne (24.72%), germacrene D (24.51%), farnesene (8.57%), and \u03b1-bisabolene (8.57%). The antimicrobial activities of the essential oils were evaluated by disk diffusion method and tested against Gram-positive and Gram-negative bacteria. The volatile oil showed a strong antibacterial activity against <jats:italic>Staphylococcus aureus, Escherichia coli<\/jats:italic>, and <jats:italic>Klebsiella pneumonia.<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These results reinforce the previous studies showing that the genus <jats:italic>Ferula<\/jats:italic> is considered as a good source of essential oils. The results presented here can be considered as the first information on the antimicrobial properties of <jats:italic>F. vesceritensis.<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/2191-2858-2-31","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T08:14:23Z","timestamp":1346660063000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Chemical composition and antibacterial activity of the essential oils of Ferula vesceritensis Coss et Dur. leaves, endemic in Algeria"],"prefix":"10.1186","volume":"2","author":[{"given":"Amar","family":"Zellagui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noueddine","family":"Gherraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah","family":"Rhouati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"38_CR1","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","volume":"46","author":"F Bakkali","year":"2008","unstructured":"Bakkali F, Averbeck D, Idaomar MM: Biological effects of essential oils\u2014a review. 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