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Our mathematical algorithm was tested for 42 described mutations in multiple genes including renin (\n                      <jats:italic>REN<\/jats:italic>\n                      ), beta-tubulin (\n                      <jats:italic>TUBB2B<\/jats:italic>\n                      ), biotinidase (\n                      <jats:italic>BTD<\/jats:italic>\n                      ), sphingomyelin phosphodiesterase-1 (\n                      <jats:italic>SMPD1<\/jats:italic>\n                      ), phenylalanine hydroxylase (\n                      <jats:italic>PAH<\/jats:italic>\n                      ) and medium chain Acyl-Coa dehydrogenase (\n                      <jats:italic>ACADM<\/jats:italic>\n                      ). Moreover,\n                      <jats:sc>modict<\/jats:sc>\n                      scores corresponded to experimentally verified residual enzyme activities in mutated biotinidase, phenylalanine hydroxylase and medium chain Acyl-CoA dehydrogenase. Several commercially available prediction algorithms were tested and results were compared. The\n                      <jats:sc>modict<\/jats:sc>\n                      <jats:sc>perl<\/jats:sc>\n                      package and the manual can be downloaded from\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/IbrahimTanyalcin\/MODICT\">https:\/\/github.com\/IbrahimTanyalcin\/MODICT<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We show here that\n                      <jats:sc>modict<\/jats:sc>\n                      is capable tool for mutation effect prediction at the protein level, using superimposed 3D protein models instead of sequence based algorithms used by\n                      <jats:sc>polyphen<\/jats:sc>\n                      and\n                      <jats:sc>sift<\/jats:sc>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12859-016-1286-0","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T23:25:04Z","timestamp":1476833104000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Convert your favorite protein modeling program into a mutation predictor: \u201cMODICT\u201d"],"prefix":"10.1186","volume":"17","author":[{"given":"Ibrahim","family":"Tanyalcin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Stouffs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorien","family":"Daneels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Al Assaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Lissens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gheldof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"issue":"4","key":"1286_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. 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