{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:04:09Z","timestamp":1773270249391,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,19]],"date-time":"2015-04-19T00:00:00Z","timestamp":1429401600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12859-015-0554-8","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T23:46:55Z","timestamp":1429314415000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["PaPI: pseudo amino acid composition to score human protein-coding variants"],"prefix":"10.1186","volume":"16","author":[{"given":"Ivan","family":"Limongelli","sequence":"first","affiliation":[]},{"given":"Simone","family":"Marini","sequence":"additional","affiliation":[]},{"given":"Riccardo","family":"Bellazzi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,4,19]]},"reference":[{"issue":"7333","key":"554_CR1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nature09796","volume":"470","author":"ER Mardis","year":"2011","unstructured":"Mardis ER. A decade's perspective on DNA sequencing technology. Nature. 2011;470(7333):198\u2013203.","journal-title":"Nature"},{"issue":"1","key":"554_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrg2626","volume":"11","author":"ML Metzker","year":"2010","unstructured":"Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet. 2010;11(1):31\u201346.","journal-title":"Nat Rev Genet"},{"issue":"12","key":"554_CR3","doi-asserted-by":"publisher","first-page":"i197","DOI":"10.1093\/bioinformatics\/bts208","volume":"28","author":"D Golan","year":"2012","unstructured":"Golan D, Erlich Y, Rosset S. Weighted pooling\u2013practical and cost-effective techniques for pooled high-throughput sequencing. Bioinformatics. 2012;28(12):i197\u2013206.","journal-title":"Bioinformatics"},{"issue":"1","key":"554_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/ng.499","volume":"42","author":"SB Ng","year":"2010","unstructured":"Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, et al. Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010;42(1):30\u20135.","journal-title":"Nat Genet"},{"issue":"12","key":"554_CR5","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/ng.712","volume":"42","author":"LE Vissers","year":"2010","unstructured":"Vissers LE, de Ligt J, Gilissen C, Janssen I, Steehouwer M, de Vries P, et al. A de novo paradigm for mental retardation. Nat Genet. 2010;42(12):1109\u201312.","journal-title":"Nat Genet"},{"issue":"4","key":"554_CR6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/ng.788","volume":"43","author":"XJ Yan","year":"2011","unstructured":"Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4):309\u201315.","journal-title":"Nat Genet"},{"issue":"2","key":"554_CR7","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ajhg.2014.01.010","volume":"94","author":"LA Lange","year":"2014","unstructured":"Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, et al. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014;94(2):233\u201345.","journal-title":"Am J Hum Genet"},{"issue":"4","key":"554_CR8","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/bib\/bbr070","volume":"13","author":"E Capriotti","year":"2012","unstructured":"Capriotti E, Nehrt NL, Kann MG, Bromberg Y. Bioinformatics for personal genome interpretation. Brief Bioinform. 2012;13(4):495\u2013512.","journal-title":"Brief Bioinform"},{"issue":"7319","key":"554_CR9","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature09534","volume":"467","author":"C Genomes Project","year":"2010","unstructured":"Genomes Project C, Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, et al. A map of human genome variation from population-scale sequencing. Nature. 2010;467(7319):1061\u201373.","journal-title":"Nature"},{"issue":"6090","key":"554_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1126\/science.1219240","volume":"337","author":"JA Tennessen","year":"2012","unstructured":"Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science. 2012;337(6090):64\u20139.","journal-title":"Science"},{"issue":"Database issue","key":"554_CR11","doi-asserted-by":"publisher","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","volume":"42","author":"MJ Landrum","year":"2014","unstructured":"Landrum MJ, Lee JM, Riley GR, Jang W, Rubinstein WS, Church DM, et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res. 2014;42(Database issue):D980\u2013985.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"554_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/gm13","volume":"1","author":"PD Stenson","year":"2009","unstructured":"Stenson PD, Mort M, Ball EV, Howells K, Phillips AD, Thomas NS, et al. The human gene mutation database: 2008 update. Genome Med. 2009;1(1):13.","journal-title":"Genome Med"},{"issue":"8","key":"554_CR13","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1101\/gr.133702.111","volume":"22","author":"JT Dudley","year":"2012","unstructured":"Dudley JT, Kim Y, Liu L, Markov GJ, Gerold K, Chen R, et al. Human genomic disease variants: a neutral evolutionary explanation. Genome Res. 2012;22(8):1383\u201394.","journal-title":"Genome Res"},{"issue":"17","key":"554_CR14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr407","volume":"39","author":"B Reva","year":"2011","unstructured":"Reva B, Antipin Y, Sander C. Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res. 2011;39(17):e118.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"554_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/humu.22225","volume":"34","author":"HA Shihab","year":"2013","unstructured":"Shihab HA, Gough J, Cooper DN, Stenson PD, Barker GL, Edwards KJ, et al. Predicting the functional, molecular, and phenotypic consequences of amino acid substitutions using hidden Markov models. Hum Mutat. 2013;34(1):57\u201365.","journal-title":"Hum Mutat"},{"issue":"7","key":"554_CR16","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","volume":"4","author":"P Kumar","year":"2009","unstructured":"Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc. 2009;4(7):1073\u201381.","journal-title":"Nat Protoc"},{"issue":"4","key":"554_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, et al. A method and server for predicting damaging missense mutations. Nat Methods. 2010;7(4):248\u20139.","journal-title":"Nat Methods"},{"issue":"12","key":"554_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001025","volume":"6","author":"EV Davydov","year":"2010","unstructured":"Davydov EV, Goode DL, Sirota M, Cooper GM, Sidow A, Batzoglou S. Identifying a high fraction of the human genome to be under selective constraint using GERP++. PLoS Comput Biol. 2010;6(12):e1001025.","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"554_CR19","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1101\/gr.097857.109","volume":"20","author":"KS Pollard","year":"2010","unstructured":"Pollard KS, Hubisz MJ, Rosenbloom KR, Siepel A. Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res. 2010;20(1):110\u201321.","journal-title":"Genome Res"},{"issue":"12","key":"554_CR20","doi-asserted-by":"publisher","first-page":"i54","DOI":"10.1093\/bioinformatics\/btp190","volume":"25","author":"M Garber","year":"2009","unstructured":"Garber M, Guttman M, Clamp M, Zody MC, Friedman N, Xie X. Identifying novel constrained elements by exploiting biased substitution patterns. Bioinformatics. 2009;25(12):i54\u201362.","journal-title":"Bioinformatics"},{"issue":"9","key":"554_CR21","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1101\/gr.092619.109","volume":"19","author":"S Chun","year":"2009","unstructured":"Chun S, Fay JC. Identification of deleterious mutations within three human genomes. Genome Res. 2009;19(9):1553\u201361.","journal-title":"Genome Res"},{"key":"554_CR22","doi-asserted-by":"publisher","first-page":"948617","DOI":"10.1155\/2013\/948617","volume":"2013","author":"B Gemovic","year":"2013","unstructured":"Gemovic B, Perovic V, Glisic S, Veljkovic N. Feature-based classification of amino acid substitutions outside conserved functional protein domains. Sci World J. 2013;2013:948617.","journal-title":"Sci World J"},{"issue":"3","key":"554_CR23","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ejhg.2014.92","volume":"23","author":"E Della Mina","year":"2015","unstructured":"Della Mina E, Ciccone R, Brustia F, Bayindir B, Limongelli I, Vetro A, et al. Improving molecular diagnosis in epilepsy by a dedicated high-throughput sequencing platform. Eur J Hum Genet. 2015;23(3):354\u201362.","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"554_CR24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/humu.22525","volume":"35","author":"KS Kassahn","year":"2014","unstructured":"Kassahn KS, Scott HS, Caramins MC. Integrating massively parallel sequencing into diagnostic workflows and managing the annotation and clinical interpretation challenge. Hum Mutat. 2014;35(4):413\u201323.","journal-title":"Hum Mutat"},{"issue":"4","key":"554_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ygeno.2013.06.005","volume":"102","author":"K Frousios","year":"2013","unstructured":"Frousios K, Iliopoulos CS, Schlitt T, Simpson MA. Predicting the functional consequences of non-synonymous DNA sequence variants\u2013evaluation of bioinformatics tools and development of a consensus strategy. Genomics. 2013;102(4):223\u20138.","journal-title":"Genomics"},{"issue":"4","key":"554_CR26","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.ajhg.2011.03.004","volume":"88","author":"A Gonzalez-Perez","year":"2011","unstructured":"Gonzalez-Perez A, Lopez-Bigas N. Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, condel. Am J Hum Genet. 2011;88(4):440\u20139.","journal-title":"Am J Hum Genet"},{"issue":"1","key":"554_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000334984","volume":"73","author":"MC Lopes","year":"2012","unstructured":"Lopes MC, Joyce C, Ritchie GR, John SL, Cunningham F, Asimit J, et al. A combined functional annotation score for non-synonymous variants. Hum Hered. 2012;73(1):47\u201351.","journal-title":"Hum Hered"},{"issue":"11","key":"554_CR28","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.2656","volume":"10","author":"A Sifrim","year":"2013","unstructured":"Sifrim A, Popovic D, Tranchevent LC, Ardeshirdavani A, Sakai R, Konings P, et al. eXtasy: variant prioritization by genomic data fusion. Nat Methods. 2013;10(11):1083\u20134.","journal-title":"Nat Methods"},{"issue":"4","key":"554_CR29","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ajhg.2014.03.010","volume":"94","author":"MV Singleton","year":"2014","unstructured":"Singleton MV, Guthery SL, Voelkerding KV, Chen K, Kennedy B, Margraf RL, et al. Phevor combines multiple biomedical ontologies for accurate identification of disease-causing alleles in single individuals and small nuclear families. Am J Hum Genet. 2014;94(4):599\u2013610.","journal-title":"Am J Hum Genet"},{"issue":"3","key":"554_CR30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/prot.1035","volume":"43","author":"KC Chou","year":"2001","unstructured":"Chou KC. Prediction of protein cellular attributes using pseudo-amino acid composition. Proteins. 2001;43(3):246\u201355.","journal-title":"Proteins"},{"issue":"1","key":"554_CR31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/bioinformatics\/bth466","volume":"21","author":"KC Chou","year":"2005","unstructured":"Chou KC. Using amphiphilic pseudo amino acid composition to predict enzyme subfamily classes. Bioinformatics. 2005;21(1):10\u20139.","journal-title":"Bioinformatics"},{"key":"554_CR32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1186\/1471-2105-10-434","volume":"10","author":"JS Chauhan","year":"2009","unstructured":"Chauhan JS, Mishra NK, Raghava GP. Identification of ATP binding residues of a protein from its primary sequence. BMC Bioinformatics. 2009;10:434.","journal-title":"BMC Bioinformatics."},{"issue":"11","key":"554_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003321","volume":"9","author":"NA Khazanov","year":"2013","unstructured":"Khazanov NA, Carlson HA. Exploring the composition of protein-ligand binding sites on a large scale. PLoS Comput Biol. 2013;9(11):e1003321.","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"554_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020488","volume":"6","author":"AM Szalkowski","year":"2011","unstructured":"Szalkowski AM, Anisimova M. Markov models of amino acid substitution to study proteins with intrinsically disordered regions. PLoS One. 2011;6(5):e20488.","journal-title":"PLoS One"},{"issue":"12","key":"554_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003382","volume":"9","author":"TA de Beer","year":"2013","unstructured":"de Beer TA, Laskowski RA, Parks SL, Sipos B, Goldman N, Thornton JM. Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset. PLoS Comput Biol. 2013;9(12):e1003382.","journal-title":"PLoS Comput Biol"},{"key":"554_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1472-6807-7-56","volume":"7","author":"S Khan","year":"2007","unstructured":"Khan S, Vihinen M. Spectrum of disease-causing mutations in protein secondary structures. BMC Struct Biol. 2007;7:56.","journal-title":"BMC Struct Biol."},{"key":"554_CR37","first-page":"27","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman L. Random forests. Mach Learn. 2001;45:27.","journal-title":"Mach Learn."},{"issue":"6","key":"554_CR38","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ygeno.2012.04.003","volume":"99","author":"X Chen","year":"2012","unstructured":"Chen X, Ishwaran H. Random forests for genomic data analysis. Genomics. 2012;99(6):323\u20139.","journal-title":"Genomics"},{"issue":"10","key":"554_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046688","volume":"7","author":"Y Choi","year":"2012","unstructured":"Choi Y, Sims GE, Murphy S, Miller JR, Chan AP. Predicting the functional effect of amino acid substitutions and indels. PLoS One. 2012;7(10):e46688.","journal-title":"PLoS One"},{"issue":"5","key":"554_CR40","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.ajhg.2012.03.022","volume":"90","author":"H Romi","year":"2012","unstructured":"Romi H, Cohen I, Landau D, Alkrinawi S, Yerushalmi B, Hershkovitz R, et al. Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C. Am J Hum Genet. 2012;90(5):893\u20139.","journal-title":"Am J Hum Genet"},{"issue":"2","key":"554_CR41","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1399-3011.2005.00218.x","volume":"65","author":"M Hasegawa","year":"2005","unstructured":"Hasegawa M, Shimonishi Y. Recognition and signal transduction mechanism of Escherichia coli heat-stable enterotoxin and its receptor, guanylate cyclase C. J Peptide Res Off J Am Peptide Soc. 2005;65(2):261\u201371.","journal-title":"J Peptide Res Off J Am Peptide Soc"},{"issue":"Database issue","key":"554_CR42","doi-asserted-by":"publisher","first-page":"D306","DOI":"10.1093\/nar\/gkr948","volume":"40","author":"S Hunter","year":"2012","unstructured":"Hunter S, Jones P, Mitchell A, Apweiler R, Attwood TK, Bateman A, et al. InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res. 2012;40(Database issue):D306\u2013312.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"554_CR43","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1373\/clinchem.2004.036053","volume":"50","author":"D Tchernitchko","year":"2004","unstructured":"Tchernitchko D, Goossens M, Wajcman H. In silico prediction of the deleterious effect of a mutation: proceed with caution in clinical genetics. Clin Chem. 2004;50(11):1974\u20138.","journal-title":"Clin Chem"},{"issue":"4","key":"554_CR44","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/humu.21445","volume":"32","author":"J Thusberg","year":"2011","unstructured":"Thusberg J, Olatubosun A, Vihinen M. Performance of mutation pathogenicity prediction methods on missense variants. Hum Mutat. 2011;32(4):358\u201368.","journal-title":"Hum Mutat"},{"issue":"8","key":"554_CR45","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/humu.22600","volume":"35","author":"M Vihinen","year":"2014","unstructured":"Vihinen M. Majority vote and other problems when using computational tools. Hum Mutat. 2014;35(8):912\u20134.","journal-title":"Hum Mutat"},{"issue":"2","key":"554_CR46","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/(SICI)1097-0134(199710)29:2<172::AID-PROT5>3.0.CO;2-F","volume":"29","author":"I Bahar","year":"1997","unstructured":"Bahar I, Atilgan AR, Jernigan RL, Erman B. Understanding the recognition of protein structural classes by amino acid composition. Proteins. 1997;29(2):172\u201385.","journal-title":"Proteins"},{"issue":"1","key":"554_CR47","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/prot.10251","volume":"50","author":"GP Zhou","year":"2003","unstructured":"Zhou GP, Doctor K. Subcellular location prediction of apoptosis proteins. Proteins. 2003;50(1):44\u20138.","journal-title":"Proteins"},{"issue":"2","key":"554_CR48","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ab.2012.03.015","volume":"425","author":"P Du","year":"2012","unstructured":"Du P, Wang X, Xu C, Gao Y. PseAAC-Builder: a cross-platform stand-alone program for generating various special Chou's pseudo-amino acid compositions. Anal Biochem. 2012;425(2):117\u20139.","journal-title":"Anal Biochem"},{"issue":"Suppl 2","key":"554_CR49","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1186\/1471-2164-9-S2-S26","volume":"9","author":"S Ren","year":"2008","unstructured":"Ren S, Uversky VN, Chen Z, Dunker AK, Obradovic Z. Short linear motifs recognized by SH2, SH3 and Ser\/Thr kinase domains are conserved in disordered protein regions. BMC Genomics. 2008;9 Suppl 2:S26.","journal-title":"BMC Genomics"},{"issue":"6161","key":"554_CR50","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1126\/science.1244730","volume":"342","author":"BF Koel","year":"2013","unstructured":"Koel BF, Burke DF, Bestebroer TM, van der Vliet S, Zondag GC, Vervaet G, et al. Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution. Science. 2013;342(6161):976\u20139.","journal-title":"Science"},{"issue":"1","key":"554_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1145\/1656274.1656278","volume":"11","author":"M Hall","year":"2009","unstructured":"Hall M, Frank E, Holmes G, Pfahringer B, Reutemann P, Witten IH. The WEKA data mining software: an update. SIGKDD Explor Newsl. 2009;11(1):10\u20138.","journal-title":"SIGKDD Explor Newsl"},{"issue":"16","key":"554_CR52","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010;38(16):e164.","journal-title":"Nucleic Acids Res"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-015-0554-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-015-0554-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-015-0554-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-015-0554-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T10:47:36Z","timestamp":1630579656000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-015-0554-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,19]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["554"],"URL":"https:\/\/doi.org\/10.1186\/s12859-015-0554-8","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,19]]},"assertion":[{"value":"20 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"123"}}