{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:38:41Z","timestamp":1774690721438,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U01 HG006476"],"award-info":[{"award-number":["U01 HG006476"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5 UL1 RR025774"],"award-info":[{"award-number":["5 UL1 RR025774"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12859-017-1778-6","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T12:00:14Z","timestamp":1503057614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["SG-ADVISER mtDNA: a web server for mitochondrial DNA annotation with data from 200 samples of a healthy aging cohort"],"prefix":"10.1186","volume":"18","author":[{"given":"Manuel","family":"Rueda","sequence":"first","affiliation":[]},{"given":"Ali","family":"Torkamani","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"1778_CR1","doi-asserted-by":"publisher","first-page":"16080","DOI":"10.1038\/nrdp.2016.80","volume":"2","author":"G Gorman","year":"2016","unstructured":"Gorman G, Chinnery P, Dimauro S, Hirano M, Koga Y, Mcfarland R, Suomalainen A, Thorburn D, Zeviani M, Turnbull D. Mitochondrial diseases. Nature Reviews Disease Primers. 2016;2:16080.","journal-title":"Nature Reviews Disease Primers"},{"issue":"5","key":"1778_CR2","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nrg1606","volume":"6","author":"R Taylor","year":"2005","unstructured":"Taylor R, Turnbull D. Mitochondrial Dna mutations in human disease. Nat Rev Genet. 2005;6(5):389\u2013402.","journal-title":"Nat Rev Genet"},{"issue":"2","key":"1778_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/88859","volume":"28","author":"H Coller","year":"2001","unstructured":"Coller H, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG. High frequency of Homoplasmic mitochondrial Dna mutations in human tumors can be explained without selection. Nat Genet. 2001;28(2):147\u201350.","journal-title":"Nat Genet"},{"issue":"Pt 3","key":"1778_CR4","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1042\/bj20021594","volume":"370","author":"R Rossignol","year":"2003","unstructured":"Rossignol R, Faustin B, Rocher C, Malgat M, Mazat JP, Letellier T. Mitochondrial threshold effects. The Biochemical Journal. 2003;370(Pt 3):751\u201362.","journal-title":"The Biochemical Journal"},{"issue":"2","key":"1778_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.bbabio.2009.09.005","volume":"1797","author":"H Tuppen","year":"2010","unstructured":"Tuppen H, Blakely E, Turnbull D, Taylor R. Mitochondrial Dna mutations and human disease. Biochim Biophys Acta. 2010;1797(2):113\u201328.","journal-title":"Biochim Biophys Acta"},{"key":"1778_CR6","doi-asserted-by":"crossref","unstructured":"Stewart J, Larsson NG. Keeping Mtdna in shape between generations. PLoS Genet. 2014:10(10).","DOI":"10.1371\/journal.pgen.1004670"},{"issue":"29","key":"1778_CR7","doi-asserted-by":"publisher","first-page":"10654","DOI":"10.1073\/pnas.1403521111","volume":"111","author":"K Ye","year":"2014","unstructured":"Ye K, Lu J, Ma F, Keinan A, Gu Z. Extensive Pathogenicity of mitochondrial Heteroplasmy in healthy human individuals. Proc Natl Acad Sci U S A. 2014;111(29):10654\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"1778_CR8","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nrg3966","volume":"16","author":"J Stewart","year":"2015","unstructured":"Stewart J, Chinnery P. The dynamics of mitochondrial Dna Heteroplasmy: implications for human health and disease. Nat Rev Genet. 2015;16(9):530\u201342.","journal-title":"Nat Rev Genet"},{"issue":"Pt 10","key":"1778_CR9","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1093\/brain\/121.10.1889","volume":"121","author":"P Chinnery","year":"1998","unstructured":"Chinnery P, Howell N, Lightowlers R, Turnbull DM. Melas and Merrf. The relationship between maternal mutation load and the frequency of clinically affected offspring. Brain : A Journal Of Neurology. 1998;121(Pt 10):1889\u201394.","journal-title":"Brain : A Journal Of Neurology"},{"issue":"1\u20132","key":"1778_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mito.2006.11.025","volume":"7","author":"L Wong","year":"2007","unstructured":"Wong L. Diagnostic challenges of mitochondrial Dna disorders. Mitochondrion. 2007;7(1\u20132):45\u201352.","journal-title":"Mitochondrion"},{"key":"1778_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.mrfmmm.2015.06.009","volume":"779","author":"Y Yao","year":"2015","unstructured":"Yao Y, Kajigaya S, Young NS. Mitochondrial Dna mutations in single human blood cells. Mutat Res. 2015;779:68\u201377.","journal-title":"Mutat Res"},{"issue":"W1","key":"1778_CR12","doi-asserted-by":"publisher","first-page":"W3","DOI":"10.1093\/nar\/gkw343","volume":"44","author":"E Afgan","year":"2016","unstructured":"Afgan E, Baker D, Van Den Beek M, Blankenberg D, Bouvier D, Cech M, Chilton J, Clements D, Coraor N, Eberhard C, et al. The galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update. Nucleic Acids Res. 2016;44(W1):W3\u2013W10.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"1778_CR13","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ng0506-500","volume":"38","author":"M Reich","year":"2006","unstructured":"Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP. Genepattern 2.0. Nat Genet. 2006;38(5):500\u20131.","journal-title":"Nat Genet"},{"issue":"Suppl 7","key":"1778_CR14","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1471-2105-14-S7-S11","volume":"14","author":"M D'antonio","year":"2013","unstructured":"D'antonio M, D'onorio De Meo P, Paoletti D, Elmi B, Pallocca M, Sanna N, Picardi E, Pesole G, Castrignano T. Wep: a high-performance analysis pipeline for whole-exome data. Bmc Bioinformatics. 2013;14(Suppl 7):S11.","journal-title":"Bmc Bioinformatics"},{"issue":"W1","key":"1778_CR15","doi-asserted-by":"publisher","first-page":"W64","DOI":"10.1093\/nar\/gkw247","volume":"44","author":"H Weissensteiner","year":"2016","unstructured":"Weissensteiner H, Forer L, Fuchsberger C, Schopf B, Kloss-Brandstatter A, Specht G, Kronenberg F, Schonherr S. Mtdna-server: next-generation sequencing data analysis of human mitochondrial Dna in the cloud. Nucleic Acids Res. 2016;44(W1):W64\u20139.","journal-title":"Nucleic Acids Res"},{"issue":"21","key":"1778_CR16","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1093\/bioinformatics\/btu483","volume":"30","author":"C Calabrese","year":"2014","unstructured":"Calabrese C, Simone D, Diroma MA, Santorsola M, Gutta C, Gasparre G, Picardi E, Pesole G, Attimonelli M. Mtoolbox: a highly automated pipeline for Heteroplasmy annotation and prioritization analysis of human mitochondrial variants in high-throughput sequencing. Bioinformatics. 2014;30(21):3115\u20137.","journal-title":"Bioinformatics"},{"issue":"9","key":"1778_CR17","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1093\/bioinformatics\/btt118","volume":"29","author":"Y Guo","year":"2013","unstructured":"Guo Y, Li J, Li CI, Shyr Y, Samuels DC. MitoSeek: extracting mitochondria information and performing high-throughput mitochondria sequencing analysis. Bioinformatics. 2013;29(9):1210\u20131.","journal-title":"Bioinformatics"},{"issue":"4","key":"1778_CR18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/humu.22767","volume":"36","author":"S Vellarikkal","year":"2015","unstructured":"Vellarikkal S, Dhiman H, Joshi K, Hasija Y, Sivasubbu S, Scaria V. Mit-O-Matic: a comprehensive computational pipeline for clinical evaluation of mitochondrial variations from next-generation sequencing datasets. Hum Mutat. 2015;36(4):419\u201324.","journal-title":"Hum Mutat"},{"issue":"6","key":"1778_CR19","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.mito.2011.08.005","volume":"11","author":"I Zhidkov","year":"2011","unstructured":"Zhidkov I, Nagar T, Mishmar D, Rubin E. Mitobamannotator: a web-based tool for detecting and annotating Heteroplasmy in human mitochondrial Dna sequences. Mitochondrion. 2011;11(6):924\u20138.","journal-title":"Mitochondrion"},{"issue":"9","key":"1778_CR20","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1093\/bioinformatics\/bti310","volume":"21","author":"T Wu","year":"2005","unstructured":"Wu T, Watanabe C. Gmap: a genomic mapping and alignment program for Mrna and Est sequences. Bioinformatics. 2005;21(9):1859\u201375.","journal-title":"Bioinformatics"},{"issue":"6","key":"1778_CR21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nmeth.2029","volume":"9","author":"E Picardi","year":"2012","unstructured":"Picardi E, Pesole G. Mitochondrial genomes gleaned from human whole-exome sequencing. Nat Methods. 2012;9(6):523\u20134.","journal-title":"Nat Methods"},{"issue":"Database Issue","key":"1778_CR22","doi-asserted-by":"publisher","first-page":"D1150","DOI":"10.1093\/nar\/gkr1086","volume":"40","author":"F Rubino","year":"2012","unstructured":"Rubino F, Piredda R, Calabrese F, Simone D, Lang M, Calabrese C, Petruzzella V, Tommaseo-Ponzetta M, Gasparre G, Attimonelli M. Hmtdb, a genomic resource for mitochondrion-based human variability studies. Nucleic Acids Res. 2012;40(Database Issue):D1150\u20139.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1778_CR23","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00439-015-1615-9","volume":"135","author":"M Santorsola","year":"2016","unstructured":"Santorsola M, Calabrese C, Girolimetti G, Diroma M, Gasparre G, Attimonelli M. A multi-parametric workflow for the prioritization of mitochondrial Dna variants of clinical interest. Hum Genet. 2016;135(1):121\u201336.","journal-title":"Hum Genet"},{"issue":"14","key":"1778_CR24","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1001\/jama.2016.11445","volume":"316","author":"A Torkamani","year":"2016","unstructured":"Torkamani A, Muse E, Spencer E, Rueda M, Wagner G, Lucas JR, Topol EJ. Molecular autopsy for sudden unexpected death. Jama-J Am Med Assoc. 2016;316(14):1492\u20134.","journal-title":"Jama-J Am Med Assoc"},{"issue":"12","key":"1778_CR25","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/gim.2015.21","volume":"17","author":"C Bloss","year":"2015","unstructured":"Bloss C, Zeeland A, Topol S, Darst B, Boeldt D, Erikson G, Bethel K, Bjork R, Friedman J, Hwynn N, et al. A genome sequencing program for novel undiagnosed diseases. Genet Med. 2015;17(12):995\u20131001.","journal-title":"Genet Med"},{"issue":"4","key":"1778_CR26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.ajhg.2012.03.002","volume":"90","author":"D Behar","year":"2012","unstructured":"Behar D, Van Oven M, Rosset S, Metspalu M, Loogvali E, Nm S, Kivisild T, Torroni A, Villems R. A \"Copernican\" reassessment of the human mitochondrial Dna tree from its root. Am J Hum Genet. 2012;90(4):675\u201384.","journal-title":"Am J Hum Genet"},{"issue":"16","key":"1778_CR27","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R. Genome project data processing S: the sequence alignment\/map format and Samtools. Bioinformatics. 2009;25(16):2078\u20139.","journal-title":"Bioinformatics"},{"issue":"4","key":"1778_CR28","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.cell.2016.03.022","volume":"165","author":"G Erikson","year":"2016","unstructured":"Erikson G, Bodian D, Rueda M, Molparia B, Scott E, Scott-Van Zeeland A, Topol S, Wineinger N, Niederhuber J, Topol E, et al. Whole-genome sequencing of a healthy aging cohort. Cell. 2016;165(4):1002\u201311.","journal-title":"Cell"},{"issue":"3","key":"1778_CR29","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nbt.2833","volume":"32","author":"V Kuleshov","year":"2014","unstructured":"Kuleshov V, Xie D, Chen R, Pushkarev D, Ma Z, Blauwkamp T, Kertesz M, Snyder M. Whole-genome Haplotyping using long reads and statistical methods. Nat Biotechnol. 2014;32(3):261\u20136.","journal-title":"Nat Biotechnol"},{"issue":"5","key":"1778_CR30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.stem.2016.02.005","volume":"18","author":"E Kang","year":"2016","unstructured":"Kang E, Wang X, Tippner-Hedges R, Ma H, Cd F, Gutierrez N, Lee Y, Van Dyken C, Ahmed R, Li Y, et al. Age-related accumulation of somatic mitochondrial Dna mutations in adult-derived human Ipscs. Cell Stem Cell. 2016;18(5):625\u201336.","journal-title":"Cell Stem Cell"},{"issue":"9","key":"1778_CR31","doi-asserted-by":"publisher","first-page":"E1003794","DOI":"10.1371\/journal.pgen.1003794","volume":"9","author":"S Kennedy","year":"2013","unstructured":"Kennedy S, Salk J, Schmitt M, Loeb L. Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet. 2013;9(9):E1003794.","journal-title":"PLoS Genet"},{"key":"1778_CR32","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.exger.2014.03.022","volume":"56","author":"F Sevini","year":"2014","unstructured":"Sevini F, Giuliani C, Vianello D, Giampieri E, Santoro A, Biondi F, Garagnani P, Passarino G, Luiselli D, Capri M, et al. Mtdna mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies. Exp Gerontol. 2014;56:234\u201344.","journal-title":"Exp Gerontol"},{"issue":"5","key":"1778_CR33","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","volume":"61","author":"N Sun","year":"2016","unstructured":"Sun N, Youle R, Finkel T. The mitochondrial basis of aging. Mol Cell. 2016;61(5):654\u201366.","journal-title":"Mol Cell"},{"key":"1778_CR34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.arr.2016.04.006","volume":"33","author":"K Debalsi","year":"2017","unstructured":"Debalsi K, Hoff K, Copeland W. Role of the mitochondrial Dna replication machinery in mitochondrial Dna mutagenesis, aging and age-related diseases. Ageing Res Rev. 2017;33:89\u2013104.","journal-title":"Ageing Res Rev"},{"issue":"3","key":"1778_CR35","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1172\/JCI64125","volume":"123","author":"A Bratic","year":"2013","unstructured":"Bratic A, Larsson N. The role of mitochondria in aging. J Clin Invest. 2013;123(3):951\u20137.","journal-title":"J Clin Invest"},{"issue":"12","key":"1778_CR36","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/nrg3275","volume":"13","author":"E Schon","year":"2012","unstructured":"Schon E, Dimauro S, Hirano M. Human mitochondrial Dna: roles of inherited and somatic mutations. Nat Rev Genet. 2012;13(12):878\u201390.","journal-title":"Nat Rev Genet"},{"issue":"9","key":"1778_CR37","doi-asserted-by":"publisher","first-page":"E1004620","DOI":"10.1371\/journal.pgen.1004620","volume":"10","author":"L Greaves","year":"2014","unstructured":"Greaves L, Nooteboom M, Elson J, Tuppen H, Taylor G, Commane D, Arasaradnam R, Khrapko K, Rw T, Kirkwood T, et al. Clonal expansion of early to mid-life mitochondrial Dna point mutations drives mitochondrial dysfunction during human ageing. PLoS Genet. 2014;10(9):E1004620.","journal-title":"PLoS Genet"},{"issue":"7467","key":"1778_CR38","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nature12474","volume":"501","author":"J Ross","year":"2013","unstructured":"Ross J, Stewart J, Hagstrom E, Brene S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer B, Olson L, et al. Germline mitochondrial Dna mutations aggravate ageing and can impair brain development. Nature. 2013;501(7467):412\u20135.","journal-title":"Nature"},{"issue":"3","key":"1778_CR39","doi-asserted-by":"publisher","first-page":"E1005939","DOI":"10.1371\/journal.pgen.1005939","volume":"12","author":"M Wachsmuth","year":"2016","unstructured":"Wachsmuth M, Hubner A, Li M, Madea B, Stoneking M. Age-related and Heteroplasmy-related variation in human Mtdna copy number. PLoS Genet. 2016;12(3):E1005939.","journal-title":"PLoS Genet"},{"key":"1778_CR40","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev-biochem-060408-093701","volume":"79","author":"N Larsson","year":"2010","unstructured":"Larsson N. Somatic mitochondrial Dna mutations in mammalian aging. Annu Rev Biochem. 2010;79:683\u2013706.","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"1778_CR41","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0925-4439(95)00034-2","volume":"1271","author":"G Attardi","year":"1995","unstructured":"Attardi G, Yoneda M, Chomyn A. Complementation and segregation behavior of disease-causing mitochondrial Dna mutations in cellular model systems. Biochim Biophys Acta. 1995;1271(1):241\u20138.","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 3","key":"1778_CR42","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/1471-2164-15-S3-S2","volume":"15","author":"M Diroma","year":"2014","unstructured":"Diroma M, Calabrese C, Simone D, Santorsola M, Calabrese F, Gasparre G, Attimonelli M. Extraction and annotation of human mitochondrial genomes from 1000 genomes whole exome sequencing data. BMC Genomics. 2014;15(Suppl 3):S2.","journal-title":"BMC Genomics"},{"key":"1778_CR43","doi-asserted-by":"crossref","first-page":"1 23 21","DOI":"10.1002\/0471250953.bi0123s44","volume":"44","author":"M Lott","year":"2013","unstructured":"Lott M, Leipzig J, Derbeneva O, Xie H, Chalkia D, Sarmady M, Procaccio V, Wallace D. Mtdna variation and analysis using Mitomap and Mitomaster. Curr Protoc Bioinformatics. 2013;44:1 23 21\u20136.","journal-title":"Curr Protoc Bioinformatics"},{"issue":"Database Issue","key":"1778_CR44","doi-asserted-by":"publisher","first-page":"D611","DOI":"10.1093\/nar\/gki079","volume":"33","author":"M Brandon","year":"2005","unstructured":"Brandon M, Lott M, Nguyen K, Spolim S, Navathe S, Baldi P, Wallace D. Mitomap: a human mitochondrial genome database--2004 update. Nucleic Acids Res. 2005;33(Database Issue):D611\u20133.","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"1778_CR45","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.ajhg.2009.10.023","volume":"85","author":"Y Yao","year":"2009","unstructured":"Yao Y, Salas A, Logan I, Bandelt H. Mtdna Data Mining In Genbank Needs Surveying. Am J Hum Genet. 2009;85(6):929\u201333. Author Reply 933","journal-title":"Am J Hum Genet"},{"key":"1778_CR46","doi-asserted-by":"crossref","unstructured":"Diroma M, Calabrese C, Simone D, Santorsola M, Calabrese F, Gasparre G, Attimonelli M. Extraction and annotation of human mitochondrial genomes from 1000 genomes whole exome sequencing data. BMC Genomics. 2014;15","DOI":"10.1186\/1471-2164-15-S3-S2"},{"issue":"7571","key":"1778_CR47","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"Genomes Project C, Auton A, Brooks L, Durbin R, Garrison E, Kang H, Korbel J, Marchini J, Mccarthy S, Mcvean G, et al. A global reference for human genetic variation. Nature. 2015;526(7571):68\u201374.","journal-title":"Nature"},{"issue":"26","key":"1778_CR48","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","volume":"371","author":"S Jaiswal","year":"2014","unstructured":"Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman P, Mar B, Lindsley R, Mermel C, Burtt N, Chavez A, et al. Age-related Clonal Hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371(26):2488\u201398.","journal-title":"N Engl J Med"},{"issue":"1","key":"1778_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nbt.3749","volume":"35","author":"V Lo Sardo","year":"2017","unstructured":"Lo Sardo V, Ferguson W, Erikson G, Topol E, Baldwin K, Torkamani A. Influence of donor age on induced Pluripotent stem cells. Nat Biotechnol. 2017;35(1):69\u201374.","journal-title":"Nat Biotechnol"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1778-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-017-1778-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1778-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T10:53:12Z","timestamp":1589453592000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-017-1778-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1778"],"URL":"https:\/\/doi.org\/10.1186\/s12859-017-1778-6","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"assertion":[{"value":"7 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Healthy Elderly Active Longevity Cohort Study (IRB-13-6142) was approved by the Scripps Institutional Review Board in July 2007. Participants consented to broad sharing of anonymized phenotypic data.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"373"}}