{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:27:49Z","timestamp":1767173269989,"version":"build-2238731810"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["258068"],"award-info":[{"award-number":["258068"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["284209"],"award-info":[{"award-number":["284209"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2012-33110"],"award-info":[{"award-number":["SAF2012-33110"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006461","name":"Agencia de Innovaci\u00f3n y Desarrollo de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS-486"],"award-info":[{"award-number":["CTS-486"]}],"id":[{"id":"10.13039\/501100006461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERER"],"award-info":[{"award-number":["CIBERER"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12859-017-1503-5","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T20:07:56Z","timestamp":1486670876000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["How can functional annotations be derived from profiles of phenotypic annotations?"],"prefix":"10.1186","volume":"18","author":[{"given":"Beatriz","family":"Serrano-Solano","sequence":"first","affiliation":[]},{"given":"Antonio","family":"D\u00edaz Ramos","sequence":"additional","affiliation":[]},{"given":"Jean-Karim","family":"H\u00e9rich\u00e9","sequence":"additional","affiliation":[]},{"given":"Juan A. G.","family":"Ranea","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"issue":"8","key":"1503_CR1","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.yexcr.2010.04.001","volume":"316","author":"JG Lock","year":"2010","unstructured":"Lock JG, Str\u00f6mblad S. Systems microscopy: an emerging strategy for the life sciences. Exp Cell Res. 2010; 316(8):1438\u201344. doi: 10.1016\/j.yexcr.2010.04.001 .","journal-title":"Exp Cell Res"},{"issue":"7289","key":"1503_CR2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nature08869","volume":"464","author":"B Neumann","year":"2010","unstructured":"Neumann B, Walter T, H\u00e9rich\u00e9 JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Poser I, Held M, Liebel U, Cetin C, Sieckmann F, Pau G, Kabbe R, W\u00fcnsche A, Satagopam V, Schmitz MHA, Chapuis C, Gerlich DW, Schneider R, Eils R, Huber W, Peters JM, Hyman AA, Durbin R, Pepperkok R, Ellenberg J. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature. 2010; 464(7289):721\u20137. doi: 10.1038\/nature08869 .","journal-title":"Nature"},{"issue":"370","key":"1503_CR3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/msb.2010.25","volume":"6","author":"F Fuchs","year":"2010","unstructured":"Fuchs F, Pau G, Kranz D, Sklyar O, Budjan C, Steinbrink S, Horn T, Pedal A, Huber W, Boutros M. Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol. 2010; 6(370):370. doi: 10.1038\/msb.2010.25 .","journal-title":"Mol Syst Biol"},{"issue":"7","key":"1503_CR4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ncb2510","volume":"14","author":"JC Simpson","year":"2012","unstructured":"Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, H\u00e9rich\u00e9 JK, Neumann B, Mateos A, Blake J, Bechtel S, Benes V, Wiemann S, Ellenberg J, Pepperkok R. Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol. 2012; 14(7):764\u201374. doi: 10.1038\/ncb2510 .","journal-title":"Nat Cell Biol"},{"issue":"13","key":"1503_CR5","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/bioinformatics\/bts250","volume":"28","author":"R Hoehndorf","year":"2012","unstructured":"Hoehndorf R, Harris MA, Herre H, Rustici G, Gkoutos GV. Semantic integration of physiology phenotypes with an application to the Cellular Phenotype Ontology. Bioinforma (Oxford, England). 2012; 28(13):1783\u20139. doi: 10.1093\/bioinformatics\/bts250 .","journal-title":"Bioinforma (Oxford, England)"},{"issue":"1","key":"1503_CR6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13326-016-0074-0","volume":"7","author":"S Jupp","year":"2016","unstructured":"Jupp S, Malone J, Burdett T, H\u00e9rich\u00e9 JK, Williams E, Ellenberg J, Parkinson H, Rustici G. The cellular microscopy phenotype ontology. J Biomed Semant. 2016; 7(1):28. doi: 10.1186\/s13326-016-0074-0 .","journal-title":"J Biomed Semant"},{"issue":"16","key":"1503_CR7","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1091\/mbc.E13-04-0221","volume":"25","author":"JK H\u00e9rich\u00e9","year":"2014","unstructured":"H\u00e9rich\u00e9 JK, Lees JG, Morilla I, Walter T, Petrova B, Roberti MJ, Hossain MJ, Adler P, Fernandez JM, Krallinger M, Haering CH, Vilo J, Valencia A, Ranea JA, Orengo C, Ellenberg J. Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation. Mol Biol Cell. 2014; 25(16):2522\u201336. doi: 10.1091\/mbc.E13-04-0221 .","journal-title":"Mol Biol Cell"},{"issue":"5","key":"1503_CR8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/cdd.2011.150","volume":"19","author":"P Moudry","year":"2012","unstructured":"Moudry P, Lukas C, Macurek L, Neumann B, Heriche JK, Pepperkok R, Ellenberg J, Hodny Z, Lukas J, Bartek J. Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Cell Death Differ. 2012; 19(5):798\u2013807. doi: 10.1038\/cdd.2011.150 .","journal-title":"Cell Death Differ"},{"issue":"6","key":"1503_CR9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.devcel.2013.05.016","volume":"25","author":"F Balestra","year":"2013","unstructured":"Balestra F, Strnad P, Fl\u00fcckiger I, G\u00f6nczy P. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev Cell. 2013; 25(6):555\u201371. doi: 10.1016\/j.devcel.2013.05.016 .","journal-title":"Dev Cell"},{"issue":"2","key":"1503_CR10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.molcel.2009.06.021","volume":"35","author":"RD Paulsen","year":"2009","unstructured":"Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability. Mol Cell. 2009; 35(2):228\u201339. doi: 10.1016\/j.molcel.2009.06.021 .","journal-title":"Mol Cell"},{"issue":"D1","key":"1503_CR11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/nar\/gks1170","volume":"41","author":"EE Schmidt","year":"2013","unstructured":"Schmidt EE, Pelz O, Buhlmann S, Kerr G, Horn T, Boutros M. GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Res. 2013; 41(D1):1021\u20136. doi: 10.1093\/nar\/gks1170 .","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1503_CR12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000; 25(1):25\u20139. doi: 10.1038\/75556 .","journal-title":"Nat Genet"},{"issue":"16","key":"1503_CR13","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1093\/bioinformatics\/btv199","volume":"31","author":"C Kirsanova","year":"2015","unstructured":"Kirsanova C, Brazma A, Rustici G, Sarkans U. Cellular phenotype database: a repository for systems microscopy data. Bioinformatics. 2015; 31(16):2736\u201340. doi: 10.1093\/bioinformatics\/btv199 .","journal-title":"Bioinformatics"},{"key":"1503_CR14","unstructured":"Wild F. Lsa: Latent Semantic Analysis. 2015. R package version 0.73.1. https:\/\/CRAN.R-project.org\/package=lsa ."},{"key":"1503_CR15","unstructured":"Hennig C, Hausdorf B. Prabclus: functions for clustering of presence-absence, abundance and multilocus genetic data. 2015. R package version 2.2-6. https:\/\/CRAN.R-project.org\/package=prabclus ."},{"issue":"5","key":"1503_CR16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1108\/00220410410560582","volume":"60","author":"S Robertson","year":"2004","unstructured":"Robertson S. Understanding inverse document frequency: on theoretical arguments for IDF. J Doc. 2004; 60(5):503\u201320. doi: 10.1108\/00220410410560582 .","journal-title":"J Doc"},{"key":"1503_CR17","first-page":"64","volume":"6","author":"H Fang","year":"2014","unstructured":"Fang H, Gough J. The \u2018dnet\u2019 approach promotes emerging research on cancer patient survival. Genome Med. 2014; 6:64. doi: 10.1186\/s13073-014-0064-8 .","journal-title":"Genome Med"},{"issue":"D1","key":"1503_CR18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/nar\/gkt1115","volume":"42","author":"S Orchard","year":"2014","unstructured":"Orchard S, Ammari M, Aranda B, Breuza L, Briganti L, Broackes-Carter F, Campbell NH, Chavali G, Chen C, Del-Toro N, Duesbury M, Dumousseau M, Galeota E, Hinz U, Iannuccelli M, Jagannathan S, Jimenez R, Khadake J, Lagreid A, Licata L, Lovering RC, Meldal B, Melidoni AN, Milagros M, Peluso D, Perfetto L, Porras P, Raghunath A, Ricard-Blum S, Roechert B, Stutz A, Tognolli M, Van Roey K, Cesareni G, Hermjakob H. The MIntAct project - IntAct as a common curation platform for 11 molecular interaction databases. Nucleic Acids Res. 2014; 42(D1):358\u201363. doi: 10.1093\/nar\/gkt1115 .","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"1503_CR19","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/bioinformatics\/bti115","volume":"21","author":"P Pagel","year":"2005","unstructured":"Pagel P, Kovac S, Oesterheld M, Brauner B, Dunger-Kaltenbach I, Frishman G, Montrone C, Mark P, St\u00fcmpflen V, Mewes HW, Ruepp A, Frishman D. The MIPS mammalian protein-protein interaction database. Bioinformatics. 2005; 21(6):832\u20134. doi: 10.1093\/bioinformatics\/bti115 .","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"1503_CR20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/nar\/gkh086","volume":"32","author":"L Salwinski","year":"2004","unstructured":"Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D. The Database of Interacting Proteins: 2004 update. Nucleic Acids Res. 2004; 32(Database issue):449\u201351. doi: 10.1093\/nar\/gkh086 .","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"1503_CR21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/nar\/gkj109","volume":"34","author":"C Stark","year":"2006","unstructured":"Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M. BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 2006; 34(Database issue):535\u20139. doi: 10.1093\/nar\/gkj109 .","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"1503_CR22","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/cancers4041180","volume":"4","author":"M Milacic","year":"2012","unstructured":"Milacic M, Haw R, Rothfels K, Wu G, Croft D, Hermjakob H, D\u2019Eustachio P, Stein L. Annotating cancer variants and anti-cancer therapeutics in Reactome. Cancers. 2012; 4(4):1180\u2013211. doi: 10.3390\/cancers4041180 .","journal-title":"Cancers"},{"issue":"D1","key":"1503_CR23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/nar\/gkv1351","volume":"44","author":"A Fabregat","year":"2016","unstructured":"Fabregat A, Sidiropoulos K, Garapati P, Gillespie M, Hausmann K, Haw R, Jassal B, Jupe S, Korninger F, McKay S, Matthews L, May B, Milacic M, Rothfels K, Shamovsky V, Webber M, Weiser J, Williams M, Wu G, Stein L, Hermjakob H, D\u2019Eustachio P. The Reactome pathway Knowledgebase. Nucleic Acids Res. 2016; 44(D1):481\u20137. doi: 10.1093\/nar\/gkv1351 .","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"1503_CR24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/nar\/gkt1079","volume":"42","author":"P Blohm","year":"2014","unstructured":"Blohm P, Frishman G, Smialowski P, Goebels F, Wachinger B, Ruepp A, Frishman D. Negatome 2.0: A database of non-interacting proteins derived by literature mining, manual annotation and protein structure analysis. Nucleic Acids Res. 2014; 42(D1):396\u2013400. doi: 10.1093\/nar\/gkt1079 .","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"1503_CR25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ymeth.2012.07.028","volume":"58","author":"LG Trabuco","year":"2012","unstructured":"Trabuco LG, Betts MJ, Russell RB. Negative protein-protein interaction datasets derived from large-scale two-hybrid experiments. Methods. 2012; 58(4):343\u20138. doi: 10.1016\/j.ymeth.2012.07.028 .","journal-title":"Methods"},{"key":"1503_CR26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, M\u00fcller M. Proc: an open-source package for r and s+ to analyze and compare roc curves. BMC Bioinforma. 2011; 12:77.","journal-title":"BMC Bioinforma"},{"key":"1503_CR27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/1471-2105-9-405","volume":"9","author":"S Razick","year":"2008","unstructured":"Razick S, Magklaras G, Donaldson IM. iRefIndex: a consolidated protein interaction database with provenance. BMC Bioinforma. 2008; 9:405. doi: 10.1186\/1471-2105-9-405 .","journal-title":"BMC Bioinforma"},{"issue":"11","key":"1503_CR28","doi-asserted-by":"crossref","first-page":"1004565","DOI":"10.1371\/journal.pcbi.1004565","volume":"11","author":"K Glass","year":"2015","unstructured":"Glass K, Girvan M. Finding New Order in Biological Functions from the Network Structure of Gene Annotations. PLoS Comput Biol. 2015; 11(11):1004565. doi: 10.1371\/journal.pcbi.1004565 .","journal-title":"PLoS Comput Biol"},{"key":"1503_CR29","unstructured":"Meila M, Shi J. A Random Walks View of Spectral Segmentation. In: Proceedings of the International Conference on AI and Statistics (AISTATS): 2001. http:\/\/citeseerx.ist.psu.edu\/viewdoc\/summary?doi=10.1.1.30.8065 ."},{"issue":"5","key":"1503_CR30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nmeth.2436","volume":"10","author":"C Laufer","year":"2013","unstructured":"Laufer C, Fischer B, Billmann M, Huber W, Boutros M. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. Nat Methods. 2013; 10(5):427\u201331. doi: 10.1038\/nmeth.2436 .","journal-title":"Nat Methods"},{"issue":"June","key":"1503_CR31","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1126\/science.1140324","volume":"316","author":"C Bakal","year":"2007","unstructured":"Bakal C, Church G, Perrimon N. Regulating Cell Morphology. Science. 2007; 316(June):1753\u20136.","journal-title":"Science"},{"issue":"5","key":"1503_CR32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nmeth1032","volume":"4","author":"LH Loo","year":"2007","unstructured":"Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007; 4(5):445\u201353. doi: 10.1038\/nmeth1032 .","journal-title":"Nat Methods"},{"issue":"6","key":"1503_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1002566","volume":"8","author":"X Wang","year":"2012","unstructured":"Wang X, Castro MA, Mulder KW, Markowetz F. Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations. PLoS Comput Biol. 2012; 8(6):1\u201316. doi: 10.1371\/journal.pcbi.1002566 .","journal-title":"PLoS Comput Biol"},{"issue":"Database issue","key":"1503_CR34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/nar\/gkh110","volume":"32","author":"KC Gunsalus","year":"2004","unstructured":"Gunsalus KC, Yueh WC, MacMenamin P, Piano F. RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects. Nucleic Acids Res. 2004; 32(Database issue):406\u201310. doi: 10.1093\/nar\/gkh110 .","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1503_CR35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1471-2105-9-136","volume":"9","author":"P Groth","year":"2008","unstructured":"Groth P, Weiss B, Pohlenz HD, Leser U. Mining phenotypes for gene function prediction. BMC Bioinforma. 2008; 9(1):136. doi: 10.1186\/1471-2105-9-136 .","journal-title":"BMC Bioinforma"},{"issue":"88","key":"1503_CR36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/msb4100129","volume":"3","author":"R Sharan","year":"2007","unstructured":"Sharan R, Ulitsky I, Shamir R. Network-based prediction of protein function. Mol Syst Biol. 2007; 3(88):88. doi: 10.1038\/msb4100129 .","journal-title":"Mol Syst Biol"},{"issue":"5","key":"1503_CR37","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/bib\/bbr066","volume":"13","author":"PH Guzzi","year":"2012","unstructured":"Guzzi PH, Mina M, Guerra C, Cannataro M. Semantic similarity analysis of protein data: Assessment with biological features and issues. Brief Bioinform. 2012; 13(5):569\u201385. doi: 10.1093\/bib\/bbr066 .","journal-title":"Brief Bioinform"},{"issue":"12","key":"1503_CR38","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/bioinformatics\/btv073","volume":"31","author":"JG Lees","year":"2015","unstructured":"Lees JG, H\u00e9rich\u00e9 JK, Morilla I, Fernandez JM, Adler P, Krallinger M, Vilo J, Valencia A, Ellenberg J, Ranea JA, Orengo C. FUN-L: gene prioritization for RNAi screens. Bioinformatics. 2015; 31(12):2052\u20133.","journal-title":"Bioinformatics"},{"key":"1503_CR39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/gb-2008-9-s1-s4","volume":"9 Suppl 1","author":"S Mostafavi","year":"2008","unstructured":"Mostafavi S, Ray D, Warde-Farley D, Grouios C, Morris Q. GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function. Genome Biol. 2008; 9 Suppl 1:4. doi: 10.1186\/gb-2008-9-s1-s4 .","journal-title":"Genome Biol"},{"issue":"4","key":"1503_CR40","first-page":"1","volume":"2015","author":"B Fischer","year":"2015","unstructured":"Fischer B, Sandmann T, Horn T, Billmann M, Chaudhary V, Huber W, Boutros M. A map of directional genetic interactions in a metazoan cell. eLife. 2015; 2015(4):1\u201321. doi: 10.7554\/eLife.05464 .","journal-title":"eLife"},{"issue":"8","key":"1503_CR41","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1091\/mbc.E15-07-0467","volume":"27","author":"M Billmann","year":"2016","unstructured":"Billmann M, Horn T, Fischer B, Sandmann T, Huber W, Boutros M. A genetic interaction map of cell cycle regulators. Mol Biol Cell. 2016; 27(8):1397\u2013407. doi: 10.1091\/mbc.E15-07-0467 .","journal-title":"Mol Biol Cell"}],"updated-by":[{"DOI":"10.1186\/s12859-017-1607-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000}}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1503-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T09:56:35Z","timestamp":1568800595000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-017-1503-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1503"],"URL":"https:\/\/doi.org\/10.1186\/s12859-017-1503-5","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]},"article-number":"96"}}