{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:28:08Z","timestamp":1782847688144,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"S16","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12859-017-1966-4","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T08:29:38Z","timestamp":1514449778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related protein"],"prefix":"10.1186","volume":"18","author":[{"given":"Matloob","family":"Khushi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imraan M.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdahl T.","family":"Teber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Chircop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neftali","family":"Flores-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"issue":"5","key":"1966_CR1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrm2163","volume":"8","author":"A Musacchio","year":"2007","unstructured":"Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007;8(5):379\u201393.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7037","key":"1966_CR2","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nature03502","volume":"434","author":"SJ Royle","year":"2005","unstructured":"Royle SJ, Bright NA, Lagnado L. Clathrin is required for the function of the mitotic spindle. Nature. 2005;434(7037):1152\u20137.","journal-title":"Nature"},{"issue":"7","key":"1966_CR3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.200911120","volume":"189","author":"CH Lin","year":"2010","unstructured":"Lin CH, Hu CK, Shih HM. Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J Cell Biol. 2010;189(7):1097\u2013105.","journal-title":"J Cell Biol"},{"issue":"5","key":"1966_CR4","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/emboj.2011.15","volume":"30","author":"DG Booth","year":"2011","unstructured":"Booth DG, et al. A TACC3\/ch-TOG\/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 2011;30(5):906\u201319.","journal-title":"EMBO J"},{"issue":"Pt 1","key":"1966_CR5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1242\/jcs.094607","volume":"125","author":"SJ Royle","year":"2012","unstructured":"Royle SJ. The role of clathrin in mitotic spindle organisation. J Cell Sci. 2012;125(Pt 1):19\u201328.","journal-title":"J Cell Sci"},{"issue":"1","key":"1966_CR6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","volume":"9","author":"N Otsu","year":"1979","unstructured":"Otsu N. A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern. 1979;9(1):62\u20136.","journal-title":"IEEE Trans Syst Man Cybern"},{"issue":"6","key":"1966_CR7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1600-0854.2011.01183.x","volume":"12","author":"MKE Blixt","year":"2011","unstructured":"Blixt MKE, Royle SJ. Clathrin heavy chain gene fusions expressed in human cancers: analysis of cellular functions. Traffic. 2011;12(6):754\u201361.","journal-title":"Traffic"},{"issue":"9","key":"1966_CR8","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrm3641","volume":"14","author":"SJ Royle","year":"2013","unstructured":"Royle SJ. Protein adaptation: mitotic functions for membrane trafficking proteins. Nat Rev Mol Cell Biol. 2013;14(9):592\u20139.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1966_CR9","doi-asserted-by":"crossref","first-page":"18046","DOI":"10.1038\/srep18046","volume":"5","author":"M Giladi","year":"2015","unstructured":"Giladi M, et al. Mitotic spindle disruption by alternating electric fields leads to improper chromosome segregation and mitotic catastrophe in cancer cells. Sci Rep. 2015;5:18046.","journal-title":"Sci Rep"},{"key":"1966_CR10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.compbiomed.2016.06.020","volume":"76","author":"SM Plourde","year":"2016","unstructured":"Plourde SM, et al. Computational growth model of breast microcalcification clusters in simulated mammographic environments. Comput Biol Med. 2016;76:7\u201313.","journal-title":"Comput Biol Med"},{"key":"1966_CR11","unstructured":"Costa, A. Hausdorff (box-counting) fractal dimension. 2013; Available from: \nhttp:\/\/mathworks.com\/matlabcentral\/fileexchange\/30329-hausdorff%2D-box-counting%2D-fractal-dimension\n\n."},{"issue":"1","key":"1966_CR12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01457179","volume":"79","author":"F Hausdorff","year":"1918","unstructured":"Hausdorff F. Dimension und \u00e4u\u00dferes Ma\u00df. Math Ann. 1918;79(1):157\u201379.","journal-title":"Math Ann"},{"issue":"5","key":"1966_CR13","first-page":"1","volume":"7","author":"IT Gram","year":"2005","unstructured":"Gram IT, et al. Percentage density, Wolfe\u2019s and Tabar's mammographic patterns: agreement and association with risk factors for breast cancer. Breast Cancer Res. 2005;7(5):1.","journal-title":"Breast Cancer Res"},{"issue":"1","key":"1966_CR14","doi-asserted-by":"crossref","first-page":"8879","DOI":"10.1038\/s41598-017-08786-1","volume":"7","author":"M Khushi","year":"2017","unstructured":"Khushi M, et al. MatCol: a tool to measure fluorescence signal colocalisation in biological systems. Sci Rep. 2017;7(1):8879.","journal-title":"Sci Rep"},{"issue":"5","key":"1966_CR15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1083\/jcb.201506107","volume":"210","author":"N Schweizer","year":"2015","unstructured":"Schweizer N, et al. An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region. J Cell Biol. 2015;210(5):695\u2013704.","journal-title":"J Cell Biol"},{"key":"1966_CR16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-0329-0_2","volume":"1136","author":"J Decarreau","year":"2014","unstructured":"Decarreau J, et al. Rapid measurement of mitotic spindle orientation in cultured mammalian cells. Methods Mol Biol. 2014;1136:31\u201340.","journal-title":"Methods Mol Biol"},{"issue":"5","key":"1966_CR17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/cm.20510","volume":"68","author":"L Sironi","year":"2011","unstructured":"Sironi L, et al. Automatic quantification of microtubule dynamics enables RNAi-screening of new mitotic spindle regulators. Cytoskeleton (Hoboken). 2011;68(5):266\u201378.","journal-title":"Cytoskeleton (Hoboken)"},{"issue":"6","key":"1966_CR18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/jcb.25049","volume":"116","author":"M Khushi","year":"2015","unstructured":"Khushi M. Benchmarking database performance for genomic data. J Cell Biochem. 2015;116(6):877\u201383.","journal-title":"J Cell Biochem"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1966-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T08:35:58Z","timestamp":1514450158000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-017-1966-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":18,"journal-issue":{"issue":"S16","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1966"],"URL":"https:\/\/doi.org\/10.1186\/s12859-017-1966-4","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"article-number":"566"}}