{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:04:10Z","timestamp":1759482250268},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ICMx"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/2197-425x-2-7","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T12:11:34Z","timestamp":1392984694000},"source":"Crossref","is-referenced-by-count":2,"title":["Acute organ injury is associated with alterations in the cell-free plasma transcriptome"],"prefix":"10.1186","volume":"2","author":[{"given":"John H","family":"Boyd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"McConechy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith R","family":"Walley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"5_CR1","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.2353\/ajpath.2008.080228","volume":"173","author":"A Agouni","year":"2008","unstructured":"Agouni A, Lagrue-Lak-Hal AH, Ducluzeau PH, Mostefai HA, Draunet-Busson C, Leftheriotis G, Heymes C, Martinez MC, Andriantsitohaina R: Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. Am J Pathol 2008, 173: 1210\u20131219. 10.2353\/ajpath.2008.080228","journal-title":"Am J Pathol"},{"key":"5_CR2","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1096\/fj.07-8079com","volume":"21","author":"A Agouni","year":"2007","unstructured":"Agouni A, Mostefai HA, Porro C, Carusio N, Favre J, Richard V, Henrion D, Mart\u00ednez MC, Andriantsitohaina R: Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB J 2007, 21: 2735\u20132741. 10.1096\/fj.07-8079com","journal-title":"FASEB J"},{"key":"5_CR3","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.4049\/jimmunol.180.7.5028","volume":"180","author":"HA Mostefai","year":"2008","unstructured":"Mostefai HA, Agouni A, Carusio N, Mastronardi ML, Heymes C, Henrion D, Andriantsitohaina R, Martinez MC: Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells. J Immunol 2008, 180: 5028\u20135035.","journal-title":"J Immunol"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1164\/rccm.200712-1835OC","volume":"178","author":"HA Mostefai","year":"2008","unstructured":"Mostefai HA, Meziani F, Mastronardi ML, Agouni A, Heymes C, Sargentini C, Asfar P, Martinez MC, Andriantsitohaina R: Circulating microparticles from patients with septic shock exert protective role in vascular function. Am J Respir Crit Care Med 2008, 178: 1148\u20131155. 10.1164\/rccm.200712-1835OC","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR5","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1261\/rna.755908","volume":"14","author":"JM Garcia","year":"2008","unstructured":"Garcia JM, Garc\u00eda V, Pe\u00f1a C, Dom\u00ednguez G, Silva J, Diaz R, Espinosa P, Citores MJ, Collado M, Bonilla F: Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched. RNA 2008, 14: 1424\u20131432. 10.1261\/rna.755908","journal-title":"RNA"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.yexcr.2008.12.014","volume":"315","author":"CF Reich 3rd","year":"2009","unstructured":"Reich CF 3rd, Pisetsky DS: The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis. Exp Cell Res 2009, 315: 760\u2013768. 10.1016\/j.yexcr.2008.12.014","journal-title":"Exp Cell Res"},{"key":"5_CR7","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1161\/CIRCULATIONAHA.113.001720","volume":"128","author":"F Jansen","year":"2013","unstructured":"Jansen F, Yang X, Hoelscher M, Cattelan A, Schmitz T, Proebsting S, Wenzel D, Vosen S, Franklin BS, Fleischmann BK, Nickenig G, Werner N: Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles. Circulation 2013, 128: 2026\u20132038. 10.1161\/CIRCULATIONAHA.113.001720","journal-title":"Circulation"},{"key":"5_CR8","doi-asserted-by":"publisher","first-page":"R98","DOI":"10.1186\/cc7930","volume":"13","author":"T Indrambarya","year":"2009","unstructured":"Indrambarya T, Boyd JH, Wang Y, McConechy M, Walley KR: Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. Crit Care 2009, 13: R98. 10.1186\/cc7930","journal-title":"Crit Care"},{"key":"5_CR9","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1373\/clinchem.2004.045336","volume":"51","author":"TR Gingeras","year":"2005","unstructured":"Gingeras TR, Higuchi R, Kricka LJ, Lo YM, Wittwer CT: Fifty years of molecular (DNA\/RNA) diagnostics. Clin Chem 2005, 51: 661\u2013671. 10.1373\/clinchem.2004.045336","journal-title":"Clin Chem"},{"key":"5_CR10","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1373\/clinchem.2005.056366","volume":"51","author":"RW Chiu","year":"2005","unstructured":"Chiu RW, Lui WB, El-Sheikhah A, Chan AT, Lau TK, Nicolaides KH, Lo YM: Comparison of protocols for extracting circulating DNA and RNA from maternal plasma. Clin Chem 2005, 51: 2209\u20132210. 10.1373\/clinchem.2005.056366","journal-title":"Clin Chem"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1586\/14737159.3.6.785","volume":"3","author":"BC Wong","year":"2003","unstructured":"Wong BC, Lo YM: Cell-free DNA and RNA in plasma as new tools for molecular diagnostics. Expert Rev Mol Diagn 2003, 3: 785\u2013797. 10.1586\/14737159.3.6.785","journal-title":"Expert Rev Mol Diagn"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0070-2153(04)61004-0","volume":"61","author":"RW Chiu","year":"2004","unstructured":"Chiu RW, Lo YM: The biology and diagnostic applications of fetal DNA and RNA in maternal plasma. Curr Top Dev Biol 2004, 61: 81\u2013111.","journal-title":"Curr Top Dev Biol"},{"key":"5_CR13","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1158\/1078-0432.CCR-05-2572","volume":"12","author":"BC Wong","year":"2006","unstructured":"Wong BC, Chan KC, Chan AT, Leung SF, Chan LY, Chow KC, Lo YM: Reduced plasma RNA integrity in nasopharyngeal carcinoma patients. Clin Cancer Res 2006, 12: 2512\u20132516. 10.1158\/1078-0432.CCR-05-2572","journal-title":"Clin Cancer Res"},{"key":"5_CR14","doi-asserted-by":"publisher","first-page":"e60989","DOI":"10.1371\/journal.pone.0060989","volume":"8","author":"P Pacheco","year":"2013","unstructured":"Pacheco P, White D, Sulchek T: Effects of microparticle size and Fc density on macrophage phagocytosis. PLoS One 2013, 8: e60989. 10.1371\/journal.pone.0060989","journal-title":"PLoS One"},{"key":"5_CR15","volume-title":"Innate Immunity","author":"R Ovstebo","year":"2013","unstructured":"Ovstebo R, Hellum M, Aass HC, Tr\u00f8seid AM, Brandtzaeg P, Mollnes TE, Henriksson CE: Microparticle-associated tissue factor activity is reduced by inhibition of the complement protein 5 in Neisseria meningitidis -exposed whole blood. Innate Immunity 2013. doi: 10.1177\/1753425913502099"},{"key":"5_CR16","volume-title":"Thrombosis Res","author":"FS Orhon","year":"2013","unstructured":"Orhon FS, Egin Y, Ulukol B, Baskan S, Akar N: Evaluation of indirect microparticle activity and parameters of thrombin generation test in healthy infants. Thrombosis Res 2013. doi: 10.1016\/j.thromres.2013.11.011"},{"key":"5_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/09537104.2011.654292","volume":"24","author":"M Lukasik","year":"2013","unstructured":"Lukasik M, Rozalski M, Luzak B, Michalak M, Ambrosius W, Watala C, Kozubski W: Enhanced platelet-derived microparticle formation is associated with carotid atherosclerosis in convalescent stroke patients. Platelets 2013, 24: 63\u201370. 10.3109\/09537104.2011.654292","journal-title":"Platelets"},{"key":"5_CR18","volume-title":"Int J Lab Hematol","author":"V Karlaftis","year":"2013","unstructured":"Karlaftis V, Attard C, Summerhayes R, Monagle P, Ignjatovic V: The microparticle-specific procoagulant phospholipid activity changes with age. Int J Lab Hematol 2013. doi: 10.1111\/ijlh.12144"},{"key":"5_CR19","volume-title":"Thrombosis Res","author":"D Gheldof","year":"2013","unstructured":"Gheldof D, Mullier F, Bailly N, Devalet B, Dogn\u00e9 JM, Chatelain B, Chatelain C: Microparticle bearing tissue factor: a link between promyelocytic cells and hypercoagulable state. Thrombosis Res 2013. in press"},{"key":"5_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.phrs.2013.08.001","volume":"76","author":"S Fogli","year":"2013","unstructured":"Fogli S, Stefanelli F, Neri T, Bardelli C, Amoruso A, Brunelleschi S, Celi A, Breschi MC: Montelukast prevents microparticle-induced inflammatory and functional alterations in human bronchial smooth muscle cells. Pharmacol Res 2013, 76: 149\u2013156.","journal-title":"Pharmacol Res"},{"key":"5_CR21","first-page":"123","volume":"336","author":"NB Tsui","year":"2006","unstructured":"Tsui NB, Ng EK, Lo YM: Molecular analysis of circulating RNA in plasma. Methods Mol Biol 2006, 336: 123\u2013134.","journal-title":"Methods Mol Biol"},{"key":"5_CR22","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1200\/JCO.2005.03.7598","volume":"24","author":"Y Li","year":"2006","unstructured":"Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT: Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol 2006, 24: 1754\u20131760. 10.1200\/JCO.2005.03.7598","journal-title":"J Clin Oncol"}],"container-title":["Intensive Care Medicine Experimental"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2197-425X-2-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/2197-425X-2-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/2197-425X-2-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:15:27Z","timestamp":1548202527000},"score":1,"resource":{"primary":{"URL":"https:\/\/icm-experimental.springeropen.com\/articles\/10.1186\/2197-425X-2-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,21]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["5"],"URL":"https:\/\/doi.org\/10.1186\/2197-425x-2-7","relation":{},"ISSN":["2197-425X"],"issn-type":[{"value":"2197-425X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,21]]},"article-number":"7"}}