{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:20:44Z","timestamp":1780636844354,"version":"3.54.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"S12","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1186\/s12859-017-1818-2","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T11:34:12Z","timestamp":1508153652000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predicting combinative drug pairs towards realistic screening via integrating heterogeneous features"],"prefix":"10.1186","volume":"18","author":[{"given":"Jian-Yu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu-Ming","family":"Yiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"1818_CR1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd2683","volume":"8","author":"J Jia","year":"2009","unstructured":"Jia J, Zhu F, Ma X, Cao Z, Li Y, Chen YZ. Mechanisms of drug combinations: interaction and network perspectives. Nat Rev Drug Discov. 2009;8:111\u201328.","journal-title":"Nat Rev Drug Discov"},{"key":"1818_CR2","first-page":"12","volume":"33","author":"J Henkel","year":"1999","unstructured":"Henkel J. Attacking AIDS with a 'cocktail' therapy? FDA Consum. 1999;33:12\u20137.","journal-title":"FDA Consum"},{"key":"1818_CR3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ctrv.2008.11.004","volume":"35","author":"J Feliu","year":"2009","unstructured":"Feliu J, Sereno M, De Castro J, Belda C, Casado E, Gonzalez-Baron M. Chemotherapy for colorectal cancer in the elderly: who to treat and what to use. Cancer Treat Rev. 2009;35:246\u201354.","journal-title":"Cancer Treat Rev"},{"key":"1818_CR4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/bioinformatics\/btp697","volume":"26","author":"Y Liu","year":"2010","unstructured":"Liu Y, Hu B, Fu C, Chen X. DCDB: drug combination database. Bioinformatics. 2010;26:587\u20138.","journal-title":"Bioinformatics"},{"key":"1818_CR5","doi-asserted-by":"crossref","first-page":"e1002323","DOI":"10.1371\/journal.pcbi.1002323","volume":"7","author":"XM Zhao","year":"2011","unstructured":"Zhao XM, Iskar M, Zeller G, Kuhn M, van Noort V, Bork P. Prediction of drug combinations by integrating molecular and pharmacological data. PLoS Comput Biol. 2011;7:e1002323.","journal-title":"PLoS Comput Biol"},{"key":"1818_CR6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jep.2013.07.001","volume":"151","author":"P Li","year":"2014","unstructured":"Li P, Chen J, Wang J, Zhou W, Wang X, Li B, Tao W, Wang W, Wang Y, Yang L. Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases. J Ethnopharmacol. 2014;151:93\u2013107.","journal-title":"J Ethnopharmacol"},{"key":"1818_CR7","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.1038\/srep07160","volume":"4","author":"H Huang","year":"2014","unstructured":"Huang H, Zhang P, Qu XA, Sanseau P, Yang L. Systematic prediction of drug combinations based on clinical side-effects. Sci Rep. 2014;4:7160.","journal-title":"Sci Rep"},{"key":"1818_CR8","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/bioinformatics\/btu046","volume":"30","author":"K Pang","year":"2014","unstructured":"Pang K, Wan YW, Choi WT, Donehower LA, Sun J, Pant D, Liu Z. Combinatorial therapy discovery using mixed integer linear programming. Bioinformatics. 2014;30:1456\u201363.","journal-title":"Bioinformatics"},{"key":"1818_CR9","doi-asserted-by":"crossref","first-page":"i228","DOI":"10.1093\/bioinformatics\/btu278","volume":"30","author":"L Huang","year":"2014","unstructured":"Huang L, Li F, Sheng J, Xia X, Ma J, Zhan M, Wong ST. DrugComboRanker: drug combination discovery based on target network analysis. Bioinformatics. 2014;30:i228\u201336.","journal-title":"Bioinformatics"},{"key":"1818_CR10","unstructured":"ATC\/DDD Methodology: History. WHO Collaborating Centre for Drug Statistics Methodology. http:\/\/www.whocc.no\/atc_ddd_index . Accessed 16 Dec 2015."},{"key":"1818_CR11","doi-asserted-by":"crossref","first-page":"D1075","DOI":"10.1093\/nar\/gkv1075","volume":"44","author":"M Kuhn","year":"2016","unstructured":"Kuhn M, Letunic I, Jensen LJ, Bork P. The SIDER database of drugs and side effects. Nucleic Acids Res. 2016;44:D1075\u20139.","journal-title":"Nucleic Acids Res"},{"key":"1818_CR12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/bioinformatics\/btv563","volume":"32","author":"S Wang","year":"2016","unstructured":"Wang S, Zhang Y, Dai W, Lauter K, Kim M, Tang Y, Xiong H, Jiang X. HEALER: homomorphic computation of ExAct logistic rEgRession for secure rare disease variants analysis in GWAS. Bioinformatics. 2016;32:211\u20138.","journal-title":"Bioinformatics"},{"key":"1818_CR13","first-page":"S2","volume":"8","author":"B Chen","year":"2015","unstructured":"Chen B, Li M, Wang J, Shang X, Wu FX. A fast and high performance multiple data integration algorithm for identifying human disease genes. BMC Med Genet. 2015;8:S2.","journal-title":"BMC Med Genet"},{"key":"1818_CR14","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","volume":"34","author":"DS Wishart","year":"2006","unstructured":"Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006;34:D668\u201372.","journal-title":"Nucleic Acids Res"},{"key":"1818_CR15","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1093\/bioinformatics\/btv055","volume":"31","author":"Z Liu","year":"2015","unstructured":"Liu Z, Guo F, Gu J, Wang Y, Li Y, Wang D, Lu L, Li D, He F. Similarity-based prediction for anatomical therapeutic chemical classification of drugs by integrating multiple data sources. Bioinformatics. 2015;31:1788\u201395.","journal-title":"Bioinformatics"},{"key":"1818_CR16","doi-asserted-by":"crossref","unstructured":"Chen L. et al. Prediction of effective drug combinations by chemical interaction, protein interaction and target enrichment of KEGG pathways. BioMed Res Int. 2013, Article ID 723780, 10 pages.","DOI":"10.1155\/2013\/723780"},{"key":"1818_CR17","unstructured":"Kenneth, H.R.: Discrete Mathematics and Its Applications, 5th Edition. Addison Wesley. ISBN 0-07-119881-4; 2003."},{"key":"1818_CR18","first-page":"297","volume":"9683","author":"J-X Li","year":"2016","unstructured":"Li J-X, Shi J-Y, Gao K, Lei P, Yiu S-M, et al. Predicting combinative drug pairs via integrating heterogeneous features for both known and new drugs. Lect Notes Comput Sci: Bioinform Res Appl. 2016;9683:297\u20138.","journal-title":"Lect Notes Comput Sci: Bioinform Res Appl"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1818-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T05:58:41Z","timestamp":1693115921000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-017-1818-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":18,"journal-issue":{"issue":"S12","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["1818"],"URL":"https:\/\/doi.org\/10.1186\/s12859-017-1818-2","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"article-number":"409"}}