{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:50:14Z","timestamp":1772765414042,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"National Natural Science Foundation of China (CN)","award":["3127076"],"award-info":[{"award-number":["3127076"]}]},{"name":"Priority Academic Program Development of the Jiangsu Higher Education Institutions (PAPD)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12859-017-1908-1","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T12:02:15Z","timestamp":1511438535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MVQTLCIM: composite interval mapping of multivariate traits in a hybrid F1 population of outbred species"],"prefix":"10.1186","volume":"18","author":[{"given":"Fenxiang","family":"Liu","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-211X","authenticated-orcid":false,"given":"Chunfa","family":"Tong","sequence":"additional","affiliation":[]},{"given":"Shentong","family":"Tao","sequence":"additional","affiliation":[]},{"given":"Jiyan","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Yuhua","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Dan","family":"Yao","sequence":"additional","affiliation":[]},{"given":"Huogen","family":"Li","sequence":"additional","affiliation":[]},{"given":"Jisen","family":"Shi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"1908_CR1","first-page":"41","volume":"19","author":"RL Wu","year":"2000","unstructured":"Wu RL, Zeng ZB, McKend SE, O'Malley DM. The case for molecular mapping in forest tree breeding. Plant Breed Rev. 2000;19:41\u201368.","journal-title":"Plant Breed Rev"},{"issue":"3","key":"1908_CR2","doi-asserted-by":"crossref","first-page":"e0150692","DOI":"10.1371\/journal.pone.0150692","volume":"11","author":"CF Tong","year":"2016","unstructured":"Tong CF, Li HG, Wang Y, Li XR, Ou JJ, Wang DY, et al. Construction of high-density linkage maps of Populus deltoides \u00d7 P. simonii using restriction-site associated DNA sequencing. PLoS One. 2016;11(3):e0150692.","journal-title":"PLoS One"},{"key":"1908_CR3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1186\/s12864-016-3003-9","volume":"17","author":"M Mousavi","year":"2016","unstructured":"Mousavi M, Tong C, Liu F, Tao S, Wu J, Li H, et al. De novo SNP discovery and genetic linkage mapping in poplar using restriction site associated DNA and whole-genome sequencing technologies. BMC Genomics. 2016;17:656.","journal-title":"BMC Genomics"},{"key":"1908_CR4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0016672397003005","volume":"70","author":"C Maliepaard","year":"1997","unstructured":"Maliepaard C, Jansen J, Van Ooijen JW. Linkage analysis in a full-sib family of an outbreeding plant species: overview and consequences for applications. Genet Res. 1997;70:237\u201350.","journal-title":"Genet Res"},{"issue":"3","key":"1908_CR5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/tpbi.2002.1577","volume":"61","author":"RL Wu","year":"2002","unstructured":"Wu RL, Ma CX, Painter I, Zeng ZB. Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species. Theor Popul Biol. 2002;61(3):349\u201363.","journal-title":"Theor Popul Biol"},{"issue":"3","key":"1908_CR6","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1590\/S1415-47572012005000044","volume":"35","author":"CF Tong","year":"2012","unstructured":"Tong CF, Zhang B, Li HG, Shi JS. Model selection for quantitative trait loci mapping in a full-sib family. Genet Mol Biol. 2012;35(3):622\u201331.","journal-title":"Genet Mol Biol"},{"key":"1908_CR7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/121.1.185","volume":"121","author":"ES Lander","year":"1989","unstructured":"Lander ES, Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989;121:185\u201399.","journal-title":"Genetics"},{"issue":"1","key":"1908_CR8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrg703","volume":"3","author":"RW Doerge","year":"2002","unstructured":"Doerge RW. Mapping and analysis of quantitative trait loci in experimental populations. Nat Rev Genet. 2002;3(1):43\u201352.","journal-title":"Nat Rev Genet"},{"issue":"23","key":"1908_CR9","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1073\/pnas.90.23.10972","volume":"90","author":"Z-B Zeng","year":"1993","unstructured":"Zeng Z-B. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci. Proc Natl Acad Sci U S A. 1993;90(23):10972\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1908_CR10","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/genetics\/136.4.1457","volume":"136","author":"Z-B Zeng","year":"1994","unstructured":"Zeng Z-B. Precision mapping of quantitative trait loci. Genetics. 1994;136:1457\u201368.","journal-title":"Genetics"},{"issue":"3","key":"1908_CR11","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/genetics\/152.3.1203","volume":"152","author":"C-H Kao","year":"1999","unstructured":"Kao C-H, Zeng Z-B, Teasdale RD. Multiple interval mapping for quantitative trait loci. Genetics. 1999;152(3):1203\u201316.","journal-title":"Genetics"},{"key":"1908_CR12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/S0016672399004255","volume":"74","author":"Z-B Zeng","year":"1999","unstructured":"Zeng Z-B, Kao C-H, Basten CJ. Estimating the genetics architecture of quantitative traits. Genet Res. 1999;74:279\u201389.","journal-title":"Genet Res"},{"key":"1908_CR13","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/genetics\/143.3.1417","volume":"143","author":"S Xu","year":"1996","unstructured":"Xu S, Atchley WR. Mapping quantitative trait loci for complex binary diseases using line crosses. Genetics. 1996;143:1417\u201324.","journal-title":"Genetics"},{"key":"1908_CR14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1534\/genetics.103.019406","volume":"169","author":"C Xu","year":"2005","unstructured":"Xu C, Li Z, Xu S. Joint mapping of quantitative trait loci for multiple binary characters. Genetics. 2005;169:1045\u201359.","journal-title":"Genetics"},{"key":"1908_CR15","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/genetics\/144.2.805","volume":"144","author":"JM Satagopan","year":"1996","unstructured":"Satagopan JM, Yandell BS, Newton MA, Osborn TC. A Bayesian approach to detect quantitative trait loci using Markov chain Monte Carlo. Genetics. 1996;144:805\u201316.","journal-title":"Genetics"},{"issue":"3","key":"1908_CR16","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1534\/genetics.104.040386","volume":"170","author":"N Yi","year":"2005","unstructured":"Yi N, Yandell BS, Churchill GA, Allison DB, Eisen EJ, Pomp D. Bayesian model selection for genome-wide epistatic quantitative trait loci analysis. Genetics. 2005;170(3):1333\u201344.","journal-title":"Genetics"},{"issue":"2","key":"1908_CR17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1541-0420.2006.00711.x","volume":"63","author":"S Xu","year":"2007","unstructured":"Xu S. An empirical Bayes method for estimating epistatic effects of quantitative trait loci. Biometrics. 2007;63(2):513\u201321.","journal-title":"Biometrics"},{"issue":"1","key":"1908_CR18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/hdy.2014.79","volume":"114","author":"A Huang","year":"2015","unstructured":"Huang A, Xu S, Cai X. Empirical Bayesian elastic net for multiple quantitative trait locus mapping. Heredity (Edinb). 2015;114(1):107\u201315.","journal-title":"Heredity (Edinb)"},{"issue":"2","key":"1908_CR19","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1534\/genetics.107.085589","volume":"179","author":"N Yi","year":"2008","unstructured":"Yi N, Xu S. Bayesian LASSO for quantitative trait loci mapping. Genetics. 2008;179(2):1045\u201355.","journal-title":"Genetics"},{"key":"1908_CR20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1534\/genetics.110.119586","volume":"186","author":"CM Mutshinda","year":"2010","unstructured":"Mutshinda CM, Sillanp\u00e4\u00e4 MJ. Extended Bayesian LASSO for multiple quantitative trait loci mapping and unobserved phenotype prediction. Genetics. 2010;186:1067\u201375.","journal-title":"Genetics"},{"key":"1908_CR21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1471-2105-12-211","volume":"12","author":"X Cai","year":"2011","unstructured":"Cai X, Huang A, Xu S. Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping. BMC Bioinformatics. 2011;12:211.","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"1908_CR22","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00122-012-1789-7","volume":"124","author":"M Fang","year":"2012","unstructured":"Fang M, Jiang D, Li D, Yang R, Fu W, Pu L, et al. Improved LASSO priors for shrinkage quantitative trait loci mapping. Theor Appl Genet. 2012;124(7):1315\u201324.","journal-title":"Theor Appl Genet"},{"issue":"2","key":"1908_CR23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1214\/15-AOAS808","volume":"9","author":"J Li","year":"2015","unstructured":"Li J, Wang Z, Li R, Wu R. Bayesian group lasso for nonparametric varying-coefficient models with application to functional genome-wide association studies. Ann Appl Stat. 2015;9(2):640\u201364.","journal-title":"Ann Appl Stat"},{"issue":"3","key":"1908_CR24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/genetics\/140.3.1111","volume":"140","author":"C Jiang","year":"1995","unstructured":"Jiang C, Zeng Z-B. Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics. 1995;140(3):1111\u201327.","journal-title":"Genetics"},{"key":"1908_CR25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2156","volume":"13","author":"ESL Da Costa","year":"2012","unstructured":"Da Costa ESL, Wang S, Zeng Z-B. Multiple trait multiple interval mapping of quantitative trait loci from inbred line crosses. BMC Genet. 2012;13:67.","journal-title":"BMC Genet"},{"issue":"3","key":"1908_CR26","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1534\/genetics.105.043828","volume":"171","author":"S Macgregor","year":"2005","unstructured":"Macgregor S, Knott SA, White I, Visscher PM. Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees. Genetics. 2005;171(3):1365\u201376.","journal-title":"Genetics"},{"key":"1908_CR27","first-page":"229","volume":"7","author":"RL Wu","year":"2006","unstructured":"Wu RL, Lin M. Functional mapping \u2013 how to map and study the genetic architecture of complex dynamic traits. Nat Rev Genet. 2006;7:229\u201337.","journal-title":"Nat Rev Genet"},{"issue":"2","key":"1908_CR28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1469-185X.2009.00096.x","volume":"85","author":"Y Li","year":"2010","unstructured":"Li Y, Wu R. Functional mapping of growth and development. Biol Rev Camb Philos Soc. 2010;85(2):207\u201316.","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"1","key":"1908_CR29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/bib\/bbs049","volume":"15","author":"Z Wang","year":"2014","unstructured":"Wang Z, Wang Y, Wang N, Wang J, Wang Z, Vallejos CE, et al. Towards a comprehensive picture of the genetic landscape of complex traits. Brief Bioinform. 2014;15(1):30\u201342.","journal-title":"Brief Bioinform"},{"issue":"1","key":"1908_CR30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s13253-016-0275-0","volume":"22","author":"J Cao","year":"2016","unstructured":"Cao J, Wang L, Huang Z, Gai J, Wu R. Functional mapping of multiple dynamic traits. J Agric Biol Environ Stat. 2016;22(1):60\u201375.","journal-title":"J Agric Biol Environ Stat"},{"key":"1908_CR31","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/genetics\/136.3.1195","volume":"136","author":"CS Haley","year":"1994","unstructured":"Haley CS, Knott SA, Elsen JM. Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics. 1994;136:1195\u2013207.","journal-title":"Genetics"},{"issue":"2","key":"1908_CR32","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/genetics\/165.2.901","volume":"165","author":"M Lin","year":"2003","unstructured":"Lin M, Lou XY, Chang M, Wu R. A general statistical framework for mapping quantitative trait loci in nonmodel systems: issue for characterizing linkage phases. Genetics. 2003;165(2):901\u201313.","journal-title":"Genetics"},{"issue":"4","key":"1908_CR33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s11295-013-0664-2","volume":"10","author":"R Gazaffi","year":"2014","unstructured":"Gazaffi R, Margarido GRA, Pastina MM, Mollinari M, Garcia AAF. A model for quantitative trait loci mapping, linkage phase, and segregation pattern estimation for a full-sib progeny. Tree Genet Genomes. 2014;10(4):791\u2013801.","journal-title":"Tree Genet Genomes"},{"key":"1908_CR34","unstructured":"Van Ooijen JW. MapQTL 6, Software for the mapping of quantitative trait loci in experimental populations of diploid species. Kyazma BV. Wageningen, Netherlands.\u00a0 https:\/\/www.kyazma.nl\/index.php\/MapQTL .\u00a0Accessed 1 Jan 2009."},{"key":"1908_CR35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11295-009-0207-z","volume":"5","author":"B Zhang","year":"2009","unstructured":"Zhang B, Tong CF, Yin T, Zhang X, Zhuge Q, Huang M, et al. Detection of quantitative trait loci influencing growth trajectories of adventitious roots in Populus using functional mapping. Tree Genet Genomes. 2009;5:539\u201352.","journal-title":"Tree Genet Genomes"},{"key":"1908_CR36","volume-title":"Linear statistical inference and its applications","author":"CR Rao","year":"1973","unstructured":"Rao CR. Linear statistical inference and its applications. 2nd ed. New York: Wiley; 1973.","edition":"2"},{"key":"1908_CR37","volume-title":"Applied multivariate statistical analysis","author":"RA Johnson","year":"2008","unstructured":"Johnson RA, Wichern DW. Applied multivariate statistical analysis. 6th ed. Beijing: Tsinghua University Press; 2008.","edition":"6"},{"key":"1908_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2517-6161.1977.tb01600.x","volume":"39","author":"AP Dempster","year":"1977","unstructured":"Dempster AP, Laird NM, Rubin DB. Maximum likelihood from incomplete data via EM algorithm. J R Stat Soc Ser B (Methodological). 1977;39:1\u201338.","journal-title":"J R Stat Soc Ser B (Methodological)"},{"key":"1908_CR39","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","volume":"138","author":"GA Churchill","year":"1994","unstructured":"Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics. 1994;138:963\u201371.","journal-title":"Genetics"},{"issue":"1","key":"1908_CR40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/genetics\/142.1.285","volume":"142","author":"RW Doerge","year":"1996","unstructured":"Doerge RW, Churchill GA. Permutation tests for multiple loci affecting a quantitative character. Genetics. 1996;142(1):285\u201394.","journal-title":"Genetics"},{"key":"1908_CR41","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","volume":"19","author":"H Akaike","year":"1974","unstructured":"Akaike H. A new look at the statistical model identification. IEEE Trans Automatic Control AC. 1974;19:716\u201323.","journal-title":"IEEE Trans Automatic Control AC"},{"key":"1908_CR42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1214\/aos\/1176344136","volume":"6","author":"G Schwarz","year":"1978","unstructured":"Schwarz G. Estimating the dimension of a model. Ann Stat. 1978;6:461\u20134.","journal-title":"Ann Stat"},{"key":"1908_CR43","first-page":"12","volume":"153","author":"K Takeuchi","year":"1976","unstructured":"Takeuchi K. Distribution of informational statistics and a criterion of model fitting. Suri-Kagaku (Mathematic Sciences, In Japanese). 1976;153:12\u20138.","journal-title":"Suri-Kagaku (Mathematic Sciences, In Japanese)"},{"key":"1908_CR44","unstructured":"Wang S, Basten CJ, Zeng Z-B. Windows QTL Cartographer 2.5. Department of Statistics, North Carolina State University, Raleigh, NC. http:\/\/statgen.ncsu.edu\/qtlcart\/WQTLCart.htm. . Accessed 1 July 2006."},{"key":"1908_CR45","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1471-2229-12-173","volume":"12","author":"R Monclus","year":"2012","unstructured":"Monclus R, Leple JC, Bastien C, Bert PF, Villar M, Marron N, et al. Integrating genome annotation and QTL position to identify candidate genes for productivity, architecture and water-use efficiency in Populus spp. BMC Plant Biol. 2012;12:173.","journal-title":"BMC Plant Biol"},{"key":"1908_CR46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.plantsci.2013.08.006","volume":"212","author":"JG Dubouzet","year":"2013","unstructured":"Dubouzet JG, Strabala TJ, Wagner A. Potential transgenic routes to increase tree biomass. Plant Sci. 2013;212:72\u2013101.","journal-title":"Plant Sci"},{"issue":"1","key":"1908_CR47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00438-016-1257-1","volume":"292","author":"L Wang","year":"2016","unstructured":"Wang L, Wang B, Du Q, Chen J, Tian J, Yang X, et al. Allelic variation in PtoPsbW associated with photosynthesis, growth, and wood properties in Populus Tomentosa. Mol Gen Genomics. 2016;292(1):77\u201391.","journal-title":"Mol Gen Genomics"},{"issue":"4","key":"1908_CR48","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/bib\/bbt019","volume":"15","author":"ZW Huang","year":"2014","unstructured":"Huang ZW, Tong CF, Bo WH, Pang XM, Wang Z, Xu JC, et al. An allometric model for mapping seed development in plants. Brief Bioinform. 2014;15(4):562\u201370.","journal-title":"Brief Bioinform"},{"issue":"1","key":"1908_CR49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/bib\/bbs067","volume":"15","author":"CF Tong","year":"2014","unstructured":"Tong CF, Shen LY, Lv YF, Wang Z, Wang XL, Feng SS, et al. Structural mapping: how to study the genetic architecture of a phenotypic trait through its formation mechanism. Brief Bioinform. 2014;15(1):43\u201353.","journal-title":"Brief Bioinform"},{"key":"1908_CR50","volume-title":"Growth curves","author":"AM Kshirsagar","year":"1995","unstructured":"Kshirsagar AM, Smith WB. Growth curves. New York: Marcel Dekker; 1995."},{"key":"1908_CR51","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/139.2.963","volume":"139","author":"HD Bradshaw","year":"1995","unstructured":"Bradshaw HD, Stettler RF. Molecular genetics of growth and development in Populus. IV. Mapping QTLs with large effects on growth, form, and phenology traits in a forest tree. Genetics. 1995;139:963\u201373.","journal-title":"Genetics"},{"key":"1908_CR52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s001220050761","volume":"96","author":"RL Wu","year":"1998","unstructured":"Wu RL. Genetic mapping of QTLs affecting tree growth and architecture in Populus: implication for ideotype breeding. Theor Appl Genet. 1998;96:447\u201357.","journal-title":"Theor Appl Genet"},{"issue":"3","key":"1908_CR53","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/nph.13695","volume":"209","author":"Q Du","year":"2016","unstructured":"Du Q, Gong C, Wang Q, Zhou D, Yang H, Pan W, et al. Genetic architecture of growth traits in Populus revealed by integrated quantitative trait locus (QTL) analysis and association studies. New Phytol. 2016;209(3):1067\u201382.","journal-title":"New Phytol"},{"key":"1908_CR54","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3389\/fpls.2017.00706","volume":"8","author":"C Su","year":"2017","unstructured":"Su C, Wang W, Gong S, Zuo J, Li S, Xu S. High density linkage map construction and mapping of yield trait QTLs in maize (Zea mays) using the genotyping-by-sequencing (GBS) technology. Front Plant Sci. 2017;8:706.","journal-title":"Front Plant Sci"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1908-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T23:57:30Z","timestamp":1719619050000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-017-1908-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,23]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1908"],"URL":"https:\/\/doi.org\/10.1186\/s12859-017-1908-1","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,23]]},"article-number":"515"}}