{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:00:12Z","timestamp":1762808412760,"version":"3.37.3"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:00:00Z","timestamp":1456531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:00:00Z","timestamp":1456531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BIO2014-57291-R"],"award-info":[{"award-number":["BIO2014-57291-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["MLPM2012 318861"],"award-info":[{"award-number":["MLPM2012 318861"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["PROMETEOII\/2014\/025"],"award-info":[{"award-number":["PROMETEOII\/2014\/025"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The use of nanopore technologies is expected to spread in the future because they are portable and can sequence long fragments of DNA molecules without prior amplification. The first nanopore sequencer available, the MinION\u2122 from Oxford Nanopore Technologies, is a USB-connected, portable device that allows real-time DNA analysis. In addition, other new instruments are expected to be released soon, which promise to outperform the current short-read technologies in terms of throughput. Despite the flood of data expected from this technology, the data analysis solutions currently available are only designed to manage small projects and are not scalable.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Here we present HPG Pore, a toolkit for exploring and analysing nanopore sequencing data. HPG Pore can run on both individual computers and in the Hadoop distributed computing framework, which allows easy scale-up to manage the large amounts of data expected to result from extensive use of nanopore technologies in the future.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>HPG Pore allows for virtually unlimited sequencing data scalability, thus guaranteeing its continued management in near future scenarios. HPG Pore is available in GitHub at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/github.com\/opencb\/hpg-pore\">http:\/\/github.com\/opencb\/hpg-pore<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-016-0966-0","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:25:20Z","timestamp":1456532720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["HPG pore: an efficient and scalable framework for nanopore sequencing data"],"prefix":"10.1186","volume":"17","author":[{"given":"Joaquin","family":"Tarraga","sequence":"first","affiliation":[]},{"given":"Asunci\u00f3n","family":"Gallego","sequence":"additional","affiliation":[]},{"given":"Vicente","family":"Arnau","sequence":"additional","affiliation":[]},{"given":"Ignacio","family":"Medina","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-120X","authenticated-orcid":false,"given":"Joaquin","family":"Dopazo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,2,27]]},"reference":[{"key":"966_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/2047-217X-3-22","volume":"3","author":"J Quick","year":"2014","unstructured":"Quick J, Quinlan AR, Loman NJ. A reference bacterial genome dataset generated on the MinION portable single-molecule nanopore sequencer. GigaScience. 2014;3:22.","journal-title":"GigaScience"},{"issue":"3","key":"966_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nbt.3103","volume":"33","author":"PM Ashton","year":"2015","unstructured":"Ashton PM, Nair S, Dallman T, Rubino S, Rabsch W, Mwaigwisya S, et al. MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island. Nat Biotechnol. 2015;33(3):296\u2013300.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"966_CR3","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nmeth.3290","volume":"12","author":"M Jain","year":"2015","unstructured":"Jain M, Fiddes IT, Miga KH, Olsen HE, Paten B, Akeson M. Improved data analysis for the MinION nanopore sequencer. 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