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However, in designing the panel of genes to be sequenced, investigators need to consider the tradeoff between the better sensitivity of a broad panel and the higher specificity of a potentially more relevant panel. Although tools to prioritize candidate disease genes have been developed, the great majority of these require prior knowledge and a set of seed genes as input, which is only possible for diseases with a known genetic etiology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>To meet the demands of both researchers and clinicians, we have developed a user-friendly website called <jats:italic>SoftPanel<\/jats:italic>. This website is intended to serve users by allowing them to input a single disorder or a disorder group and generate a panel of genes predicted to underlie the disorder of interest. Various methods of retrieval including a keyword search, browsing of an arborized list of International Classification of Diseases, 10th revision (ICD-10) codes or using disorder phenotypic similarities can be combined to define a group of disorders and the genes known to be associated with them. Moreover, SoftPanel enables users to expand or refine a gene list by utilizing several biological data resources. In addition to providing users with the facility to create a \u201chard\u201d panel that contains an exact gene list for targeted sequencing, SoftPanel also enables generation of a \u201csoft\u201d panel of genes, which may be used to further filter a significantly altered set of genes identified through whole genome or whole exome sequencing. The service and data provided by SoftPanel can be accessed at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isb.pku.edu.cn\/SoftPanel\/\">http:\/\/www.isb.pku.edu.cn\/SoftPanel\/<\/jats:ext-link>. A tutorial page is included for trying out sample data and interpreting results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>SoftPanel provides a convenient and powerful tool for creating a targeted panel of potential disease genes while supporting different forms of input. SoftPanel may be utilized in both genomics research and personalized medicine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-016-0998-5","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T23:47:38Z","timestamp":1459813658000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SoftPanel: a website for grouping diseases and related disorders for generation of customized panels"],"prefix":"10.1186","volume":"17","author":[{"given":"Likun","family":"Wang","sequence":"first","affiliation":[]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Johnathan","family":"Watkins","sequence":"additional","affiliation":[]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[]},{"given":"Michael","family":"McNutt","sequence":"additional","affiliation":[]},{"given":"Yuxin","family":"Yin","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"issue":"11","key":"998_CR1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/nrg3031","volume":"12","author":"MJ Bamshad","year":"2011","unstructured":"Bamshad MJ, Ng SB, Bigham AW, Tabor HK, Emond MJ, Nickerson DA, et al. 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