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Although these two bacteria cause different diseases, they share multiple virulence factors, including bacterial secretion systems, which represent key components of bacterial pathogenicity. Despite recent progress, the secretion system proteins for <jats:italic>B. mallei<\/jats:italic> and <jats:italic>B. pseudomallei,<\/jats:italic> their pathogenic mechanisms of action, and host factors are not well characterized.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We previously developed a manually curated database, DBSecSys, of bacterial secretion system proteins for <jats:italic>B. mallei<\/jats:italic>. Here, we report an expansion of the database with corresponding information about <jats:italic>B. pseudomallei<\/jats:italic>. DBSecSys 2.0 contains comprehensive literature-based and computationally derived information about <jats:italic>B. mallei<\/jats:italic> ATCC 23344 and literature-based and computationally derived information about <jats:italic>B. pseudomallei<\/jats:italic> K96243. The database contains updated information for 163 <jats:italic>B. mallei<\/jats:italic> proteins from the previous database and 61 additional <jats:italic>B. mallei<\/jats:italic> proteins, and new information for 281 <jats:italic>B. pseudomallei<\/jats:italic> proteins associated with 5 secretion systems, their 1,633 human- and murine-interacting targets, and 2,400 host-<jats:italic>B. mallei<\/jats:italic> interactions and 2,286 host-<jats:italic>B. pseudomallei<\/jats:italic> interactions. The database also includes information about 13 pathogenic mechanisms of action for <jats:italic>B. mallei<\/jats:italic> and <jats:italic>B. pseudomallei<\/jats:italic> secretion system proteins inferred from the available literature or computationally. Additionally, DBSecSys 2.0 provides details about 82 virulence attenuation experiments for 52 <jats:italic>B. mallei<\/jats:italic> secretion system proteins and 98 virulence attenuation experiments for 61 <jats:italic>B. pseudomallei<\/jats:italic> secretion system proteins. We updated the Web interface and data access layer to speed-up users\u2019 search of detailed information for orthologous proteins related to secretion systems of the two pathogens.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The updates of DBSecSys 2.0 provide unique capabilities to access comprehensive information about secretion systems of <jats:italic>B. mallei<\/jats:italic> and <jats:italic>B. pseudomallei<\/jats:italic>. They enable studies and comparisons of corresponding proteins of these two closely related pathogens and their host-interacting partners.<\/jats:p>\n                <jats:p>The database is available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dbsecsys.bhsai.org\">http:\/\/dbsecsys.bhsai.org<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-016-1242-z","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T02:56:24Z","timestamp":1474340184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia pseudomallei secretion systems"],"prefix":"10.1186","volume":"17","author":[{"given":"Vesna","family":"Memi\u0161evi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nela","family":"Zavaljevski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"DeShazer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Wallqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaques","family":"Reifman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"1242_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1093\/gbe\/evq003","volume":"2","author":"L Losada","year":"2010","unstructured":"Losada L, Ronning CM, DeShazer D, Woods D, Fedorova N, Kim HS, Shabalina SA, Pearson TR, Brinkac L, Tan P, et al. 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