{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:37:37Z","timestamp":1775255857873,"version":"3.50.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"publisher","award":["JenAge"],"award-info":[{"award-number":["JenAge"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"publisher","award":["SyStaR"],"award-info":[{"award-number":["SyStaR"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1074, Project Z1"],"award-info":[{"award-number":["SFB 1074, Project Z1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"publisher","award":["e:Med, SYMBOL-HF, ID 01ZX1407A"],"award-info":[{"award-number":["e:Med, SYMBOL-HF, ID 01ZX1407A"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["CAM-PaC, 602783"],"award-info":[{"award-number":["CAM-PaC, 602783"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12859-018-2393-x","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T11:17:17Z","timestamp":1540293437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["3D Network exploration and visualisation for lifespan data"],"prefix":"10.1186","volume":"19","author":[{"given":"Rolf","family":"H\u00fchne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"F\u00fcrstberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"K\u00fchlwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Platzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"S\u00fchnel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Lausser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-5254","authenticated-orcid":false,"given":"Hans A.","family":"Kestler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"issue":"1","key":"2393_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1371\/journal.pgen.0010017","volume":"1","author":"M Hansen","year":"2005","unstructured":"Hansen M, Hsu A-L, Dillin A, Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a caenorhabditis elegans genomic rnai screen. PLoS Genet. 2005; 1(1):17\u201301190128.","journal-title":"PLoS Genet"},{"issue":"5","key":"2393_CR2","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cell.2006.01.039","volume":"124","author":"RJ Berman","year":"2006","unstructured":"Berman RJ, Kenyon C. Germ-cell loss extends c. elegans life span through regulation of daf-16 by kri-1 and lipophilic-hormone signaling. Cell. 2006; 124(5):1055\u201368.","journal-title":"Cell"},{"issue":"8","key":"2393_CR3","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1093\/bioinformatics\/bti169","volume":"21","author":"HA Kestler","year":"2005","unstructured":"Kestler HA, M\u00fcller A, Gress TM, M B. Generalized venn diagrams: a new method of visualizing complex genetic set relations. Bioinformatics. 2005; 21(8):1592\u20135.","journal-title":"Bioinformatics"},{"key":"2393_CR4","volume-title":"Perception and Interactive Technologies","author":"HA Kestler","year":"2006","unstructured":"Kestler HA, M\u00fcller A, Buchholz M, Gress TM, Palm G. A perceptually optimized scheme for visualizing gene expression ratios with confidence values In: Andr\u00e9 E, Dybkj\u00e6r L, Minker W, Neumann H, Weber M, editors. Perception and Interactive Technologies. Berlin: Springer: 2006. p. 73\u201384."},{"issue":"4","key":"2393_CR5","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/bioinformatics\/btl608","volume":"23","author":"A M\u00fcller","year":"2007","unstructured":"M\u00fcller A, Holzmann K, Kestler HA. Visualization of genomic aberrations using affymetrix snp arrays. Bioinformatics. 2007; 23(4):496\u20137.","journal-title":"Bioinformatics"},{"key":"2393_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1471-2105-9-67","volume":"9","author":"HA Kestler","year":"2008","unstructured":"Kestler HA, M\u00fcller A, Kraus JM, Buchholz M, Gress TM, Liu H, Kane DW, Zeeberg BR, Weinstein JN. Vennmaster: area-proportional euler diagrams for functional go analysis of microarrays. BMC Bioinforma. 2008; 9:67.","journal-title":"BMC Bioinforma"},{"issue":"9","key":"2393_CR7","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/nmeth.2151","volume":"9","author":"N Gehlenborg","year":"2012","unstructured":"Gehlenborg N, Wong B. Into the third dimension. Nat Methods. 2012; 9(9):851.","journal-title":"Nat Methods"},{"issue":"2","key":"2393_CR8","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/BF02522826","volume":"17","author":"RF Cohen","year":"1997","unstructured":"Cohen RF, Eades P, Lin T, Ruskey F. Three-dimensional graph drawing. Algorithmica. 1997; 17(2):199\u2013208.","journal-title":"Algorithmica"},{"issue":"6059","key":"2393_CR9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/320264a0","volume":"320","author":"K Nakayama","year":"1986","unstructured":"Nakayama K, Siverman GH. Serial and parallel processing of visual feature conjunctions. Nature. 1986; 320(6059):264\u20135.","journal-title":"Nature"},{"issue":"4943","key":"2393_CR10","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1126\/science.2300824","volume":"247","author":"JT Enns","year":"1990","unstructured":"Enns JT, Rensink RA. Influence of scene-based properties on visual search. Science. 1990; 247(4943):721\u20133.","journal-title":"Science"},{"issue":"1","key":"2393_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/00335557743000080","volume":"29","author":"WA Phillips","year":"1977","unstructured":"Phillips WA, Christie DFM. Components of visual memory. Q J Exp Psychol. 1977; 29(1):117\u201333.","journal-title":"Q J Exp Psychol"},{"issue":"4","key":"2393_CR12","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1037\/0096-3445.136.4.653","volume":"136","author":"Y Xu","year":"2007","unstructured":"Xu Y, Nakayama K. Visual Short-Term Memory Benefit for Objects on Different 3-D Surfaces. J Exp Psychol Gen. 2007; 136(4):653\u201362.","journal-title":"J Exp Psychol Gen"},{"key":"2393_CR13","volume-title":"Visualization Analysis & Design","author":"T Munzner","year":"2015","unstructured":"Munzner T. Rules of thumb In: Munzner T, editor. Visualization Analysis & Design. Boca Raton: A K Peters\/CRC press: 2015. p. 116\u2013144."},{"issue":"Database issue","key":"2393_CR14","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1093\/nar\/gkt1073","volume":"42","author":"R H\u00fchne","year":"2014","unstructured":"H\u00fchne R, Thalheim T, S\u00fchnel J. AgeFactDB \u2013 The JenAge Ageing Factor Database \u2013 Towards data integration in ageing research. Nucleic Acids Res. 2014; 42(Database issue):892\u20136.","journal-title":"Nucleic Acids Res"},{"key":"#cr-split#-2393_CR15.1","unstructured":"NCBI Resource Coordinators. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 2015"},{"key":"#cr-split#-2393_CR15.2","unstructured":"43(Database issue):6-17. http:\/\/www.ncbi.nlm.nih.gov\/homologene . Accessed 03 Nov 2017."},{"key":"2393_CR16","unstructured":"AgeFactDB Lifespan Observation OB_000094. http:\/\/agefactdb.jenage.de\/cgi-bin\/jaDB.cgi?RKEY=r001&SEARCH=OB_000094&TYPE=d_ob&VIEW=detail . Accessed 03 Nov 2017."},{"key":"2393_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1046\/j.1474-9728.2003.00033.x","volume":"2","author":"P Fabrizio","year":"2003","unstructured":"Fabrizio P, Longo VD. The chronological life span of Saccharomyces cerevisiae,. Aging Cell. 2003; 2:73\u201381.","journal-title":"Aging Cell"},{"key":"2393_CR18","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1038\/1831751a0","volume":"183","author":"RK Mortimer","year":"1959","unstructured":"Mortimer RK, Johnston JR. Life Span of Individual Yeast Cells. Nature. 1959; 183:1751\u20132.","journal-title":"Nature"},{"key":"2393_CR19","doi-asserted-by":"crossref","unstructured":"Hagberg AA, Schult DA, Swart PJ. Exploring network structure dynamics, and function using NetworkX In: Varoquaux G, Vaught T, Millman J, editors. Proceedings of the 7th Python in Science Conference(SciPy2008).2008. p. 11\u20135.","DOI":"10.25080\/TCWV9851"},{"issue":"1695","key":"2393_CR20","first-page":"1","volume":"Complex Systems","author":"G Csardi","year":"2006","unstructured":"Csardi G, Nepusz T. The igraph software package for complex network research. Inter Journal. 2006; Complex Systems(1695):1\u20139.","journal-title":"Inter Journal"},{"key":"2393_CR21","unstructured":"vis.js - A dynamic, browser based visualization library. http:\/\/visjs.org Accessed 03 Nov 2017."},{"key":"2393_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/1752-0509-6-139","volume":"6","author":"H Rohn","year":"2012","unstructured":"Rohn H, Junker A, Hartmann A, Grafahrend-Belau E, Treutler H, Klapperst\u00fcck M, Czauderna T, Klukas C, Schreiber F. VANTED v2: a framwork for systems biology applications. BMC Syst Biol. 2012; 6:139.","journal-title":"BMC Syst Biol"},{"issue":"4","key":"2393_CR23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1145\/245882.245901","volume":"25","author":"CK Cox","year":"1996","unstructured":"Cox CK, Eick GS, He T. 3D Geographic Network Displays. ACM SIGMOD Record. 1996; 25(4):50\u20134.","journal-title":"ACM SIGMOD Record"},{"key":"2393_CR24","unstructured":"Cy, 3D. Simple 3D Network Renderer App. http:\/\/apps.cytoscape.org\/apps\/cy3d . Accessed 03 Nov 2017."},{"issue":"11","key":"2393_CR25","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, A M, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Research. 2003; 13(11):2498\u2013504.","journal-title":"Genome Research"},{"issue":"10","key":"2393_CR26","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/nprot.2009.177","volume":"4","author":"A Theocharidis","year":"2009","unstructured":"Theocharidis A, van Dongen S, Enright AJ, Freeman TC. Network visualization and analysis of gene expression data using BioLayout Express3D. Nature Protocols. 2009; 4(10):1535\u201350.","journal-title":"Nature Protocols"},{"key":"2393_CR27","volume-title":"Large-graph layout with the fast multipole multilevel method. Technical report","author":"S Hachul","year":"2005","unstructured":"Hachul S, J\u00fcnger M. Large-graph layout with the fast multipole multilevel method. Technical report. Cologne: University of Cologne, Computer Science Department; 2005. http:\/\/e-archive.informatik.uni-koeln.de\/509\/ ."},{"issue":"8","key":"2393_CR28","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1101\/gr.180801","volume":"11","author":"Gene Ontology Consortium","year":"2001","unstructured":"Gene Ontology Consortium. Creating the gene ontology resource: design and implementation. Genome Res. 2001; 11(8):1425\u201333.","journal-title":"Genome Res"},{"issue":"Database issue","key":"2393_CR29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/nar\/gkt1076","volume":"42","author":"M Kanehisa","year":"2014","unstructured":"Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M, Tanabe M. Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res. 2014; 42(Database issue):199\u2013205.","journal-title":"Nucleic Acids Res"},{"key":"2393_CR30","unstructured":"Wiki WP. Main Page \u2014 WebGL Public Wiki."},{"key":"2393_CR31","volume-title":"Three.js Framework","author":"B Danchilla","year":"2012","unstructured":"Danchilla B. Three.js Framework. Berkeley: Apress; 2012, pp. 173\u2013203."},{"key":"2393_CR32","volume-title":"Learning Neo4j","author":"R Van Bruggen","year":"2014","unstructured":"Van Bruggen R. Learning Neo4j. Birmingham: Packt Publishing; 2014."},{"key":"2393_CR33","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1103\/PhysRev.159.98","volume":"159","author":"L Verlet","year":"1967","unstructured":"Verlet L. Computer \u201cexperiments\u201d on classical fluids. i. thermodynamical properties of lennard-jones molecules. Phys Rev. 1967; 159:98\u2013103.","journal-title":"Phys Rev"},{"issue":"11","key":"2393_CR34","first-page":"1129","volume":"21","author":"TMJ Fruchterman","year":"1991","unstructured":"Fruchterman TMJ, Reingold EM. Graph drawing by force-directed placement. Softw: Pract Experience. 1991; 21(11):1129\u201364.","journal-title":"Softw: Pract Experience"},{"issue":"2","key":"2393_CR35","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.arr.2010.04.001","volume":"10","author":"DS Evans","year":"2011","unstructured":"Evans DS, Kapahi P, Hsueh W-C. TOR signaling never gets old: Aging, longevity and TORC1 activity. Ageing Res Rev. 2011; 10(2):225\u201337.","journal-title":"Ageing Res Rev"},{"issue":"3","key":"2393_CR36","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0092-8674(84)90340-4","volume":"36","author":"S Powers","year":"1984","unstructured":"Powers S, Kataoka T, Fasano O, Goldfarb M, Strathern J, Wigler M. Genes in S. cerevisiae Encoding Proteins with Domains Homologous to the Mammalian ras Proteins. Cell. 1984; 36(3):607\u201312.","journal-title":"Cell"},{"key":"2393_CR37","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1038\/ncomms4563","volume":"5","author":"S Weimer","year":"2014","unstructured":"Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M. D-glucosamine supplementation extends life span of nematodes and of ageing mice. Nat Commun. 2014; 5:3563.","journal-title":"Nat Commun"},{"issue":"Database issue","key":"2393_CR38","first-page":"991","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H, Zhang N, Robertson CL, Serova N, Davis S, Soboleva A. NCBI GEO: archive for functional genomics data sets\u2013update. Nucleic Acids Res. 2013; 41(Database issue):991\u20135.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"2393_CR39","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/nar\/gku1055","volume":"43","author":"GR Brown","year":"2015","unstructured":"Brown GR, Hem V, Katz KS, Ovetsky M, Wallin C, Ermolaeva O, Tolstoy I, Tatusova T, Pruitt KD, Maglott DR, Murphy TD. Gene: a gene-centered information resource at NCBI. Nucleic Acids Res. 2015; 43(Database issue):36\u201342.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"2393_CR40","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/nar\/gkp858","volume":"38","author":"LY Geer","year":"2010","unstructured":"Geer LY, Marchler-Bauer A, Geer RC, Han L, He J, He S, Liu C, Shi W, Bryant SH. The NCBI BioSystems database. Nucleic Acids Res. 2010; 38(Database issue):492\u20136.","journal-title":"Nucleic Acids Res"},{"issue":"37","key":"2393_CR41","doi-asserted-by":"publisher","first-page":"31414","DOI":"10.1074\/jbc.M112.377275","volume":"287","author":"Y Yuan","year":"2012","unstructured":"Yuan Y, Kadiyala CS, Ching TT, Hakimi P, Saha S, Xu H, Yuan C, Mullangi V, Wang L, Fivenson E, Hanson R, Ewing R, Hsu A, Miyagi M, Feng Z. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012; 287(37):31414\u201326.","journal-title":"J Biol Chem"},{"issue":"2","key":"2393_CR42","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.jmb.2004.07.036","volume":"342","author":"YI Kim","year":"2004","unstructured":"Kim YI, Cho JH, Yoo OJ, Ahnn J. Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C. elegans. J Mol Biol. 2004; 342(2):421\u201333.","journal-title":"J Mol Biol"},{"issue":"4","key":"2393_CR43","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.cell.2013.01.020","volume":"152","author":"R Xiao","year":"2013","unstructured":"Xiao R, Zhang B, Dong Y, Gong J, Xu T, Liu J, Xu XZ. A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell. 2013; 152(4):806\u201317.","journal-title":"Cell"},{"issue":"4","key":"2393_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/jbiol61","volume":"6","author":"M Ralser","year":"2007","unstructured":"Ralser M, Wamelink MM, Kowald A, Gerisch B, Heeren G, Struys EA, Klipp E, Jakobs C, Breitenbach M, Lehrach H, Krobitsch S. Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress. J Biol. 2007; 6(4):10.","journal-title":"J Biol"},{"key":"2393_CR45","unstructured":"Digital Ageing Atlas. Human Gene ACADM. http:\/\/ageing-map.org\/atlas\/gene\/34\/ Accessed 03 Nov 2017."},{"key":"2393_CR46","unstructured":"WormBase. Caenorhabditis elegans Gene alh-4. http:\/\/www.wormbase.org\/species\/c_elegans\/gene\/WBGene00000110 Accessed 03 Nov 2017."},{"issue":"4","key":"2393_CR47","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cmet.2012.02.013","volume":"15","author":"K Zarse","year":"2012","unstructured":"Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M. Impaired insulin\/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab. 2012; 15(4):451\u201365.","journal-title":"Cell Metab"},{"issue":"9","key":"2393_CR48","doi-asserted-by":"publisher","first-page":"1001125","DOI":"10.1371\/journal.pgen.1001125","volume":"6","author":"B Thyagarayan","year":"2010","unstructured":"Thyagarayan B, Blaszczak AG, Chandler KJ, Watts JL, Johnson WE, Graves BJ. ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet. 2010; 6(9):1001125.","journal-title":"PLoS Genet"},{"key":"2393_CR49","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/B978-0-12-384878-9.00015-7","volume":"100","author":"B Wolozin","year":"2011","unstructured":"Wolozin B, Gabel C, Ferree A, Guillily M, Ebata A. Watching worms whither: modeling neurodegeneration in C. elegans. Prog Mol Biol Transl Sci. 2011; 100:499\u2013514.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"6","key":"2393_CR50","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/bies.201100189","volume":"34","author":"D Ackerman","year":"2012","unstructured":"Ackerman D, Gems D. The mystery of C. elegans aging: An emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome?. Bioessays. 2012; 34(6):466\u201371.","journal-title":"Bioessays"},{"issue":"10","key":"2393_CR51","doi-asserted-by":"publisher","first-page":"1003908","DOI":"10.1371\/journal.pgen.1003908","volume":"9","author":"AA Soukas","year":"2013","unstructured":"Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet. 2013; 9(10):1003908.","journal-title":"PLoS Genet"},{"issue":"3","key":"2393_CR52","doi-asserted-by":"publisher","first-page":"92552","DOI":"10.1371\/journal.pone.0092552","volume":"9","author":"JD Ward","year":"2014","unstructured":"Ward JD, Mullaney B, Schiller BJ, He LD, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, et al.Defects in the c. elegans acyl-coa synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One. 2014; 9(3):92552.","journal-title":"PLoS One"},{"issue":"1","key":"2393_CR53","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1474-9726.2011.00765.x","volume":"11","author":"P Reis-Rodrigues","year":"2012","unstructured":"Reis-Rodrigues P, Czerwieniec G, Peters TW, Evani US, Alavez S, Gaman EA, Vantipalli M, Mooney SD, Gibson BW, Lithgow GJ, et al.Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell. 2012; 11(1):120\u20137.","journal-title":"Aging Cell"},{"issue":"19","key":"2393_CR54","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cub.2007.08.058","volume":"17","author":"WM Shaw","year":"2007","unstructured":"Shaw WM, Luo S, Landis J, Ashraf J, Murphy CT. The c. elegans tgf- \u03b2 dauer pathway regulates longevity via insulin signaling. Curr Biol. 2007; 17(19):1635\u201345.","journal-title":"Curr Biol"},{"issue":"6946","key":"2393_CR55","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nature01789","volume":"424","author":"CT Murphy","year":"2003","unstructured":"Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. Genes that act downstream of daf-16 to influence the lifespan of caenorhabditis elegans. Nature. 2003; 424(6946):277\u201383.","journal-title":"Nature"},{"key":"2393_CR56","doi-asserted-by":"crossref","unstructured":"Gao A, Smith R, Van Weeghel M, Kamble R, Houtkooper R. Identification of key pathways and metabolic fingerprints of longevity in c. elegans. bioRxiv; 2017.","DOI":"10.1101\/222554"},{"issue":"5","key":"2393_CR57","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00284-017-1416-6","volume":"75","author":"G Kwon","year":"2018","unstructured":"Kwon G, Lee J, Koh J-H, Lim Y-H. Lifespan extension of caenorhabditis elegans by butyricicoccus pullicaecorum and megasphaera elsdenii with probiotic potential. Curr Microbiol. 2018; 75(5):557\u201364.","journal-title":"Curr Microbiol"},{"issue":"1","key":"2393_CR58","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.celrep.2012.12.018","volume":"3","author":"M Uno","year":"2013","unstructured":"Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, Ebisuya M, Yamamoto T, Matsumoto K, Nishida E. A fasting-responsive signaling pathway that extends life span in c. elegans. Cell Rep. 2013; 3(1):79\u201391.","journal-title":"Cell Rep"},{"issue":"4","key":"2393_CR59","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/j.1474-9726.2010.00575.x","volume":"9","author":"H Iwasa","year":"2010","unstructured":"Iwasa H, Yu S, Xue J, Driscoll M. Novel egf pathway regulators modulate c. elegans healthspan and lifespan via egf receptor, plc- \u03b3, and ip3r activation. Aging Cell. 2010; 9(4):490\u2013505.","journal-title":"Aging Cell"},{"key":"2393_CR60","first-page":"10","volume":"2018","author":"F Meng","year":"2018","unstructured":"Meng F, Li J, Rao Y, Wang W, Fu Y. Gengnianchun extends the lifespan of caenorhabditis elegans via the insulin\/igf-1 signalling pathway. Oxidative Med Cell Longev. 2018; 2018:10.","journal-title":"Oxidative Med Cell Longev"},{"issue":"11","key":"2393_CR61","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1046\/j.1365-2443.2003.00682.x","volume":"8","author":"Y Sasagawa","year":"2003","unstructured":"Sasagawa Y, Urano T, Kohara Y, Takahashi H, Higashitani A. Caenorhabditis elegans rbx1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis. Genes to Cells. 2003; 8(11):857\u201372.","journal-title":"Genes to Cells"},{"issue":"3","key":"2393_CR62","doi-asserted-by":"publisher","first-page":"59493","DOI":"10.1371\/journal.pone.0059493","volume":"8","author":"C Pujol","year":"2013","unstructured":"Pujol C, Bratic-Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, Pavlenko V, Trifunovic A. Succinate dehydrogenase upregulation destabilize complex i and limits the lifespan of gas-1 mutant. PloS one. 2013; 8(3):59493.","journal-title":"PloS one"},{"issue":"3","key":"2393_CR63","doi-asserted-by":"publisher","first-page":"215","DOI":"10.18632\/aging.100648","volume":"6","author":"K He","year":"2014","unstructured":"He K, Zhou T, Shao J, Ren X, Zhao Z, Liu D. Dynamic regulation of genetic pathways and targets during aging in caenorhabditis elegans. Aging (Albany NY). 2014; 6(3):215\u201330.","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"2393_CR64","doi-asserted-by":"publisher","first-page":"1004752","DOI":"10.1371\/journal.pgen.1004752","volume":"10","author":"MC Wang","year":"2014","unstructured":"Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G. Gene pathways that delay caenorhabditis elegans reproductive senescence. PLoS Genet. 2014; 10(12):1004752.","journal-title":"PLoS Genet"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-018-2393-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-018-2393-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-018-2393-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:17:11Z","timestamp":1775251031000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-018-2393-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2393"],"URL":"https:\/\/doi.org\/10.1186\/s12859-018-2393-x","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]},"assertion":[{"value":"10 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"390"}}