{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:48:10Z","timestamp":1761490090915},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"S8","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1186\/s12859-016-1115-5","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T03:23:57Z","timestamp":1472613837000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Predicting essential proteins based on subcellular localization, orthology and PPI networks"],"prefix":"10.1186","volume":"17","author":[{"given":"Gaoshi","family":"Li","sequence":"first","affiliation":[]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Jingli","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Fang-Xiang","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,8,31]]},"reference":[{"key":"1115_CR1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/msb.2009.89","volume":"5","author":"JI Glass","year":"2009","unstructured":"Glass JI, Hutchison 3rd CA, Smith HO, Venter JC. A systems biology tour deforce for a near-minimal bacterium. Mol Syst Biol. 2009;5:330.","journal-title":"Mol Syst Biol"},{"key":"1115_CR2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1471-2164-7-165","volume":"7","author":"SJ Furney","year":"2006","unstructured":"Furney SJ, Alba MM, Lopez-Bigas N. Differences in the evolutionary history of disease genes affected by dominant or recessive mutations. BMC Genomics. 2006;7:165.","journal-title":"BMC Genomics"},{"issue":"2","key":"1115_CR3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/1574893611666160125220905","volume":"11","author":"M Li","year":"2016","unstructured":"Li M, Zheng R, Li Q, Wang J, Wu F, Zhang Z. Prioritizing Disease Genes By Using Search Engine Algorithm. Curr Bioinforma. 2016;11(2):195\u2013202.","journal-title":"Curr Bioinforma"},{"issue":"5","key":"1115_CR4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1109\/TST.2015.7297749","volume":"20","author":"W Lan","year":"2015","unstructured":"Lan W, Wang J, Li M, Peng W, Wu F. Computational approaches for prioritizing candidate disease genes based on PPI networks. Tsinghua Sci Technol. 2015;20(5):500\u201312.","journal-title":"Tsinghua Sci Technol"},{"key":"1115_CR5","doi-asserted-by":"crossref","unstructured":"Giaever G, Chu AM, Ni L, Connelly C, Riles L, Veronneau S, Dow S, Lucau-Danila A, Anderson K, Andre B, et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002;418:387\u201391.","DOI":"10.1038\/nature00935"},{"key":"1115_CR6","doi-asserted-by":"crossref","unstructured":"Roemer T, Jiang B, Davison J, Ketela T, Veillette K, Breton A, Tandia F, Linteau A, Sillaots S, Marta C, et al. Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol. 2003;50:167\u201381.","DOI":"10.1046\/j.1365-2958.2003.03697.x"},{"key":"1115_CR7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1440-1711.2005.01332.x","volume":"83","author":"LM Cullen","year":"2005","unstructured":"Cullen LM, Arndt GM. Genome-wide screening for gene function using RNAi in mammalian cells. Immunol Cell Biol. 2005;83:217\u201323.","journal-title":"Immunol Cell Biol"},{"key":"1115_CR8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/molbev\/msi072","volume":"22","author":"MW Hahn","year":"2005","unstructured":"Hahn MW, Kern AD. Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks. Mol Biol Evol. 2005;22:803\u20136.","journal-title":"Mol Biol Evol"},{"key":"1115_CR9","first-page":"96","volume":"2","author":"MP Joy","year":"2005","unstructured":"Joy MP, Brock A, Ingber DE, Huang S. High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol. 2005;2:96\u2013103.","journal-title":"J Biomed Biotechnol"},{"key":"1115_CR10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0022-5193(03)00071-7","volume":"223","author":"S Wuchty","year":"2003","unstructured":"Wuchty S, Stadler PF. Centers of complex networks. J Theor Biol. 2003;223:45\u201353.","journal-title":"J Theor Biol"},{"key":"1115_CR11","doi-asserted-by":"crossref","first-page":"056103","DOI":"10.1103\/PhysRevE.71.056103","volume":"71","author":"E Estrada","year":"2005","unstructured":"Estrada E, Rodriguez-Velazquez JA. Subgraph centrality in complex networks. Phys Rev E. 2005;71:056103.","journal-title":"Phys Rev E"},{"key":"1115_CR12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1086\/228631","volume":"92","author":"P Bonacich","year":"1987","unstructured":"Bonacich P. Power and centrality: A family of measures. Am J Sociol. 1987;92:12.","journal-title":"Am J Sociol"},{"key":"1115_CR13","first-page":"37","volume":"11","author":"S Karen","year":"2002","unstructured":"Karen S, Zelen M. Rethinking centrality: Methods and examples. Soc Networks. 2002;11:37.","journal-title":"Soc Networks"},{"key":"1115_CR14","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1109\/TCBB.2011.147","volume":"9","author":"JX Wang","year":"2012","unstructured":"Wang JX, Li M, Wang H, Pan Y. Identification of Essential Proteins Based on Edge Clustering Coefficient. IEEE\/ACM trans comput biol bioinforma\/IEEE, ACM. 2012;9:1070\u201380.","journal-title":"IEEE\/ACM trans comput biol bioinforma\/IEEE, ACM"},{"key":"1115_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","volume":"127","author":"Y Tang","year":"2015","unstructured":"Tang Y, Li M, Wang JX, Pan Y, Wu FX. CytoNCA: a cytoscape plugin for centrality analysis and evaluation of biological networks. BioSysts. 2015;127:67\u201372. doi: 10.1016\/j.biosystems.2014.11.005 .","journal-title":"BioSysts"},{"issue":"4","key":"1115_CR16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1109\/TCBB.2014.2361348","volume":"12","author":"J Wang","year":"2015","unstructured":"Wang J, Zhong J, Chen G, Li M, Wu F-X, Pan Y. ClusterViz: A Cytoscape APP for Cluster Analysis of Biological Network. IEEE\/ACM Trans Comput Biology Bioinform. 2015;12(4):815\u201322.","journal-title":"IEEE\/ACM Trans Comput Biology Bioinform"},{"key":"1115_CR17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.compbiolchem.2011.04.002","volume":"35","author":"M Li","year":"2011","unstructured":"Li M, Wang JX, et al. A local average connectivity-based method for identifying essential proteins from the network level. Comput Biol Chem. 2011;35:143\u201350.","journal-title":"Comput Biol Chem"},{"issue":"2","key":"1115_CR18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1109\/TCBB.2014.2361350","volume":"12","author":"M Li","year":"2015","unstructured":"Li M, Lu Y, Wang JX, Wu FX, Pan Y. A topology potential-based method for identifying essential proteins from PPI networks. IEEE\/ACM Trans Comput Biol Bioinform. 2015;12(2):372\u201383.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"1115_CR19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1471-2105-10-290","volume":"10","author":"ML Acencio","year":"2009","unstructured":"Acencio ML, Lemke N. Towards the prediction of essential genes by integration of network topology, cellular localization and biological process information. BMC Bioinform. 2009;10:290.","journal-title":"BMC Bioinform"},{"key":"1115_CR20","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1068696","volume":"296","author":"HB Fraser","year":"2002","unstructured":"Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, et al. Evolutionary rate in the protein interaction network. Science. 2002;296:750\u20132.","journal-title":"Science"},{"key":"1115_CR21","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1101\/gr.87702. Article published online before print in May 2002","volume":"12","author":"IK Jordan","year":"2002","unstructured":"Jordan IK, Rogozin IB, Wolf YI, Koonin EV. Essential genes are more evolutionarily conserved than are nonessential genes in bacteria. Genome Res. 2002;12:962\u20138.","journal-title":"Genome Res"},{"key":"1115_CR22","volume":"2","author":"NN Batada","year":"2006","unstructured":"Batada NN, Hurst LD, Tyers M. Evolutionary and physiological importance of hub proteins. PLoS Comput Biol. 2006;2, e88.","journal-title":"PLoS Comput Biol"},{"key":"1115_CR23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02100192","volume":"33","author":"PM Sharp","year":"1991","unstructured":"Sharp PM. Determinants of DNA sequence divergence between Escherichia coli and Salmonella typhimurium : Codon usage, map position, and concerted evolution. J Mol Evol. 1991;33:23\u201333.","journal-title":"J Mol Evol"},{"key":"1115_CR24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/molbev\/msh004","volume":"21","author":"EPC Rocha","year":"2004","unstructured":"Rocha EPC. Danchin A, An Analysis of Determinants of Amino Acids Substitution Rates in Bacterial Proteins. Mol Biol Evol. 2004;21:108\u201316.","journal-title":"Mol Biol Evol"},{"key":"1115_CR25","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1101\/gr.1589103","volume":"13","author":"DM Krylov","year":"2003","unstructured":"Krylov DM, Wolf YI, Rogozin IB, Koonin EV. Gene Loss: Protein Sequence Divergence, Gene Dispensability, Expression Level, and Interactivity Are Correlated in Eukaryotic Evolution. Genome Res. 2003;13:2229\u201335.","journal-title":"Genome Res"},{"issue":"3","key":"1115_CR26","doi-asserted-by":"crossref","first-page":"1341002","DOI":"10.1142\/S0219720013410023","volume":"11","author":"M Li","year":"2013","unstructured":"Li M, Wang JX, Wang H, Pan Y. Identification of Essential Proteins from Weighted Protein Interaction Networks. J Bioinform Comput Biol. 2013;11(3):1341002.","journal-title":"J Bioinform Comput Biol"},{"key":"1115_CR27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1752-0509-6-15","volume":"6","author":"M Li","year":"2012","unstructured":"Li M, Zhang H, Wang JX, et al. A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data. BMC Syst Biol. 2012;6:15.","journal-title":"BMC Syst Biol"},{"issue":"3","key":"1115_CR28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ymeth.2014.02.016","volume":"67","author":"M Li","year":"2014","unstructured":"Li M, Zheng RQ, Zheng HH, Wang JX, Pan Y. Effective identification of essential proteins based on prior knowledge, network topology and gene expressions. Methods. 2014;67(3):325\u201333.","journal-title":"Methods"},{"key":"1115_CR29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2105-13-109","volume":"13","author":"M Li","year":"2012","unstructured":"Li M, Wu XH, Wang JX, Pan Y. Towards the identification of protein Complexes and Functional Modules by integrating PPI network and gene expression data. BMC Bioinform. 2012;13:109.","journal-title":"BMC Bioinform"},{"key":"1115_CR30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/1471-2105-12-339","volume":"12","author":"XW Tang","year":"2011","unstructured":"Tang XW, Wang JX, Liu BB, Li M, Chen G, Pan Y. A comparison of the functional modules identified from time course and static PPI network data. BMC Bioinform. 2011;12:339.","journal-title":"BMC Bioinform"},{"issue":"Suppl 3","key":"1115_CR31","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2164-16-S3-S1","volume":"16","author":"QH Xiao","year":"2015","unstructured":"Xiao QH, Wang JX, Peng XQ, Wu FX, Pan Y. Identifying essential proteins from active PPI networks constructed with dynamic gene expression. BMC Genomics. 2015;16 Suppl 3:S1.","journal-title":"BMC Genomics"},{"issue":"1","key":"1115_CR32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1504\/IJDMB.2015.068951","volume":"12","author":"J Ren","year":"2015","unstructured":"Ren J, Wang JX, Li M, Wu FX. Discovering essential proteins based on PPI network and protein complex. Int J DataMing Bioinform. 2015;12(1):24\u201343.","journal-title":"Int J DataMing Bioinform"},{"key":"1115_CR33","doi-asserted-by":"publisher","unstructured":"Li M, Lu Y, Niu ZB, Wu FX: United complex centrality for identification of essential proteins from PPI networks. IEEE\/ACM Transactions on Computational Biology and Bioinformatics. DOI 10.1109\/TCBB.2015.2394487","DOI":"10.1109\/TCBB.2015.2394487"},{"key":"1115_CR34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/1471-2105-9-398","volume":"9","author":"M Li","year":"2008","unstructured":"Li M, Chen JE, Wang JX, Hu B, Chen G. Modifying the DPClus algorithm for identifying protein complexes based on new topological structures. BMC Bioinform. 2008;9:398.","journal-title":"BMC Bioinform"},{"issue":"2","key":"1115_CR35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1109\/TCBB.2014.2338317","volume":"12","author":"W Peng","year":"2015","unstructured":"Peng W, Wang J, Cheng Y, et al. UDoNC: an algorithm for identifying essential proteins based on protein domains and protein-protein interaction networks [J]. IEEE\/ACM Trans Comput Biol Bioinform. 2015;12(2):276\u201388.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"issue":"2","key":"1115_CR36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1109\/TCBB.2013.2295318","volume":"11","author":"X Tang","year":"2014","unstructured":"Tang X, Wang J, Zhong J, Pan Y. Predicting essential proteins based on weighted degree centrality. Comput Biology Bioinform, IEEE\/ACM Transactions on. 2014;11(2):407\u201318.","journal-title":"Comput Biology Bioinform, IEEE\/ACM Transactions on"},{"key":"1115_CR37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1752-0509-6-87","volume":"6","author":"W Peng","year":"2012","unstructured":"Peng W, Wang JX, Wang WP, et al. Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks. BMC Syst Biol. 2012;6:87.","journal-title":"BMC Syst Biol"},{"issue":"4","key":"1115_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TNB.2014.2337912","volume":"13","author":"B Zhao","year":"2014","unstructured":"Zhao B, Wang J, Li M, Wu F-X, Pan Y. Prediction of essential proteins based on overlapping essential modules. IEEE Trans Nanobioscience. 2014;13(4):1\u201310.","journal-title":"IEEE Trans Nanobioscience"},{"issue":"1","key":"1115_CR39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1504\/IJDMB.2010.030969","volume":"4","author":"M Li","year":"2010","unstructured":"Li M, Wang JX, Chen JE, Cai Z, Chen G. Identifying the Overlapping Complexes in Protein Interaction Networks. Int J DataMing Bioinform. 2010;4(1):91\u2013108.","journal-title":"Int J DataMing Bioinform"},{"issue":"5","key":"1115_CR40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1109\/TST.2015.7297748","volume":"20","author":"JC Zhong","year":"2015","unstructured":"Zhong JC, Wang JX, Peng W, Zhang Z, Li M. A Feature Selection Method for Prediction Essential Protein. Tsinghua sci Technol. 2015;20(5):491\u20139.","journal-title":"Tsinghua sci Technol"},{"key":"1115_CR41","doi-asserted-by":"crossref","first-page":"D142","DOI":"10.1093\/nar\/gkp846","volume":"38","author":"TU Consortium","year":"2010","unstructured":"Consortium TU. The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 2010;38:D142\u20138.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/nar\/30.1.303","volume":"30","author":"I Xenarios","year":"2002","unstructured":"Xenarios I, Salwinski L, Duan XQJ, Higney P, Kim SM, Eisenberg D. DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res. 2002;30:303\u20135.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR43","doi-asserted-by":"crossref","first-page":"D169","DOI":"10.1093\/nar\/gkj148","volume":"34","author":"HW Mewes","year":"2006","unstructured":"Mewes HW, Frishman D, Mayer KFX, Munsterkotter M, Noubibou O, Pagel P, et al. MIPS: analysis and annotation of proteins from whole genomes in 2005. Nucleic Acids Res. 2006;34:D169\u201372.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/nar\/26.1.73","volume":"26","author":"JM Cherry","year":"1998","unstructured":"Cherry JM. SGD: Saccharomyces Genome Database. Nucleic Acids Res. 1998;26:9.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR45","doi-asserted-by":"crossref","first-page":"D455","DOI":"10.1093\/nar\/gkn858","volume":"37","author":"R Zhang","year":"2009","unstructured":"Zhang R, Lin Y. DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res. 2009;37:D455\u20138.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR46","unstructured":"Saccharomyces Genome Deletion Project [ http:\/\/yeastdeletion.stanford.edu\/ ]. Accessed 20 June 2012."},{"key":"1115_CR47","unstructured":"COMPARTMENTS [ http:\/\/compartments.jensenlab.org ]. Accessed 28 Dec 2014."},{"key":"1115_CR48","doi-asserted-by":"publisher","unstructured":"Magrane M and Consortium U: UniProt Knowledgebase: a hub of integrated protein data. Database, 2011: doi: 10.1093\/database\/bar009 .","DOI":"10.1093\/database\/bar009"},{"key":"1115_CR49","doi-asserted-by":"crossref","first-page":"D881","DOI":"10.1093\/nar\/gkr974","volume":"40","author":"JT Eppig","year":"2012","unstructured":"Eppig JT, Blake JA, Bult CJ, et al. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res. 2012;40:D881\u20136.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR50","doi-asserted-by":"crossref","first-page":"D700","DOI":"10.1093\/nar\/gkr1029","volume":"40","author":"JM Cherry","year":"2011","unstructured":"Cherry JM, Hong EL, Amundsen C, et al. Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res. 2011;40:D700\u20135.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR51","doi-asserted-by":"crossref","first-page":"D706","DOI":"10.1093\/nar\/gkr1030","volume":"40","author":"P Mcquilton","year":"2011","unstructured":"Mcquilton P, St Pierre SE, Thurmond J, et al. FlyBase 101\u2014the basics of navigating FlyBase. Nucleic Acids Res. 2011;40:D706\u201314.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR52","doi-asserted-by":"crossref","first-page":"D463","DOI":"10.1093\/nar\/gkp952","volume":"38","author":"TW Harris","year":"2009","unstructured":"Harris TW, Antoshechkin I, Bieri T, et al. WormBase: a comprehensive resource for nematode research. Nucleic Acids Res. 2009;38:D463\u20137.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR53","doi-asserted-by":"crossref","first-page":"D196","DOI":"10.1093\/nar\/gkp931","volume":"38","author":"G Ostlund","year":"2010","unstructured":"Ostlund G, Schmitt T, Forslund K, et al. InParanoid 7: new algorithms and tools for eukaryotic orthology analysis. Nucleic Acids Res. 2010;38:D196\u2013203.","journal-title":"Nucleic Acids Res"},{"key":"1115_CR54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/pmic.200500209","volume":"6","author":"E Estrada","year":"2006","unstructured":"Estrada E. Virtual identification of essential proteins within the protein interaction network of yeast. Proteomics. 2006;6:35\u201340.","journal-title":"Proteomics"},{"issue":"3","key":"1115_CR55","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1109\/TCBB.2010.75","volume":"8","author":"JX Wang","year":"2011","unstructured":"Wang JX, Li M, Chen JE, Pan Y. A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networks. IEEE\/ACM Trans Comput Biol Bioinform. 2011;8(3):607\u201320.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"1115_CR56","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1073\/pnas.0400054101","volume":"101","author":"F Radicchi","year":"2004","unstructured":"Radicchi F, Castellano C, Cecconi F, et al. Defining and identifying communities in networks. Proc Nat Acad Sci U S A. 2004;101:2658\u2013632.","journal-title":"Proc Nat Acad Sci U S A"},{"key":"1115_CR57","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/1471-2105-8-236","volume":"8","author":"GT Hart","year":"2007","unstructured":"Hart GT, Lee I, Marcotte E. A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. BMC Bioinform. 2007;8:236.","journal-title":"BMC Bioinform"},{"key":"1115_CR58","doi-asserted-by":"crossref","unstructured":"Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barab\u00e1si AL. Uncovering disease-disease relationships through the incomplete interactome. Science. 2015;347(6224):1257601.","DOI":"10.1126\/science.1257601"},{"key":"1115_CR59","doi-asserted-by":"publisher","unstructured":"Peng X, Wang J, Wang J, Wu F-X, Pan Y: Rechecking the Centrality-Lethality Rule in the Scope of Protein Subcellular Localization Interaction Networks. Plos ONE, DOI: 10.1371\/journal.pone.0130743 .","DOI":"10.1371\/journal.pone.0130743"},{"key":"1115_CR60","unstructured":"Li G, Li M, Wang J, Wu F.X and Pan Y: A novel method for predicting essential proteins based on subcellular localization, orthology and PPI networks. Proceeding of International Symposium on Bioinformatics Research and Applications (ISBRA2015), 2015;9096 pp.427, June 2015."}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-016-1115-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T17:43:13Z","timestamp":1498326193000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-016-1115-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":60,"journal-issue":{"issue":"S8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1115"],"URL":"https:\/\/doi.org\/10.1186\/s12859-016-1115-5","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"article-number":"279"}}