{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:15:29Z","timestamp":1788952529588,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"S16","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12859-017-1969-1","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T08:29:38Z","timestamp":1514449778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Refine gene functional similarity network based on interaction networks"],"prefix":"10.1186","volume":"18","author":[{"given":"Zhen","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maozu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"issue":"1","key":"1969_CR1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","volume":"12","author":"A-L Barab\u00e1si","year":"2011","unstructured":"Barab\u00e1si A-L, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12(1):56\u201368.","journal-title":"Nat Rev Genet"},{"issue":"5","key":"1969_CR2","doi-asserted-by":"crossref","first-page":"e19349","DOI":"10.1371\/journal.pone.0019349","volume":"6","author":"Y Fang","year":"2011","unstructured":"Fang Y, Benjamin W, Sun M, Ramani K. Global geometric affinity for revealing high fidelity protein interaction network. PLoS One. 2011;6(5):e19349.","journal-title":"PLoS One"},{"issue":"6","key":"1969_CR3","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2105-8-S6-S5","volume":"8","author":"F Markowetz","year":"2007","unstructured":"Markowetz F, Spang R. Inferring cellular networks\u2013a review. BMC bioinformatics. 2007;8(6):S5.","journal-title":"BMC bioinformatics"},{"issue":"1","key":"1969_CR4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1109\/TCBB.2015.2456876","volume":"13","author":"Y Fang","year":"2016","unstructured":"Fang Y, Sun M, Dai G, Ramain K. The intrinsic geometric structure of protein-protein interaction networks for protein interaction prediction. IEEE\/ACM Transactions on Computational Biology and Bioinformatics. 2016;13(1):76\u201385.","journal-title":"IEEE\/ACM Transactions on Computational Biology and Bioinformatics"},{"issue":"6","key":"1969_CR5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","volume":"144","author":"M Vidal","year":"2011","unstructured":"Vidal M, Cusick ME, Barabasi A-L. Interactome networks and human disease. Cell. 2011;144(6):986\u201398.","journal-title":"Cell"},{"issue":"5","key":"1969_CR6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1109\/TNB.2015.2420754","volume":"14","author":"L Zhu","year":"2015","unstructured":"Zhu L, Deng S-P, Huang D-S. A two-stage geometric method for pruning unreliable links in protein-protein networks. IEEE transactions on nanobioscience. 2015;14(5):528\u201334.","journal-title":"IEEE transactions on nanobioscience"},{"issue":"13","key":"1969_CR7","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/bioinformatics\/btq241","volume":"26","author":"D Wang","year":"2010","unstructured":"Wang D, Wang J, Lu M, Song F, Cui Q. Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases. Bioinformatics. 2010;26(13):1644\u201350.","journal-title":"Bioinformatics"},{"key":"1969_CR8","doi-asserted-by":"crossref","unstructured":"Luo J, Dai D, Cao B, Yin Y: Inferring human miRNA functional similarity based on gene ontology annotations. In: Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD), 2016 12th International Conference on: 2016. IEEE: 1407\u20131413.","DOI":"10.1109\/FSKD.2016.7603384"},{"issue":"1","key":"1969_CR9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12859-015-0789-4","volume":"16","author":"J Meng","year":"2015","unstructured":"Meng J, Liu D, Luan Y. Inferring plant microRNA functional similarity using a weighted protein-protein interaction network. BMC bioinformatics. 2015;16(1):361.","journal-title":"BMC bioinformatics"},{"issue":"2","key":"1969_CR10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1109\/TCBB.2015.2459713","volume":"13","author":"G Yu","year":"2016","unstructured":"Yu G, Fu G, Wang J, Zhu H. Predicting protein function via semantic integration of multiple networks. IEEE\/ACM Transactions on Computational Biology and Bioinformatics. 2016;13(2):220\u201332.","journal-title":"IEEE\/ACM Transactions on Computational Biology and Bioinformatics"},{"issue":"Suppl 2","key":"1969_CR11","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1752-0509-5-S2-S2","volume":"5","author":"R Jiang","year":"2011","unstructured":"Jiang R, Gan M, He P. Constructing a gene semantic similarity network for the inference of disease genes. BMC Syst Biol. 2011;5(Suppl 2):S2.","journal-title":"BMC Syst Biol"},{"issue":"20","key":"1969_CR12","first-page":"e152","volume":"44","author":"Y Xu","year":"2016","unstructured":"Xu Y, Guo M, Liu X, Wang C, Liu Y, Liu G. Identify bilayer modules via pseudo-3D clustering: applications to miRNA-gene bilayer networks. Nucleic Acids Res. 2016;44(20):e152.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1969_CR13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/bioinformatics\/btt605","volume":"30","author":"Y Xu","year":"2014","unstructured":"Xu Y, Guo M, Liu X, Wang C, Liu Y. Inferring the soybean (Glycine max) microRNA functional network based on target gene network. Bioinformatics. 2014;30(1):94\u2013103.","journal-title":"Bioinformatics"},{"issue":"1","key":"1969_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jb\/mvi094","volume":"138","author":"M Arita","year":"2005","unstructured":"Arita M. Scale-freeness and biological networks. J Biochem. 2005;138(1):1\u20134.","journal-title":"J Biochem"},{"issue":"1","key":"1969_CR15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1209\/epl\/i2004-10531-8","volume":"71","author":"MP Stumpf","year":"2005","unstructured":"Stumpf MP, Ingram PJ. Probability models for degree distributions of protein interaction networks. EPL (Europhysics Letters). 2005;71(1):152.","journal-title":"EPL (Europhysics Letters)"},{"issue":"3","key":"1969_CR16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1089\/cmb.2006.13.810","volume":"13","author":"R Khanin","year":"2006","unstructured":"Khanin R, Wit E. How scale-free are biological networks. J Comput Biol. 2006;13(3):810\u20138.","journal-title":"J Comput Biol"},{"issue":"7","key":"1969_CR17","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1186\/1471-2164-13-S7-S27","volume":"13","author":"Y Li","year":"2012","unstructured":"Li Y, Li J. Disease gene identification by random walk on multigraphs merging heterogeneous genomic and phenotype data. BMC Genomics. 2012;13(7):S27.","journal-title":"BMC Genomics"},{"issue":"18","key":"1969_CR18","doi-asserted-by":"crossref","first-page":"i561","DOI":"10.1093\/bioinformatics\/btq384","volume":"26","author":"A Schlicker","year":"2010","unstructured":"Schlicker A, Lengauer T, Albrecht M. Improving disease gene prioritization using the semantic similarity of gene ontology terms. Bioinformatics. 2010;26(18):i561\u20137.","journal-title":"Bioinformatics"},{"issue":"5","key":"1969_CR19","first-page":"429","volume":"4","author":"NT Doncheva","year":"2012","unstructured":"Doncheva NT, Kacprowski T, Albrecht M. Recent approaches to the prioritization of candidate disease genes. Wiley Interdisciplinary Reviews: Systems Biology and. Medicine. 2012;4(5):429\u201342.","journal-title":"Medicine"},{"key":"1969_CR20","doi-asserted-by":"crossref","unstructured":"Tian Z, Guo M, Wang C, Xing L, Wang L, Zhang Y: Constructing an integrated gene similarity network for the identification of disease genes. In: Bioinformatics and Biomedicine (BIBM), 2016 IEEE International Conference on: 2016. IEEE: 1663\u20131668.","DOI":"10.1109\/BIBM.2016.7822768"},{"issue":"16","key":"1969_CR21","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/bioinformatics\/btm309","volume":"23","author":"LL Elo","year":"2007","unstructured":"Elo LL, J\u00e4rvenp\u00e4\u00e4 H, Ore\u0161i\u010d M, Lahesmaa R, Aittokallio T. Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process. Bioinformatics. 2007;23(16):2096\u2013103.","journal-title":"Bioinformatics"},{"issue":"11","key":"1969_CR22","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2105-10-S11-S4","volume":"10","author":"AD Perkins","year":"2009","unstructured":"Perkins AD, Langston MA. Threshold selection in gene co-expression networks using spectral graph theory techniques. BMC bioinformatics. 2009;10(11):S4.","journal-title":"BMC bioinformatics"},{"issue":"5","key":"1969_CR23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.ejhg.5201585","volume":"14","author":"MA van Driel","year":"2006","unstructured":"van Driel MA, Bruggeman J, Vriend G, Brunner HG, Leunissen JA. A text-mining analysis of the human phenome. European journal of human genetics : EJHG. 2006;14(5):535\u201342.","journal-title":"European journal of human genetics : EJHG"},{"issue":"9","key":"1969_CR24","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/bioinformatics\/btq108","volume":"26","author":"Y Li","year":"2010","unstructured":"Li Y, Patra JC. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics. 2010;26(9):1219\u201324.","journal-title":"Bioinformatics"},{"issue":"5","key":"1969_CR25","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2105-14-S5-S5","volume":"14","author":"J Zhu","year":"2013","unstructured":"Zhu J, Qin Y, Liu T, Wang J, Zheng X. Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles. BMC bioinformatics. 2013;14(5):S5.","journal-title":"BMC bioinformatics"},{"issue":"1","key":"1969_CR26","doi-asserted-by":"crossref","first-page":"e1000641","DOI":"10.1371\/journal.pcbi.1000641","volume":"6","author":"O Vanunu","year":"2010","unstructured":"Vanunu O, Magger O, Ruppin E, Shlomi T, Sharan R. Associating genes and protein complexes with disease via network propagation. PLoS Comput Biol. 2010;6(1):e1000641.","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"1969_CR27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1109\/TCBB.2016.2520947","volume":"14","author":"X Zeng","year":"2017","unstructured":"Zeng X, Liao Y, Liu Y, Zou Q. Prediction and validation of disease genes using HeteSim scores. IEEE\/ACM Transactions on Computational Biology and Bioinformatics. 2017;14(3):687\u201395.","journal-title":"IEEE\/ACM Transactions on Computational Biology and Bioinformatics"},{"issue":"suppl_1","key":"1969_CR28","doi-asserted-by":"crossref","first-page":"D712","DOI":"10.1093\/nar\/gkq1156","volume":"39","author":"A Kamburov","year":"2010","unstructured":"Kamburov A, Pentchev K, Galicka H, Wierling C, Lehrach H, Herwig R. ConsensusPathDB: toward a more complete picture of cell biology. Nucleic Acids Res. 2010;39(suppl_1):D712\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"1969_CR29","doi-asserted-by":"crossref","first-page":"e1000443","DOI":"10.1371\/journal.pcbi.1000443","volume":"5","author":"C Pesquita","year":"2009","unstructured":"Pesquita C, Faria D, Falcao AO, Lord P, Couto FM. Semantic similarity in biomedical ontologies. PLoS Comput Biol. 2009;5(7):e1000443.","journal-title":"PLoS Comput Biol"},{"key":"1969_CR30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1613\/jair.514","volume":"11","author":"P Resnik","year":"1999","unstructured":"Resnik P. Semantic similarity in a taxonomy: an information-based measure and its application to problems of ambiguity in natural language. J Artif Intell Res. 1999;11:95\u2013130.","journal-title":"J Artif Intell Res"},{"issue":"10","key":"1969_CR31","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/bioinformatics\/btm087","volume":"23","author":"JZ Wang","year":"2007","unstructured":"Wang JZ, Du Z, Payattakool R, Philip SY, Chen C-F. A new method to measure the semantic similarity of GO terms. Bioinformatics. 2007;23(10):1274\u201381.","journal-title":"Bioinformatics"},{"key":"1969_CR32","first-page":"38","volume-title":"Proc 10th annual bio-Ontologies meeting","author":"C Pesquita","year":"2007","unstructured":"Pesquita C, Faria D, Bastos H, Falc\u00e3o A, Couto F. Evaluating GO-based semantic similarity measures. In: Proc 10th annual bio-Ontologies meeting; 2007. p. 38."},{"issue":"11","key":"1969_CR33","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/bioinformatics\/btt160","volume":"29","author":"Z Teng","year":"2013","unstructured":"Teng Z, Guo M, Liu X, Dai Q, Wang C, Xuan P. Measuring gene functional similarity based on group-wise comparison of GO terms. Bioinformatics. 2013;29(11):1424\u201332.","journal-title":"Bioinformatics"},{"issue":"4","key":"1969_CR34","first-page":"465","volume":"10","author":"Z Tian","year":"2016","unstructured":"Tian Z, Wang C, Guo M, Liu X, Teng Z. An improved method for functional similarity analysis of genes based on gene ontology. BMC Syst Biol. 2016;10(4):465.","journal-title":"BMC Syst Biol"},{"issue":"1","key":"1969_CR35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12859-016-1160-0","volume":"17","author":"R Ehsani","year":"2016","unstructured":"Ehsani R, Drablos F. TopoICSim: a new semantic similarity measure based on gene ontology. BMC bioinformatics. 2016;17(1):296.","journal-title":"BMC bioinformatics"},{"issue":"1","key":"1969_CR36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s12859-016-1294-0","volume":"17","author":"Z Tian","year":"2016","unstructured":"Tian Z, Wang C, Guo M, Liu X, Teng Z. SGFSC: speeding the gene functional similarity calculation based on hash tables. BMC bioinformatics. 2016;17(1):445.","journal-title":"BMC bioinformatics"},{"issue":"5","key":"1969_CR37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1186\/s12864-016-2828-6","volume":"17","author":"J Peng","year":"2016","unstructured":"Peng J, Li H, Liu Y, Juan L, Jiang Q, Wang Y, Chen J. InteGO2: a web tool for measuring and visualizing gene semantic similarities using gene ontology. BMC Genomics. 2016;17(5):530.","journal-title":"BMC Genomics"},{"issue":"4","key":"1969_CR38","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1109\/TCBB.2011.147","volume":"9","author":"J Wang","year":"2012","unstructured":"Wang J, Li M, Wang H, Pan Y. Identification of essential proteins based on edge clustering coefficient. IEEE\/ACM Transactions on Computational Biology and Bioinformatics. 2012;9(4):1070\u201380.","journal-title":"IEEE\/ACM Transactions on Computational Biology and Bioinformatics"},{"issue":"1","key":"1969_CR39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12918-017-0398-0","volume":"11","author":"J Yang","year":"2017","unstructured":"Yang J, Yang T, Wu D, Lin L, Yang F, Zhao J. The integration of weighted human gene association networks based on link prediction. BMC Syst Biol. 2017;11(1):12.","journal-title":"BMC Syst Biol"},{"key":"1969_CR40","doi-asserted-by":"crossref","first-page":"12261","DOI":"10.1038\/srep12261","volume":"5","author":"J Zhao","year":"2015","unstructured":"Zhao J, Miao L, Yang J, Fang H, Zhang Q-M, Nie M, Holme P, Zhou T. Prediction of links and weights in networks by reliable routes. Sci Rep. 2015;5:12261.","journal-title":"Sci Rep"},{"issue":"1","key":"1969_CR41","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1209\/0295-5075\/89\/18001","volume":"89","author":"L L\u00fc","year":"2010","unstructured":"L\u00fc L, Zhou T. Link prediction in weighted networks: the role of weak ties. EPL (Europhysics Letters). 2010;89(1):18001.","journal-title":"EPL (Europhysics Letters)"},{"issue":"12","key":"1969_CR42","first-page":"128902","volume":"20","author":"B Meng","year":"2011","unstructured":"Meng B, Ke H, Yi T. Link prediction based on a semi-local similarity index. Chinese. Phys B. 2011;20(12):128902.","journal-title":"Phys B"},{"key":"1969_CR43","doi-asserted-by":"crossref","unstructured":"Mazandu G K, Chimusa E R, Mulder N J. Gene Ontology semantic similarity tools: survey on features and challenges for biological knowledge discovery[J]. Briefings in Bioinformatics, 2016:1-16.","DOI":"10.1093\/bib\/bbw067"},{"issue":"2","key":"1969_CR44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/bioinformatics\/btm554","volume":"24","author":"Y Assenov","year":"2008","unstructured":"Assenov Y, Ram\u00edrez F, Schelhorn S-E, Lengauer T, Albrecht M. Computing topological parameters of biological networks. Bioinformatics. 2008;24(2):282\u20134.","journal-title":"Bioinformatics"},{"key":"1969_CR45","unstructured":"Moskvina A, Liu J: How to build your network? a structural analysis. arXiv preprint arXiv:160503644 2016."},{"issue":"1","key":"1969_CR46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/cercor\/bhj127","volume":"17","author":"C Stam","year":"2007","unstructured":"Stam C, Jones B, Nolte G, Breakspear M, Scheltens P. Small-world networks and functional connectivity in Alzheimer's disease. Cereb Cortex. 2007;17(1):92\u20139.","journal-title":"Cereb Cortex"},{"issue":"12","key":"1969_CR47","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1073\/pnas.122653799","volume":"99","author":"M Girvan","year":"2002","unstructured":"Girvan M, Newman ME. Community structure in social and biological networks. Proc Natl Acad Sci. 2002;99(12):7821\u20136.","journal-title":"Proc Natl Acad Sci"},{"issue":"18","key":"1969_CR48","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/bioinformatics\/bth436","volume":"20","author":"N Pr\u017eulj","year":"2004","unstructured":"Pr\u017eulj N, Corneil DG, Jurisica I. Modeling interactome: scale-free or geometric? Bioinformatics. 2004;20(18):3508\u201315.","journal-title":"Bioinformatics"},{"issue":"6","key":"1969_CR49","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s11390-014-1492-z","volume":"29","author":"Q-G Dai","year":"2014","unstructured":"Dai Q-G, Guo M-Z, Liu X-Y, Teng Z-X, Wang C-Y. CPL: detecting protein complexes by propagating labels on protein-protein interaction network. J Comput Sci Technol. 2014;29(6):1083\u201393.","journal-title":"J Comput Sci Technol"},{"issue":"1","key":"1969_CR50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2105-14-163","volume":"14","author":"N Zaki","year":"2013","unstructured":"Zaki N, Efimov D, Berengueres J. Protein complex detection using interaction reliability assessment and weighted clustering coefficient. BMC bioinformatics. 2013;14(1):163.","journal-title":"BMC bioinformatics"},{"issue":"7","key":"1969_CR51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12859-016-1096-4","volume":"17","author":"E Ramadan","year":"2016","unstructured":"Ramadan E, Naef A, Ahmed M. Protein complexes predictions within protein interaction networks using genetic algorithms. BMC bioinformatics. 2016;17(7):269.","journal-title":"BMC bioinformatics"},{"issue":"suppl 1","key":"1969_CR52","doi-asserted-by":"crossref","first-page":"D497","DOI":"10.1093\/nar\/gkp914","volume":"38","author":"A Ruepp","year":"2010","unstructured":"Ruepp A, Waegele B, Lechner M, Brauner B, Dunger-Kaltenbach I, Fobo G, Frishman G, Montrone C, Mewes H-W. CORUM: the comprehensive resource of mammalian protein complexes\u20142009. Nucleic Acids Res. 2010;38(suppl 1):D497\u2013501.","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"1969_CR53","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1101\/gr.118992.110","volume":"21","author":"I Lee","year":"2011","unstructured":"Lee I, Blom UM, Wang PI, Shim JE, Marcotte EM. Prioritizing candidate disease genes by network-based boosting of genome-wide association data. Genome Res. 2011;21(7):1109\u201321.","journal-title":"Genome Res"},{"issue":"D1","key":"1969_CR54","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2014","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP. STRING v10: protein\u2013protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2014;43(D1):D447\u201352.","journal-title":"Nucleic Acids Res"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-017-1969-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T08:22:21Z","timestamp":1751185341000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-017-1969-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":54,"journal-issue":{"issue":"S16","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1969"],"URL":"https:\/\/doi.org\/10.1186\/s12859-017-1969-1","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"article-number":"550"}}