{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:07:31Z","timestamp":1767276451405,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DBI 0701846"],"award-info":[{"award-number":["DBI 0701846"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 GM108538"],"award-info":[{"award-number":["P41 GM108538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12859-018-2564-9","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T12:20:51Z","timestamp":1547209251000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["MS-Helios: a Circos wrapper to visualize multi-omic datasets"],"prefix":"10.1186","volume":"20","author":[{"given":"Harald","family":"Marx","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua J.","family":"Coon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"2564_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1471-2105-13-58","volume":"13","author":"J Boyle","year":"2012","unstructured":"Boyle J, Kreisberg R, Bressler R, Killcoyne S. Methods for visual mining of genomic and proteomic data atlases. BMC bioinformatics. 2012;13:58.","journal-title":"BMC bioinformatics"},{"issue":"11","key":"2564_CR2","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/nbt.3683","volume":"34","author":"JA Stefely","year":"2016","unstructured":"Stefely JA, et al. Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling. Nat Biotechnol. 2016;34(11):1191\u20137.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"2564_CR3","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/bib\/bbv108","volume":"17","author":"C Meng","year":"2016","unstructured":"Meng C, et al. Dimension reduction techniques for the integrative analysis of multi-omics data. Brief Bioinform. 2016;17(4):628\u201341.","journal-title":"Brief Bioinform"},{"issue":"11","key":"2564_CR4","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/nbt.3681","volume":"34","author":"H Marx","year":"2016","unstructured":"Marx H, et al. A proteomic atlas of the legume Medicago truncatula and its nitrogen-fixing endosymbiont Sinorhizobium meliloti. Nat Biotechnol. 2016;34(11):1198\u2013205.","journal-title":"Nat Biotechnol"},{"issue":"9","key":"2564_CR5","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1101\/gr.092759.109","volume":"19","author":"M Krzywinski","year":"2009","unstructured":"Krzywinski M, et al. Circos: an information aesthetic for comparative genomics. Genome Res. 2009;19(9):1639\u201345.","journal-title":"Genome Res"},{"issue":"19","key":"2564_CR6","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","volume":"30","author":"Z Gu","year":"2014","unstructured":"Gu Z, Gu L, Eils R, Schlesner M, Brors B. Circlize implements and enhances circular visualization in R. Bioinformatics (Oxford, England). 2014;30(19):2811\u20132.","journal-title":"Bioinformatics (Oxford, England)"},{"key":"2564_CR7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4137\/CIN.S13495","volume":"13","author":"Y Hu","year":"2014","unstructured":"Hu Y, et al. OmicCircos: a simple-to-use R package for the circular visualization of multidimensional omics data. Cancer Informat. 2014;13:13\u201320.","journal-title":"Cancer Informat"},{"key":"2564_CR8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/1471-2105-15-198","volume":"15","author":"D Naquin","year":"2014","unstructured":"Naquin D, d\u00c1ubenton Carafa Y, Thermes C, Silvain M. CIRCUS: a package for Circos display of structural genome variations from paired-end and mate-pair sequencing data. BMC bioinformatics. 2014;15:198.","journal-title":"BMC bioinformatics"},{"key":"2564_CR9","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/1471-2105-14-244","volume":"14","author":"H Zhang","year":"2013","unstructured":"Zhang H, Meltzer P, Davis S. RCircos: an R package for Circos 2D track plots. BMC bioinformatics. 2013;14:244.","journal-title":"BMC bioinformatics"},{"issue":"9","key":"2564_CR10","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/bioinformatics\/btu842","volume":"31","author":"J An","year":"2015","unstructured":"An J, et al. J-Circos: an interactive Circos plotter. Bioinformatics (Oxford, England). 2015;31(9):1463\u20135.","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"8","key":"2564_CR11","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1021\/acs.jproteome.7b00184","volume":"16","author":"H Marx","year":"2017","unstructured":"Marx H, et al. Annotation of the domestic pig genome by quantitative Proteogenomics. J Proteome Res. 2017;16(8):2887\u201398.","journal-title":"J Proteome Res"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-018-2564-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-018-2564-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-018-2564-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T11:18:33Z","timestamp":1589455113000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-018-2564-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,11]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2564"],"URL":"https:\/\/doi.org\/10.1186\/s12859-018-2564-9","relation":{},"ISSN":["1471-2105"],"issn-type":[{"type":"electronic","value":"1471-2105"}],"subject":[],"published":{"date-parts":[[2019,1,11]]},"assertion":[{"value":"17 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"21"}}