{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:30:17Z","timestamp":1772469017777,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T00:00:00Z","timestamp":1241049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T00:00:00Z","timestamp":1241049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The stromal microenvironment has a profound influence on tumour cell behaviour. In tumours, the extracellular matrix (ECM) composition differs from normal tissue and allows novel interactions to influence tumour cell function. The ECM protein tenascin-C (TNC) is frequently up-regulated in breast cancer and we have previously identified two novel isoforms \u2013 one containing exon 16 (TNC-16) and one containing exons 14 plus 16 (TNC-14\/16).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>The present study has analysed the functional significance of this altered TNC isoform profile in breast cancer. TNC-16 and TNC-14\/16 splice variants were generated using PCR-ligation and over-expressed in breast cancer cells (MCF-7, T47D, MDA-MD-231, MDA-MB-468, GI101) and human fibroblasts. The effects of these variants on tumour cell invasion and proliferation were measured and compared with the effects of the large (TNC-L) and fully spliced small (TNC-S) isoforms.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>TNC-16 and TNC-14\/16 significantly enhanced tumour cell proliferation (<jats:italic>P<\/jats:italic> &lt; 0.05) and invasion, both directly (<jats:italic>P<\/jats:italic> &lt; 0.01) and as a response to transfected fibroblast expression (<jats:italic>P<\/jats:italic> &lt; 0.05) with this effect being dependent on tumour cell interaction with TNC, because TNC-blocking antibodies abrogated these responses. An analysis of 19 matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases 1 to 4 (TIMP 1 to 4) revealed that TNC up-regulated expression of MMP-13 and TIMP-3 two to four fold relative to vector, and invasion was reduced in the presence of MMP inhibitor GM6001. However, this effect was not isoform-specific but was elicited equally by all TNC isoforms.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>These results demonstrate a dual requirement for TNC and MMP in enhancing breast cancer cell invasion, and identify a significant role for the tumour-associated TNC-16 and TNC-14\/16 in promoting tumour invasion, although these isoform-specific effects appear to be mediated through MMP-independent mechanisms.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr2251","type":"journal-article","created":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T18:15:46Z","timestamp":1241115346000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms"],"prefix":"10.1186","volume":"11","author":[{"given":"Rachael A","family":"Hancox","sequence":"first","affiliation":[]},{"given":"Michael D","family":"Allen","sequence":"additional","affiliation":[]},{"given":"Deborah L","family":"Holliday","sequence":"additional","affiliation":[]},{"given":"Dylan R","family":"Edwards","sequence":"additional","affiliation":[]},{"given":"Caroline J","family":"Pennington","sequence":"additional","affiliation":[]},{"given":"David S","family":"Guttery","sequence":"additional","affiliation":[]},{"given":"Jacqueline A","family":"Shaw","sequence":"additional","affiliation":[]},{"given":"Rosemary A","family":"Walker","sequence":"additional","affiliation":[]},{"given":"J Howard","family":"Pringle","sequence":"additional","affiliation":[]},{"given":"J Louise","family":"Jones","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,4,30]]},"reference":[{"key":"2215_CR1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1091\/mbc.10.3.785","volume":"10","author":"AJ Garcia","year":"1999","unstructured":"Garcia AJ, Vega MD, Boettiger D: Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. Mol Biol Cell. 1999, 10: 785-798.","journal-title":"Mol Biol Cell"},{"key":"2215_CR2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0955-0674(98)80144-0","volume":"10","author":"A Howe","year":"1998","unstructured":"Howe A, Aplin AE, Alahari SK, Juliano RL: Integrin signaling and cell growth control. Curr Opin Cell Biol. 1998, 10: 220-231. 10.1016\/S0955-0674(98)80144-0.","journal-title":"Curr Opin Cell Biol"},{"key":"2215_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s004280050433","volume":"435","author":"T Yoshida","year":"1999","unstructured":"Yoshida T, Yoshimura E, Numata H, Sakakura Y, Sakakura T: Involvement of tenascin-C in proliferation and migration of laryngeal carcinoma cells. Virchows Arch. 1999, 435: 496-500. 10.1007\/s004280050433.","journal-title":"Virchows Arch"},{"key":"2215_CR4","first-page":"1041","volume":"5","author":"LF Brown","year":"1999","unstructured":"Brown LF, Guidi AJ, Schnitt SJ, Water Van De L, Iruela-Arispe ML, Yeo TK, Tognazzi K, Dvorak HF: Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin Cancer Res. 1999, 5: 1041-1056.","journal-title":"Clin Cancer Res"},{"key":"2215_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","volume":"121","author":"A Orimo","year":"2005","unstructured":"Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion. Cell. 2005, 121: 335-348. 10.1016\/j.cell.2005.02.034.","journal-title":"Cell"},{"key":"2215_CR6","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1016\/S0959-8049(02)00210-1","volume":"38","author":"E Ioachim","year":"2002","unstructured":"Ioachim E, Charchanti A, Briasoulis E, Karavasilis V, Tsanou H, Arvanitis DL, Agnantis NJ, Pavlidis N: Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur J Cancer. 2002, 38: 2362-2370. 10.1016\/S0959-8049(02)00210-1.","journal-title":"Eur J Cancer"},{"key":"2215_CR7","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1038\/bjc.1998.714","volume":"78","author":"T Jahkola","year":"1998","unstructured":"Jahkola T, Toivonen T, Virtanen I, von Smitten K, Nordling S, von Boguslawski K, Haglund C, Nevanlinna H, Blomqvist C: Tenascin-C expression in invasion border of early breast cancer: a predictor of local and distant recurrence. Br J Cancer. 1998, 78: 1507-1513.","journal-title":"Br J Cancer"},{"key":"2215_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/path.1711670409","volume":"167","author":"JL Jones","year":"1992","unstructured":"Jones JL, Critchley DR, Walker RA: Alteration of stromal protein and integrin expression in breast \u2013 a marker of premalignant change?. J Pathol. 1992, 167: 399-406. 10.1002\/path.1711670409.","journal-title":"J Pathol"},{"key":"2215_CR9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1091\/mbc.7.6.883","volume":"7","author":"CY Chung","year":"1996","unstructured":"Chung CY, Murphy-Ullrich JE, Erickson HP: Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II. Mol Biol Cell. 1996, 7: 883-892.","journal-title":"Mol Biol Cell"},{"key":"2215_CR10","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1083\/jcb.115.4.1127","volume":"115","author":"JE Murphy-Ullrich","year":"1991","unstructured":"Murphy-Ullrich JE, Lightner VA, Aukhil I, Yan YZ, Erickson HP, Hook M: Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. J Cell Biol. 1991, 115: 1127-1136. 10.1083\/jcb.115.4.1127.","journal-title":"J Cell Biol"},{"issue":"Pt 8","key":"2215_CR11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1242\/jcs.111.8.1095","volume":"111","author":"GR Phillips","year":"1998","unstructured":"Phillips GR, Krushel LA, Crossin KL: Domains of tenascin involved in glioma migration. J Cell Sci. 1998, 111 (Pt 8): 1095-1104.","journal-title":"J Cell Sci"},{"key":"2215_CR12","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0945-053X(00)00106-2","volume":"19","author":"PL Jones","year":"2000","unstructured":"Jones PL, Jones FS: Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol. 2000, 19: 581-596. 10.1016\/S0945-053X(00)00106-2.","journal-title":"Matrix Biol"},{"key":"2215_CR13","doi-asserted-by":"publisher","first-page":"17144","DOI":"10.1074\/jbc.274.24.17144","volume":"274","author":"A Joester","year":"1999","unstructured":"Joester A, Faissner A: Evidence for combinatorial variability of tenascin-C isoforms and developmental regulation in the mouse central nervous system. J Biol Chem. 1999, 274: 17144-17151. 10.1074\/jbc.274.24.17144.","journal-title":"J Biol Chem"},{"key":"2215_CR14","doi-asserted-by":"publisher","first-page":"6431","DOI":"10.4049\/jimmunol.167.11.6431","volume":"167","author":"MD Puente Navazo","year":"2001","unstructured":"Puente Navazo MD, Valmori D, Ruegg C: The alternatively spliced domain TnFnIII A1A2 of the extracellular matrix protein tenascin-C suppresses activation-induced T lymphocyte proliferation and cytokine production. J Immunol. 2001, 167: 6431-6440.","journal-title":"J Immunol"},{"key":"2215_CR15","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1006\/mcne.1997.0643","volume":"10","author":"S Meiners","year":"1997","unstructured":"Meiners S, Geller HM: Long and short splice variants of human tenascin differentially regulate neurite outgrowth. Mol Cell Neurosci. 1997, 10: 100-116. 10.1006\/mcne.1997.0643.","journal-title":"Mol Cell Neurosci"},{"key":"2215_CR16","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0002-9440(10)65388-6","volume":"154","author":"B Carnemolla","year":"1999","unstructured":"Carnemolla B, Castellani P, Ponassi M, Borsi L, Urbini S, Nicolo G, Dorcaratto A, Viale G, Winter G, Neri D, Zardi L: Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody. Am J Pathol. 1999, 154: 1345-1352.","journal-title":"Am J Pathol"},{"key":"2215_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/(SICI)1097-0215(19990812)82:4<477::AID-IJC2>3.0.CO;2-5","volume":"82","author":"M Dueck","year":"1999","unstructured":"Dueck M, Riedl S, Hinz U, Tandara A, Moller P, Herfarth C, Faissner A: Detection of tenascin-C isoforms in colorectal mucosa, ulcerative colitis, carcinomas and liver metastases. Int J Cancer. 1999, 82: 477-483. 10.1002\/(SICI)1097-0215(19990812)82:4<477::AID-IJC2>3.0.CO;2-5.","journal-title":"Int J Cancer"},{"key":"2215_CR18","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/path.1589","volume":"203","author":"K Katenkamp","year":"2004","unstructured":"Katenkamp K, Berndt A, Hindermann W, Wunderlich H, Haas KM, Borsi L, Zardi L, Kosmehl H: mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma. J Pathol. 2004, 203: 771-779. 10.1002\/path.1589.","journal-title":"J Pathol"},{"key":"2215_CR19","first-page":"3289","volume":"62","author":"M Adams","year":"2002","unstructured":"Adams M, Jones JL, Walker RA, Pringle JH, Bell SC: Changes in tenascin-C isoform expression in invasive and preinvasive breast disease. Cancer Res. 2002, 62: 3289-3297.","journal-title":"Cancer Res"},{"key":"2215_CR20","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/bjc.1996.480","volume":"74","author":"KE Wilson","year":"1996","unstructured":"Wilson KE, Langdon SP, Lessells AM, Miller WR: Expression of the extracellular matrix protein tenascin in malignant and benign ovarian tumours. Br J Cancer. 1996, 74: 999-1004.","journal-title":"Br J Cancer"},{"key":"2215_CR21","first-page":"273","volume":"149","author":"KJ Heppner","year":"1996","unstructured":"Heppner KJ, Matrisian LM, Jensen RA, Rodgers WH: Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol. 1996, 149: 273-282.","journal-title":"Am J Pathol"},{"key":"2215_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<161::AID-PATH406>3.0.CO;2-2","volume":"189","author":"JL Jones","year":"1999","unstructured":"Jones JL, Glynn P, Walker RA: Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas. J Pathol. 1999, 189: 161-168. 10.1002\/(SICI)1096-9896(199910)189:2<161::AID-PATH406>3.0.CO;2-2.","journal-title":"J Pathol"},{"key":"2215_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1023\/A:1006762425323","volume":"18","author":"M Balduyck","year":"2000","unstructured":"Balduyck M, Zerimech F, Gouyer V, Lemaire R, Hemon B, Grard G, Thiebaut C, Lemaire V, Dacquembronne E, Duhem T, Lebrun A, Dejonghe MJ, Huet G: Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro. Clin Exp Metastasis. 2000, 18: 171-178. 10.1023\/A:1006762425323.","journal-title":"Clin Exp Metastasis"},{"key":"2215_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0092-8674(00)81009-0","volume":"98","author":"MD Sternlicht","year":"1999","unstructured":"Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ, Werb Z: The stromal proteinase MMP3\/stromelysin-1 promotes mammary carcinogenesis. Cell. 1999, 98: 137-146. 10.1016\/S0092-8674(00)81009-0.","journal-title":"Cell"},{"key":"2215_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ijc.11037","volume":"105","author":"I Kalembeyi","year":"2003","unstructured":"Kalembeyi I, Inada H, Nishiura R, Imanaka-Yoshida K, Sakakura T, Yoshida T: Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1. Int J Cancer. 2003, 105: 53-60. 10.1002\/ijc.11037.","journal-title":"Int J Cancer"},{"key":"2215_CR26","doi-asserted-by":"publisher","first-page":"11771","DOI":"10.1158\/0008-5472.CAN-05-0470","volume":"66","author":"S Sarkar","year":"2006","unstructured":"Sarkar S, Nuttall RK, Liu S, Edwards DR, Yong VW: Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. Cancer Res. 2006, 66: 11771-11780. 10.1158\/0008-5472.CAN-05-0470.","journal-title":"Cancer Res"},{"key":"2215_CR27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1091\/mbc.5.4.439","volume":"5","author":"P Tremble","year":"1994","unstructured":"Tremble P, Chiquet-Ehrismann R, Werb Z: The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts. Mol Biol Cell. 1994, 5: 439-453.","journal-title":"Mol Biol Cell"},{"key":"2215_CR28","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/path.1483","volume":"201","author":"JL Jones","year":"2003","unstructured":"Jones JL, Shaw JA, Pringle JH, Walker RA: Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol. 2003, 201: 562-572. 10.1002\/path.1483.","journal-title":"J Pathol"},{"key":"2215_CR29","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0021-9258(18)53809-6","volume":"268","author":"I Aukhil","year":"1993","unstructured":"Aukhil I, Joshi P, Yan Y, Erickson HP: Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. J Biol Chem. 1993, 268: 2542-2553.","journal-title":"J Biol Chem"},{"key":"2215_CR30","first-page":"333","volume":"1","author":"RK Nuttall","year":"2003","unstructured":"Nuttall RK, Pennington CJ, Taplin J, Wheal A, Yong VW, Forsyth PA, Edwards DR: Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells. Mol Cancer Res. 2003, 1: 333-345.","journal-title":"Mol Cancer Res"},{"key":"2215_CR31","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1096\/fj.03-1110fje","volume":"18","author":"O De Wever","year":"2004","unstructured":"De Wever O, Nguyen QD, Van Hoorde L, Bracke M, Bruyneel E, Gespach C, Mareel M: Tenascin-C and SF\/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. Faseb J. 2004, 18: 1016-1018.","journal-title":"Faseb J"},{"key":"2215_CR32","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.280.5366.1036","volume":"280","author":"KW Kinzler","year":"1998","unstructured":"Kinzler KW, Vogelstein B: Landscaping the cancer terrain. Science. 1998, 280: 1036-1037. 10.1126\/science.280.5366.1036.","journal-title":"Science"},{"key":"2215_CR33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/scbi.2001.0417","volume":"12","author":"CD Roskelley","year":"2002","unstructured":"Roskelley CD, Bissell MJ: The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol. 2002, 12: 97-104. 10.1006\/scbi.2001.0417.","journal-title":"Semin Cancer Biol"},{"key":"2215_CR34","first-page":"1320","volume":"61","author":"MP Shekhar","year":"2001","unstructured":"Shekhar MP, Werdell J, Santner SJ, Pauley RJ, Tait L: Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res. 2001, 61: 1320-1326.","journal-title":"Cancer Res"},{"key":"2215_CR35","doi-asserted-by":"publisher","first-page":"9172","DOI":"10.1074\/jbc.M608067200","volume":"282","author":"A von Holst","year":"2007","unstructured":"von Holst A, Egbers U, Prochiantz A, Faissner A: Neural stem\/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6. J Biol Chem. 2007, 282: 9172-9181. 10.1074\/jbc.M608067200.","journal-title":"J Biol Chem"},{"key":"2215_CR36","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","volume":"10","author":"RM Neve","year":"2006","unstructured":"Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006, 10: 515-527. 10.1016\/j.ccr.2006.10.008.","journal-title":"Cancer Cell"},{"key":"2215_CR37","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1523\/JNEUROSCI.4519-03.2004","volume":"24","author":"ML Mercado","year":"2004","unstructured":"Mercado ML, Nur-e-Kamal A, Liu HY, Gross SR, Movahed R, Meiners S: Neurite outgrowth by the alternatively spliced region of human tenascin-C is mediated by neuronal alpha7beta1 integrin. J Neurosci. 2004, 24: 238-247. 10.1523\/JNEUROSCI.4519-03.2004.","journal-title":"J Neurosci"},{"key":"2215_CR38","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.1523\/JNEUROSCI.22-15-06596.2002","volume":"22","author":"F Rigato","year":"2002","unstructured":"Rigato F, Garwood J, Calco V, Heck N, Faivre-Sarrailh C, Faissner A: Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3\/contactin. J Neurosci. 2002, 22: 6596-6609.","journal-title":"J Neurosci"},{"key":"2215_CR39","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1083\/jcb.126.2.539","volume":"126","author":"CY Chung","year":"1994","unstructured":"Chung CY, Erickson HP: Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. J Cell Biol. 1994, 126: 539-548. 10.1083\/jcb.126.2.539.","journal-title":"J Cell Biol"},{"key":"2215_CR40","doi-asserted-by":"publisher","first-page":"8650","DOI":"10.1074\/jbc.270.15.8650","volume":"270","author":"A Siri","year":"1995","unstructured":"Siri A, Knauper V, Veirana N, Caocci F, Murphy G, Zardi L: Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. J Biol Chem. 1995, 270: 8650-8654. 10.1074\/jbc.270.15.8650.","journal-title":"J Biol Chem"},{"key":"2215_CR41","first-page":"1152","volume":"8","author":"M Cai","year":"2002","unstructured":"Cai M, Onoda K, Takao M, Kyoko IY, Shimpo H, Yoshida T, Yada I: Degradation of tenascin-C and activity of matrix metalloproteinase-2 are associated with tumor recurrence in early stage non-small cell lung cancer. Clin Cancer Res. 2002, 8: 1152-1156.","journal-title":"Clin Cancer Res"},{"key":"2215_CR42","first-page":"8586","volume":"61","author":"W Huang","year":"2001","unstructured":"Huang W, Chiquet-Ehrismann R, Moyano JV, Garcia-Pardo A, Orend G: Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation. Cancer Res. 2001, 61: 8586-8594.","journal-title":"Cancer Res"},{"key":"2215_CR43","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1083\/jcb.129.3.867","volume":"129","author":"P Huhtala","year":"1995","unstructured":"Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH: Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol. 1995, 129: 867-879. 10.1083\/jcb.129.3.867.","journal-title":"J Cell Biol"},{"key":"2215_CR44","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1158\/0008-5472.CAN-06-2808","volume":"67","author":"J Symowicz","year":"2007","unstructured":"Symowicz J, Adley BP, Gleason KJ, Johnson JJ, Ghosh S, Fishman DA, Hudson LG, Stack MS: Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 2007, 67: 2030-2039. 10.1158\/0008-5472.CAN-06-2808.","journal-title":"Cancer Res"},{"key":"2215_CR45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"M Egeblad","year":"2002","unstructured":"Egeblad M, Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002, 2: 161-174. 10.1038\/nrc745.","journal-title":"Nat Rev Cancer"},{"key":"2215_CR46","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0002-9440(10)61698-7","volume":"159","author":"B Jian","year":"2001","unstructured":"Jian B, Jones PL, Li Q, Mohler ER, Schoen FJ, Levy RJ: Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis. Am J Pathol. 2001, 159: 321-327.","journal-title":"Am J Pathol"},{"key":"2215_CR47","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.oraloncology.2004.08.002","volume":"41","author":"TH Westernoff","year":"2005","unstructured":"Westernoff TH, Jordan RC, Regezi JA, Ramos DM, Schmidt BL: Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms. Oral Oncol. 2005, 41: 170-174. 10.1016\/j.oraloncology.2004.08.002.","journal-title":"Oral Oncol"},{"key":"2215_CR48","first-page":"7091","volume":"61","author":"BS Nielsen","year":"2001","unstructured":"Nielsen BS, Rank F, Lopez JM, Balbin M, Vizoso F, Lund LR, Dano K, Lopez-Otin C: Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. Cancer Res. 2001, 61: 7091-7100.","journal-title":"Cancer Res"},{"key":"2215_CR49","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1158\/1078-0432.CCR-05-2804","volume":"12","author":"SS Brack","year":"2006","unstructured":"Brack SS, Silacci M, Birchler M, Neri D: Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C. Clin Cancer Res. 2006, 12: 3200-3208. 10.1158\/1078-0432.CCR-05-2804.","journal-title":"Clin Cancer Res"},{"key":"2215_CR50","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1586\/14737140.7.5.675","volume":"7","author":"DA Reardon","year":"2007","unstructured":"Reardon DA, Zalutsky MR, Bigner DD: Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients. Expert Rev Anticancer Ther. 2007, 7: 675-687. 10.1586\/14737140.7.5.675.","journal-title":"Expert Rev Anticancer Ther"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr2251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/bcr2251\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr2251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:51:22Z","timestamp":1728384682000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/bcr2251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,30]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,4]]}},"alternative-id":["2215"],"URL":"https:\/\/doi.org\/10.1186\/bcr2251","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,30]]},"assertion":[{"value":"4 August 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2009","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2009","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R24"}}